Abstract: The invention relates to a method for obtaining a layer at least partially made of a nitride (N), first comprising the provision of a stack comprising at least one assembly of pads (1000A1-1000B4) extending from a substrate (100). Each pad comprises at least one creep section (220A1-220A5) and one crystalline section (300A1,300A5) surmounting the creep section (200A1-200A5). Then, a crystallite (510A1-510A5) is epitaxially grown on at least some of said pads until coalescence of the crystallites, so as to form a nitride layer (550A). The pads of the assembly are distributed over the substrate, such that the relative arrangement of the pads of the assembly is such that during the epitaxy of the crystallites, the progressive coalescence of the crystallites is always done between, on the one hand, a crystallite or a plurality of coalesced crystallites and, on the other hand, an isolated crystallite.

Abstract: A new peptide and its use as a vector for the transport of molecules after conjugation through cellular barriers for the diagnosis, prognosis or treatment of pathologies of the central nervous system (CNS).

Abstract: A method for producing nanostructures having a metal oxide shell, carried by a top face of a substrate whose greatest dimension is greater than or equal to 100 mm by MOCVD metalorganic chemical vapour deposition, including successive steps carried out in a reactor configured for MOCVD deposition of nucleation and growth. The nucleation step includes forming non-contiguous metal nuclei by depositing a metal by MOCVD using a metalorganic precursor on the top face of the substrate and oxidising the metal of the metal nuclei, to form oxidised nuclei and ensure stabilisation of the nuclei. The growth step includes depositing a metal by MOCVD using the metalorganic precursor, to form non-contiguous nanostructures by growth of the oxidised nanostructures, and oxidising the deposited metal of the nanostructures formed in the nucleation to form oxidised nanostructures.

Abstract: The present invention relates to new glycomimetic molecules which selectively bind to the L-SIGN receptor, finding application in the medical field and, in particular, in the prevention and treatment of viral infections, in the immunotherapy of liver tumors and in the treatment of immune diseases.

Abstract: The invention is a device and method for detecting an analyte in a medium. An exciting light source produces an exciting light wave, which propagates to the medium and heats the latter. The device comprises a transducer for detecting the heating of the medium. According to one embodiment, the transducer is a thermal transducer, configured to detect a variation in the temperature of the medium. According to another embodiment, the transducer is an acoustic transducer, configured to detect a photoacoustic wave propagating from the medium. Whatever the embodiment, the transducer employs a membrane, on which a waveguide is placed. The waveguide comprises a resonant optical cavity. Transduction is achieved by analyzing a variation in a resonant wavelength of the optical cavity.

Abstract: A support for a biological species sample collected on a sampling device including a gripping rod and a capture element having a capture surface for receiving the sample. The capture element being assembled with the gripping rod in order to form a distal portion of the sampling device. The support has a flat main face delimited by at least one side and a recess opening on the side of the support in which the sampling device can be inserted. The recess has a groove formed on the main face of the support in order to receive the distal portion of the sampling device. The groove being configured to interact with the distal portion in order to securely hold it on or in the support.

Abstract: A method for purifying a protein of interest includes the preparation of a fusion protein in which this protein of interest is fused to a protein tag having the protein Mmi1 of a microorganism of the genus Schizosaccharomyces or a fragment thereof, the bringing into contact of this fusion protein with a ribonucleic acid molecule containing at least one motif of UNAAAC nucleotide sequence, so as to allow the affinity binding of the protein tag with this ribonucleic acid molecule, and the recovery of the protein of interest.

Abstract: A method of manufacturing an optoelectronic device including-light-emitting diodes comprising the forming of three-dimensional semiconductor elements made of a III-V compound, each comprising a lower portion and an upper portion and, for each semiconductor element, the forming of an active area covering the top of the upper portion and the forming of at least one semiconductor area of the III-V compound covering the active area. The upper portions are formed by vapor deposition at a pressure lower than 1.33 mPa.

Abstract: A light-emitting diode manufacturing method including the forming of three-dimensional semiconductor elements, extending along parallel axes, made of a III-V compound, each having a lower portion and a flared upper portion inscribed within a frustum of half apical angle ?. The method further comprises, for each semiconductor element, the forming of an active area covering the top of the upper portion and the forming of at least one semiconductor layer of the III-V compound covering the active area by vapor deposition at a pressure lower than 10 mPa, by using a flux of the group-III element along a direction inclined by an angle ?III and a flux of the group-V element along a direction inclined by an angle ?V with respect to the vertical axis, angles ?III and ?V being smaller than angle ?.

Abstract: A prognostic risk score for chemosensitive cancer, in particular acute myeloid leukemia (AML), based on somatic genetic abnormalities affecting certain genes of the mitochondrial genome.

Abstract: A device for transdermal electrochemical measurements, comprising a polymeric support having a surface provided for contact with skin, an array of polymeric microneedles integral with the support and projecting outward from the surface of the support, and a porous and/or nano/micro-structured bioelectrode. A biologically active species is immobilized on the surface of a conductive material. The microneedles and a surface of contact of the support with the skin are formed of a biocompatible crosslinked hydrogel, non-electron-conductive in the dry state and electrolyte-conductive upon contact with an aqueous fluid. The bioelectrode is arranged in contact with the hydrogel and is free of direct contact with the skin. Methods for preparing and using the device are also described.

Abstract: A device having a polymeric support with a surface for contact with skin, an array of solid polymeric microneedles integral with the support and projecting outward from the surface of the support provided for contact with the skin, and an electrode. The microneedles and the surface of contact of the support with the skin are formed of a crosslinked hydrogel, non-electron-conductive in the dry state and electrolyte-conductive upon contact with an aqueous fluid. The electrode is arranged in contact with the hydrogel provided to swell upon contact with an aqueous fluid and is free of direct contact with the skin. A method for preparing the device and uses thereof are also described.

Abstract: The invention relates to a device for identifying a fluorescent label. The detection device comprises nanowires, each nanowire acting as a transducer of fluorescence light into an electrical signal. One targeted application is sequencing of a nucleic acid.

Abstract: The application relates to a device for collecting a sample of intestinal fluid comprising a polymeric inner material having an at least partially compressed open cell structure, having a volume Vi and being suitable for swelling to a volume greater than or equal to 1.1×Vi by absorbing intestinal fluid, said material being encased with an elastic polymeric casing impervious to digestive fluid, said casing comprising at least one opening allowing the intake of intestinal fluid into the inner material, a gastro-resistant material suitable for dissolving in intestinal fluid at 37° C. being disposed on top of each opening, and at least one mechanism for closing the opening(s).

Abstract: An in vitro or ex vivo method for producing and isolating a cell subpopulation including T cells specific for an antigen linked to a disease of interest, which includes steps of obtaining, from an isolated human biological sample, a population of mononuclear cells including T cells specific for the antigen with a high proliferative capacity, culturing these mononuclear cells in a suitable cell culture medium containing the antigen, and isolating T cells specific to the antigen which do not express the CD45RO and CD27 markers at their surface. The cell subpopulation thus obtained and isolated finds application in particular for the treatment of the disease of interest.

Abstract: A device for creating a patterned field on a diopter includes: an objective lens within whose image focal plane the surface of the diopter lies; a light injection element emitting a collimated light beam; and an optical assembly between the element and the objective lens by which the object plane of the objective lens is optically conjugate with the image plane of the element. The assembly is configured so a collimated light beam from the element is emitted towards the objective lens to be reflected towards the surface of the diopter with an angle of incidence?the critical angle of the diopter, an optical device for forming patterns is in the object plane of the element, so the pattern formed by the optical device for forming patterns in transmitted light on the light beam in the object plane of the element is on the surface of the diopter.

Abstract: A classification device, including a pre-processing stage, a material system and an identification stage. The pre-processing stage transforms a signal of interest into an excitation signal; the material system includes a magnetic medium subdivided into a plurality of zones either in a first magnetic state or in a second magnetic state, an excitation module generating, from the excitation signal, a physical excitation quantity adapted to displace the magnetic domain walls in the magnetic medium, and a reading module measuring the final magnetic configuration reached by the magnetic medium; and the identification stage determines a class to which the signal of interest belongs from the final magnetic configuration.

Abstract: The present invention relates to novel trityl-nitroxide radicals as polarizing agents for Dynamic Nuclear Polarization (DNP).

Abstract: The present invention [relates to] a regulation system (28) for a multi-active bridge converter (10) with hybrid supply, comprising: an input current port (20) comprising an H-shape switch bridge (30) having a switch (T1) controlled by a first law having a first duty cycle, at least one output voltage port (22, 24) comprising an H-shape switch bridge (38, 40), one switch (T 21, T 31) of which is controlled by a second law which is phase-shifted with respect to the first law, the regulation system (28) regulates the converter (10) to a setpoint comprising a setpoint current value for the current of the current port (20) and a setpoint voltage value for a voltage port (22, 24).

Abstract: A method for producing at least one nitride layer includes providing a stack having a plurality of pillars extending from a substrate of the stack. Each pillar includes at least a crystalline section and a summit having a summit surface area The method also includes growing by epitaxy a crystallite from the summit of some the plurality of pillars and continuing the epitaxial growth of the crystallites until the crystallites supported by the pillars coalesce. The plurality of pillars includes at least one retention pillar and separation pillars. The pillars are configured so that once the nitride layer is formed, the at least one retention pillar retains the nitride layer and some of the separation pillars can fracture.