Abstract: A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.

Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.

Abstract: The present invention refers to compounds derived from hydroxyphenyl 1H-pyrrole rings, which have the following formula (I): as well as to the procedure for their preparation, pharmaceutical compositions comprising the same and the use thereof for the treatment and/or prevention of a condition mediated by histone deacetylase such as cancer, hematological malignancies, autoimmune diseases, inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases and psychiatric disorders, cardiovascular diseases, endocrine and metabolic disorders, by inhibiting histone deacetylases and the therapeutic use of biological processes related to the mentioned inhibition.

Abstract: The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.

Abstract: The invention relates to an in vitro method for the detection of bacteria of the Salmonella spp. genus by means of a quantitative polymerase chain reaction using specific primers for the pathogen from DNA and RNA samples from the microorganism. The method is useful in the detection of viable and non-viable microorganisms of Salmonella spp. in environmental, clinical and food samples. Likewise, the invention also relates to a kit used for putting the method into practice.

Abstract: The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): wherein: R1 and R2 represent, independently, an optionally substituted C6-C10 aryl radical or an optionally substituted heteroaryl radical; A and M represent, independently, a methylene group or a single bond, in which case the adjacent aromatic ring would be attached directly to the amide group; the Y?Z group represents together and indistinctly an oxygen atom, a sulfur atom, a cis-vinylidene group, an imino group, or a methine group with a sp2-hybridized carbon atom; X represents indistinctly a methine group, a cis-vinylidene group or a nitrogen atom; and W represents a hydroxyl group, an optionally substituted C1-C6 alkyl group, an optionally substituted heteroaryl group or an optionally substituted C6-C10 aryl group; or a salt, solvate or prodrug thereof, as well as to the process for their preparation and the use thereof for the treatment of cancer.

Abstract: The present invention relates to a source for emitting broad spectrum light of controllable frequency comprising boron nitride nanotubes with defects caused by the vacancy of a boron atom in the tubular structure and wherein the source is further provided with means for producing an electric field perpendicular to the tube. The invention can be used as a field-effect transistor (by adding electrodes) or as a source for converting energy of an incoming beam.

Abstract: The invention relates to a device for capturing information for virtual deployment and method associated with it, comprising a main body which allows collecting information by information collection means to perform computer-aided simulation, where said main body comprises a first part which allows coupling to the element to be captured, and where said main body further comprises a second part which allows the device to be the target of the information collection means which, in conjunction with other information collection means positioned on the element to be captured, allow obtaining optimal reference coordinates for a computer-aided system.

Abstract: The invention relates to an integral magnetic compass for obtaining deviations in real time, formed by a transparent sphere or cylinder (2), incorporating therein, in a hydrocarbon liquid (3), a polyester or silicon disk (4) to which the rose (5) and the magnet (6) are fitted, being associated with a commutation system formed by integrated software in a device or chip (7), the circuit of which has two inputs: an input (8) to the signal obtained from the magnetic compass (1) itself, obtained by means of a magnetometer (9) or optical reader (10) in association therewith, and another input (11) to the signal from the satellite compass (12) or from the gyroscopic compass (13), and said circuit having an output (14) to a display (15) for viewing and storage of the data for the corresponding deviations, thus obtaining the deviation chart for the magnetic needle in real time, said output being also applicable to the automatic pilot (16).

Abstract: The invention relates to an in vitro method for the detection of bacteria of the Salmonella spp. genus by means of a quantitative polymerase chain reaction using specific primers for the pathogen from DNA and RNA samples from the microorganism. The method is useful in the detection of viable and non-viable microorganisms of Salmonella spp. in environmental, clinical and food samples. Likewise, the invention also relates to a kit used for putting the method into practice.

Abstract: The invention relates to the use of morin and mangiferin, the pharmaceutically acceptable salts, prodrugs and/or solvates thereof in the production of a pharmaceutical composition for the prevention and/or treatment of a neurodegenerative disease and symptoms associated with ageing, as well as to food compositions comprising said compounds.

Abstract: The present invention relates to a biocompatible cationic nanogel comprising a polymer network, said polymer network comprising polymer units interconnected with one another through a cross-linking agent, wherein said polymer network can be obtained by polymerizing N-vinylcaprolactam and a cross-linking agent in a dispersed medium, in the presence of a cationic initiator and a cationic or non-ionic emulsifier. The invention also relates to methods for obtaining the mentioned nanogels as well as to pharmaceutical compositions comprising them.

Abstract: The invention relates to a system for eliminating current surges that includes a first voltage regulator (7) having a current limit programmable to a value (I(limit)) that depends on the value of the intermittent current surges (IO(surge)) required by the intermittent load (3) and the relationship thereof to the work cycle, a second voltage regulator (9), a condenser (4) connected between the first and second regulators (7, 9), that loads when the current is no longer required and that unloads when there is a need for output current to provide current to the second regulator (9) which absorbs the changes in voltage produced by the loading/unloading of the condenser and provides a constant voltage for any value of the required output current surge, independently of voltage changes in the condenser (4), and a control loop between a sensor for the output current provided to the load and an input limit (15) for the input current (II) in the first regulator (7).

Abstract: The present invention relates to thiol- or an amine-associated ferromagnetic or superparamagnetic copper nanoparticles with an average diameter less than 30 nm, to the method for obtaining them and their applications in biomedicine and other fields.

Abstract: A process for the preparation of adhesives compositions comprising polymerization of a mixture of acrylic and methacrylic monomers comprising one or more acrylate or methacrylate having active hydrogens in the presence of an isocyanate terminated polyurethane prepolymer and optionally a chain extender.

Abstract: A process for preparing a zeolite-based monolith including dry-mixing zeolite particles and a temporary binder until homogenization; adding silica and water dispersion; wet-kneading and high-shear mixing until obtaining a homogenous pulp; extrusion-molding the pulp resulting from the previous step; controlled drying of the mold obtained; and oxidizing at a high temperature to obtain the monolith.

Abstract: The invention relates to the field of biotechnology and medicine. The invention specifically relates to a compound comprising a liposome covered or decorated at least with the extracellular domain of the APO2L/TRAIL protein, and to the use thereof far developing a medicament preferably for the treatment of a cancer or inflammatory or autoimmune diseases, such as rheumatoid arthritis.

Abstract: The invention relates to non-glycosylated proteins, based on the Kre9 protein of Candida albicans, capable of stimulating cell adhesion and the use thereof in the identification of compounds potentially useful against diseases associated with unwanted cell adhesion. The invention also relates to the use of said non-glycosylated proteins in the treatment of diseases caused by infectious agents.

Abstract: The present invention relates to a lipid nanoparticle system comprising a lipid component, a cationic surfactant, a non-ionic surfactant, a polysaccharide and, optionally, a positively charged peptide, useful for the release of pharmacologically active molecules, and especially for transfecting genetic material into cells and/or tissues. It also relates to methods for obtaining nanoparticles, to pharmaceutical compositions comprising it, as well as to the use thereof in gene therapy.

Abstract: The present invention relates to the use of an antifungal agent or of a compound capable of binding to a mannoprotein and blocking the binding of said mannoprotein to an endothelial cell receptor, in the preparation of a pharmaceutical composition for treating a disease associated to an unwanted cell adhesion. Likewise, the present invention also contemplates methods aimed at identifying a compound potentially useful for preventing and/or treating a disease associated to an unwanted cell adhesion, for predicting the probability of a patient suffering from cancer to suffer from metastasis and for designing a personalized therapy for a patient suffering from cancer.