Abstract: The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I): The invention also relates to novel epicocconone analogs.
Type:
Grant
Filed:
October 25, 2010
Date of Patent:
March 11, 2014
Assignees:
Universite de Rouen, Centre National de la Recherche Scientifique-CNRS, Institut National des Sciences Appliquees de Rouen, Macquarie University
Inventors:
Xavier Franck, Philippe Peixoto, Peter Helmuth Karuso
Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.
Type:
Application
Filed:
March 5, 2012
Publication date:
December 19, 2013
Applicants:
UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITE DE ROUEN
Inventors:
Ebba Brakenhielm, Sébastien Banquet, Florence Edwards-Levy, Christian Thuillez
Abstract: The present invention relates to a method for detecting and quantifying the presence or absence of a number of biomolecules in a sample using the SIMS technique and arrays for use in said method.
Type:
Application
Filed:
June 27, 2013
Publication date:
December 19, 2013
Applicant:
UNIVERSITE DE ROUEN
Inventors:
CAMILLE RIPOLL, VICTOR NORRIS, GRADIMIR MISEVIC, GUILLAUME LEGENT, ANTHONY DELAUNE
Abstract: A precursor phase of the magnesium tetrahydrate salt of an omeprazole enantiomer, and also processes for preparing it and its use for the preparation of the magnesium tetrahydrate salt are described. Crystals of the magnesium tetrahydrate salt thus obtained, and their uses, especially in the synthesis of the dihydrate form A of the magnesium salt of the enantiomer or as medicament are also disclosed.
Type:
Grant
Filed:
March 31, 2011
Date of Patent:
November 26, 2013
Assignees:
Produits Chimiques Auxiliaires et de Synthese, Universite de Rouen
Inventors:
Snella Chouippe, Jean-Marie Schneider, Guillaume Tauvel, Gerard Coquerel
Abstract: New highly functionalizable Huprine derivatives of formula I: and a method for preparing such compounds and their use for treating neurological diseases in which the level of acetylcholine is affected such as Alzheimer's disease.
Type:
Application
Filed:
April 8, 2011
Publication date:
January 31, 2013
Applicant:
UNIVERSITE DE ROUEN
Inventors:
Cyril Ronco, Pierre Yves Renard, Ludovic Jean, Florian Nachon, Anthony Romieu
Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group of formula COR4, or R1 represents a group of formula (A): R2 represents a group of formula NR5R6, or R2 represents a nitrogen-containing heterocyclic group, an aryl group or a heteroaryl group, R3 represents a hydrogen atom or an alkyl group, m represents an integer between 1 and 6 inclusive, n represents 0, 1 or 2, their optical isomers, and also addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating and/or preventing thrombotic events.
Type:
Grant
Filed:
June 25, 2010
Date of Patent:
November 13, 2012
Assignees:
Les Laboratories Server, L'Institut National des Sciences Appliquées de Rouen, Le Centre National de la Recherche Scientifique, L'Universite de Rouen
Inventors:
Philippe Gloanec, Guillaume De Nanteuil, Jean-Gilles Parmentier, Anne-Françoise Guillouzic, Tony Verbeuren, Alain Rupin, Philippe Mennecier, Marie-Odile Vallez, Jean-Charles Quirion, Philippe Jubault, Nicolas Boyer
Abstract: A process for the resolution of two enantiomers which involves inducing the preferential crystallization of one enantiomer by adjusting the composition of a suspension or solution including a racemic mixture of the two enantiomers and a solvent, by evaporation of the latter.
Abstract: The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I): The invention also relates to novel epicocconone analogs.
Type:
Application
Filed:
October 25, 2010
Publication date:
August 23, 2012
Applicants:
UNIVERSITE DE ROUEN, MACQUARIE UNIVERSITY, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
Inventors:
Xavier Franck, Philippe Peixoto, Peter Helmuth Karuso
Abstract: A method for imaging a tissue includes collecting a light signal from at least part of said tissue, using a fiber optic probe for fluorescence imaging, wherein the fiber optic probe comprises a plurality of optic fibers, and wherein a distal tip of the fiber optic probe is placed at a distance from said tissue, said imaging being made confocal at a proximal tip of said fiber optic probe. A fluorescence imaging system includes an endoscope equipped with a working channel, in which a fiber optic probe has been inserted, wherein the fiber optic probe is movable between a retracted position and at least one position of extension, said fiber optic probe comprising a plurality of optic fibers for performing imaging of a tissue, said imaging being confocal via a processor located at a proximal tip of said fiber optic probe.
Type:
Application
Filed:
August 16, 2007
Publication date:
February 9, 2012
Applicants:
UNIVERSITE DE ROUEN, MAUNA KEA TECHNOLOGIES
Inventors:
Luc Thiberville, Charlotte Cave, Véronique Dentan, Nicolas Boularot, Geneviéve Bourg-Heckly, Eric Peltier
Abstract: The present invention belongs to the field of plant extracts with activity on the central nervous system. Specifically, the plant extract of the present invention is an extract obtained from Hypericum polyanthemum and comprising the compound uliginosin B and/or compounds from the class of benzopyrans such as. The present invention also relates to a pharmaceutical composition comprising such an extract which has pharmacological action in psychiatric disorders, such as mood disorders, specifically, anti-depressant activity. Such as HP1 (6-isobutyryl-5,7-dimethoxy-2,2-dimethyl-benzopyran), HP2 (7-hydroxy-6-isobutyryl-5-methoxy-2,2-dimethyl-benzopyran) and HP3 (5-hydroxy-6-isobutyryl-7-methoxy-2,2-dimethyl-benzopyran)).
Type:
Application
Filed:
February 12, 2010
Publication date:
December 22, 2011
Applicants:
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL, UNIVERSITE DE ROUEN
Inventors:
Stela Maris Kuze Rates, Gilsane Lino Von Poser, Alice Fialho Viana, Jean Costentin, Jean-Claude Do Rego
Abstract: A precursor phase of the magnesium tetrahydrate salt of an omeprazole enantiomer, and also processes for preparing it and its use for the preparation of the magnesium tetrahydrate salt are described. Crystals of the magnesium tetrahydrate salt thus obtained, and their uses, especially in the synthesis of the dihydrate form A of the magnesium salt of the enantiomer or as medicament are also disclosed.
Type:
Application
Filed:
March 31, 2011
Publication date:
November 3, 2011
Applicants:
UNIVERSITE DE ROUEN, PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE
Inventors:
Snella CHOUIPPE, Jean-Marie SCHNEIDER, Guillaume TAUVEL, Gerard COQUEREL
Abstract: The present invention relates to the resolution by preferential crystallization of potassium salts of racemic omeprazole which is a solvate of ethanol and/or of ethylene glycol, which consists in converting the omeprazole to the potassium salt in the form of a solvate or of a mixture of these solvates in the presence of an excess of inorganic base which is a source of potassium, the said potassium salts existing in the form of conglomerates, and in then resolving the said conglomerates, independently or simultaneously, by preferential crystallization in order to separate the two (S) and (R) enantiomers of these potassium salts of omeprazole.
Type:
Grant
Filed:
August 29, 2008
Date of Patent:
October 11, 2011
Assignee:
Universite de Rouen
Inventors:
Gérard Coquerel, Guillaume Tauvel, Marie-Noelle Petit
Abstract: A contrast agent for MRI imaging includes: (a) one cyclodextrin, whose truncated-cone-shaped structure defines a central axis, a first and a second openings along the axis, (b) one paramagnetic element, located on the cyclodextrin axis, outside the structure and proximate to the first opening, (c) one or several coordination ligand(s) of the paramagnetic element which coordinate(s) the paramagnetic element, (d) one arm covalently bound to the cyclodextrin, proximate to the second opening, which is able to form an inclusion complex with the cyclodextrin.
Abstract: The invention concerns novel 1,2-dioxetane derivatives of general formula (I) as defined in the description, capable of emitting a detectable luminescent signal, their use in a method for detecting and/or quantizing a physical, chemical or biological, in particular enzymatic, phenomenon, as well as a kit for implementing said method.
Type:
Grant
Filed:
May 24, 2006
Date of Patent:
June 28, 2011
Assignees:
Quidd, Universite de Rouen
Inventors:
Pierre-Yves Renard, Anthony Romieu, Marc Massonneau
Abstract: The present invention relates to a method for detecting and quantifying the presence or absence of a number of biomolecules in a sample using the SIMS technique and arrays for use in said method.
Type:
Application
Filed:
March 12, 2009
Publication date:
March 17, 2011
Applicant:
Universite De Rouen
Inventors:
Camille Ripoll, Victor Norris, Gradimir Misevic, Guillaume Legent, Anthony Delaune
Abstract: Transformed microalgae capable of expressing glycosylated polypeptides and methods for producing said transformed microalgae and producing glycosylated polypeptides.
Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group of formula COR4, or R1 represents a group of formula (A): R2 represents a group of formula NR5R6, or R2 represents a nitrogen-containing heterocyclic group, an aryl group or a heteroaryl group, R3 represents a hydrogen atom or an alkyl group, m represents an integer between 1 and 6 inclusive, n represents 0, 1 or 2, their optical isomers, and also addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating and/or preventing thrombotic events.
Type:
Application
Filed:
June 25, 2010
Publication date:
December 30, 2010
Applicants:
LES LABORATOIRES SERVIER, L'INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, L'UNIVERSITE DE ROUEN
Inventors:
Philippe Gloanec, Guillaume De Nanteuil, Jean-Gilles Parmentier, Anne-Françoise Guillouzic, Tony Verbeuren, Alain Rupin, Philippe Mennecier, Marie-Odile Vallez, Jean-Charles Quirion, Philippe Jubault, Nicolas Boyer
Abstract: An antigen derived from an intracellular pathogenic micro-organism characterized in that it comprises at least on peptidic fragment which essentially consists of the concatenation of sequences of at least two extracellular adjacent areas in the native structure of a membrane protein of type III of said intracellular pathogenic micro-organism, derived conformational antibodies and the application hereof.
Type:
Grant
Filed:
January 28, 2004
Date of Patent:
September 28, 2010
Assignees:
Centre National de la Recherche Scientifique, Universite de Rouen, Universite de Lille 2
Abstract: The present invention relates to the use of paraxanthine for the manufacture of a non-anxiogenic psychoanaleptic drug for the treatment of a neuropsychiatric disorder.
Type:
Application
Filed:
June 8, 2007
Publication date:
December 31, 2009
Applicants:
Pierre Fabre Medicament, Universite de Rouen
Inventors:
Jean Costentin, Lucilla Mansuy, Pierre Sokoloff
Abstract: Fiber bed, preferably negatively charged, covered with a cationic polymer having a positive net charge; antiviral filter comprising said fiber bed; and method for the fabrication of said fiber bed having antiviral characteristic.