Abstract: The present invention refers to pyridazin-3(2H)-one derivatives of general structure I, II and III, which are selective MAO-B inhibitors, and to the use thereof for preparing medicaments intended to treat disorders derived from MAO-B hyperactivity, particularly degenerative disorders of the central nervous system (CNS), such as Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. These are pyridazin-3(2H)-one derivatives having dithiocarbamate moieties bonded to position 4, 5 or 6 through an alkyl chain of variable length (n=1, 2, 3). This invention is also directed to the preparation of said compounds.

Abstract: The present invention relates to a quantitative ex vivo method for the complementary diagnosis of the degree of dental demineralization through the use of Raman spectroscopy, which comprises quantifying the intensities and areas of a plurality of Stoke bands of the spectrum, and defining and calculating indices that result from dividing the areas of certain bands of interest. The diagnosis is determined by the proximity of the values of these indices to the values previously obtained for the normal pattern of dental mineralization established by analyzing healthy dental parts. This method provides a complementary biomedical technique for quantitative ex vivo analysis of the degree of dental demineralization on dental tissue remains extracted by medical prescription, and the information obtained will facilitate the prescription of suitable treatment to reduce or prevent said demineralization.

Abstract: The present invention refers to pyridazin-3(2H)-one derivatives of general structure I, II and III, which are selective MAO-B inhibitors, and to the use thereof for preparing medicaments intended to treat disorders derived from MAO-B hyperactivity, particularly degenerative disorders of the central nervous system (CNS), such as Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. These are pyridazin-3(2H)-one derivatives having dithiocarbamate moieties bonded to position 4, 5 or 6 through an alkyl chain of variable length (n=1, 2, 3). This invention is also directed to the preparation of said compounds.

Abstract: The invention is based on a process and system for producing random numbers by means of a quantum random number generator where the method comprises the steps of operating a laser in single mode and high modulation bandwidth by means of an electrical pulse driver, transforming the phase randomized optical pulses produced before in optical pulses with random amplitude and detecting the resulting random amplitude signals by means of a fast photodiode. The numbers thus produced are truly random.

Abstract: Disclosed embodiments include a method for automatic identification of activity and rest periods based on an actigraphy signal. According to an embodiment, the method comprises (a) applying one or more filters to the actigraphy signal to generate a filtered actigraphy signal, and (b) comparing the filtered actigraphy signal against an adaptive threshold to generate an output signal corresponding to the activity and rest periods. The method can be implemented as part of a medical apparatus or medical system for automatic activity/rest identification from actigraphy signals.

Abstract: Disclosed embodiments include a web-enabled system especially adapted for clinical research and clinical management of cardiovascular risk using ambulatory blood pressure monitoring (ABPM) data, actigraphy data, and clinical data. According to a disclosed embodiment the web-enabled system comprises (a) a web-enabled graphical user interface to enable a user to securely authenticate, securely upload clinical data, and navigate through a plurality of software modules; (b) a database to store user profiles, protocols, clinical data, ambulatory blood pressure monitoring (ABPM) recordings, actigraphy recordings, research data, and study results; and (c) a plurality of statistical methods and analysis techniques especially designed to automatically analyze the clinical cardiovascular risk data, and create customized reports of the results designed to assess cardiovascular risk based on ABPM and actigraphy.

Abstract: Disclosed embodiments include methods for cleaning wax, substantially equivalent impurities, and other contaminants from porous stones in historical monuments and artworks using nondestructive means. According to one embodiment the method for removal of contaminants from porous stones using laser comprises the following method steps: (a) identifying regions of a contaminant on the porous stone monument; (b) characterizing the contaminant on the porous stone monument; (c) exposing the contaminant on the porous stone monument to irradiation from a laser characterized by a wavelength, a pulse length, a repetition rate, and a laser energy fluence determined and optimized for a given contaminant-porous stone system and the laser characteristics; and (d) adaptively evaluating the cleaning results by quantifying the thickness of the remaining contaminant.

Abstract: Disclosed embodiments include a web-enabled system especially adapted for clinical research and clinical management of cardiovascular risk using ambulatory blood pressure monitoring (ABPM) data, actigraphy data, and clinical data. According to a disclosed embodiment the web-enabled system comprises (a) a web-enabled graphical user interface to enable a user to securely authenticate, securely upload clinical data, and navigate through a plurality of software modules; (b) a database to store user profiles, protocols, clinical data, ambulatory blood pressure monitoring (ABPM) recordings, actigraphy recordings, research data, and study results; and (c) a plurality of statistical methods and analysis techniques especially designed to automatically analyze the clinical cardiovascular risk data, and create customized reports of the results designed to assess cardiovascular risk based on ABPM and actigraphy.

Abstract: Disclosed embodiments include methods for cleaning wax, substantially equivalent impurities, and other contaminants from porous stones in historical monuments and artworks using nondestructive means. According to one embodiment the method for removal of contaminants from porous stones using laser comprises the following method steps: (a) identifying regions of a contaminant on the porous stone monument; (b) characterizing the contaminant on the porous stone monument; (c) exposing the contaminant on the porous stone monument to irradiation from a laser characterized by a wavelength, a pulse length, a repetition rate, and a laser energy fluence determined and optimized for a given contaminant-porous stone system and the laser characteristics; and (d) adaptively evaluating the cleaning results by quantifying the thickness of the remaining contaminant.