Abstract: The present invention relates to the electrochemical detection of an analyte by capacitance spectroscopy using a redox active polymer-coated electrode such as a polyaniline-coated electrode.
Type:
Application
Filed:
January 29, 2021
Publication date:
March 16, 2023
Applicants:
Oxford University Innovation Limited, Universidade Estadual Paulista "Júlio De Mesquita Filho" - UNESP
Abstract: The present application relates to an electrode suitable for use in electrochemical sensing of a target species. The electrode comprises a peptide monolayer of defined length and to one end of which are attached both a redox active species and a receptor that is capable of binding to the target species. Also provided is an electrochemical method of sensing a target species, which involves the use of the electrode.
Type:
Application
Filed:
January 23, 2019
Publication date:
May 6, 2021
Applicants:
Oxford University Innovation Limited, Universidade Estadual Paulista "Júlio De Mesquita Filho' - UNESP
Inventors:
Eduardo Maffud Cilli, Paulo Roberto Bueno
Abstract: The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.
Type:
Application
Filed:
September 24, 2013
Publication date:
February 27, 2014
Applicants:
UNIVERSIDADE ESTADUAL PAULISTA JULIO DE MESQUITA FILHO - UNESP, EMS S.A.
Inventors:
Ednir de Oliveira VIZIOLI, Chung Man Chin, Renato Farina Menegon, Lorena Blau, Jean Leandro Dos Santos, Maria do Carmo Longo
Abstract: Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-? levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.
Type:
Application
Filed:
February 24, 2012
Publication date:
September 27, 2012
Applicants:
UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP, UNIVERSIDADE ESTADUAL PAULISTA " JULIO DE MESQUITA FILHO " -UNESP, UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ
Inventors:
Jean Leandro DOS SANTOS, Chin CHUNG MAN, Lídia MOREIRA LIMA, Fernando FERREIRA COSTA, Carolina LANARO
Abstract: Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-? levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.
Type:
Application
Filed:
February 24, 2012
Publication date:
June 21, 2012
Applicants:
UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP, UNIVERSIDADE ESTADUAL PAULISTA <<JULIO DE MESQUITA FILHO >> - UNESP, UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ
Inventors:
Jean Leandro DOS SANTOS, Chin CHUNG MAN, Lídia MOREIRA LIMA, Fernando FERREIRA COSTA, Carolina LANARO
Abstract: The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.
Type:
Application
Filed:
April 9, 2009
Publication date:
May 19, 2011
Applicants:
EMS S.A., Universidade Estadual Paulista Julio De Mesquita Filho - UNESP
Inventors:
Ednir de Oliveira Vizioli, Chung Man Chin, Renato Farina Menegon, Lorena Blau, Jean Leandro Dos Santos, Maria do Carmo Longo