Patents Assigned to Università degli Studi di Parma
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Patent number: 7947657Abstract: The present invention refers to sense and antisense peptide nucleic acids (PNAs). The present invention further refers to the use of said PNAs for preparing drugs for treating genetic diseases.Type: GrantFiled: April 29, 2004Date of Patent: May 24, 2011Assignees: Universita Degli Studi Di Parma, Universita Degli Studi Di BolongaInventors: Roberto Tonelli, Andrea Pession, Raffaele Fronza, Rosangela Marchelli, Roberto Corradini, Stefano Sforza
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Publication number: 20100267836Abstract: Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR8; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C6 alkyl, C3-C6 cycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, —OCF3, CF3, C1-C8 alkyl, C1-C8 alkyloxy, C1-C8 alkylthio, halogen and —Z—(CH2)p-A; R1 is selected from the group consisting of C1-C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1-C4 alkyl, hydroxy-substituted C3-C8 cycloalkyl, and NHR5, wherein R5 is C1-C3 alkyl or C3-C6 cycloalkyl; R2 is selected from the group consisting of: hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R and R3 may be connected together to form an —O—(CH2)v bridge representing with the carbon atoms to which theType: ApplicationFiled: January 12, 2007Publication date: October 21, 2010Applicants: UNIVERSITA DEGLI STUDI DI MILANO, UNIVERSITA DEGLI STUDI DI URBINO, MCGILL UNIVERSITY, UNIVERSITA DEGLI STUDI DI PARMAInventors: Gabriella Gobbi, Marco Mor, Silvia Rivara, Franco Fraschini, Giorgio Tarzia, Annalida Bedini, Gilberto Spadoni, Valeria Lucini
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Publication number: 20100233276Abstract: The described agglomeration of drug microparticles blended with excipient microparticles is a technique for the size enlargement of micronized products that could be damaged by granulation or compaction techniques. These agglomerates can be used as oral prompt or delayed-release dosage forms administered as they are or dispersed in a liquid. The composition and quantity of the excipient microparticles resulted to be the crucial factors for the agglomerate quality. Therefore, adjusting the content of surface-active agent between 8-20%, of the excipient microparticles it is possible to agglomerate microparticles of drugs that could not be agglomerated per se. Increasing the surfactant concentration in the spray-dried excipient microparticles or increasing the fraction of these excipient microparticles in the blend, the agglomeration was improved. The spray drying technique concentrates the surface-active agent on the microparticle surface.Type: ApplicationFiled: October 26, 2007Publication date: September 16, 2010Applicant: UNIVERSITA' DEGLI STUDI DI PARMAInventors: Renata Raffin, Paolo Colombo, Fabio Sonvico, Gaia Colombo, Alessandra Rossi, Francesca Buttini
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Patent number: 7718821Abstract: This invention relates to a process for producing electron deficient olefins, such as 2-cyanoacrylates, using an iminium salt.Type: GrantFiled: December 19, 2006Date of Patent: May 18, 2010Assignees: Loctite (R&D) Limited, Universita Degli Studi di ParmaInventors: Franca Bigi, Stefano Gheradi, Ciaran B. McArdle
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Publication number: 20100049104Abstract: A device for the treatment of tinnitus, comprising generator means able to generate an audio signal, and transducer means connected to the generator means in order to reproduce the audio signal. The device also comprises filter means interposed between the generator means and the transducer means in order to filter and substantially suppress the audio signal at least in correspondence with an interval of frequencies around the dominant frequency (Ft) of tinnitus, so as to obtain a silent window (silent band) having a selected width or amplitude around said dominant frequency (Ft) of tinnitus.Type: ApplicationFiled: January 16, 2008Publication date: February 25, 2010Applicant: UNIVERSITA' DEGLI STUDI DI PARMAInventors: Marco Lugli, Stefano Parmigiani, Romano Romani
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Patent number: 7625865Abstract: The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).Type: GrantFiled: March 26, 2004Date of Patent: December 1, 2009Assignee: Universita Degli Studi Di ParmaInventors: Paolo Colombo, Stefano Cagnani, Paolo Ventura
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Patent number: 7176201Abstract: Fatty acid amide hydrolase inhibitors of the Formula: are provided wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted or unsubstituted biphenylyl, substituted or unsubstituted naphthyl, and substituted or unsubstituted phenyl; substituted or unsubstituted terphenylyl; substituted or unsubstituted cycloalkyl, heteroaryl, or alkyl; and R1 and R2 are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted phenyl, substituted or unsubstituted biphenylyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; with the proviso that if Z is O, one of R1 and R2 is absent, and that if Z is N, optionally R1 and R2 may optionally be taken together to form a substituted or unsubstituted N-heterocycle or substituted or unsubstituted heteroaryl with the N atom to which theyType: GrantFiled: October 7, 2003Date of Patent: February 13, 2007Assignees: The Regents of the University of California, Universita Degli Studi di Parma, Universita Degli Studi di UrbinoInventors: Daniele Piomelli, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia
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Patent number: 6855664Abstract: A catalyst for the full oxidation of volatile organic compounds (VOC), particularly hydrocarbons, and of CO to CO2, comprising: a non-stoichiometric crystalline compound conventionally designated by a formula which corresponds to A14Cu24O41 (I), where A is Sr or a solid solution of Sr with alkaline-earth metals, alkaline metals, lanthanides; or a non-stoichiometric crystalline compound conventionally designated by a formula which corresponds to B4Cu5O10 (II), where B is Ca or a solid solution of Ca with alkaline-earth metals, alkaline metals, lanthanides; or mixtures thereof; and in that it is prepared in a form which has a large specific surface area, preferably larger than 25 m2/g; a method for preparing the catalysts; their use in methods for the full oxidation of VOC and of CO to CO2; and the oxidation methods.Type: GrantFiled: August 21, 2003Date of Patent: February 15, 2005Assignees: Consiglio Nazionale Delle Ricerche, Universita 'Degli Studi di ParmaInventors: Francesco Cino Matacotta, Gianluca Calestani, Chiara Dionigi, Petr Nozar
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Patent number: 6514320Abstract: A process for absorbing nitrogen oxides, comprising the step of placing gas mixtures containing nitrogen oxides in contact with absorbent compounds constituted by mixed copper oxides chosen among CaCuO2, Sr14Cu24O41, derivatives thereof obtained by isovalent and/or heterovalent substitutions, and mixtures thereof.Type: GrantFiled: July 2, 2001Date of Patent: February 4, 2003Assignees: Consiglio Nazional Delle Ricerche, Universita' Degli Studi di ParmaInventors: Francesco Cino Matacotta, Petr Nozar, Chiara Dionigi, Gianluca Calestani
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Patent number: 4797480Abstract: Sybthesis of new biologically active fluorescent cyclic nucleotides of general formula: ##STR1## wherein X=OH and Y=NH.sub.2 or X=NH.sub.2 and Y=H and L is a fluorescent group of the class of 5 (or 6)-thioacetamido-fluorescein or of 5(or 8)-(2 thioacetamido-ethyl)-amino-naphthalene -1-sulphonic acid.Type: GrantFiled: May 23, 1986Date of Patent: January 10, 1989Assignee: Universita Degli Studi di ParmaInventors: Robert T. Sorbi, Antonio Caretta, Andrea Cavaggioni, Liliana Marchesi Gastaldi
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Patent number: 4721585Abstract: A process is disclosed for the biological treatment of sewage, which envisages the use of raw cellulosic materials brought into contact with the fouled water in the presence of cellulose-devouring micro-organisms, and is centered particularly on separation of the sewage's nitrogen and phosphorus content.Type: GrantFiled: September 11, 1986Date of Patent: January 26, 1988Assignees: Consiglio Nazionale Delle Richerche, Universita Degli Studi Di ParmaInventors: Ulderico Melchiorri Santolini, Roberto Antonietti, Pierluigi Viaroli, Caterina Della Sala Merigo, Gianpaola Malara, Mario Contesini
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Patent number: 4710400Abstract: A solid, composite and conductor material is obtained by impregnating an impregnable solid with a pyrrolic compound, and bringing the so-impregnated solid into contact with an oxidizer solution, so to cause a pyrrolic polymer to form inside the solid material.Type: GrantFiled: June 20, 1986Date of Patent: December 1, 1987Assignee: Universita' Degli Studi Di ParmaInventors: Gian P. Gardini, Vittorio Bocchi