Patents Assigned to UNIVERSIDAD DE NAVARRA
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Patent number: 10993994Abstract: The present invention refers to nanoparticles comprising a core, said core comprising a non-crosslinked albumin matrix and a monoclonal antibody, optionally coated with a non-ionic polymer for use as a medicament, to a pharmaceutical composition comprising said nanoparticles, as well as their use in the treatment of cancer an ocular diseases.Type: GrantFiled: June 21, 2018Date of Patent: May 4, 2021Assignees: UNIVERSIDAD NACIONAL DE CÓRDOBA, CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS, UNIVERSIDAD DE NAVARRAInventors: Daniel Alberto Allemandi, Carolina Boiero, Juan Manuel Irache Garreta, Juan Manuel Llabot, Inés Luis De Redíin Subirá, Iván Peñuelas Sánchez, Gemma Quincoces Fernández
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Patent number: 10993915Abstract: The invention relates to self-assembling microparticles comprising a solid matrix and probiotic bacteria, wherein the solid matrix comprises soybean protein and a divalent or trivalent metal, and wherein the probiotic bacteria are distributed throughout the solid matrix; said matrix protects said probiotic bacteria during processing, storage, as well as during transit through the gastrointestinal tract, thus prolonging their lifetime and facilitating release into the intestine and improving their probiotic effect. The present invention also relates to the method for obtaining the self-assembling microparticles and to the products and compositions incorporating them.Type: GrantFiled: December 16, 2016Date of Patent: May 4, 2021Assignees: UNIVERSIDAD DE NAVARRA, CENTRO NACIONAL DE TECNOLOGIA Y SEGURIDAD ALIMENTARIAInventors: Carolina González Ferrero, Carlos Javier González Navarro, Juan Manuel Irache Garreta, Beatriz Marín Calvo, Ana Romo Hualde, Raquel Virto Resano
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Patent number: 10894006Abstract: The present invention relates to nanoparticles for encapsulating compounds, the preparation and uses thereof, comprising a casein matrix, a basic amino acid and a metal selected from a divalent metal, a trivalent metal and combinations thereof. Said nanoparticles can encapsulate a water soluble or fat soluble biologically active compound. The invention is applicable in the food, pharmaceutical and cosmetic sectors and in the nanotechnology sector.Type: GrantFiled: February 24, 2011Date of Patent: January 19, 2021Assignees: CENTRO NACIONAL DE TECNOLOGÍA Y SEGURIDAD ALIMENTARIA, LABORATORIO DEL EBRO, UNIVERSIDAD DE NAVARRAInventors: Maite Agüeros Bazo, Irene Esparza Catalán, Carolina González Ferrero, Carlos Javier González Navarro, Juan Manuel Irache Garreta, Ana Romo Hualde
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Patent number: 10111835Abstract: The invention relates to microparticles comprising a matrix formed by casein and chitosan, and probiotic bacteria; said matrix protects said probiotic bacteria during (i) processing, (ii) storage and (iii) transit through the gastrointestinal tract, prolonging their lifetime. The present invention also relates to the method for obtaining the microparticles and to the products and compositions incorporating them.Type: GrantFiled: July 5, 2013Date of Patent: October 30, 2018Assignees: CENTRO NACIONAL DE TECNOLOGÍA Y SEGURIDAD ALIMENTARIA, LABORATORIO DEL EBRO, UNIVERSIDAD DE NAVARRAInventors: Maite Agüeros Bazo, Irene Esparza Catalán, Carlos Gamazo De La Rasilla, Carolina González Ferrero, Carlos Javier González navarro, Juan Manuel Irache Garreta, Rebeca Peñalba Sobrón, Ana Romo Hualde, Raquel Virto Resano
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Patent number: 9381252Abstract: The present invention relates to nanoparticles for the encapsulation of compounds, the obtaining and uses thereof. The nanoparticles comprise a zein matrix and a basic amino acid. The nanoparticles can encapsulate a water-soluble or fat-soluble biologically active compound. It is applicable in the food, pharmaceutical and cosmetic sectors and in the nanotechnology sector.Type: GrantFiled: July 15, 2011Date of Patent: July 5, 2016Assignee: UNIVERSIDAD DE NAVARRAInventors: Maite Agüeros Bazo, Irene Esparza Catalán, Carolina González-Ferrero, Carlos Javier González Navarro, Juan Manuel Irache Garreta, Ana Romo Hualde
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Publication number: 20150335577Abstract: The invention relates to microparticles comprising a matrix formed by casein and chitosan, and probiotic bacteria; said matrix protects said probiotic bacteria during (i) processing, (ii) storage and (iii) transit through the gastrointestinal tract, prolonging their lifetime. The present invention also relates to the method for obtaining the microparticles and to the products and compositions incorporating them.Type: ApplicationFiled: July 5, 2013Publication date: November 26, 2015Applicant: UNIVERSIDAD DE NAVARRAInventors: Maite AGÜEROS BAZO, Irene ESPARZA CATALÁN, Carlos GAMAZO DE LA RASILLA, Carolina GONZÁLEZ FERRERO, Carlos Javier GONZÁLEZ NAVARRO, Juan Manuel IRACHE GARRETA, Rebeca PEÑALBA SOBRÓN, Ana ROMO HUALDE, Raquel VIRTO RESANO
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Patent number: 9034630Abstract: The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.Type: GrantFiled: June 5, 2014Date of Patent: May 19, 2015Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique—CNRS, Université d'Aix Marseille, UNIVERSIDAD DE NAVARRAInventors: Jean-Pierre Gorvel, Vilma Arce Gorvel, Maite Iriarte, Ignacio Moriyon, Raquel Conde-Alvarez
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Patent number: 8895067Abstract: The composition for stimulating an immune response in a subject comprises methyl vinyl ether and maleic anhydride copolymer-based nanoparticles. Said nanoparticles may further contain an allergen or an antigen and/or an immunostimulating agent, which may be contained inside said nanoparticles and/or at least partially coating the surface of said nanoparticles, and optionally a cross-linking agent. The immune response stimulating composition is useful as an adjuvant in immunotherapy and vaccines.Type: GrantFiled: April 28, 2005Date of Patent: November 25, 2014Assignee: Universidad de NavarraInventors: Juan Manuel Irache Garreta, Carlos Gamazo De La Rasilla, Maria Luisa Sanz Larruga, Marta Ferrer Puga, Beatriz San Román Aberasturi, Hesham H. A. Salman, Sara Gómez Martinez, Javier Ochoa Rep{dot over (a)}raz
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Patent number: 8864905Abstract: The present invention belongs to the field of binder compositions for construction, more specifically it relates to the use of carboxymethylchitosan as flocculating additive and setting accelerator in binder compositions of the cement, cement mortar, concrete, grout, stucco and similar type. The invention also relates to binder compositions comprising carboxymethylchitosan, as well as to the method for their preparation.Type: GrantFiled: September 28, 2011Date of Patent: October 21, 2014Assignee: Universidad De NavarraInventors: Jose Ignacio Alvarez Galindo, Jose Maria Fernandez, Maria Lasheras Zubiate, Inigo Navarro Blasco
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Publication number: 20140286996Abstract: The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.Type: ApplicationFiled: June 5, 2014Publication date: September 25, 2014Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique - CNRS, Universite de la Mediterranee - Aix-Marseille II, Universidad de NavarraInventors: Jean-Pierre Gorvel, Vilma Arce Gorvel, Maite Iriarte, Ignacio Moriyon, Raquel Conde-Alvarez
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Patent number: 8778655Abstract: The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.Type: GrantFiled: September 21, 2010Date of Patent: July 15, 2014Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique—CNRS, Universite de la Mediterranee—Aix-Marseille II, Universidad de NavarraInventors: Jean-Pierre Gorvel, Vilma Arce Gorvel, Maite Iriarte, Ignacio Moriyon, Raquel Conde-Alvarez
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Patent number: 8628801Abstract: The present invention relates to nanoparticles comprising a biodegradable polymer, preferably the vinyl methyl ether and maleic anhydride (PVM/MA) copolymer, and a polyethylene glycol or derivatives thereof. These nanoparticles are easy to produce and provide excellent bioadhesion, size and zeta potential characteristics making them suitable for the administration of active molecules. The selection of the type of polyethylene glycol used in their production allows suitably modulating the characteristics of these nanoparticles, which can be advantageously used according to the type of drug to be carried and/or the method of administration of the pharmaceutical formulation. pegylation is carried out by simple incubation for a short time period of the two macromolecules in question, without needing to have to resort to the use of organic solvents with high toxicity or long and laborious organic synthesis processes.Type: GrantFiled: April 28, 2005Date of Patent: January 14, 2014Assignee: Universidad De NavarraInventors: Juan Manuel Irache Garreta, Krassimira Pavlova Yoncheva
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Publication number: 20130209530Abstract: The present invention relates to nanoparticles for encapsulating compounds, the preparation and uses thereof, comprising a casein matrix, a basic amino acid and a metal selected from a divalent metal, a trivalent metal and combinations thereof. Said nanoparticles can encapsulate a water soluble or fat soluble biologically active compound. The invention is applicable in the food, pharmaceutical and cosmetic sectors and in the nanotechnology sector.Type: ApplicationFiled: February 24, 2011Publication date: August 15, 2013Applicants: CENTRO NACIONAL DE TECNOLOGÍA Y SEGURIDAD ALIMENTARIA, LABORATORIO DEL EBRO, UNIVERSIDAD DE NAVARRAInventors: Maite Agüeros Bazo, Irene Esparza Catalán, Carolina González Ferrero, Carlos Javier González Navarro, Juan Manuel Irache Garreta, Ana Romo Hualde
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Publication number: 20130186305Abstract: The present invention belongs to the field of binder compositions for construction, more specifically it relates to the use of carboxymethylchitosan as flocculating additive and setting accelerator in binder compositions of the cement, cement mortar, concrete, grout, stucco and similar type. The invention also relates to binder compositions comprising carboxymethylchitosan, as well as to the method for their preparation.Type: ApplicationFiled: September 28, 2011Publication date: July 25, 2013Applicant: Universidad De NavarraInventors: Jose Ignacio Alvarez Galindo, Jose Maria Femandez, Maria Lasheras Zubiate, Inigo Navarro Blasco
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Publication number: 20130116261Abstract: The present invention relates to nanoparticles for the encapsulation of compounds, the obtaining and uses thereof. The nanoparticles comprise a zein matrix and a basic amino acid. Said nanoparticles can encapsulate a water-soluble or fat-soluble biologically active compound. It is applicable in the food, pharmaceutical and cosmetic sectors and in the nanotechnology sector.Type: ApplicationFiled: July 15, 2011Publication date: May 9, 2013Applicants: UNIVERSIDAD DE NAVARRA, CENTRO NACIONAL DE TECNOLOGÍA Y SEGURIDAD ALIMENTARIA, LABORATORIO DEL EBROInventors: Maite Agüeros Bazo, Irene Esparza Catalán, Carolina González Ferrero, Carlos Javier González Navarro, Juan Manuel Irache Garreta, Ana Romo Hualde