Abstract: This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being phenotypically Pts?/glucose+. Such host cells are capable of transporting glucose without consuming PEP, resulting in conservation of PEP which can be re-directed into the pathway in order to enhance the production of desired compounds along the pathway. Pts?/glucose+ mutants have been shown to be advantageous for the enhanced production of the aromatic amino acids.
Type:
Grant
Filed:
September 30, 1997
Date of Patent:
November 8, 2005
Assignees:
Genecor International, Inc., Universidad Nacional Autonoma de Mexico
Inventors:
Fernando Valle, Noemi Mejia, Alan Berry
Abstract: This invention refers to a device and the procedure for the formation of fibrocollagen tubes that are of use as neovascularized reservoirs to favor the implant of cells and/or substances producing biological factors for the treatment of diseases like diabetes. Similarly, the neovascularized fibrocollagen tube formed is suitable for use, should it so be desired, as splints for the implantation of tissues in surgical operation involving blood vessels, urethra among others.
Abstract: The invention relates to a method of removing thiophenic and organosulfide compounds from a fossil fuel comprising the steps of contacting the fossil fuel with hemoproteins, which oxidize the sulfur containing compounds to sulfoxides and sulfones in a reaction system containing organic solvent or not, and followed by a distillation step in which sulfoxides and sulfones are removed from the fuel. Preferred biocatalysts include hemoproteins such as chloroperoxidase from Caldariomyces fumago, and peroxidases and cytochromes from animal, plant or microbial cells. The hemoprotein biocatalyst can be contacted with the fossil fuel in free or immobilized forms. The reaction can be carried out in the presence of the fuel alone or with addition of any organic solvent. The biocatalytically oxidized fuel is then distilled in order to eliminate the heavy fraction which contains most of oxidized organosulfur compounds.
Type:
Grant
Filed:
September 9, 1999
Date of Patent:
October 8, 2002
Assignees:
Instituto Mexicano del Petroleo, Universidad Nacional Autonoma de Mexico
Inventors:
Rafael Vazquez Duhalt, Maria del Pilar Bremauntz, Eduardo Barzana, Raunel Tinoco
Abstract: This invention provides insecticidally effective toxins isolated from the venom of the Mexican scorpions of the genus Centruroides and the cDNA encoding one of the toxins.
Type:
Grant
Filed:
April 1, 1998
Date of Patent:
August 7, 2001
Assignee:
Universidad Nacional Autonoma de Mexico
Inventors:
Barbara Selisko, Consuelo Garcia-Rodriguez, Angelina Ramirez-Navarro, Fernando Zamudio-Zuñiga, Baltazar Becerril-Lujan, Lourival D. Possani-Postay
Abstract: The invention reffers to an equipment for collecting and analyzing ruminal fluid and urine, to may possible the diagnosis of ruminants' diseases, as well as the corresponding treatment and prevention. The equipment was designed with the purpose of collecting, in an easy manner, ruminal fluid and urine, to the end of a fast diagnosis be attained and inclusively performing the detection of the cattle's subclinical diseases directly in the field conditions.
The equipment is easy and safe to employ, and facilitates the ruminal fluid applying from a healthy animal to a sick one, as well as the provision of other fluids and drugs directly to the rumen.
The equipment consists of the following instruments:
a) A tube with metallic head for collecting and applying the fluid to adult bovines.
b) A tube with metallic head for collecting and applying ruminal fluid to calves and to small ruminants.
c) A double metallic pump for collecting and applying ruminal fluid and other fluids.
d) A 5.
Type:
Grant
Filed:
December 8, 1998
Date of Patent:
June 5, 2001
Assignee:
Universidad Nacional Autonoma de Mexico
Inventors:
Jan Bouda, Leopoldo Henry Martinez Paasch, Adolfo Kunio Osorio Yabuta, Samuel Genaro Herrera Jardon, Rudolf Dvorak, Jaroslay Doubek
Abstract: The invention presents a residual water treatment plant for small flows, characterized by the combination of a primary sedimentation zone followed by anoxic and aerobic packed zones, placed serially all of them, with packing, alternating descending and ascending flows and aerated according to the oxygen requirement, there being a recirculation of treated water with sedimented mud between the secondary sedimentator and the first anoxic compartment or primary sedimentation zone, which produces treated water with enough quality for reutilization activities, after prior disinfecting (for example, watering, automobile-washing, flushing of sanitary facilities, floor-washing, and so forth). The plant requires the use of a low energy consumption air compressor, especially specified to minimize its maintenance and noise. The treatment microplant has a compact design, which requires a small area (of the size of a water cistern for 1100L, 1.
Type:
Grant
Filed:
October 29, 1999
Date of Patent:
April 3, 2001
Assignee:
Universidad Nacional Autonoma de Mexico
Inventors:
Juan Manuel Morgan Sagastume, Adalberto Noyola Robles
Abstract: The invention features compositions and methods for the detection of and differentiation between Taenia solium and/or Taenia saginata. Specifically, the invention features nucleic acid probes comprising specific repetitive sequences of T. solium and T. saginata. These sequences make it possible to distinguish, with a high level of sensitivity and specificity, the eggs of these species of Taenia, thus enabling the diagnosis of taeniasis and the identification of carriers of Taenia solium. The invention is of great importance in controlling spread of T. solium due to ingestion of infected pork and/or exposure to human carriers of T. solium, thus facilitating the eradication of human and swine cysticercosis. The invention is thus of great importance in supporting eradication of human and swine cysticercosis.
Type:
Grant
Filed:
March 24, 1997
Date of Patent:
December 5, 2000
Assignees:
Universidad Nacional Autonoma de Mexico, The Regents of the University of California
Inventors:
Ana Flisser Steinbruch, Alger B. Chapman, Nina M. Agabian, Diana Maria Ortiz Garcia, Veronica Vallejo Ruiz, Kevin G. Mossie
Abstract: Copper amino acidate diimine nitrate compounds of the formula [Cu(N--N)(N--O)].sup.+NO.sub.3.sup.-, where (N--N) is a diimine selected from 1,10-phenanthroline or 4,7-dimethyl 1,10-phenanthroline and (N--O) is tyrosine-alaninate, threoninate, tryptophanate, valinate, isoleucinate, cysteinate, diglycinate, phenylalaninate, glycinate, histidinate, serinate, tryosinate, aspartate or alaninate and a process for preparing the compounds in which, while maintaining a pH between 5 and 7, a first aqueous solution of Cu(NO.sub.3).sub.2.5H.sub.2 O, having 30 to 35% by weight of elemental copper, is reacted with a second aqueous solution of the diimine having a ratio of 50 to 55% by weight diimine to solution to form a monodiimine nitrate as an intermediate reaction product having the formula [Cu(N--N)(H.sub.2 O).sub.2 ].sup.+ NO.sub.3.sup.
Type:
Grant
Filed:
September 8, 1994
Date of Patent:
November 19, 1996
Assignee:
Universidad Nacional Autonoma de Mexico (UNAM)
Abstract: The invention described herein consists of a process for preparing an antigenic reagent useful for the indirect determination of Salmonella typhi, the organism that is the causal agent of typhoid fever (TF). The invention consists on the following steps: to grow Salmonella typhi in a culture medium, characterized by containing a free-iron chelator, which generates a specific S. typhi outer membrane protein (OMP) pattern, OMPs that are used as a selective antigen for the detection of specific serum antibodies, by an immunoassay technique (ELISA).
Type:
Grant
Filed:
March 21, 1991
Date of Patent:
April 11, 1995
Assignee:
Universidad Nacional Autonoma de Mexico
Inventors:
Edmundo Calva-Mercado, Guillermo M. Ruiz Palacios, Antonio V. Rodriguez, Yolanda L. Vidal
Abstract: This invention refers to a process to obtain new mixed copper aminoacidates complexes from phenanthrolines of an aromatic type to be used as anticancerigenic agents preferably with a therapeutic use for the treatment of liquid and solid cancerigenic tumors such as leukemia. The complexes obtained are of the [Cu (N-N) (N-O)].+-. NO.sub.3 type in which the N-N ligand corresponds to 4, 7 - diphenyl-1, 10 phenanthroline and the N-O ligand preferably corresponds to one of the aminoacidates such as glycinate, alaninate, isoleucinate, leucinate, serinate and valinate. The process is characterized because it includes the following steps: making an aqueous solution based on an aliphatic alcohol and 4, 7 - diphenyl - 1, 10 phenanthroline react with a copper complex preferably Cu NO.sub.3 5H.sub.2 O at room temperature, and immediately after making the obtained product react in an aqueous aminoacidate solution adjusting a slightly alkaline pH.
Type:
Grant
Filed:
December 11, 1990
Date of Patent:
April 21, 1992
Assignee:
Universidad Nacional Autonoma de Mexico (UNAM)
Abstract: The invention relates to a novel immunogenic synthetic peptide that is capable of specifically blocking potassium channels of excitable membranes and inducing immunity against an effective lethal dose of Noxiustoxin. The invention also relates to the discovery that the immunogenic and blocking properties of the peptide are severable. Peptides possessing either the immunogenic or the blocking property are disclosed.
Type:
Grant
Filed:
December 14, 1987
Date of Patent:
May 29, 1990
Assignee:
Universidad Nacional Autonoma De Mexico
Inventors:
Lourival D. P. Possani, Georgina B. Gurrola, Marco A. A. C. Bayon, Maria B. Sitges