Patents Assigned to UNIVERSITÉCITÉ
  • Method for generating T-cell progenitors
    Patent number: 12071635
    Abstract: The invention relates to the field of cell therapy and to an in vitro method for generating T-cell progenitors, comprising the step of exposing CD34+ cells in a medium containing a Notch ligand, a soluble domain of the Delta-like ligand 4, joined to an Fc region of a protein IgG, in the presence of a fragment of fibronectin comprising the motifs RGDS and CS-1 and a heparin-binding domain.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: August 27, 2024
    Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, FONDATION IMAGINE-INSTITUT DES MALADIES GÉNÉTIQUES, UNIVERSITÉCITÉ, INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE (INSERM)
    Inventors: Marina Cavazzana, Isabelle André, Chantal Lagresle-Peyrou, Salima Hacein-Bey-Abina, Christian Reimann, Corinne De Chappedelaine, Emmanuelle Six