Patents Assigned to UNIVERSITÉ DE STRASBOURG
  • CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20140171394
    Abstract: The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 19, 2014
    Applicants: Universite de Strasbourg, NormOxys, Inc.
    Inventors: Jean-Marie Lehn, Srinivasu Pothukanuri, Alexandros Koumbis, Carolina Duarte, Claude Nicolau
  • Diffractive signaling device for rear-view mirror with 2D/3D display
    Patent number: 8749371
    Abstract: Signaling device designed to be arranged on the reflective element forming a mirror of a rear-view device comprising at least an illumination unit and at least an optical device, characterized by the fact that the optical device includes a symbol generation unit which is provided with at least a diffraction grating designed to form an illuminated image corresponding to a first illuminated symbol, the symbol generation unit being generally transparent and the diffraction grating being formed on the surface of the symbol generation unit without affecting its transparency.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: June 10, 2014
    Assignees: Delphi Technologies, Inc., Universite de Strasbourg
    Inventors: Hassan Moussa, Idriss El Hafidi, Laurent Tupinier
  • POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES
    Publication number: 20140155334
    Abstract: The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.
    Type: Application
    Filed: November 25, 2013
    Publication date: June 5, 2014
    Applicants: Université de Strasbourg, NormOxys, Inc.
    Inventors: Jean-Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
  • LINEAR DNA AMPLIFICATION
    Publication number: 20140141442
    Abstract: The present invention provides materials and methods for DNA amplification, in particular linear amplification methods using RNA polymerase. These methods permit high-throughput sequencing of pictogram amounts of DNA and are of use in a range of applications including genome-wide profiling of transcription factors and epigenetic DNA and histone modifications, global transcript profiling, mapping of chromatin conformations, as well as for forensic use and archaeological studies.
    Type: Application
    Filed: May 4, 2012
    Publication date: May 22, 2014
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
    Inventors: Luisa Miguel Verdelho Trindade Van Gerven, Hinrich Gronemeyer, Shankara Narayanan Pattabhiraman
  • MACROCYCLIC PRODRUG COMPOUNDS USEFUL AS THERAPEUTICS
    Publication number: 20140135290
    Abstract: The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis.
    Type: Application
    Filed: November 4, 2013
    Publication date: May 15, 2014
    Applicants: ONCOSYNERGY, INC., LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: James HECK, Nicolas Winssinger, John C. Chabala, Sofia Barluenga, Ruihong Chen, Allan Rubenstein, Jin-Chen Yu
  • Head-up display system
    Patent number: 8724226
    Abstract: Independent optical unit for head-up display system for motor vehicle, intended for the display in the field of view of the driver of a virtual image obtained from an object image coming from a projector, including a first optical component reflecting the incident light rays emanating from the projector towards a second optical component placed in the field of view of the driver for the positioning of a final virtual image, means being provided for the adjustment of their relative position.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: May 13, 2014
    Assignees: Delphi Technologies, Inc., Universite de Strasbourg
    Inventors: Hassan Moussa, Idriss El Hafidi
  • INDUCED PRESOMITIC MESODERM (IPSM) CELLS AND THEIR USE
    Publication number: 20140127169
    Abstract: The invention relates to a method for reprogramming target cells to multipotent progenitor cells capable of differentiating into muscular, skeletal or dermal cell lines. In particular, the invention relates to an ex vivo method for preparing induced presomitic mesoderm (iPSM) cells, said method comprising the steps of: a) providing target cells to be reprogrammed, and, b) culturing said target cells under appropriate conditions for reprogramming said target cells into iPSM cells, wherein said appropriate conditions comprises increasing expression of at least one T-Box transcription factor in said target cells. The invention further relates to the use of said iPSM cells, for example, for regenerating skeletal, muscle, dermal and cartilage tissues.
    Type: Application
    Filed: January 24, 2012
    Publication date: May 8, 2014
    Applicants: UNIVERSITE DE STRASBOURG, STOWERS INSTITUTE FOR MEDICAL RESEARCH, ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES
    Inventors: Olivier Pourquie, Matthias Wahl, Jerome Chal
  • Sulfonated coumarins, their synthesis, fluorogenic substrates resulting from grafting of these coumarins on sugars, method for obtaining these substrates, and their applications
    Patent number: 8716496
    Abstract: Substituted sulfonated coumarins are expressed in the general formula (I), where: R1 is H, OH, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R2 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R1 and R2 being capable of together forming a ring, such as a substituted or unsubstituted aryl or furane, R3 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, where R4 is H, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or a substituted or unsubstituted aryl, and M is Na or K.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: May 6, 2014
    Assignees: Universite de Strasbourg
    Inventors: Antoine Drevelle, Sylvain Ladame, Majdi Najah, Estelle Mayot
  • Method of preparing an adduct
    Patent number: 8716191
    Abstract: A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is hybridized at least one PNA-encoded molecule.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 6, 2014
    Assignees: Universite de Strasbourg, Centre National de la Recherche Scientifique
    Inventors: Nicolas Winssinger, Sofia Barluenga
  • METHOD AND DEVICE TO MODIFY PROPERTIES OF MOLECULES OR MATERIALS
    Publication number: 20140102876
    Abstract: A method and a device to modify the properties of molecules or materials. A method to modify the chemical properties, the work function, the electrochemical potential and/or the NMR frequency of one or more molecules, biomolecules or materials, method includes the steps of: providing a reflective or photonic structure (1) which has an electromagnetic mode which is resonant with a transition in the molecules, biomolecules or material (2); and placing the molecule(s), biomolecule(s) or material (2) in or on a structure of the previous type.
    Type: Application
    Filed: May 7, 2012
    Publication date: April 17, 2014
    Applicant: UNIVERSITE DE STRASBOURG (Etablissement Public National a Caractere Scientifique, Culturel et P..
    Inventors: James A. Hutchison, Tal Schwartz, Cyriaque Genet, Eloise Devaux, Thomas W. Ebbesen, Paolo Samori
  • Process for Identifying Novel Anti-Inflammatory Molecules with Reduced Direct Transrepression of Genes Induced by Glucocorticoids
    Publication number: 20140093884
    Abstract: The present invention relates to a new process for identifying novel anti-inflammatory molecules with reduced direct transrepression of genes induced by glucocorticoids. The inventors have discovered that GCs-mediated transrepression can be mediated not only via the tethering indirect pathway, but also through direct binding of GR to “simple” negative GREs (nGRE), which belongs to a novel family of evolutionary-conserved cis-acting negative response elements (IR nGREs), and are found in numerous GC-repressed genes.
    Type: Application
    Filed: April 13, 2012
    Publication date: April 3, 2014
    Applicants: UNIVERSITE DE STRASBOURG, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Pierre Chambon, Daniel Metzger, Milan Surjit
  • POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES
    Publication number: 20140088036
    Abstract: The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.
    Type: Application
    Filed: September 30, 2011
    Publication date: March 27, 2014
    Applicants: UNIVERSITE DE STRASBOURG, NORMOXYS, INC.
    Inventors: Jean Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
  • RADIOPAQUE IODINATED PRODUCTS INTENDED FOR USE MEDICAL IMAGING AND THEIR METHODS
    Publication number: 20140065067
    Abstract: Iodinated amphiphilic compound of formula (I): AG1-X—R??(I) wherein AG1 represents an unsaturated (C8-C52) aliphatic hydrocarbon chain found in fatty acids having specific location of double bonds, the chain including at least one iodine atom directly linked to a carbon atom of a non-conjugated double bond by a covalent link, the second carbon atom of the double bond bearing a halogen atom different from a iodine atom, X represents a polyethylene glycol including 1 to 50 ethylene glycol groups, R represents a hydrogen atom or a group AG2 being identical to or different from AG1, AG1, X, R and AG2 being selected so that the amphiphilic compound has a hydrophilic/lipohilic balance included between 4 and 30.
    Type: Application
    Filed: December 13, 2011
    Publication date: March 6, 2014
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: François Hallouard, Nicolas Anton, Guy Zuber, Thierry Vandamme, André Constantinesco, Philippe Choquet
  • DERIVATIVES OF ALLOPREGNANOLONE AND OF EPIALLOPREGNANOLONE AND USES THEREOF FOR TREATING A NEUROPATHOLOGICAL CONDITION
    Publication number: 20140058079
    Abstract: The présent invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as médicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. Thèse molécules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulâtes neuronal prolifération.
    Type: Application
    Filed: March 23, 2012
    Publication date: February 27, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE STRASBOURG
    Inventors: Ayikoe Guy Mensah-Nyagan, Laurence Meyer, Christine Patte-Mensah, Omar Taleb, Michel Miesch, Philippe Geoffroy, Blandine Ressault
  • COMPOUND COMPRISING ALPHA-MSH FOR USE IN ENDODONTIC REGENERATION
    Publication number: 20140050773
    Abstract: The present invention concerns a compound comprising an ?-MSH peptide, coupled to a polypeptide consisting of a chain of about 15 to about 400 amino acids, for use in endodontic regeneration and/or for the treatment of dental inflammatory diseases. The invention further concerns pharmaceutical compositions, in particular nanostructured compositions, comprising such a compound.
    Type: Application
    Filed: November 26, 2010
    Publication date: February 20, 2014
    Applicant: Universite De Strasbourg
    Inventors: Nadia Benkirane-Jessel, Carlos Mendoza Palomares, Florence Fioretti
  • NOVEL AMINO-PYRROLINE DERIVATIVES, AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF METABOLIC SYNDROME
    Publication number: 20140045910
    Abstract: Novel amino-pyrrolinic derivatives, their pharmacologically acceptable salts and use thereof in the prevention and/or treatment of metabolic syndrome.
    Type: Application
    Filed: April 17, 2012
    Publication date: February 13, 2014
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: Pascal Bousquet, Jean Daniel Ehrhardt, Lyne Fellmann, Vincent Gasparik, Hugues Greney, Mohamed Hadjeri, Andre Mann, Nathalie Niederhoffer, Stephan Schann
  • COMPOUNDS HAVING CHROMOPHORE AND PHOTOREACTIVE GROUPS
    Publication number: 20140045173
    Abstract: The invention relates to the field of hydrophobic photoaffinity marking by element of probes that are multifunctional lipid compounds. The compounds include at least one chromophore group and two lipid chains, one of which includes a photoreactive group. The compounds can be used for the study and identification of hydrophobic regions or domains within proteins, particularly within viruses.
    Type: Application
    Filed: March 23, 2012
    Publication date: February 13, 2014
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: Eve-Isabelle Pecheur, Line Bourel-Bonnet, Benoit Hilbold
  • DEPLETED ANTI-STAPHYLOCOCCAL ENTEROTOXINS POLYCLONAL ANTIBODIES, PREPARATION AND USES THEREOF
    Publication number: 20140037651
    Abstract: The present invention relates to the preparation of a set of depleted polyclonal antibodies, each depleted polyclonal antibody being raised against one specific staphylococcal enterotoxin, and its use for multiplex detection.
    Type: Application
    Filed: February 28, 2012
    Publication date: February 6, 2014
    Applicant: UNIVERSITÉ DE STRASBOURG
    Inventors: Gilles Prévost, Charline Barasino, Daniel Keller, Khaldoun Masoud
  • POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES
    Publication number: 20140031302
    Abstract: The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharmaceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90).
    Type: Application
    Filed: October 24, 2011
    Publication date: January 30, 2014
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: Nicolas Winssinger, Sofia Barluenga
  • Photocatalysts based on structured three-dimensional carbide, in particular ?-SiC, foams
    Patent number: 8628726
    Abstract: The invention relates to a photocatalyst comprising a ?-SiC cellular foam and a photocatalytically active phase, deposited directly on said cellular foam or on an intermediate phase deposited on said cellular foam. The average size of the cells is between 2500 ?m and 5000 ?m. The foam can comprise nanotubes or nanofibers (particularly of carbon, SiC, and TiO2) that consist of, or carry as an intermediate phase, a photocatalytically active phase.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: January 14, 2014
    Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Cuong Pham-Huu, Nicolas Keller, Marc-Jacques Ledoux, Valérie Keller-Spitzer, Dominique Begin, Mathieu Grandcolas, Izabela Janowska, Shabnam Hajesmaili