Abstract: The invention relates to the use of an extract of Sextonia rubra or the constituents thereof, rubrenolide and/or rubrynolide, as an insecticide agent against mosquitoes, especially as a larvicide agent.
Type:
Grant
Filed:
September 22, 2015
Date of Patent:
November 17, 2020
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, INSTITUT PASTEUR, UNIVERSITÉ DE GUYANE, UNIVERSITÉ DES ANTILLES, GUYANE DÉVELOPPEMENT INNOVATION
Inventors:
Michaël Falkowski, Alice De Souza Rodrigues, Véronique Éparvier, Isabelle Dusfour, Emeline Houël, Didier Stien
Abstract: The present invention relates to polypeptides and uses thereof for reducing CD95-meditated cell motility. In particular, the present invention relates to a polypeptide having an amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the amino-acid residue at position 175 to the amino-acid residue at position 191 in SEQ ID NO:1.
Type:
Grant
Filed:
October 10, 2018
Date of Patent:
February 11, 2020
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ DE BORDEAUX, UNIVERSITÉ DE RENNES, ECOLE DES HAUTES ETUDES EN SANTÉ PUBLIQUE (EHESP), UNIVERSITÉ DES ANTILLES ET DE LA GUYANE, INSTITUT BERGONIÉ, UNIVERSITY OF NOTTINGHAM
Inventors:
Patrick Legembre, Pierre Vacher, Doriane Sanseau, Aubin Penna, Robin Flynn
Abstract: The present invention relates to polypeptides and uses thereof for reducing CD95-meditated cell motility. In particular, the present invention relates to a polypeptide having an amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the amino-acid residue at position 175 to the amino-acid residue at position 191 in SEQ ID NO:1.
Type:
Grant
Filed:
April 16, 2015
Date of Patent:
January 29, 2019
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE BORDEAUX, UNIVERSITE DE RENNES, ECOLE DES HAUTES ETUDES EN SANTE PUBLIQUE (EHESP), UNIVERSITE DES ANTILLES ET DE LA GUYANE, INSTITUTE BERGONIE, UNIVERSITY OF NOTTINGHAM
Inventors:
Patrick Legembre, Pierre Vacher, Doriane Sanseau, Aubin Penna, Robin Flynn
Abstract: The present invention relates to isolated VHHs directed against human Glycophorin A. The present invention also relates to fusion proteins comprising the VHH according to the invention that is fused to at least one heterologous polypeptide and immunoconjugates comprising the VHH according to the invention that is conjugated to at least one chemical compound and their use in therapeutic or diagnostic methods.
Type:
Grant
Filed:
March 4, 2014
Date of Patent:
January 30, 2018
Assignees:
INSERM (Institut National De La SantéEt De La Recherche Médicale, Imoversité Paris Diderot—Paris 7, Universite Des Antilles Et De La Guyane, Institut National De La Transfusion Sanguine (INTS)
Inventors:
Olivier Bertrand, Ibrahim Habib, Dorota Smolarek
Abstract: The present invention relates to methods and compositions for the treatment of retinal vein occlusion.
Type:
Grant
Filed:
February 8, 2013
Date of Patent:
October 11, 2016
Assignees:
Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes—Paris V, Université Paris Diderot—Paris VII, Université des Antilles et de la Guyane, Institut National de la Transfusion Sanguinge (INTS), Assistance Publique—Hôpitaux de Paris, CHN OPHTALMOLOGIE QUINZE-VINGTS
Abstract: Testicular germline markers and their use for predicting the presence or not of reproductive cells in testis of an infertile or hypo fertile male subject are provided. More particularly, identification of specific protein biomarkers of post-meiotic germ cells in the human seminal plasma was carried out by an integrative genomics approach. It was demonstrated that the presence of such biomarkers could be monitored in the seminal plasma of azoospermic subjects in order to select for a testis biopsy and testicular sperm extraction (TESE) only subjects for which there are high probabilities to find reproductive cells. The results indicate the analysis of seminal plasma is a non-invasive approach for predicting the presence of reproductive cells.
Type:
Grant
Filed:
October 31, 2012
Date of Patent:
November 17, 2015
Assignees:
INSERM (Institut National de la Santé et de la Recherche Médicale), Université de Rennes 1, Université des Antilles et de la Guyane
Inventors:
Charles Pineau, Antoine Rolland, Pierre Calvel, Regis Lavigne