Patents Assigned to Universidad de Salamanca
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Patent number: 12104851Abstract: The invention relates to a device and method for the simultaneous lyophilisation of a plurality of biological samples ensuring the traceability of said samples intended to be housed within coded containers (1); the device comprises a diffuser block (2) comprising a plurality of openings which define receptacles (21) to house the coded containers (1), wherein the diffuser block (2) further comprises a perimeter cavity (24) configured so that the alloy surrounding each receptacle (21) is similar in all the coded containers (1), enabling high thermal homogeneity, and the receptacles (21) have through openings defining an open bottom (23) to scan the coded containers (1). Likewise, the device further comprises a transfer lid (3) to ensure the position of each container (1) when it is transferred to the diffuser block (1) and back to the starting box (4).Type: GrantFiled: July 2, 2020Date of Patent: October 1, 2024Assignee: UNIVERSIDAD DE SALAMANCAInventors: Andrés Celestino García Montero, Alberto Orfao De Matos Correia E Vale, Francisco Javier García Palomo, Catia Daniela Quintas Faria, Roberto José García Martín, Maria Pérez Caro
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Patent number: 11919967Abstract: An antibody or fragment thereof, against presenilin, and more specifically against the luminal loop 1 of presenilin, for use in the treatment of cancer, by way of administrating a therapeutically effective quantity of the antibody or a fragment thereof, or a pharmaceutical composition comprising thereof, to a subject who suffers from cancer.Type: GrantFiled: August 3, 2018Date of Patent: March 5, 2024Assignees: ALZHEIMUR 2012 S.L., FUNDACION UNIVERSITARIA SAN ANTONIO, IBSAL (INSTITUTO DE INVESTIGACION BIOMEDICA DE SALAMANC, UNIVERSIDAD DE SALAMANCAInventors: Rogelio Gonzalez Sarmiento, Miguel Rodriguez Manotas, Javier Fernandez Mateos, Juan Carlos Gallar Ruiz, David Florenciano Gomez
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Patent number: 11833160Abstract: The present invention relates to compounds derived from ursodeoxycholic acid of formula (I), to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.Type: GrantFiled: December 28, 2018Date of Patent: December 5, 2023Assignees: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA, ADMINISTRACIO GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI, FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL), UNIVERSIDAD DE SALAMANCAInventors: Jesus Maria Banales Asurmendi, Luis Bujanda Fernandez De Pierola, Alvaro Santos Laso, Fernando Pedro Cossio Mora, Ivan Rivilla De La Cruz, Francisco Javier Caballero Camino, Manel Esteller Badosa, Jose Juan Garcia Marin
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Patent number: 11529516Abstract: A signal processing arrangement is described for signal processing in a bilateral hearing implant system. A channel compression module develops a inhibition-adjusted band pass signal for each band pass signal using a channel-specific dynamic inhibition adjustment based on a channel-normalized medial olivocochlear reflex model that reflects bandwidth energy for a corresponding contralateral band pass signal and bandwidth energy for a selected reference contralateral band pass signal.Type: GrantFiled: June 28, 2018Date of Patent: December 20, 2022Assignee: Universidad De SalamancaInventor: Enrique Alejandro López-Poveda
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Patent number: 11442060Abstract: The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.Type: GrantFiled: January 14, 2020Date of Patent: September 13, 2022Assignees: Erasmus University Medical Center Rotterdam, Universidad De SalamancaInventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale
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Patent number: 11105687Abstract: An apparatus and a method for in-line measurement of laser pulses with time-dependent polarization are described, which make possible to carry out in-line measurement of laser pulses whose polarization depends on time. For this, one or more polarization projections are selected: the spectrometer detects the projection on the extraordinary propagation axis of a birefringent system to measure the spectrum in that component, also the projection on the ordinary propagation axis, to measure the spectrum in that component, and finally a projection in an intermediate direction that allows to measure the interference spectrum between the two components. The method allows extracting the temporal evolution of the pulse and its polarization state as a function of time, spectral amplitudes and phases of the various polarization projections of the beam.Type: GrantFiled: February 20, 2018Date of Patent: August 31, 2021Assignees: UNIVERSIDAD DE SALAMANCA, SPHERE ULTRAFAST PHOTONICS, S.L.Inventors: Iñigo Sola Larrañaga, Benjamín Alonso Fernández, Rosa María Romero Muñiz
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Patent number: 11035737Abstract: The present application relates to a method and system for characterization and compression of ultrashort pulses. It is described a flexible self-calibrating dispersion-scan technique and respective system to characterize and compress ultrashort laser pulses over a broad range of pulse parameters, where previous knowledge of the amount of dispersion introduced for each position or step of the compressor is not required. The self-calibrating d-scan operation is based on the numerical retrieval of the spectral phase of the pulses using an optimization algorithm, where the spectral phase is treated as a multi-parameter unknown variable, and where the unknown dispersion of the dispersion scanning system is described by a theoretical model of its functional dependence on the compressor position.Type: GrantFiled: June 26, 2018Date of Patent: June 15, 2021Assignees: SPHERE ULTRAFAST PHOTONICS SL, UNIVERSIDAD DE SALAMANCAInventors: Benjamin Alonso Fernandez, Inigo Juan Sola Larranaga, Helder Manuel Paiva Rebelo Cerejo Crespo
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Publication number: 20200354470Abstract: An antibody or fragment thereof, against presenilin, and more specifically against the luminal loop 1 of presenilin, far use in the prevention and/or treatment of cancer, by way of administrating a therapeutically effective quantity of the antibody or a fragment thereof, or a pharmaceutical composition comprising thereof, to a subject who suffers from cancer.Type: ApplicationFiled: August 3, 2018Publication date: November 12, 2020Applicants: ALZHEIMUR 2012 S.L., FUNDACIÓN UNIVERSITARIA SAN ANTONIO, IBSAL (INSTITUTO DE INVESTIGACIÓN BIOMEDICA DE SALAMANCA), UNIVERSIDAD DE SALAMANCAInventors: Rogelio GONZALEZ SARMIENTO, Miguel RODRIGUEZ MANOTAS, Javier FERNANDEZ MATEOS, Juan Carlos GALLAR RUIZ, David FLORENCIANO GOMEZ
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Patent number: 10788481Abstract: The invention relates to methods to evaluate in one single assay the biocompatibility of materials based on the simultaneous determination of the phagocytosis, cell activation and cell death produced by said materials, preferably, in peripheral blood or other human cells and proximal fluids. The invention also relates to a kit to perform the method of the invention.Type: GrantFiled: July 5, 2017Date of Patent: September 29, 2020Assignees: UNIVERSIDAD DE SALAMANCA, IMMUNOSTEP S.L.Inventors: Manuel Fuentes Garcia, Paula Diez Garcia, Cristina Isabel Gonçalves Grunho Tedosio, Alberto Orfao de Matos, Ricardo Jara Acevedo
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Patent number: 10556109Abstract: This document mainly discloses a method and a device for sound enhancement, both aspects of the invention hereby described are directed to cochlear implants. The method for sound enhancement and the sound enhancement device comprising a component adapted to carry out said method are based on processing the envelope for frequency bands of the acoustic signal captured, said amplification is directed to the gain value of the amplification according to an amplitude of an output signal of the other sound processor.Type: GrantFiled: April 28, 2015Date of Patent: February 11, 2020Assignee: UNIVERSIDAD DE SALAMANCAInventor: Enrique Alejandro Lopez-Poveda
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Patent number: 10133962Abstract: The invention relates to a computer-implemented method for classifying events present in a sample, wherein each event is characterized by a multidimensional set of parameters obtained by means of hardware and/or software, wherein the values of the parameters associated with each event define the position coordinates of said event in a multidimensional space. Said method comprises the following stages: a) clustering the events in groups, b) checking if within each formed group there is a connection between events exceeding a maximum distance threshold, c) calculating the affinity between each pair of previously generated sample groups, d) comparing each sample group with at least one reference group stored in at least one database, e) classifying the sample groups based on the comparisons with the reference groups.Type: GrantFiled: June 9, 2017Date of Patent: November 20, 2018Assignees: Cytognos, S.L., Universidad de SalamancaInventors: Rafael Fluxá Rodriguez, José Alberto Orfao de Matos Correia E Vale, Juan Bernardo Hernández Herrero
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Publication number: 20180034227Abstract: The optical system comprises: means for introducing a controlled negative or positive chirp to an incoming ultrashort laser pulse to be characterized; a nonlinear optical medium through which said chirped ultrashort laser pulse is propagated, wherein as a result of said propagation: different chirp values are introduced in the ultrashort laser pulse at different propagation distances along the nonlinear optical medium, and a transverse nonlinear signal is generated in a direction perpendicular to the propagation axis; analyzing means configured for recording a single-shot spectral image of said generated transverse nonlinear signal; and a processing module comprising one or more processors configured to execute a numerical iterative algorithm to said single-shot spectral image to retrieve the electric field, amplitude and phase, of the ultrashort laser pulse.Type: ApplicationFiled: February 5, 2016Publication date: February 1, 2018Applicants: UNIVERSITAT POLITECNICA DE CATALUNYA, Universidad de Salamanca, Sphere Ultrafast Photonics, SAInventors: Jose Francisco Trull-Silvestre, Crina Maria Cojocaru, Inigo Juan Sola-Larranaga, Rosa Maria Romero-Muniz, Francisco Jose Maia Da Silva, Helder Manuel Paiva Rebelo Cerejo Crespo
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Patent number: 9746472Abstract: This invention relates to methods to detect the presence of cancer infiltration of the Central Nervous System (CNS) based on the detection of soluble proteins, preferably, in cerebrospinal fluid samples and vitreous fluid. The invention also relates to kits to perform the methods of the invention.Type: GrantFiled: July 25, 2012Date of Patent: August 29, 2017Assignee: UNIVERSIDAD DE SALAMANCAInventor: José Alberto Orfao De Matos Correia E Vale
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Publication number: 20170043162Abstract: This document mainly discloses a method and a device for sound enhancement, both aspects of the invention hereby described are directed to cochlear implants. The method for sound enhancement and the sound enhancement device comprising a component adapted to carry out said method are based on processing the envelope for frequency bands of the acoustic signal captured, said amplification is directed to the gain value of the amplification according to an amplitude of an output signal of the other sound processor.Type: ApplicationFiled: April 28, 2015Publication date: February 16, 2017Applicant: UNIVERSIDAD DE SALAMANCAInventor: Enrique Alejandro Lopez-Poveda
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Publication number: 20160045463Abstract: The present invention comprises the use of metalloprotease inhibitors for the treatment of polycystic liver diseases (PLDs). The invention particularly describes the use of Marimastat as the preferred metalloprotease inhibitor for the treatment of PLDs. Treatment with Marimastat is able to inhibit liver cystogenesis by blocking metalloproteolytic hyperactivity of polycystic cholangiocytes.Type: ApplicationFiled: November 27, 2013Publication date: February 18, 2016Applicant: UNIVERSIDAD DE SALAMANCAInventors: Jesús Maria BAÑALES ASURMENDI, Luis BUJANDA PIEROLA, Elizabeth HIJONA MURUAMENDIARAZ, Patricia MÚÑOZ GARRIDO, Jesús PRIETO VALTUEÑA, Aura Daniela URRIBARRI, José Juan GARCÍA MARÍN, Maria Jesús PERUGORRIA MONTIEL, Elisa LOZANO ESTEBAN
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Publication number: 20140315749Abstract: The invention relates to the field of medical diagnostics. In particular, it relates method and kits for identification and classification of IgE-related diseases, e.g. Type I hypersensitivity, as well as for monitoring of treatment efficacy, for instance anti-IgE therapy.Type: ApplicationFiled: November 15, 2011Publication date: October 23, 2014Applicants: Erasmus University Medical Center Rotterdam, Universidad De SalamancaInventors: Menno Cornelis van Zelm, Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale
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Publication number: 20140024019Abstract: The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.Type: ApplicationFiled: March 5, 2012Publication date: January 23, 2014Applicants: Universidad de Salamanca, Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria Van Dongen, José Alberto Orfao De Matos Correia E Vale
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Publication number: 20130267432Abstract: The present invention refers to an in vitro SMZL diagnostic method based on analysis of the expression of a series of genes located in a very specific deleted region of human chromosome 7. The deleted region in SMZL patients has been defined by means of high-resolution array CGH and is located at 7q22.1 between bases 99925039-101754718, preferably between 99925039-101348479, and more preferably between 100260234-100596921 and/or 101244026-101754718, which is the location for the following genes: CUX1, SH2B2, EPHB4, SLC12A9, TRIP6, SRRT, ACHE, UFSP1, TRIM56, SERPINE1, APIS1, VGF, TSC22D4, HRBL, LRCH4, MUC3, MUC12 and MUC17. The present invention further describes in vitro SMZL diagnostic kits that comprise at least one probe that recognizes the deleted region at 7q22.1 or hybridizes with at least one of the nucleotide sequences of the genes mentioned above.Type: ApplicationFiled: June 7, 2011Publication date: October 10, 2013Applicant: FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA (FICUS)Inventors: Jesús María Hernández Rivas, Juan Luis García Hernández, Cristina Robledo Montero
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Publication number: 20120220480Abstract: The invention relates to a method for determining the presence of renal damage in an individual and also to a method for detecting one or several proteins selected from the list comprising Reg3B, fetuin B, Ras-related GTP-binding protein A serine protease inhibitor A3L, subunit 1 of COP9, gamma subunit of ATP synthase, gelsolin, ribonuclease UK114, aminoacylase 1A, alpha-enolase, keratin 5, parvalbumin alpha, ribonuclease 4 or serine protease inhibitor A3K. The renal damage may be acute renal failure. Said renal pathologies may be caused by the administration of a nephrotoxic agent, wherein the nephrotoxic agent may be an aminoglycoside antibiotic such as gentamicin, or cisplatin. The invention also provides means to differentiate the renal damage or renal failure induced by gentamicin from that induced by cisplatin, through the biochemical analysis of the urinary level of Reg3B and/or gelsolin, or fragments thereof.Type: ApplicationFiled: July 19, 2010Publication date: August 30, 2012Applicant: UNIVERSIDAD DE SALAMANCAInventors: Yaremi Quiros Luis, Laura Ferreira Redondo, Sandra M. Sancho Martínez, José M. Gonzalez De Buitrago Arriero, Francisco J. Lopez Hernandez, José M. Lopez Novoa, Omar Garcia Sanchez
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Publication number: 20120129721Abstract: The invention relates to a method of determining the risk of developing acute renal failure (ARF) in an individual, or of determining an ARF, and a method of predicting the progression of an ARF, by detecting and/or quantifying the protein Ganglioside GM2 Activator Protein (GM2AP). The failure can be due to the administration of at least one nephrotoxic agent, wherein the nephrotoxic agent can be an aminoglycoside antibiotic as for example gentamicin.Type: ApplicationFiled: May 26, 2009Publication date: May 24, 2012Applicant: UNIVERSIDAD DE SALAMANCAInventors: Yaremi Quiros Luis, Laura Ferreira Redondo, Sandra María Sancho Martínez, José Manuel Gonzalez De Buitrago, Francisco Jose Lopez Hernandez, José Miguel Lopez Novoa