Abstract: The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.
Type:
Grant
Filed:
February 22, 2019
Date of Patent:
July 13, 2021
Assignees:
Universidad Tecnica Particular De Loja, Cornell University, BioVentures, LLC
Inventors:
Cesar M. Compadre, Paola E. Ordonez, Monica L. Guzman, Darin E. Jones, Omar Malagon, Giovanni Vidari, Peter Crooks
Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
Type:
Grant
Filed:
June 1, 2018
Date of Patent:
July 23, 2019
Assignees:
BIOVENTURES, LLC, UNIVERSIDAD TECNICA PARTICULAR DE LOJA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors:
Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
Type:
Application
Filed:
June 1, 2018
Publication date:
September 27, 2018
Applicants:
BioVentures, LLC, Universidad Tecnica Particular De Loja, The United States of America as Represented by the Department of Veterans Affairs
Inventors:
Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
Type:
Grant
Filed:
September 15, 2014
Date of Patent:
June 12, 2018
Assignees:
The Board of Trustees of the University of Arkansas, Universidad Tecnica Particular De Loja, The United States of America as Represented by the Department of Veterans Affairs
Inventors:
Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
Type:
Application
Filed:
September 15, 2014
Publication date:
August 4, 2016
Applicants:
The Board of Trustees of the University of Arkansas, Universidad Tecnica Particular De Loja, United States Department of Veterans Affairs
Inventors:
Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones