Abstract: A system (50) for tracking an object (1) comprises a magnetic field source (10) configured to be fixed to this object (1); a magnetometric data collection unit (20) that uses magnetic field sensors (22) fixed at predetermined positions on a support (23) to form an array (21), and that includes a sensor control unit (25) for controlling the magnetic field sensors (22); a data processing unit (30) configured to receive the magnetic field data from the sensor control unit (25) and to calculate from these data position coordinates of the magnetic field source (10) with respect to the array (21) forming a vector of such position coordinates which minimizes the distance between magnetic field values expected at the sensor positions (22) and magnetic field values collected by the collection unit (20), wherein the magnetic field source (10) is arranged to generate a local magnetic field (4), at the magnetic field sensors (22), of intensity set between 5 and 500 microtesla, so that the magnetic field sensors (22) dete

Abstract: A contact force sensor device (10) comprises a gas-inflatable balloon (20) 5 arranged to switch from a deflated state (D) to an inflated state (J) in which it protrudes out of a support member (11); a valve assembly (34) to inflate/deflate the gas-inflatable balloon (12) with a gas; a detector (41) of a force-related value related to a force acting on the inflated gas-inflatable balloon (20) including a membrane (22) due to a contact with a wall (90) 10 outside of support member (11); a processing unit (60) configured to receive a detection signal (45) and to consequently calculate a contact force signal (54) according to a predetermined function; and a notification device (70) configured to receive the contact force signal (54) and to notify it to a user.

Abstract: The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.

Abstract: An electromechanical stimulation system for treating tinnitus comprising a proximal unit (10), configured to be placed proximate to a user's ear (1), and an input interface (50) configured to be operated by the user. The proximal unit comprises an electromechanical device (30) configured to transmit mechanical vibrations (35) with predetermined frequency (f), intensity (A) and waveform, to tissues proximate to the user's ear; a control unit (20), configured to actuate the electromechanical device in such a way that the frequency, the intensity and the waveform of the mechanical vibrations can be modified; a transceiver element (40) adapted to receive control signals (45) for the control unit.

Abstract: A haptic system for providing a gait cadence to a subject comprising a portable telecommunication device with a control unit and a wireless transmission means; a vibrotactile device configured to be tightly worn on a portion of the subject's body, including at least one motor configured to generate vibrations that can be perceived by the subject and an actuation unit configured to actuate the motor. The actuation unit is configured to receive wireless signals from the wireless transmission means of the portable telecommunication device and to cause the motor to produce vibrations responsive to the wireless signals. In the control unit a generation program is resident configured to generate cadence signals and to transmit the wireless signals responsive to the cadence signals by the wireless transmission means to the actuation unit. The generation program is configured to provide corresponding cadence pulses to the motor.

Abstract: The present invention relates to compounds of formula (I) their salts and derivatives. Further object of the present invention are compositions, which comprise at least one compound of formula (I) or its pharmaceutically acceptable salts and derivatives and excipients and, optionally, a further active compound. Further object of the present invention are compounds of formula (I) or compositions which comprise them for use as antibacterial agents.

Abstract: A device for enhancing a user's grasping capability comprises a belt-like support configured to be tightly fitted about a user's part of the body; an articulated gripping element having a plurality of phalanxes: proximal, fixed to the support, intermediate and distal, which are articulated to each other by articular joints; a motor unit fixed to the support; a winding drum; a tendon partially wound on the drum and extending along the phalanxes and the joints, arranged so that, by pulling it from the drum, the phalanxes rotate about respective articular joints and move the articulated gripping element from an extended position to a gripping bow-shaped position, causing a flexion/extension movement of the articulated gripping element, the joints configured so that by releasing the tendon from the drum, the phalanxes rotate about the respective joints and move the articulated gripping element between gripping bow-shaped position and extended position.

Abstract: A contact force sensor device (10) comprises a gas-inflatable balloon (20) 5 arranged to switch from a deflated state (D) to an inflated state (J) in which it protrudes out of a support member (11); a valve assembly (34) to inflate/deflate the gas-inflatable balloon (12) with a gas; a detector (41) of a force-related value related to a force acting on the inflated gas-inflatable balloon (20) including a membrane (22) due to a contact with a wall (90) 10 outside of support member (11); a processing unit (60) configured to receive a detection signal (45) and to consequently calculate a contact force signal (54) according to a predetermined function; and a notification device (70) configured to receive the contact force signal (54) and to notify it to a user.

Abstract: An antenna assembly, comprising: a single substrate having a lower surface and an upper surface; an isotropic source of spherical electromagnetic waves configured for emitting surfaces waves on the upper surface; a ground plane formed on the lower surface comprising a metallic deposit on the entire lower surface; an antenna element formed on the upper surface comprising a periodic patterns metasurface formed on the substrate by a texture of subwavelength patches, the antenna element comprising: a first-scale metasurface defined by a two-dimensional alternation of metal or metamaterial patches having closely spaced vertices in each contiguous element to form small gaps; a plurality of switches disposed in the gap between the vertexes of the patches, each switch permitting to connect several patches through the vertexes for defining a second-scale metasurface having a pattern thus forming the antenna element; wherein each patch has dimensions which do not depend on the frequency of the waves to be radiated,

Abstract: An electromechanical stimulation system for treating tinnitus comprising a proximal unit (10), configured to be placed proximate to a user's ear (1), and an input interface (50) configured to be operated by the user. The proximal unit comprises an electromechanical device (30) configured to transmit mechanical vibrations (35) with predetermined frequency (f), intensity (A) and waveform, to tissues proximate to the user's ear; a control unit (20), configured to actuate the electromechanical device in such a way that the frequency, the intensity and the waveform of the mechanical vibrations can be modified; a transceiver element (40) adapted to receive control signals (45) for the control unit.

Abstract: A device for enhancing a user's grasping capability comprises a belt-like support configured to be tightly fitted about a user's part of the body; an articulated gripping element having a plurality of phalanxes: proximal, fixed to the support, intermediate and distal, which are articulated to each other by articular joints; a motor unit fixed to the support; a winding drum; a tendon partially wound on the drum and extending along the phalanxes and the joints, arranged so that, by pulling it from the drum, the phalanxes rotate about respective articular joints and move the articulated gripping element from an extended position to a gripping bow-shaped position, causing a flexion/extension movement of the articulated gripping element, the joints configured so that by releasing the tendon from the drum, the phalanxes rotate about the respective joints and move the articulated gripping element between gripping bow-shaped position and extended position.

Abstract: A process for manufacturing customized facemasks, includes: producing respective impressions of patient's forehead and chin, to record an anatomic structure thereof, using impression materials commonly utilized in dentistry for intraoral impressions; producing respective 3D digital images of a patient's forehead and chin through a 3d-scanning of the forehead and chin impressions; 3D printing of customized forehead and chin pads; detecting patient's side profile line from a side picture of patient's face; 3D printing of a midline rod modelled according to said profile line; and assembling the forehead and chin pads and said midline rod into a facemask featuring a facial frame providing retention to elastic bands connectable to an intraoral appliance, in the forehead pad a temperature sensor is inserted while a pressure sensor is embedded into the chin pad.

Abstract: A haptic system for providing a gait cadence to a subject comprising a portable telecommunication device with a control unit and a wireless transmission means; a vibrotactile device configured to be tightly worn on a portion of the subject's body, including at least one motor configured to generate vibrations that can be perceived by the subject and an actuation unit configured to actuate the motor. The actuation unit is configured to receive wireless signals from the wireless transmission means of the portable telecommunication device and to cause the motor to produce vibrations responsive to the wireless signals. In the control unit a generation program is resident configured to generate cadence signals and to transmit the wireless signals responsive to the cadence signals by the wireless transmission means to the actuation unit. The generation program is configured to provide corresponding cadence pulses to the motor.

Abstract: The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).

Abstract: The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).

Abstract: The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumors, in particular chronic myeloid leukemia. The invention also provides methods for the identification of 14-3-3 protein inhibitors.

Abstract: The present invention relates to linear and cyclic guanidine derivatives, method of preparation and uses thereof, pharmaceutical compositions to be used as antifungal agents, in particular against Candida species.

Abstract: The present invention relates to compound of formula I: and their use as chemiluminescent and/or bioluminescent reagents.

Abstract: The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumors, in particular chronic myeloid leukemia. The invention also provides methods for the identification of 14-3-3 protein inhibitors.

Abstract: The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumors.