Abstract: This invention relates to the field of probiotics. In particular, the invention relates to a composition comprising a probiotic for use in the prevention or treatment of a viral respiratory infection in a subject, wherein said composition is administered to the subject's pregnant or lactating mother, wherein said probiotic comprises a Lactobacillus rhamnosus strain and/or a Bifidobacteriumanimalis spp lactis strains, and related methods and uses and compositions for use in these methods.

Abstract: A diagnostic based on Angiotensin 1-7 level, possibly in synergy with other blood parameters, to predict the outcome of infected patients by respiratory viral diseases and the corresponding drugs to prevent worsening of the disease for the patients predicted to be at higher risk.

Abstract: The invention relates to a method for differentiating pluripotent stem cells into thyroid or lung organoids by forming embryoid bodies, differentiating the embryoid bodies into definitive endoderm, inducing (over) expression of NKX2-1 and PAX8, and treatment with respectively, a cyclic monophosphate, a glucocorticoid, thyroid-stimulating hormone and a TGF-? inhibitor, or with a cyclic monophosphate, insulin or IGF-1, and a TGF-? inhibitor. The invention also relates to thyroid and lung organoids obtained by the methods as well as uses thereof for therapeutic applications and medicinal applications such as drug screening or research purposes.

Abstract: An assembly for anchoring in tissue may include an anchor part and a biasing part. The anchor part has a support made of a resilient material and at least two needles. The needles have a stem and a tip end configured to engage tissue. A portion of the stem is embedded in the support. The needles are allowed to be positioned according to a first configuration. A biasing part is configured to position the anchor part according to a second configuration differing from the first configuration in an orientation of the needles relative to one another. The biasing part includes holding means configured to hold the anchor part in the second configuration. The support is allowed to be deformed, thereby acting as a pivot when the needles change between the first configuration and the second configuration.

Abstract: Some embodiments relate to a method for producing a product of interest with a microbial host using an auto-replicative extra-chromosomal nucleic acid molecule comprising a first nucleic acid sequence whose genetic activity confers an advantage to the host, optionally wherein the genetic activity of said first nucleic acid molecule is controlled.

Abstract: The present disclosure relates generally to regulatory T cells (Tregs) engineered to express a dipeptidyl aminopeptidase-like protein 6 (DPP6)-reactive chimeric antigen receptor (CAR). The engineered Tregs are suitable for use in immunotherapy regimens for autoimmune, inflammatory and degenerative diseases. In particular, the anti-DPP6 CAR expressing Tregs are suitable for treating or preventing autoimmune diseases of the pancreas or central nervous system.

Abstract: Described herein is a yeast strain wherein activity of one or more membrane transporters of the DHA1 family is reduced relative to a wild type strain or to a parental strain from which it is derived.

Abstract: The present invention concerns screening methods to identify compounds that regulate activity of RSH enzymes such as Rel, and specifically Rel synthetase and/or Rel hydrolase activity. Also intended are compounds that interact and regulate Rel synthetase and/or hydrolase activity. These compounds are valuable to target persister cells not affected by traditional antibiotics.

Abstract: An interval observer based on an equivalent circuit-thermal model for lithium-ion batteries is presented. State of charge-temperature-dependent parameters are considered as unknown but bounded uncertainties in a single cell model. A parallel and a series arrangement of five cells are used for observer design, where cell heterogeneity is accounted for through the uncertainty bounding functions.

Abstract: An interval observer based on an equivalent circuit-thermal model for lithium-ion batteries is presented. State of charge-temperature-dependent parameters are considered as unknown but bounded uncertainties in a single cell model. A parallel and a series arrangement of five cells are used for observer design, where cell heterogeneity is accounted for through the uncertainty bounding functions.

Abstract: A method for manufacturing an ?+? Ti-6Al-4V alloy includes providing a near-net shape part made of an ?+? Ti-6Al-4V alloy, The part is heat treated in the ?+? field between 875 and 920° C. The heat treated part is water quenched to transform the ? phase into ?? martensite. There is no further heat treatment after the quenching step.

Abstract: The present application provides a pharmaceutical formulation comprising a folate receptor (FR)-targeting antineoplastic substance or composition, wherein the pharmaceutical formulation is configured for administration by inhalation, wherein the FR-targeting antineoplastic substance or composition is comprised in a nanoparticle and wherein the nanoparticles are comprised in microparticles, and its use in the treatment of a proliferative disease affecting at least part of the respiratory tract. The present application further provides a pharmaceutical formulation comprising an antineoplastic agent and a FR-targeting excipient, for use in the treatment of a proliferative disease affecting at least part of the respiratory tract.

Abstract: The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.

Abstract: A method for detecting and measuring the amount of an ionic impurity, notably formula (A) and/or formula (B) in a liquid sample, notably water, comprises: Introducing the liquid sample through a liquid inlet into a measurement cell, notably an optical cavity of an optical spectrometer; Causing vaporisation of the liquid sample by maintaining the pressure in the measurement cell below the saturated vapour pressure of the liquid sample; Causing the formation of gas-phase reaction product(s) of the ionic impurity; Measuring the amount of the gas-phase reaction product(s) of the ionic impurity in the measurement cell.

Abstract: The present invention relates to a p53-activating agent capable of transferring wild-type tumor protein p53 (p53) from an inactive conformation into an active conformation capable of inducing apoptosis, for use in the treatment of melanoma, wherein said p53-activating agent is administered simultaneously or sequentially with a BRAF-inhibiting agent capable of inhibiting activity of serine/threonine-protein kinase B-Raf (BRAF) comprising an activating mutation.

Abstract: The present invention relates to a system for computer-aided intravenous delivery of anesthetics and/or other drugs to a patient, wherein said system comprises an Infusion Controller that delivers an amount of drug(s) to a patient; possibly a DataLogger Controller with one or more Sensors adapted so as to be coupled to a patient and to generate signals reflecting one or more health conditions or statuses of the patient; a Communication Controller connected with the infusion pumps and/or monitors; a Session Controller that carries out the modeling of anesthesia procedures and is arranged to run a first procedure and to dynamically adapt said first procedure and/or select and run a second procedure based upon one or more of said sensors' output and/or observation from a physician; a Graphic User Interface to display different views of the system and to accept user input; a set of interfaces used to link the Infusion, Datalogger and Session Controllers to views displayed by the Graphical User Interface; a Proces

Abstract: Device for the selective detection of benzene gas, which comprises, on a base substrate, a combination of at least one functionalized multi- or single-wall carbon nanotube sensor decorated with rhodium clusters, and at least one functionalized multi- or single-wall carbon nanotube sensor decorated with metal clusters selected from gold, palladium, nickel and titanium, and/or undecorated, where said substrate additionally comprises means for measuring the variation in the resistance of said sensors. The device is useful at ambient temperature in the presence or absence of oxygen and easy to handle. It also relates to a method for the manufacturing thereof and for detecting the gas in the chemical industry, the petrochemical industry, petrol stations, or household, aeronautical or research applications.

Abstract: The invention is related to an apparatus and method for charged hadron therapy verification by detecting and/or quantifying prompt gammas produced when irradiating a target (6) with a charged hadron beam. The apparatus comprises a collimator (1) provided with a slit-shaped portion (2) configured to be arranged perpendicularly to the beam line and facing the target, a detection means (3,4) suitable for detecting said prompt gammas and a calculation and representation means. In the apparatus and method of the invention, the slit is configured to allow the passage of prompt gammas emitted from a range of depths in said target (6), said depths being measured in the direction of the charged hadron beam.

Abstract: The present invention provides a synthetic peptide molecule that specifically binds an FXYD2-gamma isoform of pancreatic beta cells, said synthetic peptide molecule has 25 amino acids.

Abstract: An endoscopic support device configured to support an endoscope during a surgical procedure is disclosed. The endoscopic support device has a connection ring with a height smaller than its diameter and configured to be in an open or deployed position and in a closed or non-deployed position. The support device also has at least two guiding elements, an orientation component, and extension means for manipulating the ring between the deployed and non-deployed positions.