Abstract: An analytical method makes use of an oxygen-containing source having a predetermined content of an isotope of oxygen zO, which is not the same as natural composition and distribution of oxygen isotopes, to detect and/or quantify oxygen in oxidizable compound(s). The analytical method allows detecting and/or quantification with relatively high precision and accuracy oxygen in oxidizable compound(s), even at low content. The method is easy to implement and can be used for in-line analysis.

Abstract: The present invention concerns an analytical method that makes use of an oxygen-containing source having a predetermined content of an isotope of oxygen ZO, which is not the same as natural composition and distribution of oxygen isotopes, to detect and/or quantify oxygen in oxidizable compound(s). The analytical method allows detecting and/or quantification with relatively high precision and accuracy oxygen in oxidizable compound(s), even at low content. The method is easy to implement and can be used for in-line analysis.

Abstract: An airborne system and method for the characterization and measurement of radiating systems or antennas (5), including: an aerial module (1) including a unit for measuring electromagnetic emissions (11), which captures the electromagnetic field (E) radiated by the radiating system or antenna (5), and a positioning and guiding system (13) with an accuracy equal to or less than 3 cm; and a ground station (2) including a unit (23) for processing the electromagnetic emission measurements, which processes the measurements using a set of algorithms for processing electromagnetic emission measurements (25). Also, a method for measuring and characterizing radiating systems or antennas (5). The invention is suitable for use in sectors that require antennas to be characterized and measured, such as, for example, radar and radio navigation facilities, terrestrial- and satellite-based telecommunications systems, or terrestrial broadcasting facilities.

Abstract: Airborne systems and methods for the detection, location and obtaining of images of buried objects and for the characterization of the composition of the subsoil. The systems comprise at least one aerial module with a radar unit that emits and/or captures radar signals and a positioning and guidance system with an accuracy equal to or less than 3 cm, and a ground station with a flight control system and a radar signal processing unit where radar signal processing algorithms are applied. The invention also comprises a method for the detection, localization and obtaining of images of buried objects and a method for the characterization of the composition of the subsoil. Applicable in sectors where it is necessary to perform the detection of buried objects, as for example in civil applications (detection of antipersonnel mines), pipeline inspection or in archaeology.

Abstract: The invention relates to an airborne system and method for the characterization and measurement of radiating systems or antennas, comprising: an aerial module including a unit for measuring electromagnetic emissions, which captures the electromagnetic field radiated by the radiating system or antenna, and a positioning and guiding system with an accuracy equal to or less than 3 cm; and a ground station including a unit for processing the electromagnetic emission measurements, which processes the measurements using a set of algorithms for processing electromagnetic emission measurements. The invention also relates to a method for measuring and characterising radiating systems or antennas. The invention is suitable for use in sectors that require antennas to be characterised and measured, such as, for example, radar and radio navigation facilities, terrestrial and satellite-based telecommunications systems, or terrestrial broadcasting facilities.

Abstract: Airborne systems and methods for the detection, location and obtaining of images of buried objects and for the characterization of the composition of the subsoil. The systems comprise at least one aerial module with a radar unit that emits and/or captures radar signals and a positioning and guidance system with an accuracy equal to or less than 3 cm, and a ground station with a flight control system and a radar signal processing unit where radar signal processing algorithms are applied. The invention also comprises a method for the detection, localization and obtaining of images of buried objects and a method for the characterization of the composition of the subsoil. Applicable in sectors where it is necessary to perform the detection of buried objects, as for example in civil applications (detection of antipersonnel mines), pipeline inspection or in archaeology.

Abstract: The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological ageing.

Abstract: Glycosylated indolocarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.

Abstract: The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological aging.

Abstract: The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's).

Abstract: Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.

Abstract: Oviedomycin derivatives, method for obtaining same and use thereof. This invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to produce the oviedomycin derivatives. The invention further relates to bacterial strains that can be used to produce oviedomycin derivatives. Finally, said oviedomycin derivatives are applicable in the field of the human health, specifically to produce drugs for the treatment of tumour diseases.

Abstract: Glycosylated indolocarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.

Abstract: The present invention relates to the quantification of organic compounds originating from a chromatography system that does not involve the use of patterns, comprising the continuous conversion of the carbon of the compounds into carbon dioxide (CO2) involving a chemical reaction and the mixing of same, before or after separation, with a known, constant flow of a carbon compound, preferably CO2, with carbon isotope-13 (13C). The mixture is introduced into a mass spectrometer in which the isotopic ratio 12C/13C is continuously measured either in the carbon or in a characteristic ion originating from same. The isotope ratio is converted into a carbon mass flow measurement using on-line isotope dilution.

Abstract: The compounds of formula (1), their pharmaceutically acceptable salts and their solvates, wherein R1 is a radical selected between hydrogen and alkyl; R2 is selected from hydroxyalkyl, phenyl, phenyl mono-substituted and phenyl di-substituted in positions 3 and 4; R3 is selected from phenyl, phenyl mono-substituted and phenyl di-substituted in positions 3 and 4; the substituents of the phenyl of R2 and R3 selected from halogen, (C1-C4)-alkyl and (C1-C4)-alkoxyl and R4 is selected from hydrogen, alkyl allyl and homoallyl, they are useful for the treatment of mycobacterial infections, in particular for the treatment of infections produced by Mycobacterium tuberculosis, Mycobacterium avium-intracellulare complex or Mycobacterium kansasii.

Abstract: The invention, in one aspect, generally relates to mithramycin derivatives from mutated Streptomyces argillaceus and their production. The invention also relates using the derivatives for the treatment of various diseases. Finally, the invention relates to a mutated Streptomyces argillaceus useful in the production of the mithramycin derivatives.

Abstract: In the present invention new compounds of formula II, in enantiomerically enriched forms, are described for the first time, where R1 is chloroalkyl. The present invention also includes several new enzymatic processes for the resolution of the enantiomers of the aforementioned carbonates of formula II from the corresponding racemic mixture. The transformation of these carbonates into zopiclone enantiomerically enriched, constitutes an additional aspect of the invention.

Abstract: Novel proteins which belong to the papain family and are cysteine proteinase enzymes (the cysteine proteinase enzymes are expected to be involved in the turnover of intracellular proteins, antigen presentation, prohormone activation, bone remodeling, etc. and to play important roles in a variety of pathological conditions such as Alzheimer's disease, pulmonary emphysema, rheumatoid arthritis, muscular dystrophy, osteoporosis, neurodegenerative disease, and cancer invasion and metastasis), together with genes encoding the proteins and antibodies against the proteins, can be conveniently used in elucidating the function of a cysteine proteinase involved in various diseases and disorders, especially cancers, thereby not only disclosing critical mechanism leading to such diseases and disorders but also researching and developing therapy and therapeutic drugs thereagainst.

Abstract: Isolation, cloning and sequencing of the cluster of genes involved in the biosynthesis of the carbapenem thienamycin by streptomyces cattleya, and the use of those genes to increase thienamycin production, and/or related antibiotics, in the producing strains, and obtaining new derivatives by means of genetic manipulation which implies gene expression, mutagenesis by gene replacement and combinatorial biosynthesis.