Patents Assigned to Université de Bourgogne
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Patent number: 9242925Abstract: The ?,?-unsaturated ?-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.Type: GrantFiled: August 28, 2012Date of Patent: January 26, 2016Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNEInventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Marie-Joelle Ondel-Eymin
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Publication number: 20150377892Abstract: The present invention relates to a mutated heat-shock protein 110 (HSP110) lacking its substrate binding domain, which does not exhibit its chaperon activity and/or is not capable of binding to best-shock protein 70 (HSP70) and/or to beat-shock protein 27 (HSP27), but which is capable of binding to a wild-type HSP110. Such a mutated heat-shock protein 110 can be used (i) in methods for proposing survival and/or the response to a treatment of a patient suffering from a cancer, more particularly from a cancer liable to have a microsatellite instability (MSI) phenotype, such as colorectal cancer (CRC), and (ii) for treating cancers.Type: ApplicationFiled: September 14, 2015Publication date: December 31, 2015Applicants: Institut National De La Sante Et De La Recherche Medicale (Inserm), UNIVERSITE DE BOURGOGNEInventors: Carmen GARRIDO, Alex DUVAL
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Patent number: 9186661Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: GrantFiled: July 10, 2012Date of Patent: November 17, 2015Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNE, UNIVERSITE DE STRASBOURG, SYNTHELOR SASInventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
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Patent number: 9170437Abstract: The invention relates to a method and device for controlling a physical parameter of an optical signal. According to the invention, a portion of the initial optical signal (SE) having passed through an optical waveguide from the input (24.1) to the output (24.2) thereof, is returned into said optical waveguide (24) using a sequential circulator (25) and an optical amplifier (28), in order to at least partially form the optical control signal (SE2), which counter-propagates relative to said initial optical signal (SE), so as to stabilize, or at the very least control, the physical parameter of said initial optical signal when the latter exits said optical waveguide (24) via the output (24.2) thereof.Type: GrantFiled: August 2, 2012Date of Patent: October 27, 2015Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITÉ DE BOURGOGNEInventors: Stéphane Pitois, Julien Fatome, Philippe Morin, Guy Millot
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Publication number: 20150265640Abstract: The present invention relates to a pharmaceutical composition including Lipiodol and a molecule with anti-tumour activity and secondarily a hydroxyethyl starch. The present invention also relates to the use of the compositions according to the invention for treating cancer. According to one embodiment, the pharmaceutical composition according to the invention has between 0.004% and 0.2% by weight of idarubicin, between 0.38% and 2.25% by weight of hydroxyethyl starch and secondarily between 60% and 68% by weight of Lipiodol, and water for injection (or even physiological saline) in a quantity sufficient (q.s.) for 100%.Type: ApplicationFiled: July 5, 2013Publication date: September 24, 2015Applicants: UNIVERSITE DE BOURGOGNE, CHU DE DIJONInventors: Boris Guiu, Mathieu Boulin, Jean-Pierre Cercueil
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Patent number: 9097636Abstract: A thermoelectric component comprises integrated into the component: a plasmonic waveguide, an exciter element for the guided plasmonic mode, a device for measuring the power dissipated during propagation along the plasmonic waveguide, characterized in that the measurement device comprises, associated with the plasmonic guide, a thermocouple junction with two electrodes, one of the electrodes including the plasmonic waveguide.Type: GrantFiled: May 18, 2012Date of Patent: August 4, 2015Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BOURGOGNEInventors: Jean-Claude Weeber, Alain Dereux
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Patent number: 9045511Abstract: The invention relates to compounds, in particular phosphinic ligands of metal complexes, as well as to metal complexes including said ligands and to supported catalysts including said metal complexes or said compounds. The invention also relates to methods for synthesizing said compounds, to complexes, and to supported catalysts, as well as to intermediate products used in said synthesis methods. The invention further relates to the uses of said compounds. The compounds of the invention are ferrocene compounds which have been functionalized so as to be capable of being heterogenized. The invention can be used in particular in the field of heterogeneous catalysis.Type: GrantFiled: June 24, 2011Date of Patent: June 2, 2015Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BOURGOGNEInventors: Jean-Cyrille Hierso, Matthieu Beauperin, Philippe Meunier
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Patent number: 8989576Abstract: A method of processing optical signal (TE) whose power (PE) varies in a random manner in a range of variation of power (?PE) around a mean power (PE?), the processing of the optical signal (TE) generating processing noise (GELECTRONIC), characterized in that the relative variation of power (GE) of at least a temporal part at said optical signal (TE) is optically amplified.Type: GrantFiled: March 24, 2011Date of Patent: March 24, 2015Assignees: Universite de Bourgogne, CNRS—Centre National de Recherche ScientifiqueInventors: Christophe Finot, Julien Fatome
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Patent number: 8986648Abstract: The present invention relates to a method for continuously preparing mineral particles by means of the thermolysis of mineral precursors in an aqueous medium, comprising contacting: a reactive flow, including mineral precursors at a temperature lower than the conversion temperature thereof; and a heat transfer flow that is countercurrent to said reactive flow and contains water at a temperature that is sufficient to bring the precursors to a temperature higher than the conversion temperature thereof, the mixture flow that results from said reactive flow and said heat transfer flow then being conveyed into a tubular reactor, inside of which particles are formed by gradually converting the precursors, and where the reactive flow and the heat transfer flow are placed in contact with each other inside a mixing chamber, inside of which the reactive flow and the heat transfer flow are fed by supply pipes having outlet cross-sections that are smaller than the maximum cross-section of said mixing chamber.Type: GrantFiled: July 20, 2010Date of Patent: March 24, 2015Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite de BourgogneInventors: Daniel Aymes, Moustapha Ariane, Frédéric Bernard, Hervé Muhr, Frédéric Demoisson
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Publication number: 20140308343Abstract: The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorization of therapeutic agents, especially anti-tumoral agents.Type: ApplicationFiled: March 13, 2014Publication date: October 16, 2014Applicants: UNIVERSITE VICTOR SEGALEN BORDEAUX 2, UNIVERSITE DE LA MEDITERRANEE, UNIVERSITE DE BOURGOGNEInventors: Philippe BARTHELEMY, Michel CAMPLO, Nathalie CAMPINS, Bruno CHAUFFERT, Florence BOUYER
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Publication number: 20140286603Abstract: The invention relates to a method and device for controlling a physical parameter of an optical signal. According to the invention, a portion of the initial optical signal (SE) having passed through an optical waveguide from the input (24.1) to the output (24.2) thereof, is returned into said optical waveguide (24) using a sequential circulator (25) and an optical amplifier (28), in order to at least partially form the optical control signal (SE2), which counter-propagates relative to said initial optical signal (SE), so as to stabilize, or at the very least control, the physical parameter of said initial optical signal when the latter exits said optical waveguide (24) via the output (24.2) thereof.Type: ApplicationFiled: August 2, 2012Publication date: September 25, 2014Applicants: UNIVERSITÉ DE BOURGOGNE, CENTRE NATIONAL DE LA RECHERCHE SIENTIFIQUE-CNRSInventors: Stéphane Pitois, Julien Fatome, Philippe Morin, Guy Millot
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Publication number: 20140142298Abstract: The present invention embodiments relate to a compound with formula (V?) The invention also relates in certain embodiments to the synthesis method for compound (V?) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.Type: ApplicationFiled: November 13, 2013Publication date: May 22, 2014Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNEInventors: Franck Denat, Pauline Desogere, Claire Bernhard, Yoann Rousselin, Frederic Boschetti
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Publication number: 20140038900Abstract: The present invention relates to a mutated heat-shock protein 110 (HSP110) lacking its substrate binding domain, which does not exhibit its chaperone activity and/or is not capable of binding to heat-shock protein 70 (HSP70) and/or to heat-shock protein 27 (HSP27), but which is capable of binding to a wild-type HSP 110. Such a mutated heat-shock protein 110 can be used (i) in methods for prognosing survival and/or the response to a treatment of a patient suffering from a cancer, more particularly from a cancer liable to have a microsatellite instability (MSI) phenotype, such as colorectal cancer (CRC), and (ii) for treating cancers.Type: ApplicationFiled: March 26, 2012Publication date: February 6, 2014Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE BOURGOGNEInventors: Carmen Garrido, Alex Duval
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Publication number: 20130158219Abstract: The invention relates to compounds, in particular phosphinic ligands of metal complexes, as well as to metal complexes including said ligands and to supported catalysts including said metal complexes or said compounds. The invention also relates to methods for synthesizing said compounds, to complexes, and to supported catalysts, as well as to intermediate products used in said synthesis methods. The invention further relates to the uses of said compounds. The compounds of the invention are ferrocene compounds which have been functionalized so as to be capable of being heterogenized. The invention can be used in particular in the field of heterogeneous catalysis.Type: ApplicationFiled: June 24, 2011Publication date: June 20, 2013Applicants: Universite de Bourgogne, Centre National De La Recherche ScientifiqueInventors: Jean-Cyrille Hierso, Matthieu Beauperin, Philippe Meunier
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Publication number: 20130128917Abstract: A thermoelectric component comprises integrated into the component: a plasmonic waveguide, an exciter element for the guided plasmonic mode, a device for measuring the power dissipated during propagation along the plasmonic waveguide, characterized in that the measurement device comprises, associated with the plasmonic guide, a thermocouple junction with two electrodes, one of the electrodes including the plasmonic waveguide.Type: ApplicationFiled: May 18, 2012Publication date: May 23, 2013Applicants: UNIVERSITE DE BOURGOGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Jean-Claude WEEBER, Alain DEREUX
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Publication number: 20130039653Abstract: A method of processing optical signal (TE) whose power (PE) varies in a random manner in a range of variation of power (?PE) around a mean power (PE?), the processing of the optical signal (TE) generating processing noise (GELECTRONIC), characterized in that the relative variation of power (GE) of at least a temporal part at said optical signal (TE) is optically amplified.Type: ApplicationFiled: March 24, 2011Publication date: February 14, 2013Applicants: Université de Bourgogne, CNRS - Centre National de Recherche ScientifiqueInventors: Christophe Finot, Julien Fatome
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Patent number: 8313638Abstract: The invention relates to a method and a collection for the electrochemical detection of target nucleic acid sequences. According to the method, a biological sample that may contain a nucleic acid is provided, said nucleic acid being capable of containing a target sequence, said biological sample being mixed with an oxidizing agent, said target sequence comprising at least one nucleotide base that can be oxidized by said oxidizing agent; complementary means capable of coupling with said target sequence are provided; according to the invention, said complementary means comprise activatable amplification means suitable for replicating said target sequence, said amplification means comprising at least nucleotides which include said nucleotide base, wherein said nucleotides are able to be consumed during replication so as to constitute replicated nucleic acids; and the presence of said target sequence is determined by applying an electric field to said sample and recording the decrease in the electric current.Type: GrantFiled: March 2, 2007Date of Patent: November 20, 2012Assignees: Universite Paris Diderot-Paris 7, Universite de Bourgogne, Centre National de la Recherche ScientifiqueInventors: Damien Marchal, Benoît Limoges, Murielle Dequaire
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Patent number: 8229764Abstract: A method of identifying data relating to individuals in order to establish chains in said data, the method consisting, in a local center for collecting data, in creating an encoded first identifier of an individual from identification data of said individual, and of said individual's father and mother, in transmitting said first identifier to a central unit, and in said central unit creating an encoded second identifier which is recorded in a database, and in establishing chains in the data by comparing the second identifiers recorded in the database. The invention applies to treating data concerning individuals and having a family component.Type: GrantFiled: March 7, 2007Date of Patent: July 24, 2012Assignee: Universite de BourgogneInventors: Olivier Cohen, Catherine Quantin
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Publication number: 20120183470Abstract: The present invention relates to a method for continuously preparing mineral particles by means of the thermolysis of mineral precursors in an aqueous medium, comprising contacting: a reactive flow, including mineral precursors at a temperature lower than the conversion temperature thereof; and a coolant flow that is countercurrent to said reactive flow and contains water at a temperature that is sufficient to bring the precursors to a temperature higher than the conversion temperature thereof, the mixture flow that results from said reactive flow and said coolant flow then being conveyed into a tubular reactor, inside of which particles are formed by gradually converting the precursors, and where the reactive flow and the coolant flow are placed in contact with each other inside a mixing chamber, inside of which the reactive flow and the coolant flow are fed by supply pipes having outlet cross-sections that are smaller than the maximum cross-section of said mixing chamber.Type: ApplicationFiled: July 20, 2010Publication date: July 19, 2012Applicants: UNIVERSITE DE BOURGOGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)Inventors: Daniel Aymes, Moustapha Ariane, Frédéric Bernard, Hervé Muhr, Frédéric Demolsson
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Patent number: 7935360Abstract: The invention concerns the application of compositions of micro-organisms in biological control of vine cryptogamic diseases. Said composition comprises a mixture of at least one bacterium and at least one yeast, the bacterium or bacteria and the yeast(s) being non-toxic for the plant. The invention also concerns bacterial and yeast strains, as well as biofungicide formulations containing an efficient amount of at least one composition of micro-organisms including in mixture at least one bacterium and one yeast, the bacterium or bacteria and the yeast(s) being non-toxic for the plant, and a composition of filamentous fungi, in particular of the genus Pichia, Pythium, Trichoderma, Gliocladium, Ampelomyces, Talaromyces, Epicococcum, combined with an inert carrier. The invention is useful for treating cryptogamic plant diseases, in particular crop plants and vine.Type: GrantFiled: July 1, 2003Date of Patent: May 3, 2011Assignee: Universite de BourgogneInventor: Bernard Paul