Patents Assigned to Université du Québec à Trois-Rivirères
  • TRIM5alpha mutants and uses thereof
    Patent number: 8623815
    Abstract: New mutant forms of TRIM5? comprising one or more mutations at amino acid positions corresponding to amino acids 324, 328, 330, 333, 335, 336 and/or 337 of wild-type human TRIM5? and which inhibit retrovirus replication are described. These mutants may be used, for example, in gene therapy applications for the prevention and/or treatment of retroviral infection and associated conditions, such as HIV-1 infection and AIDS.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: January 7, 2014
    Assignee: Université du Québec à Trois-Rivirères
    Inventors: Lionel Berthoux, Amélie Bouchard, Quang Toan Pham