Abstract: Devices and methods for the stimulation of neural signaling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.

Abstract: Disclosed are new peptides derived from the neurotensin receptor 3 (NTSR3), and to their use, particularly in the treatment of various diseases, especially depression.

Abstract: A process for isolating or extracting rare cells from a biological sample comprising filtering a biological sample, which may be treated or diluted, through a filter that has a pore size, pore density or other physical properties that retain rare cells, but which permits other kinds of cells to pass through the filter. This process also comprises multiple analyses performed on rare cells after their extraction or isolation by filtration to diagnostically identify the presence of rare cells in a biological sample and to use their diagnostic identification and molecular characterization for diagnostic purposes such as for early diagnosis of diseases, namely for early diagnosis of cancer and to select, guide, monitor treatments and in particular to select targeted treatments and to monitor the response and/or resistance to them.

Abstract: Disclosed is a method for assessing the prognosis of idiopathic membranous nephropathy in a body fluid sample from a human subject, based on profiling PLA2R1 epitopes recognized by autoantibodies in the sample. The method further relates to analysis of PLA2R1 epitope spreading amongst three PLA2R1 domains (Cys R, CTLD1 and CTLD7) that are recognized by anti-PLA2R1 autoantibodies, two of which (CTLD1 and CTLD7) are more closely associated with active idiopathic membranous nephropathy and likely linked by a mechanism of epitope spreading.

Abstract: An electronic circuit includes at least one first multi-gate transistor including a first gate and a second gate different from the first gate; and a regulation unit designed to measure a variable representing the drain-source voltage of the first transistor and to apply a polarization potential as a function of the variable to the second gate of the first transistor.

Abstract: The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy.

Abstract: Stimulation of neural signalling of an apical splenic nerve can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders.

Abstract: Antenna system comprising at least two radiating elements, a first line for neutralizing electromagnetic coupling between the at least two radiating elements, at least one radiofrequency power supply line for each radiating element and at least one short-circuiting line to a ground plane of the antenna system per radiating element, characterized in that the antenna system further comprises: at least one second line for neutralizing electromagnetic coupling between said at least two radiating elements; elements for activating at least some of the neutralization lines; and in that the activation elements are configured to selectively activate or deactivate at least some of the neutralization lines, in such a way that depending on the activation/deactivation thereof the neutralization lines provide a maximum neutralization of the electromagnetic coupling of the radiating elements for a plurality of different frequencies.

Abstract: The invention relates to a vetiveryl ester comprising at least 0.5 weight percent of secondary alcohol compounds with respect to the total weight of the vetiveryl ester and to a process for the preparation a vetiveryl ester, the process comprising: providing a vetiver oil, at least one enzyme preparation and at least one acylating compound; and allowing sufficient time for the enzyme preparation to esterify the alcohol compounds of the vetiver oil with the acylating compound. The invention also relates to a vetiveryl ester obtainable by the above process, a fragrance composition comprising an above-mentioned vetiveryl ester and the use of an above-mentioned vetiveryl ester for the preparation of a perfumed product.

Abstract: The present invention concerns an in vitro method of diagnosis or prognosis of an atherosclerosis-related disorder by detecting a small Y RNA (s-RNY), as well as the use of an inhibitor of s-RNY as a medicament against atherosclerosis-related disorders. The invention also concerns a method for screening for a compound suitable for the treatment of an atherosclerosis-related disorder.

Abstract: An alcoholic extract of aerial parts of Solidago virgaurea subsp. alpestris, the method of production thereof, a cosmetic or dermatological composition containing it, as well as cosmetic and dermatological uses thereof, notably in the treatment of signs of skin ageing.

Abstract: An alarm device comprises an RFID circuit that is configured to store identification information and is coupled to an antenna designed to receive and to emit, from and to an RFID reader, signals at the frequency of the RFID reader, and a switch coupled to the antenna and able to be activated by a user, enabling the antenna to be matched to the frequency of the RFID reader. The alarm device comprises the RFID circuit, the antenna and the switch designed to be incorporated into an object worn by a user, and enable the alarm to be activated discreetly.

Abstract: An electronic circuit includes at least one first multi-gate transistor including a first gate and a second gate different from the first gate; and a regulation unit designed to measure a variable representing the drain-source voltage of the first transistor and to apply a polarization potential as a function of the variable to the second gate of the first transistor.

Abstract: The invention provides an isolated antibody or a fragment thereof, which is directed to the human chemokines CXCL1, CXCL7 and CXCL8, said antibody or fragment being capable of binding to the human chemokine CXCL1 with an equilibrium dissociation constant (KD) of at most 16 nM, to the human chemokine CXCL7 with an equilibrium dissociation constant (KD) of at most 5 nM and to the human chemokine CXCL8 with an equilibrium dissociation constant (KD) of at most 45 nM, as determined by surface plasmon resonance. The invention also provides some applications of said isolated antibody.

Abstract: The invention relates to a vetiveryl ester comprising at least 0.5 weight percent of secondary alcohol compounds with respect to the total weight of the vetiveryl ester and to a process for the preparation a vetiveryl ester, the process comprising: providing a vetiver oil, at least one enzyme preparation and at least one acylating compound; and allowing sufficient time for the enzyme preparation to esterify the alcohol compounds of the vetiver oil with the acylating compound. The invention also relates to a vetiveryl ester obtainable by the above process, a fragrance composition comprising an above-mentioned vetiveryl ester and the use of an above-mentioned vetiveryl ester for the preparation of a perfumed product.

Abstract: The first subject matter of the invention is the (3R) epimer of octahydro-7,7-dimethyl-8-methylene-1H-3a,6-methanoazulen-3-yl acetate [(octahydro-7,7-dimethyl-8-methylene-[3R,3aR,6R,8aR]-1H-3a,6-methanoazulen-3-yl acetate) or (R)-norzizaenylacetate] of formula I (I). The subject matter of the invention is also compositions comprising (R)norzizaenyl acetate and also a novel synthesis process and the use of said ester.

Abstract: A device and a method for synchronizing entanglement sources with optical pump in a quantum communication network are disclosed. The device includes a pulsed optical source allowing emission of telecom wavelength optical clock pulses distributed in parallel to the entanglement sources to ensure synchronization of the entanglement sources; and for each of the entanglement sources, a frequency conversion device, allowing frequency conversion of the distributed telecom wavelength optical clock pulses to a wavelength adapted to optically pump the entanglement source. The method includes emitting and distributing in parallel, to the entanglement sources, telecom wavelength optical clock pulses; and locally, at each of the entanglement sources, frequency converting the telecom wavelength optical clock pulses to a wavelength adapted to optically pump the entanglement source.

Abstract: The subject matter of the invention is a functional population of human brown adipocytes, in which the expression of UCP1, CIDEA, CPT1B and Bc12 is higher, the expression of Bax is lower and the expression of PPAR-alpha, PGC-1alpha, PGC-1 beta and PRDM16 is similar compared with the corresponding expressions of a population of human white adipocytes. The invention also relates to a method for differentiation of hMADS cells into the functional population of human brown adipocytes, to a method for conversion of a population of human white adipocytes into the functional population of human brown adipocytes, and also to a method of screening for molecules capable of modulating the bodyweight in an individual.

Abstract: A novel method for synthesis of khusimone, by bringing zizanal into contact with an oxidizing reagent in the presence of a base and an organic solvent.

Abstract: Antenna system comprising at least two radiating elements, a first line for neutralising electromagnetic coupling between the at least two radiating elements, at least one radiofrequency power supply line for each radiating element and at least one short-circuiting line to a ground plane of the antenna system per radiating element, characterised in that the antenna system further comprises: at least one second line for neutralising electromagnetic coupling between said at least two radiating elements; elements for activating at least some of the neutralisation lines; and in that the activation elements are configured to selectively activate or deactivate at least some of the neutralisation lines, in such a way that depending on the activation/deactivation thereof the neutralisation lines provide a maximum neutralisation of the electromagnetic coupling of the radiating elements for a plurality of different frequencies.