Abstract: Antibodies for molecular imaging of vulnerable plaques in atherosclerosis Antibody specifically binding to atherosclerosis lesions for in vivo imaging and methods for in vivo imaging of atherosclerosis lesions in a patient.
Type:
Grant
Filed:
November 15, 2012
Date of Patent:
October 10, 2017
Assignees:
Centre National De La Recherche Scientifique (CNRS), Universite Bordeaux Segalen
Abstract: Described herein are methods and compositions that can be used for diagnosis and treatment of soft tissue sarcoma cancer phenotypes and soft tissue sarcoma cancer-associated diseases. Also described herein are methods that can be used to identify modulators of soft tissue sarcoma cancer.
Abstract: The invention relates to a microfluidic system for controlling a card for the concentration of molecules capable of stimulating a target, for example formed by an assembly of living cells, characterized in that the system comprises a microfluidic device (1) comprising: n?1 microfluidic channel(s) (4, 40), the or each channel being provided with at least one inlet orifice for at least one fluid and with at least one outlet orifice for this fluid; n?2 openings (47, 470) formed in the microfluidic channel or distributed in the various microfluidic channels, said openings being arranged in one and the same plane so that they form a network having at least one dimension in this plane, the numbers n of microfluidic channel(s) and n of openings being linked by the relationship (I) with 1?i?n and n the number of openings for the channel c; at least one microporous membrane (5) covering the network of openings, the target being intended to be positioned on the side of the membrane which is opposite the microfluidic ch
Type:
Grant
Filed:
April 20, 2012
Date of Patent:
October 20, 2015
Assignees:
Centre National de la Recherche Scientifique-CNRS, Ecole Normale Supérieure, Univerité Pierre et Marie Curie (Paris 6), Fonds de l'ESPCI-Georges Charpak, Université Bordeaux Segalen
Inventors:
Maxime Dahan, Mathieu Morel, Jean-Christophe Galas, Vincent Studer, Denis Bartolo
Abstract: Antibodies for molecular imaging of vulnerable plaques in atherosclerosis Antibody specifically binding to atherosclerosis lesions for in vivo imaging and methods for in vivo imaging of atherosclerosis lesions in a patient.
Type:
Application
Filed:
November 15, 2012
Publication date:
November 6, 2014
Applicants:
UNIVERSITE BORDEAUX SEGALEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The invention relates to a gaseous mixture containing oxygen (O2) and a volume proportion of 20 to 70% of xenon (Xe) for use as an inhalable drug for preventing or treating hypersensitivity to pain in humans or animals, in particular hypersensitivity to pain expressed as hyperalgesia or allodynia.
Type:
Grant
Filed:
July 13, 2010
Date of Patent:
January 21, 2014
Assignees:
L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude, Université Bordeaux Segalen
Abstract: A method for in vitro predicting survival and/or metastatic outcome of gastrointestinal stromal tumors (GISTs), characterized in that it comprises the measure of the level, in a patient-derived biological sample of GIST, of a pool of polypeptides or polynucleotides consisting in Aurora kinase A (AURKA); a kit for the in vitro prediction of the survival outcome of a patient suffering from GIST, and/or the development of metastases in a patient treated for or suffering from GIST, and/or the prediction of the efficacy of a treatment for GIST, characterized in that it comprises means for detecting and/or quantify, in a sample, AURKA expression or level, and means for the calculation of the GI; and a method for screening for compounds for the use in the treatment of GISTs and to an AURKA inhibitor for its use in the treatment of GISTs.
Abstract: Described herein are methods and compositions that can be used for diagnosis and treatment of soft tissue sarcoma cancer phenotypes and soft tissue sarcoma cancer-associated diseases. Also described herein are methods that can be used to identify modulators of soft tissue sarcoma cancer.
Abstract: The invention relates to novel functional amphiphilic molecule or macromolecule formulations with multiple compartments for transporting or targeting at least one therapeutic agent, in particular an antitumor agent, as well as to a method for preparing such formulations and to the use thereof.
Type:
Application
Filed:
May 28, 2010
Publication date:
March 22, 2012
Applicants:
UNIVERSITE DE LA MEDITERRANEE, UNIVERSITE BORDEAUX SEGALEN
Inventors:
Philippe Barthelemy, Salim Khiati, Michel Camplo