Abstract: The present invention concerns clusterin for use in the treatment of thrombotic microangiopathies, and a pharmaceutical composition comprising clusterin for use in the treatment of thrombotic microangiopathies, said composition not comprising von Willebrand factor protease. The present invention also concerns an ex vivo method for stratifying a patient suffering, or likely to be suffering, from TMA, comprising the following steps: 1) measuring, in a biological sample from said patient, the amount LC of clusterin, and 2) comparing the amount Lc measured in step 1) with an amount Lref of clusterin by calculating the score S1=LC/Lref, in which: •If S1?1, the patient is considered to be likely to benefit from a treatment of the TMA with clusterin, •If S1>1, the patient is not considered to be likely to benefit from treatment of TMA with clusterin.

Abstract: The invention relates to a method for depositing an environmental barrier on a part made of composite material having a ceramic matrix comprising silicon carbide fibres. The method comprises the deposition of a joining layer on at least one surface of the part, the joining layer comprising mullite or a mullite precursor, and the deposition of a protective layer on the joining layer, the protective layer comprising a rare earth disilicate.

Abstract: A device for depositing a thick metal nitride on a sample by supercritical fluids includes a first enclosure forming a first closed volume; a second enclosure placed in the first enclosure and delimited by internal walls transparent to electromagnetic radiation forming a second closed volume intended to include fluid under supercritical conditions; a heat transfer dielectric fluid circulating in the first volume around the second enclosure; a sample holder present in the second volume; an induction heating device surrounding the second enclosure; inlets for introducing a fluid and at least one precursor material into the second enclosure, and an outlet to purge the second volume.

Abstract: A method for manufacturing a part from a first ceramic or from carbon, consolidated by a second ceramic, having a determined geometry, that involves carrying out the following sequence of steps: a) manufacturing a preform made from an organic polymer; b) impregnating the preform made from an organic polymer with a resin that is a precursor of the first ceramic or a resin that is a precursor of carbon; c) crosslinking and/or polymerising, then pyrolysing the resin that is a precursor of the first ceramic or the resin that is a precursor of carbon; to obtain a part made from a first ceramic or from carbon having the same geometry as the part to be manufactured; e) depositing the second ceramic on the part made from a first ceramic or from carbon by means of a chemical vapour deposition or CVD process or a chemical vapour infiltration or CVI process.

Abstract: The invention relates to a cellular microcompartment comprising successively, organized around a lumen, at least one layer of pluripotent cells, an extracellular matrix layer and an outer hydrogel layer. The invention also relates to processes for preparing such cellular microcompartments.

Abstract: The invention relates to a copolymer comprising units derived from monomers of vinylidene fluoride and/or trifluoroethylene, as well as fluorinated monomers X comprising a double bond and a leaving group selected from among chlorine, bromine and iodine atoms, the leaving groups being partially replaced by azide groups in the copolymer.

Abstract: The invention relates to a process for the manufacture of a tablet comprising a nucleic acid vector.

Abstract: A laser amplifier head is provided. The laser amplifier head includes a plurality of plates of a solid-state laser active medium disposed in a housing, arranged parallel to one another with their main surfaces facing one another, the housing being provided with an inlet port and an outlet port for a cooling liquid, and also at least one window allowing a laser beam to pass through the laser active medium plates, wherein it also includes: a mechanical connection device allowing a cyclic movement at least of the laser active medium plates in relation to the laser beam in a plane (xy) perpendicular to the direction (z) of their thickness; and cooling liquid guide plates arranged in the extension of the laser active medium plates, between the latter and the inlet port of said liquid.

Abstract: The present invention relates to a fusion peptide having one of the following formulae: P1-L-P2 (I) or P2-L-P1 (II) wherein P1 is chosen from the proline-rich antimicrobial peptides; Lisa peptide linker; and P2 has the following formula (III): wherein m is 0 or 1; n is an integer comprised between 0 and 9; p is an integer comprised between 0 and 10; r is 0, 1 or 2; s is 0 or 1; Gln is glutamine; R1 is the side chain of arginine or lysine; R2 is for example a —(CH2)—C3-6-cycloalkyl group optionally substituted; R3 is for example a C1-8-alkyl group; R4 is in particular a C1-8-alkyl group optionally substituted by a C3-6-cycloalkyl group; R5 is for example a —(CH2)—C3-6-cycloalkyl group; R6 is in particular —COOH, wherein, when the fusion peptide has the formula (II), its C-terminus contains a —CO— group engaged in a peptide bond with said linker.

Abstract: A process for coating a substrate with tantalum nitride by the high-power impulse magnetron sputtering technique, wherein a tantalum target is used and wherein the coating of the substrate is carried out in an atmosphere containing nitrogen, the bias of the target being controlled during the coating by imposing on it the superposition of a continuous bias at a potential between ?300 V and ?100 V and of a pulsed bias whose pulses have a potential between ?1200 V and ?400 V.

Abstract: The present invention concerns a block copolymer having at least one oligo- or polysaccharide block and at least one elastin-like polypeptide block, wherein said block copolymer comprises at least one repetitive unit having the following formula (I): wherein R? is the side chain of a natural or synthetic amino acid other than proline and derivatives thereof.

Abstract: A Method for generating a biomarker includes acquiring an image using an MRI system; processing the MRI image to generate a three-dimensional image of the lung; generating a first function corresponding to the distribution of the different signal intensity values; automatically calculating a filtering threshold of the first function from a second signal intensity value distribution function; segmenting a lung volume comprising: a main volume; a filtered volume of a volume of voxels quantified by the first function and filtered by at least the calculated filtering threshold, normalizing the values of the three-dimensional image of the lung volume; generating a biomarker indicating a normalized segmented volume ratio.

Abstract: A method for determining a stereotactic brain target includes at least one target point, the method comprising the following steps: selecting patients for whom the result measured following treatment at at least one target point is greater than or equal to a threshold, postoperative imaging having been performed for each of the patients; processing the postoperative imaging so as to determine coordinates of the at least one target point; selecting brain marker points; processing the postoperative imaging so as to determine coordinates of the marker points; creating a learning database comprising the coordinates of the target points and the coordinates of the marker points determined for all of the selected patients; determining a prediction function giving the coordinates of at least one target point according to the coordinates of the marker points by using the learning database and a supervised statistical learning method; processing preoperative imaging of a new patient to be treated so as to determine coo

Abstract: An apparatus includes a shaft and an end effector at a distal end of the shaft. The end effector is sized to fit in an anatomical passageway within a subject's cardiovascular system. The end effector includes at least one electrode pair that is configured to contact cardiovascular tissue and thereby pick up electrocardiogram signals. Each electrode pair includes first and second electrodes spaced apart along a longitudinal axis from each other by a gap area located between the electrodes, the gap area having a gap length with respect to the longitudinal axis such that a length of one of the electrodes along the longitudinal axis is equal to or greater than the gap length; and a ratio of an area defined by the gap area to one electrode area is equal to or less than one.

Abstract: Disclosed is a multi-axis atom interferometer system, including a source of cold atoms, a laser source generating a first light pulse configured in such a way as to spatially split the source of cold atoms into a first cloud of atoms propagating along a first trajectory along a first axis and a second cloud of atoms propagating along a second trajectory along a second axis, a second light pulse adapted to spatially deflect the first trajectory along the second axis and simultaneously the second trajectory along the first axis towards a first point and a last light pulse adapted to recombine the at least one part of the first cloud of atoms and the at least one part of the second cloud of atoms at the first point, and a detection system measuring an interferometric phase-shift accumulated between the first light pulse and the last light pulse.

Abstract: A method for producing a part having improved resistance to oxidation and high temperature-corrosion, includes the formation of an environmental barrier coating on an at least partially ceramic matrix composite material, the environmental barrier coating being formed by direct liquid injection-metal organic chemical vapor deposition.

Abstract: A process for depositing a coating on a continuous fibre of carbon or silicon carbide from a precursor of the coating, includes heating a segment of the fibre in the presence of the coating precursor in a microwave field so as to bring the surface of the segment to a temperature allowing the coating to form on the segment from the coating precursor, wherein the segment of fibre is in the presence of a supercritical phase of the precursor of the coating in the reactor and the coating is formed by supercritical phase chemical deposition in the reactor.

Abstract: The present invention relates the field of reducing CD95-mediated cell motility in a subject, in particular for their use in the reduction of CD-95 mediated cancer cell motility, the reduction of CD95-mediated lymphocyte motility and/or B cell maturation, or the treatment of B-cell tumors, in a subject. The inventors identified a novel family of compounds having the ability to disrupt CD95/PLC?1 interaction and to neutralize the CD95-mediated calcium signaling pathway and cell migration in human peripheral blood lymphocytes (PBLs) and Th17 cells.

Abstract: A nanoporous carbon-loaded cement composite that conducts electricity. The nanoporous carbon-loaded cement composite can be used in a variety of different fields of use, including, for example, a structural super-capacitor as an energy solution for autonomous housing and other buildings, a heated cement for pavement deicing or house basement insulation against capillary rise, a protection of concrete against freeze-thaw (FT) or alkali silica reaction (ASR) or other crystallization degradation processes, and as a conductive cable, wire or concrete trace.

Abstract: Disclosed is a method for cutting dielectric or semiconducting material with a laser. The method includes the following steps: emission of a laser beam including at least one burst of N femtoseconds laser pulses; spatial separation of the laser beam into a first split beam having a first energy, and respectively, a second split beam having a second energy; spatial concentration of energy of the first split beam in a first zone of the material, respectively, of the second split beam in a second zone of the material, the first zone and the second zone being separate and staggered by a distance dx; and adjustment of the distance between the first zone and the second zone in such a way as to initiate a straight micro-fracture oriented between the first zone and the second zone.