Patents Assigned to UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
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Publication number: 20230035094Abstract: Procedure for the generation of a reflex tear secretion, which comprises the chemical stimulation of the cornea of the eye of a subject by applying a controlled jet of a gas with a high CO2 content, of at least 80% of CO2. Compact device (1,1?) for the generation of a reflex tear secretion, comprising a gas source (7) in the form of a disposable type cartridge containing a pressurized gas with a composition of at least 80% of CO2; and a pneumatic circuit connecting an outlet mouth of said gas source (7) with a gas outlet nozzle (3) of the device (1,1?), the circuit comprising pressure regulation means (8) and flow rate (17) regulation means suitable for ejecting puffs of gas through the outlet nozzle (3) at a predetermined pressure and flow rates.Type: ApplicationFiled: December 30, 2020Publication date: February 2, 2023Applicants: UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (UNH), CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICASInventors: Carlos BELMONTE MARTÍNEZ, Juana GALLAR MARTÍNEZ, Maria Carmen ACOSTA BOJ, Maria Luisa MERINO SUÁREZ
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Patent number: 10905679Abstract: The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)—(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; f) C(O)—(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted; g) CH(OH)—(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; and h) CH(OH)—(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.Type: GrantFiled: January 17, 2017Date of Patent: February 2, 2021Assignee: UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHEInventors: Antonio Vicente Ferrer Montiel, Asia Fernandez Carvajal, Carlos Belmonte Martinez, Juana Gallar Martinez, Roberto De La Torre, Armando Genazzani, Gian Cesare Tron, Valentina Mercalli
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Publication number: 20190022068Abstract: The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)—(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; f) C(O)—(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted; g) CH(OH)—(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; and h) CH(OH)—(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.Type: ApplicationFiled: January 17, 2017Publication date: January 24, 2019Applicant: Universidad Miguel Hernandez De ElcheInventors: Antonio Vicente FERRER MONTIEL, Asia FERNANDEZ CARVAJAL, Carlos BELMONTE MARTINEZ, Juana GALLAR MARTINEZ, Roberto DE LA TORRE, Armando GENAZZANI, Gian Cesare TRON, Valentina MERCALLI
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Patent number: 10028920Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.Type: GrantFiled: November 14, 2016Date of Patent: July 24, 2018Assignees: UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFÍCAS C.S.I.C.Inventors: Carlos Belmonte Martínez, Juana Gallar Martínez, Antonio Ferrer Montiel, Asia Fernández Carvajal, Félix Viana De La Iglesia
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Patent number: 9901549Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.Type: GrantFiled: August 3, 2016Date of Patent: February 27, 2018Assignees: UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (C.S.I.C.)Inventors: Carlos Belmonte Martínez, Juana Gallar Martinez, Antonio Ferrer Montiel, Asia Fernández Carvajal, Félix Viana De La Iglesia
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Patent number: 9433679Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.Type: GrantFiled: April 29, 2015Date of Patent: September 6, 2016Assignees: UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (C.S.I.C.)Inventors: Carlos Belmonte Martínez, Juana Gallar Martínez, Antonio Ferrer Montiel, Asia Fernández Carvajal, Félix Viana de la Iglesia
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Patent number: 9095609Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.Type: GrantFiled: September 8, 2011Date of Patent: August 4, 2015Assignees: UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (C.S.I.C.)Inventors: Carlos Belmonte Martnez, Juana Gallar Martinez, Antonio Ferrer Montiel, Asia Fernández Carvajal, Félix Viana De La Iglesia
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Publication number: 20150010674Abstract: The invention relates to gelled products such as gelatins for food consumption or wine gums, comprising probiotic microorganisms and, in some of the variants thereof, prebiotic microorganisms, said products being developed from drinks of plant origin such as juices made from fruit, vegetables and cereals, which are subjected to a lactic fermentation process with at least one probiotic strain. The invention also relates to the method for producing such products, consisting of the following basic steps: a) production of a pasteurised or sterilised substrate; b) fermentation of the substrate; c) hydration of the gelatin and dissolution thereof in hot water; d) cooling of the hydrated gelatin; e) mixing of the fermented plant drink with the selected prebiotic and additives; h) homogenisation of the mixture; and g) packaging of the product.Type: ApplicationFiled: September 27, 2012Publication date: January 8, 2015Applicant: UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHEInventors: Maria Jose Frutos Fernandez, Estefania Valero Cases
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Publication number: 20130245231Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.Type: ApplicationFiled: September 8, 2011Publication date: September 19, 2013Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C., UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHEInventors: Carlos Belmonte Martínez, Juana Gallar Martínez, Antonio Ferrer Montiel, Asia Fernández Carvajal, Félix Viana De La Iglesia
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Patent number: D856362Type: GrantFiled: May 10, 2016Date of Patent: August 13, 2019Assignee: UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHEInventor: Joaquín Ibañez Ballesteros