Patents Assigned to UNIVERSITÁ DEGLI STUDI DI MILANO-BICOCCA
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Publication number: 20170224898Abstract: The present invention relates to an extracorporeal circuit for CO2 removal from blood comprising a line for taking blood from the patient, a decarboxylation assembly and a line for returning the blood to the patient; said decarboxylation assembly comprising a first filtering unit, an oxygenator, an electrodialyzer adapted to generate an acid solution and a basic solution and means for the infusion of said acid solution upstream of said oxygenator, wherein said electrodialyzer comprises a first electrodialysis chamber and a second electrodialysis chamber, said first and second electrodialysis chambers being separated by an ionic membrane, and in that wherein said first chamber and said second chamber are respectively separated from the positive electrode, or anode, and from the negative electrode, or cathode, by means of a bipolar membrane.Type: ApplicationFiled: July 31, 2015Publication date: August 10, 2017Applicant: UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCAInventors: Antonio Maria Pesenti, Alberto Zanella, Domenico Salerno, Nicolò Antonino Patroniti, Francesco Mantegazza
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Publication number: 20170218264Abstract: Disclosed herein are embodiments of a composition comprising a polymer or sol-gel matrix and one or more nanocrystals. The composition is useful for making various products, including a luminescent solar concentrator. The nanocrystals are dispersed in the polymer or sol-gel matrix to reduce or substantially prevent nanocrystal-to-nanocrystal energy transfer and a subsequent reduction in the emission efficiency of the composition. The nanocrystals may comprise an antenna portion and an emitter portion, and in some embodiments the materials for the antenna and emitter portions are selected to produce a large Stokes shift between the absorption and emission wavelengths. In some embodiments, the polymer matrix comprises an acrylate polymer. Also disclosed herein is a method for making the composition, which may comprise a pre-polymerization step before the nanocrystals are introduced. Devices comprising the composition and a photovoltaic cell also are disclosed. In some examples, the device is a window.Type: ApplicationFiled: October 13, 2014Publication date: August 3, 2017Applicants: Los Alamos National Security, LLC, Universita Degli Studi Di Milano-BicoccaInventors: Victor I. Klimov, Hunter McDANIEL, Sergio BROVELLI, Francesco MEINARDI
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Publication number: 20160346734Abstract: The present invention relates to novel molecules suitable to the use in the separation/removal of carbon dioxide from gaseous mixtures as liquid-phase carbon dioxide absorbers and suitable to allow the subsequent release of the absorbed carbon dioxide in form of different ionic liquids, preferentially a glycine salt with choline hexanoate, ester between glycine and hexanoic alcohol (hexyl glycinate) and glycerol ester with glycine and hexanoic acid. The present invention also relates to a method and a plant for the capture of carbon dioxide from gaseous mixtures by using an absorber for carbon dioxide in liquid phase with a heating jacket.Type: ApplicationFiled: January 16, 2015Publication date: December 1, 2016Applicant: UNIVERSITA DEGLI STUDI DI MILANO-BICOCCAInventors: Maurizio Filippo ACCIARRI, Simona Olga BINETTI, Bruno VODOPIVEC, Maurilio Giuseppe MESCHIA
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Publication number: 20160203385Abstract: An image processing system includes a first processor that acquires frames of image data. For each frame of data, the first processor generates a Gaussian pyramid for the frame of data, extract histogram of oriented gradient (HOG) descriptors for each level of the Gaussian pyramid, compresses the HOG descriptors, and sends the compressed HOG descriptors. A second processor is coupled to the first processor and is configured to receive the compressed HOG descriptors, aggregate the compressed HOG descriptors into windows, compare data of each window to at least one stored model, and generate output based upon the comparison.Type: ApplicationFiled: January 9, 2015Publication date: July 14, 2016Applicants: STMICROELECTRONICS S.R.L., UNIVERSITA DEGLI STUDI DI MILANO - BICOCCAInventors: Alberto Margari, Danilo Pietro Pau, Raimondo Schettini
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Patent number: 9249353Abstract: A flexible transparent electrochromic device, which includes the following components, each of which is a flexible film: a working electrode comprising a transparent conducting substrate supporting an working electrode active material; a counter electrode including a transparent conducting substrate supporting a counter electrode active material; a solid polymer electrolyte (SPE) including a solution of a lithium salt in a polymer solvent. A method for preparing an electrochromic device includes the steps of: preparing a working electrode film, preparing a counter electrode film, preparing a polymer electrolyte film, and assembling the electrodes and the electrolyte, the method being implemented continuously.Type: GrantFiled: September 19, 2012Date of Patent: February 2, 2016Assignees: HYDRO-QUEBEC, FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V., CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI INSTM, UNIVERSITA DEGLI STUDI DI MILANO-BICOCCAInventors: Uwe Posset, Bettina Herbig, Gerhard Schottner, Karim Zaghib, Jean-François Labrecque, Abdelbast Guerfi, Michel Perrier, Riccardo Ruffo, Matteo Marco Salamone, Claudio Maria Mari, Luca Beverina, Giorgio Pagani, Martin Dontigny
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Patent number: 9169995Abstract: The present invention relates to a device to convert the blue light from solid-state sources into white light, and includes a transparent polymer matrix with a laminar structure, diffusing particles and phosphors.Type: GrantFiled: September 26, 2011Date of Patent: October 27, 2015Assignee: UNIVERSITA' DEGLI STUDI DI MILANO BICOCCAInventors: Leonida Miglio, Francesco Tassone, Franco Fattorini, Raffaello Nemni, Pierangelo Pasquettin, Sonia Pasquettin, Loretta Pasquettin, Elisa Pasquettin, Irene Pasquettin
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Publication number: 20150094218Abstract: An in vitro method and a kit for the quantification of antibodies anti-beta amyloid protein in a sample of cerebrospinal fluid comprising the following steps a) concentrating the quantity of said antibodies of said sample with magnetic micro beads coated with macromolecules capable of binding said antibodies b) analysing the concentrated sample obtained in step a) by immunoenzyme assay or by radioimmunoassay; c) analysing a sample comprising antibodies anti-beta amyloid protein having a known titre with the same assay used in step b) and elaborating the related calibration curve, wherein said antibody having a known titre is a murine antibody belonging to the IgG2a or IgG2b class or a human or humanized antibody belonging to the IgG2b or IgGi class.Type: ApplicationFiled: March 20, 2013Publication date: April 2, 2015Applicant: UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCAInventors: Fabrizio Piazza, Carlo Ferrarese
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Patent number: 8895744Abstract: The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, to their pharmaceutical compositions and use thereof for the treatment of cancer expressing oncogenic ALK protein, particularly anaplastic large cell lymphoma (ALCL), diffuse large B cell lymphoma (DLBCL), inflammatory myofibroblastic tumors (IMT) and non-small cell lung cancer (NSCLC).Type: GrantFiled: August 27, 2009Date of Patent: November 25, 2014Assignees: Universita' Degli Studi di Milano-Bicocca, Universite' de Geneve, Universite' Claude Bernard de Lyon 1Inventors: Carlo Gambacorti Passerini, Luca Mologni, Leonardo Scapozza, Shaheen Ahmed, Peter G. Goekjian, David Gueyrard, Florence Popowycz, Benoit Joseph, Cedric Schneider, Pierre Garcia
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Patent number: 8877236Abstract: New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.Type: GrantFiled: June 28, 2012Date of Patent: November 4, 2014Assignee: Universita Degli Studi di Milano-BicoccaInventors: Massimo Masserini, Francesca Re, Giulio Sancini, Gianluigi Forloni, Mario Salmona
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Publication number: 20140219867Abstract: A blood treatment method is described that is adapted to at least partially eliminate the carbon dioxide content of the type comprising a step of drawing a blood flow. Advantageously according to the invention, the method further comprises the steps of: acidifying the blood flow with transformation of the related blood bicarbonate content into gaseous carbon dioxide; and eliminating the gaseous carbon dioxide content by means of a pressure gradient.Type: ApplicationFiled: April 14, 2014Publication date: August 7, 2014Applicant: Universita degli Studi di Milano-BicoccaInventors: Antonio Maria Pesenti, Nicolo Antonino Patroniti
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Patent number: 8734375Abstract: A blood treatment method is described that is adapted to at least partially eliminate the carbon dioxide content of the type comprising a step of drawing a blood flow. Advantageously according to the invention, the method further comprises the steps of: acidifying the blood flow with transformation of the related blood bicarbonate content into gaseous carbon dioxide; and eliminating the gaseous carbon dioxide content by means of a pressure gradient.Type: GrantFiled: May 7, 2008Date of Patent: May 27, 2014Assignee: Universitá degli Studi di Milano-BicoccaInventors: Antonio Maria Pesenti, Nicolò Antonino Patroniti
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Patent number: 8722850Abstract: There is described a group of novel self-assembling peptides (SAPs), comprising biotinylated and unbiotinylated sequences, hybrid peptide-peptoid sequences, branched sequences for a total of 48 tested motifs, showing a heterogeneous ensemble of spontaneously self-assembled structures at the nano- and microscale, ranging from short tabular fibers to twisted ribbons, nanotubes and hierarchical self-assembled micrometer-long sheets. Specifically, the SAPs according to the present invention which initially spontaneous assemble, surprisingly form stable solid scaffolds upon exposure to neutral pH buffer. Further these SAPs allow adhesion, proliferation and differentiation of murine and human neural stem cells and have self-healing propensity. They also did not exert toxic effects in the central nervous system, can stop bleeding and foster nervous regeneration.Type: GrantFiled: April 19, 2011Date of Patent: May 13, 2014Assignee: Universita' Degli Studi di Milano BicoccaInventors: Angelo Luigi Vescovi, Fabrizio Gelain
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Patent number: 8592003Abstract: The present invention relates to a method for the preparation of a novel hybrid electrochromic coating material with superior performance in terms of transparency, electrochromic contrast, coloration efficiency, and adhesion, for a use in electrochromic devices for applications where a high transparency is required in the bleached state.Type: GrantFiled: November 28, 2007Date of Patent: November 26, 2013Assignees: Fraunhofer-Gesellschaft zur forderung der angewandten Forschung e.V., Universita Degli Studi di Milano-BicoccaInventors: Ayse Cochet, Uwe Posset, Gerhard Schottner, Giorgio Pagani, Ricardo Ruffo, Luca Beverina, Claudio Maria Mari, Giorgio Patriarca, Alessandro Abbotto
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Publication number: 20130053324Abstract: There is described a group of novel self-assembling peptides (SAPs), comprising biotinylated and unbiotinylated sequences, hybrid peptide-peptoid sequences, branched sequences for a total of 48 tested motifs, showing a heterogeneous ensemble of spontaneously self-assembled structures at the nano- and microscale, ranging from short tabular fibers to twisted ribbons, nanotubes and hierarchical self-assembled micrometer-long sheets. Specifically, the SAPs according to the present invention which initially spontaneous assemble, surprisingly form stable solid scaffolds upon exposure to neutral pH buffer. Further these SAPs allow adhesion, proliferation and differentiation of murine and human neural stem cells and have self-healing propensity. They also did not exert toxic effects in the central nervous system, can stop bleeding and foster nervous regeneration.Type: ApplicationFiled: April 19, 2011Publication date: February 28, 2013Applicant: UNIVERSITA' DEGLI STUDI DI MILANO BICOCCAInventors: Angelo Luigi Vescovi, Fabrizio Gelain
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Publication number: 20130017342Abstract: A method for producing, by means of plasma, nanostructured thin layers particularly of the hierarchically organized type, and an apparatus for implementing the method, are described. At least a first chamber (10) is provide in which are present an injector (14) of a reagent gas, means (31, 31?) for feeding inert gases, and an antenna (16) for the creation of a plasma in said first chamber. Enclosing said first chamber is a second chamber (11) to which a pumping system is connected, containing a housing for the substrate (35) on which the nanostructured film is produced. A wall (12) separates said first chamber from said second chamber and has at least one opening (13). The injector and antenna are arranged in the first chamber with a geometry such that the distance between the outlet of said injector is at a distance of no more than 5 cm from the plane of the surface of said antenna farther from said wall, and said surface is at a distance of no more than 5 cm from said opening.Type: ApplicationFiled: November 30, 2010Publication date: January 17, 2013Applicants: POLITECNICO DI MILANO, UNIVERSITA' DEGLI STUDI DI MILANO BICOCCAInventors: Claudia Riccardi, Moreno Piselli, Francesco Sirio Fumagalli, Fabio Di Fonzo, Carlo Enrico Bottani
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Publication number: 20120253043Abstract: The present invention provides new bi- and polypyridine ligands of ruthenium dyes. The invention also provides solar cells, in particular dye-sensitized solar cells comprising the dyes.Type: ApplicationFiled: September 29, 2010Publication date: October 4, 2012Applicants: Ecole Polytechnique Federale De Lausanne (EPFL), Consiglio Nazionale Delle Ricerche, Universita Degli Studi Di Milano-BicoccaInventors: Mohammad Khaja Nazeeruddin, Michael Graetzel, Alessandro Abbotto, Chiara Marinzi, Norberto Manfredi, Filippo De Angelis
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Publication number: 20120104375Abstract: A method for producing electrical contacts on organic semiconductors is described. The method, which involves low energy impact and can be carried out under ambient conditions, comprises covering the relevant surface of the semiconductor with a layer of an appropriate solvent: a metal leaf having an appropriate thickness and work function containing metal oxide impurities is deposited onto the area treated in this manner. Electrical contacts with elevated conductivity are obtained by evaporating the solvent. One embodiment of the invention describes a family of crystalline semiconductors, preferably based on perylene or ?-quaterthiophene, provided with the electrical contacts according to the method described herein and provided with particular structural characteristics. The use of metal leaf satisfying the above-stated requirements (for example imitation gold leaf, gold leaf etc.). in the above-described method is furthermore described.Type: ApplicationFiled: May 6, 2010Publication date: May 3, 2012Applicant: UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCAInventors: Marcello Campione, Adele Sassella, Massimo Moret, Daniele Braga
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Publication number: 20110281862Abstract: The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, to their pharmaceutical compositions and use thereof for the treatment of cancer expressing oncogenic ALK protein, particularly anaplastic large cell lymphoma (ALCL), diffuse large B cell lymphoma (DLBCL), inflammatory myofibroblastic tumours (IMT) and non-small cell lung cancer (NSCLC).Type: ApplicationFiled: August 27, 2009Publication date: November 17, 2011Applicants: Universita' Degli Studi di Milano - Bicocca, Universite' Claude Bernard de Lyon 1, Universite' de GeneveInventors: Carlo Gambacorti Passerini, Luca Mologni, Leonardo Scapozza, Shaheen Ahmed, Peter G. Goekjian, David Gueyrard, Florence Popowycz, Benoit Joseph, Cedric Schneider, Pierre Garcia
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Publication number: 20110177158Abstract: Novel liposomes are described which are capable of effectively binding beta amyloid peptide and are useful for the treatment, prevention and diagnosis of Alzheimer's disease. Binding ability is provided by the presence in the formulation of particular natural lipids identified by the Applicant. These comprise a constant component, made up of cholesterol and sphingomyelin, and an additional variable component, made up of selected lipids.Type: ApplicationFiled: June 10, 2009Publication date: July 21, 2011Applicant: Universita degli Studi di Milano-BicoccaInventors: Massimo Masserini, Francesca Re, Maria Silvia Sesana
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Publication number: 20110104769Abstract: The present invention relates to the production of organic acids with yeasts that overexpress at least one sugar transporter. The yeast might express further genes related to the production of the desired organic acid. The organic acid is produced by cultivation of the yeast overexpressing a sugar transporter in an adequate culture medium, whereupon the desired organic acid is accumulated in the culture medium and subsequently purified to the desired degree by techniques known in the art.Type: ApplicationFiled: May 27, 2009Publication date: May 5, 2011Applicant: UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCAInventors: Danilo Porro, Paola Branduardi, Michael Sauer