Abstract: Compounds of formula (I): able to inhibit nicotinamide phosphoribosyltransferase. The disclosure also relates to the use of compounds of formula (I) for treatment of pathological conditions in which NAMPT inhibition might be beneficial, such as acute and chronic inflammation, cancer and metabolic disorders.
Type:
Application
Filed:
April 29, 2014
Publication date:
March 17, 2016
Applicant:
UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO"
Inventors:
Armando A. GENAZZANI, Gian Cesare TRON, Ubaldina GALLI, Cristina TRAVELLI, Salvatore CUZZOCREA, Giorgio GROSA, Giovanni SORBA, Pier Luigi CANONICO
Abstract: Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phosphatidylinositol 3-Kinases activity.
Type:
Application
Filed:
November 28, 2011
Publication date:
September 19, 2013
Applicants:
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO", UNIVERSITA DEGLI STUDI DI TORINO
Inventors:
Giovanni Sorba, Gian Cesare Tron, Ubaldina Galli, Alberto Massarotti, Emilio Hirsch, Elisa Ciraolo, Tracey Pirali
Abstract: Disclosed is a spontaneously immortalized multipotent mesenchymal cell-line, wherein the cell-line has been isolated from mouse subcutaneous adipose tissue, and wherein the cell-line presents fibroblastoid morphology and expresses Sca-1, c-Kit/CD117, nestin, nucleostemin, CD44 and CD106 markers.
Type:
Application
Filed:
December 1, 2011
Publication date:
June 7, 2012
Applicant:
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO"
Inventors:
Maria G. PRAT, Stefano Pietronave, Andrea Zamperone