Abstract: A therapeutic combination of a compound having antiestrogenic activity and a CDK4/6 inhibitor is used in a method for the treatment of BC or other estrogen-responsive tumors in a human patient, wherein the method comprises subjecting the patient to a fasting mimicking diet for a period of 24-190 hours while the patient is being treated with the therapeutic combination, in which the compound having antiestrogenic activity can be a selective estrogen receptor modulator (SERM), a selective estrogen receptor degrader (SERD) or an aromatase inhibitor (AI).

Abstract: The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.

Abstract: An underactuated exoskeleton for lower-limbs, for supporting the knee of a user, includes a first and a second coupling frame and a movement means associated with the first and with the second frame configured to confer to the second frame a roto-translation movement with respect to the first frame or vice versa. The exoskeleton further includes a junction means operatively interposed between the movement means and the first frame and/or the second frame configured to allow a relative rotation between the first and the second frame in a second plane, orthogonal to the first plane, a rotation of said second frame about said main axis of the leg and a relative translation between the first and the second frame in the second plane.

Abstract: A modular frame structure for a machining center which includes at least one modular unit having a first and a second individual module. Each individual module includes two mutually parallel vertical columns, each one extending parallel to a vertical direction; a pair of first horizontal cross-members, each one extending parallel to a first horizontal direction, each horizontal cross-member of the pair of first cross-members being joined to both columns. The modular unit further includes two pairs of second horizontal cross-members, each horizontal cross-member parallel to a second horizontal direction that is perpendicular to the first horizontal direction.

Abstract: The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.

Abstract: The present invention refers to a process for the preparation of a graphene dispersion comprising the following steps: i) providing cellulose acetate flakes or powders; ii) swelling the cellulose acetate flakes or powders in an alcohol having from 1 to 3 carbon atoms; iii) adding acetic anhydride in a concentration range from 30 to 50 wt % referred to the total weight of the mixture; iv) adding graphene nanoplatelets to yield a graphene dispersion. The graphene dispersion is used as ink for composite materials that are employed in the field of foldable electronics. The invention relates also to a composite material comprising uniformly dispersed graphene nanoplatelets and its use for manufacturing electronic devices.

Abstract: A comprehensive system for treatment of wrist joint proprioception. The system includes a manipulandum unit and a controller. The unit includes a base, a handle, a linkage assembly, and motors. The base supports a subject's forearm, and the handle is gripped by the palm. The linkage assembly connects the handle to the base, and establishes three DOFs. The motors are operatively connected to the linkage assembly. The controller is programmed to actuate, and receive feedback information from, each of the plurality of motors. Further, the controller is programmed to perform wrist proprioception assessment operations by actuating the plurality of motors to effectuate movement of the handle relative to the base in a prescribed manner indicative of position motion sense acuity as an objective measure of wrist proprioception functioning. The controller is optionally further programmed to perform rehabilitation training via controlled operation of the unit and a virtually reality environment.

Abstract: The present invention concerns a method for the preparation of metal oxide hollow nanoparticles comprising the steps of: —providing an aqueous suspension of nanoparticles of an oxide of a first element having at least two oxidation states coupled with a substrate; —placing in contact the aqueous suspension with an aqueous solution of a salt of a second element having at least two oxidation states having a standard reduction potential lower than the standard reduction potential of said first transition metal to obtain hollow nanoparticles.

Abstract: A system for monitoring and private assistance to people includes sensors that detect descriptive parameters of environmental conditions, and sensors and/or devices that monitor a person's position and, optionally, her physiological parameters. In particular, the system includes sensors and/or devices that monitor a person's position at the topological level and generate tracking signals in time and within a digital topological model of the environment; sensors that monitor posture and/or its variations in time and that provide status signals corresponding to predetermined postures and/or signals, indicating posture variations in time, which are processed by a logic control unit and software that evaluates position and posture and its variation in time and that classifies the signals according to predetermined categories of motor and/or postural activities, and that performs a comparison between detected parameters and predefined patterns of execution.

Abstract: A humanoid robot foot (10) comprises: a foot base (12), at least one leaf spring (14) acting as a flexible toe of the foot, said at least one leaf spring (14) having a rear portion (14a) rigidly connected to a flat surface (12b) of the foot base (12), a front portion (14b) projecting from the foot base (12) and an intermediate portion (14c) which is not rigidly connected to the foot base (12) and is therefore freely deflectable, along with the front portion (14b), as a result of the application of an external force on the front portion (14b), and a stiffness adjustment device (26) for actively changing the stiffness (K) of said at least one leaf spring (14).

Abstract: A tyrosine kinase inhibitor (TKI) for use in a method for the treatment of cancer in a patient, wherein the method comprises subjecting the patient to reduced caloric intake, i.e a daily caloric intake reduced by 10-100%, including starvation, for a period of 24-190 hours and administering the tyrosine kinase inhibitor to the patient during such period; the tyrosine kinase inhibitor is preferably selected among Lapatinib, Crizotinib, Gefitinib, Erlotinib, Afatinib and Regorafenib.

Abstract: A diet composition for use in the prevention and/or the treatment of endometrial hyperplasia in a human subject is provided. It has a) a fasting mimicking diet component to be administered for a first period of time and providing less than 50% of the normal caloric intake of the subject with both protein restriction and sugar restriction; and b) a re-feeding diet component to be administered for a second time period, which provides 60-100% of the normal caloric intake of the subject, wherein the fasting mimicking diet component and the re-feeding diet component are administered over multiple cycles.

Abstract: The present invention refers to a process for the preparation of a graphene dispersion comprising the following steps: i) providing cellulose acetate flakes or powders; ii) swelling the cellulose acetate flakes or powders in an alcohol having from 1 to 3 carbon atoms; iii) adding acetic anhydride in a concentration range from 30 to 50 wt % referred to the total weight of the mixture; iv) adding graphene nanoplatelets to yield a graphene dispersion. The graphene dispersion is used as ink for composite materials that are employed in the field of foldable electronics.

Abstract: The disclosure provides methods and compositions useful for treating autoimmune diseases and disorders. For example, the disclosure demonstrates that hypergammaglobulinemia and subsequent accelerated kidney disease can be suppressed by Ig minigene-induced CD8+ T cells that make CD4+T cells hyporesponsive to antigenic stimulation, thus causing inhibition of renal disease and subsequent increased survival.

Abstract: A tyrosine kinase inhibitor (TKI) for use in a method for the treatment of cancer in a patient, wherein the method comprises subjecting the patient to reduced caloric intake, i.e a daily caloric intake reduced by 10-100%, including starvation, for a period of 24-190 hours and administering the tyrosine kinase inhibitor to the patient during such period; the tyrosine kinase inhibitor is preferably selected among Lapatinib, Crizotinib, Gefitinib, Erlotinib, Afatinib and Regorafenib.

Abstract: A compound having antiestrogenic activity is used in a method for the treatment of BC or other estrogen-responsive tumors in a human patient, wherein the method comprises subjecting the patient to a fasting mimicking diet for a period of 24-190 hours while the patient is being treated with the compound having antiestrogenic activity, which can be a selective estrogen receptor modulator (SERM), a selective estrogen receptor downregulator (SERD) or an aromatase inhibitor (AI).

Abstract: A tyrosine kinase inhibitor (TKI) for use in a method for the treatment of cancer in a patient, wherein the method comprises subjecting the patient to reduced caloric intake, i.e a daily caloric intake reduced by 10-100%, including starvation, for a period of 24-190 hours and administering the tyrosine kinase inhibitorto the patient during such period; the tyrosine kinase inhibitor is preferably selected among Lapatinib, Crizotinib, Gefitinib, Erlotinib, Afatinib and Regorafenib.

Abstract: Compounds of formula (I), wherein Z=cyclopentyl. cyclopropylmethyl, —CH3; R??—CH3, CHF2, X=formula (II) (III) (IV) (V) Y=—CO; —C?O(CH2), —CH(OH)—CH2, —CH2—C?O, —CH2—CH2—C?O; —CH2—CH(OH)—CH2, —CH2—CH(OCOR1)—CH2 NR2? —N(CH2—CH2OH)2, formula (VI) (VII) (VIII) (IX) (X) (XI) R1=optionally substituted C1-C8 alkyl, optionally substituted aryl; optionally substituted aralkyl, preferably C1-C3 alkyl, more preferably CH3; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; these compounds have a PDE4D inhibiting activity and can be used as a medicament for treating dementia, in particular Alzheimer disease, and for improving memory.

Abstract: An organic transistor-based system for electrophysiological monitoring of cells is disclosed. The system includes a plurality of organic transistors each comprising: a floating gate electrode; a source electrode and a drain electrode; an organic semiconductor; an insulating layer; and a sensing area. A barrier mechanically separates said sensing area and a transistor area. Each organic transistor includes a control gate electrode coupled to a second portion of said floating gate electrode external to said sensing area by a capacitor. The control gate electrode is separated from said floating gate electrode by said insulating layer. The control gate electrode sets a working point of the organic transistor to which the control gate electrode belongs to by a control voltage (VGS) applied to it. In each organic transistor, an overlapping area defined by said control gate electrode formed above said floating gate is comprised between 9*10?4 cm2 and 2*10?3 cm2.

Abstract: A creatine derivative, (Boc)2-creatine, is used as a medicament, in particular in a therapeutic antitumor treatment. I (Boc)2-creatine.