Abstract: The object of the present invention relates to a nanoparticulate aerosol generator comprising a compressed gas reservoir (1) connected to a nanoparticulate material receptacle (2) through an operational valve (8?), wherein said receptacle (2) comprises an outlet hole (3) for the aerosol. Advantageously, the outlet of said nanoparticulate material receptacle (2) is connected to or inserted into a pressurized aerosol distribution chamber (4) equipped with a hole (9) for the exit of said aerosol out of the chamber (4). The invention provides the possibility of using different types of nanoparticles with sizes less than 100 nanometers continuously over time during long production periods of more than three hours. The invention also relates to a method for continuously generating nanoparticulate aerosols associated with the mentioned generator.

Abstract: The present invention relates to granulysin, method of obtaining same, and uses, specifically to the granulysin polypeptide for the use thereof as a medicinal product via the systemic route and to a chimeric molecule comprising a recombinant antibody targeting a tumor antigen and the granulysin polypeptide.

Abstract: The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberculosis complex, preferably a M. tuberculosis clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP? phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM? phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberculosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.

Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

Abstract: The present invention relates to a novel microfluidic device and a microfluidic system for culturing cell samples based on: one or more culture wells (2) forming cell housing volumes for three-dimensional cell culture; one or more capillary channels (1) for circulating cells and/or fluid media, said channels (1) being connected to the wells (2) as well perfusion means; and an inlet port (3) and an outlet port (3?) for seeding cells and/or for circulating fluid in said channel (1), said ports (3, 3?) being connected to the ends of each capillary channel (1). The novel configuration of the ports (3, 3?) and their corresponding channels (1) allows known microfluidic perfusion media to be improved, dispensing with the use of complex elements for injecting the fluid media, such as syringe pumps, for example. The invention also allows two-dimensional and three-dimensional culture studies to be performed simultaneously.

Abstract: The invention relates to a channel comprising device (1) comprising a channel (10) with a channel wall (15), a channel inlet (11) and a channel outlet (12), wherein the channel wall comprises a polymer (150),wherein the polymer (150) comprises an epoxy-based polymer. The invention further relates to a system (1000) comprising a Coriolis-type flow measuring device(50) comprising the channel comprising device (1) according to the invention and an actuation system (450) configured to let at least part of the channel (10) vibrate thereby causing temporary displacements. The invention, further relates a method for measuring a property of a fluid, wherein the property of the fluid is a property selected form the group consisting of a mass flow rate of the fluid and a density of the fluid.

Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

Abstract: The present invention relates to compounds able to inhibit ?-synuclein aggregation, their use in the treatment or prophylaxis of a synucleinopathy and to pharmaceutical compositions comprising said compounds.

Abstract: The present invention discloses a biosensor for visual detection of an analyte, based on the light to heat conversion properties of metal nanoparticles: the analyte is visually detected by the color change in the support areas (where the analyte is present), produced as a result of the heat generated by the metal nanoparticles where they are irradiated with an external light source. Use of said biosensor in a method for the detection of analytes is also claimed.

Abstract: The invention relates to a material comprising oligoglycine tectomers and nanowires. This material is useful as an electrode, as a conductive and transparent hybrid material, and as a pH sensor, as well as in biomedical applications.

Abstract: A system and a method for liquefaction of gases which are utilized in their liquid state as refrigerants in applications that require low temperatures, throughout various pressure ranges, from slightly above atmospheric pressures to pressures near the critical point. The system and method are based on closed-cycle cryocoolers and utilize the thermodynamic properties of the gas to achieve optimal liquefaction rates.

Abstract: An identification and verification system and a process for said identification and verification of documents is disclosed, which is based on the use of nanoparticles embedded or adsorbed in the document support, utilizing the different optical reflectance characteristics thereof in order to obtain, by combining several nanoparticles with specific characteristics, a high effectiveness in the identification of counterfeits.

Abstract: The present invention is generally related to the prevention of leishmaniasis in animals, particularly infection caused by Leishmania sp., based on the use of Leishmania infantum P36 protein or an immunogenic fragment of the latter, or involving an expression system for the mentioned protein or fragment—optionally in combination with a compound stimulating the production of a Th1-type cellular immune response—and comprising various vaccination protocols in application to Leishmania sp. based on the mentioned vaccine.

Abstract: A helium recovery plant adapted to filter, compress, and purify helium gas collected from one or more helium-using instruments, as well as to liquefy and redistribute the purified gas within a closed system. The recovery plant is adapted to match the purification and liquefaction rate of the system with the consumption rate of the coupled instruments. Additionally, the recovery plant is adapted to match the liquefaction rate of a liquefaction module with a boil-off rate of liquid helium within a Dewar thereof. The recovery plant is further adapted to recycle helium therein in an effort to achieve zero loss.

Abstract: The present invention starts with a method for obtaining organic extracts of the Artemisia absinthium L. plant, which includes: a methodology phase for producing said plant, an extraction phase during which said essential oil and a non-volatile extract are obtained, and a phase of extracting supercritical extracts with CO2, and refers specifically to the use of the essential oil and/or the supercritical extract extracted as fungicides against phytopathogenic fungi. For said purpose, the Artemisia absinthium L. plant is used, specifically the Candial variety from Teruel and/or Sierra Nevada in Spain. The present invention also relates to the aqueous residue generated during said method, which includes an organic compound which in turn contains (Z)-2,6-dimethylocta-5,7-diene-2,3-diol as an active organic compound against nematodes. The method for obtaining said organic portion and the corresponding active organic component thereof is protected by the present application.

Abstract: The present invention describes a method for producing multifunctional materials comprising the steps of: a) chemically activating functional groups present in a micro- or nanoparticulate base material; b) performing a nucleophilic substitution reaction between at least one terminal amino, carboxyl or thiol group of a PNA or DNA type A chain and at least one activated functional group of the base material produced in step (a); c) conjugating to a biomolecule by means of chemically activating functional groups of a PNA/DNA type B chain, which is complementary to the PNA/DNA type A chain; and d) hybridizing the PNA/DNA type A chains which are bound to the base material according to step b) and the PNA/DNA type B chains having biomolecules bound thereto according to step c) by means of PNA-PNA or PNA-DNA molecular recognition.

Abstract: The system is based on the arrangement of a plurality of terminals (1), (I?) . . . (In), which are interconnected with one another to form a digital network by means of two databuses, one write and one read, by means of differential transmission, with a hybrid connection topology based inter alia on UTP-type cables (4). Each terminal is constituted by a DLP-type card (7), which contains a programmable logic device for the management of a series of cards associated with the card (7), said cards being a main card (8) and a user-interface card (9), which enable the user to configure the various system options, it being possible, also, to incorporate one or more extension cards (H-H?) for the input and output of audio/video signals, the Internet, a telephone line or an automatic-door-entry line, and also a remote-control and alarm card (10) for activating external loads, activating alarms and receiving signals originating from sensors.

Abstract: The present invention relates to novel smart packaging, designed using a novel material comprising a partially polar adsorbent solid base impregnated with a solution of vanillin, which allows the growth of microorganisms in different types of products to be detected visually without having to be in direct contact with the microorganism or with the medium containing same.

Abstract: Process for obtaining aromatic hydrocarbons from a stream containing at least one light hydrocarbon selected from the list comprising methane, ethane, ethylene, propane, propene, propylene, butane, butene or butadiene, which comprises putting said stream into contact with a catalyst, which comprises a catalytic material and a binder, in a fluidized bed reactor. Said reactor may have two reaction zones, an oxidizing zone and a reducing zone.

Abstract: The present invention relates to an isolated microorganism belonging to the genus Mycobacterium, characterized in that it comprises inactivating the gene Rv0757 that confers a PhoP? phenotype and inactivating a second gene that prevents the production of DIM (DIM-phenotype). Additionally, the present invention comprises the use of said microorganism for producing a vaccine for immunizing against or preventing tuberculosis.