Abstract: The present invention relates to a new composition of human recombinant antibody fragments in both single chain or Fab format, which is capable of completely neutralizing the venom of the scorpion Centruroides sculpturatus Ewing (C. sculpturatus. In particular the new composition comprises the scFv fragment 10FG2 (SEQ. ID. No: 1), which has broad cross-reactivity against various Mexican scorpion venom toxins, and the scFv fragment LR (SEQ. ID. No: 2), with more limited cross-reactivity. Alternatively, the new composition comprises the Fab 10FG2 fragment (SEQ. ID. No: 3 and SEQ.ID. No:4) and the Fab LR fragment (SEQ. ID. No: 5 and SEQ.ID. No 6). The two antibody fragments recognize independent epitopes, present in the two main toxins of the scorpion C. sculpturatus, so that they do not interfere with each other during their binding to the same, on the contrary the antibody fragments of the present invention complement the neutralizing activity.

Abstract: Peptides endowed with an anti-inflammatory, anti-angiogenic and/or antimicrobial activity, a medicament or a pharmaceutical composition including such peptides, and the use thereof in the prevention or treatment of inflammatory diseases, and more particularly inflammatory diseases due to or associated with microbial infections, or in the prevention or treatment of angiogenesis-related diseases.

Abstract: A hydrodynamically optimized mixer module, to be coupled to a deterministic hydrodynamic tool that allows pulsed polishing of optical surfaces is described. This module allows the supply of abrasive foam or fluid that enters the tool to be interrupted without impairing the operational stability of the polishing process and of said hydrodynamic tool. The mixer module includes at least one interrupter element for switching high-velocity fluids; a first inlet through which air is injected under pressure and in a controlled manner; a second inlet through which a polishing fluid is injected in a controlled manner, said polishing fluid filling a predetermined volume with a hydrodynamically optimized shape and being transferred to a mixing zone where, together with the pressure-injected air, an abrasive foam is produced that is injected into at least one rotational acceleration chamber of the hydrodynamic tool to which the mixer module is coupled.

Abstract: The present invention relates to a catalytic formulation used in the hydroprocessing of light and middle oil fractions, preferably in hydrodesulfurization and hydrodenitrogenation reactions to obtain diesel with ultra low sulfur content less than or equal to 15 ppm in weight. The catalytic formulation, object of the present invention, consists of at least one metal of Group VI B and at least one metal of Group VIII B and one element of Group V A of the periodic table deposited on a support based on surface modified alumina with an inorganic oxide of a metal of Group II A, IV A and/or IV B. And containing an impregnated organic compound containing at least one hydroxyl group and at least one carboxyl group and that can contain or not at least one sulfide group in its structure. The catalytic formulation, object of the present invention, allows processing of the oil fractions with initial and final boiling temperatures between 150 and 450° C.

Abstract: The present invention refers to the use of the peptide defined by the amino acid sequence G-Y-Y-Y-P-S-D-P-N-T-F-Y-A-P-P-Y-S-A, named GK-1, to be used as an antitumor and antimetastatic agent or for the treatment of cancer, specifically of basal cell carcinoma, squamous cell carcinoma, transitional cell carcinoma, and adenocarcinoma, and preferably for the treatment of breast cancer.

Abstract: The disclosure provides nucleic acids encoding variant polypeptides having pesticidal activity against insect pests, including Lepidoptera and Diptera. Particular embodiments provide isolated nucleic acids encoding Cyt1A variant polypeptides, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, particularly Diptera pests.

Abstract: Hybrid proteins with cytochrome P450 activity and which are encapsulated in a nanocapsid (nanoparticles charged with cytochrome P450 activity) are designed and synthesized, these hybrid proteins being immunologically inert and recognized by breast cancer cells.

Abstract: The disclosure provides nucleic acids encoding variant polypeptides having pesticidal activity against insect pests, including Lepidoptera and Diptera. Particular embodiments provide isolated nucleic acids encoding Cyt1A variant polypeptides, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, particularly Diptera pests.

Abstract: The instant invention is related with new perimidine derivatives synthesized via direct condensation between naphthalene-1,8-diamine and itaconic or citraconic anhydrides at low temperature. The targeting itaco-perinone (IP) molecule formed via double low temperature cyclization has fluorescence properties emitting white light intensively. Besides, 9-methylene-8H-pyrrolo[1,2-a]perimidin-10(9H)-one is copolymerizable with several kind of organic monomer compounds via free radical mechanism maintaining the ability to emit white light even within the polymer film.

Abstract: The present invention relates to hydrosoluble compounds derived from benzimidazole represented by general formula I: wherein: Y1 e Y2 are independently O or S, and at least one of Y1 and Y2 is O; R1 and R2 are independently hydrogen or a cation, both are hydrogen or both are cations; R3 is a C1-4 alkyl; R4 and R5 are independently halogen or a —OR6 alkoxide; R6 is C6-C10 aryl linked in 5- or 6-position of benzimidazole nucleus.

Abstract: The present invention provides a method to obtain DNA constructs that encode 3-domain Cry toxins (also called Cry toxins, Bt toxins, or ?-endotoxins) lacking helix ?-1. These DNA constructs have been modified to encode proteins that kill insects that are resistant to the corresponding unmodified Cry toxins. The DNA constructs encoding the Modified 3-Domain Cry Toxins and the encoded Modified 3-Domain Cry Toxins are provided together with the molecular vectors and the host cell comprising said constructs and the recombinant methods to produce the Modified 3-Domain Cry Toxins. Additionally, compositions comprising the Modified 3-Domain Cry Toxins are disclosed. The resistance of the insects to unmodified Cry toxins is due to reduced toxin binding to the insects' midgut receptors. The invention further provides methods to overcome resistance in crop pests.

Abstract: The invention relates to the production and the characterization of new murine monoclonal antibodies that recognize the domain CTDL-2 (SEQ ID NO: 1) of the cell receptor DEC-205 of dendritic cells in chickens (Gallus gallus), pigs, (Sus scrofa) and humans (Homo sapiens). The invention also relates to the capacity of the new antibodies to direct and modulate the immune response at different levels in chickens (Gallus gallus) and pigs (Sus scrofa), as well as recognizing the receptor DEC-205 in dentritic cells and cell lines in humans. In addition, the invention is used to quickly produce a specific humoral immune response against Hemaglutinina H5 of the H5N2-type avian flu virus.

Abstract: An improvement of a worm gear speed reducer is provided where the output gear is substituted by a threaded chain comprised of nut-like threaded bodies mounted on the extended rods of two parallel endless chains, thus the contact surfaces of the drive screw and the threaded chain are much greater than the contact surfaces of the worm gear reducer, and thus the load capacity and wear resistance are much higher. The screw applies the driving force at the centroid of the contact surface of the threaded chain. There are three embodiments which may be a roller screw, a ball screw or a plain translation screw. With the roller screw or the ball screw there is rolling contact and thus the efficiency of the present invention is higher than that of the worm gear reducer which permits it to be used as an amplifier.

Abstract: Process and system for identifying and quantifying helminth eggs in water, sludge, biosolid and/or excreta samples among others, from images comprising filtering the images with an anisotropic filter maintaining the borders of the images, obtaining filtered images; filtering the filtered images applying Laplacian of Gaussian detecting changes in the filtered images, and obtaining binarized images; separating the binarized images by means of a filtered distance field Watershed filter, obtaining the images; filtering the images eliminating objects by perimeter compactness, considering the size of the objects in the images filtered again and separating the differences to avoid false positives, obtaining images with identified objects; characterizing the objects identified in the images segmenting the objects by means of gray profiles; and classifying the characterized objects according to a statistic classifier for identifying and quantifying different species of helminth eggs.

Abstract: Three adhesives formulated with Trimethylolpropane Trimethacrylate (TMPTMA) that do not contain BisGMA were developed, whereby the mutagenic and teratogenic risk by the release of bisphenol A is eliminated, and presented a better performance compared to the three commercial adhesives prepared with BisGMA (Adhesive A, Adhesive C and Adhesive B). The invention provides an adhesive used in one-step and provides a system which is formed by a primer and a slurry. The adhesives of the invention were compared with two commercial controls. They were physically characterized by assessing: hardening time, adhesion stress, elastic modulus, sorption and solubility at different pHs (6.8 and 7.7); by the obtained values premature detachments, white lesions below the appliance and microfiltration are avoided; its fluidity, film thickness were evaluated and were compared with those obtained from the three commercial adhesives. Storage stability and thermogravimetric analysis were assessed.

Abstract: The present invention relates to the preparation of catalysts used in the hydrodesulfurization of fossil fuels and proposes a method for preparing thermally stable, low-cost catalysts for the hydrodesulfurization of petrol and diesel, based on highly active CoMo and NiMo. The catalyst for the hydroprocessing of gasoil or petrol in the present invention comprises a precursor which consists of chemical compounds obtained from organic acids and metal salts, and a support containing an ultra-stable Y-type zeolite useful in the hydroprocessing of heavy gas oil and/or light cyclic gas oil with high conversion rates.

Abstract: Process and system for identifying and quantifying helminth eggs in water, sludge, biosolid and/or excreta samples among others, from images comprising filtering the images with an anisotropic filter maintaining the borders of the images, obtaining filtered images; filtering the filtered images applying Laplacian of Gaussian detecting changes in the filtered images, and obtaining binarized images; separating the binarized images by means of a filtered distance field Watershed filter, obtaining the images; filtering the images eliminating objects by perimeter compactness, considering the size of the objects in the images filtered again and separating the differences to avoid false positives, obtaining images with identified objects; characterizing the objects identified in the images segmenting the objects by means of gray profiles; and classifying the characterized objects according to a statistic classifier for identifying and quantifying different species of helminth eggs.

Abstract: The biphasic extraction from coffee waste without a prior drying process, to obtain coffee oil, which is transesterified with KOH catalyzed methanol to produce mixtures of glycerol free methylic esters, also known as coffee oil biodiesel, which is subjected to an aminolysis reaction with aminoethylethanolamine (AEEA) by heating to 140-160° C. at atmospheric pressure with a subsequent dehydration reaction at the same temperature but at a reduced pressure of 200 to 300 mmHg, in order to achieve cyclization of the intermediary amides into the corresponding imidazolines. Alternatively process, coffee oil can be submitted to the same aminolysis procedure with aminoethylethanolamine (AEEA) at 140 to 160° C. and atmospheric pressure with a subsequent dehydration reaction at the same temperature but at a reduced pressure of 200 to 300 mmHg, to produce imidazolines that contain the residual glycerol of the original triglycerides.

Abstract: The present invention provides a novel vaccine compound of micellar nanoparticles to be administered intranasally to treat and/or prevent the disease called atherosclerosis, which results from an abnormal metabolism of circulating lipids. The novelty of the vaccine compound of the present invention is the use of Archaebacterian lipids, lysophosphatidylcholine, and phosphatidylcholine, which give nanoparticles stability and facilitates antigen presentation in its appropriate secondary peptidic conformation. A novel process for the preparation of vaccine compounds which allows obtaining homogeneous nanoparticles with high stability is also presented in this invention.

Abstract: The instant invention is related with new perimidine derivatives synthesized via direct condensation between naphthalene-1,8-diamine and itaconic or citraconic anhydrides at low temperature. The targeting itaco-perinone (IP) molecule formed via double low temperature cyclization has fluorescence properties emitting white light intensively. Besides, 9-methylene-8H-pyrrolo[1,2-a]perimidin-10(9H)-one is copolymerizable with several kind of organic monomer compounds via free radical mechanism maintaining the ability to emit white light even within the polymer film.