Abstract: The present invention relates to the production of gene sequences encoding chimerical membrane glycosyltransferases presenting an optimized glycosylation activity in cells transformed with the sequences, the gene sequences corresponding to the fusion: of a first nucleic acid coding for a C-terminal minimal fragment of the catalytic domain (CD) of the native full length glycosyltransferase, to a second nucleic acid coding for a transmembrane peptide comprising in its N-terminal region a cytoplasmic tail (CT) region located upstream from a transmembrane domain (TMD), itself located upstream of a stem region (SR), provided that at least one of these CT, TMD, SR peptides being different from the primary structure of the naturally occurring peptide counterparts present in the native glycosyltransferase from which is derived the CD fragment with optimal glycosyltransferase activity as defined above.

Abstract: The appliance designed to allow a living being to perceive sensations of virtual movements of part of his body comprises a control unit in which is stored a table containing a first plurality of basic excitation signals, a second plurality of macro-motifs each formed by a third plurality proper of the basic signals, a sequencer reading the macro-motifs in order to emit a second plurality of corresponding commands for excitation, each time, of a third plurality proper of vibrators selected from among a first plurality of vibrators carried by a coupling support in predetermined respective zones of the part of the body, the excitation of the third plurality proper of vibrators by the second plurality of commands being intended to mechanically stimulate elements of the body, to provoke the creation of bioelectrical signals in the living being, allowing him to perceive sensations of a given virtual movement.

Abstract: The pulse train of a signal is modulated by a DPIM modulation involving a discrete random time parameter. A first processing is performed on the signal to deliver a sampled signal. A second processing is performed on the sampled signal, comprising a correlation processing including at least one elementary correlation processing with a correlation mask corresponding to the shape of at least part of a sampled pulse, and delivering second information items. A third processing is performed for detecting the pulses following a first pulse by taking account of the position of the first pulse, on packets of second information items, which are separated by a duration related to the discrete random parameter.

Abstract: The use of monokaryotic strains of filamentous fungi of the Pycnoporus species of the basidiomycete group, for implementing a method for preparing a specific recombinant protein, the method being carried out by overexpressing the gene encoding the protein in the Pycnoporus monokaryotic strain.

Abstract: An integrated circuit including a semiconductor layer; and a MOS transistor including first and second power terminals and a bulk insulated from the semiconductor layer, the first power terminal being intended to receive an oscillating signal, the transistor gate and the bulk being connected to the first power terminal.

Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.

Abstract: The present invention relates to the use of the assessment of the binding between—antibodies elicited against a first glycoprotein, and—at least one glycoform of a second glycoprotein, said second glycoprotein being itself a glycoform of the first protein, wherein said glycoform of the second glycoprotein is selected from a group of glycoforms of the second glycoprotein, each glycoform of said group corresponding to a determined glycosylation state defined by a determined sialylation state, and/or a determined branching state, and/or a determined fucosylation state, provided that said glycosylation state is not uniquely defined by a substantially unsialylated state, for the screening of glycoform specific antibodies directed against a given glycoform of the second glycoprotein.

Abstract: The waveform of the signal varies according to the distance at which the signal was emitted, and several correlation signals are defined and correspond respectively to at least part of several sampled waveforms of the signal respectively emitted at several distances of different values so that the sum of the maxima of intercorrelations performed respectively between the various correlation signals and the various sampled waveforms is substantially constant over an interval including all the values of the distances. The correlation processing includes several elementary correlation processings respectively performed with the correlation signals and each delivering initial correlation values, as well as a summation of the homologous initial correlation values respectively delivered by the elementary correlation processings so as to obtain the correlation values.

Abstract: The disclosure relates to an amplifier comprising a digital delta-sigma modulator, a quantifier receiving a signal supplied by a delta-sigma stage and supplying a quantified signal, and a power circuit supplying an output signal. The device comprises N state loops of a first type configured to send the output signal to adders of N delta-sigma stages of lower rank, each state loop of the first type comprising an analog low-pass filter for supplying a filtered output signal, and an analog to digital converter for supplying a digital filtered output signal.

Abstract: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative cellulose-binding module function, and its uses in chimeric proteins for depolymerization of cellulose containing substrates.

Abstract: Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of interest for directly detecting free radicals, especially free radicals in biological samples.

Abstract: The disclosure relates to a method for generating UWB waveforms, each comprising a sequence of pulses, the method comprising: generating consecutive elementary pulses having durations corresponding to setpoint durations and a constant amplitude, amplifying each elementary pulse separately as a function of a respective setpoint amplitude, and combining the amplified elementary pulses to obtain a waveform successively comprising each of the amplified alternately positive and negative, elementary pulses.

Abstract: The invention relates to applications of a cellulase of Pseudomonas sp. ND137, functional fragments and/or variants and engineered forms thereof, in the context of industrial bioprocessing, more particularly solvent production.

Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.

Abstract: The disclosure relates to an amplifier comprising a digital delta-sigma modulator, a quantifier receiving a signal supplied by a delta-sigma stage and supplying a quantified signal, and a power circuit supplying an output signal. The device comprises N state loops of a first type configured to send the output signal to adders of N delta-sigma stages of lower rank, each state loop of the first type comprising an analog low-pass filter for supplying a filtered output signal, and an analog to digital converter for supplying a digital filtered output signal.

Abstract: A device for decoding a direct sequence spread spectrum-encoded binary message includes a sampler that captures at least one sequence of binary samples corresponding to one bit of the transmitted message. The captured sequence of samples are applied to a filter matched to the spreading code used, thus making it possible to delete the spreading applied to the original message. The device further includes, at the output of the sampler, an error correction block including a memory storing a plurality of binary sequences corresponding to all of the possible values for a captured sequence of samples. A replacement circuit replaces the captured sequence of samples with the stored sequence, thereby minimizing the number of samples different from the captured sequence of samples, and allowing the stored sequence to be applied to the matched filter.

Abstract: Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.

Abstract: The appliance designed to allow a living being to perceive sensations of virtual movements of part of his body comprises a control unit in which is stored a table containing a first plurality of basic excitation signals, a second plurality of macro-motifs each formed by a third plurality proper of the basic signals, a sequencer reading the macro-motifs in order to emit a second plurality of corresponding commands for excitation, each time, of a third plurality proper of vibrators selected from among a first plurality of vibrators carried by a coupling support in predetermined respective zones of the part of the body, the excitation of the third plurality proper of vibrators by the second plurality of commands being intended to mechanically stimulate elements of the body, to provoke the creation of bioelectrical signals in the living being, allowing him to perceive sensations of a given virtual movement.

Abstract: The invention relates to a measuring tape (10) comprising a stack of at least two layers, characterized in that it also includes a first layer, called support layer, based on composite material (11) and a layer, called top layer, (12) based on a polymer having a high glass transition temperature so that, in conditions of use, said polymer is in a glassy state to maintain the element in the wound or folded position. The invention also relates to a deployable structure including said measuring tape intended notably for space applications.

Abstract: The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.