Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
Type:
Grant
Filed:
December 5, 2013
Date of Patent:
August 1, 2017
Assignees:
International Business Machines Corporation, Agency For Science, Technology And Research, Universidad del ParĂs Vasco/Euskal Herriko Unibertsitatea
Inventors:
Julian M. W. Chan, Amanda C. Engler, James L. Hedrick, Xiyu Ke, Victor W. L. Ng, Haritz Sardon, Jeremy P. K. Tan, Yi Yan Yang
Abstract: The present invention relates to a method for producing nanocomposite dispersions comprising composite particles of inorganic nanoparticles and organic polymers in a continuous phase, especially in a dispersion medium, as well as to the nanocomposite dispersions thus obtained and to the use thereof.
Type:
Grant
Filed:
May 15, 2013
Date of Patent:
May 16, 2017
Assignees:
Akzo Nobel Coatings International B.V., BYK-Chemie GmbH, Energenics Europe Ltd., Universidad del Paris Vasco, YKI, Ytkemiska Institutet AB
Inventors:
Nils Erik Ronne, Melanie Hormann, Janin Tecklenburg, Carsten Nagel, Ulrich Nolte, Michael Berkei, Yingqian Xu, Jose Ramon Leiza, Yuri Reyes, Maria Paulis, Miren Aguirre Arrese, Anwar Ahniyaz, Andrea Fornara, Ninja Hanitzsch