Patents Assigned to UNIVERSITÉ PARIS EST CRETEIL VAL DE MARNE
  • Chemical model of a neurodegenerative disease, method for preparation and uses of same
    Patent number: 9744250
    Abstract: The invention concerns the use of pyridinium furosemide or one of the derivatives, analogs, salts, metabolites, or prodrugs thereof in the preparation of a chemical model of a neurodegenerative disease, preferably Parkinson's disease. The invention also concerns the corresponding chemical model and the uses of same, in particular in screening tests for identifying drug candidates.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: August 29, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE
    Inventors: Thierry Martens, Michaël Rivard, Céline Laurencé, Christophe Morin, Sonia Lehri-Boufala, Narimane Zeghbib
  • POPULATION OF IMMUNOREGULATORY T CELLS SPECIFIC FOR AN IRRELEVANT ANTIGEN AND USES THEREOF FOR PREVENTING OR TREATING IMMUNE DISEASES
    Publication number: 20170216417
    Abstract: The present invention relates methods and compositions for preventing or treating various immune diseases including graft-versus-host disease (GVHD) using populations or compositions of immunoregulatory T cells specific for an irrelevant antigen; such cells being activated in vivo by a simultaneous, separate or sequential administration of said antigen.
    Type: Application
    Filed: February 7, 2017
    Publication date: August 3, 2017
    Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris Diderot Paris 7, Universite Paris Est Creteil Val De Marne
    Inventors: José Cohen, Gaelle Martin, Sébastein Maury, Benoit Salomon
  • FUMARATE-CO-RELEASING MOLECULE HYBRIDS, THEIR USE IN THE TREATMENT OF INFLAMMATORY OR CARDIOVASCULAR DISEASES AND THEIR PROCESS OF PREPARATION
    Publication number: 20170174716
    Abstract: The present invention relates to hybrid fumarate-CO-releasing molecules capable of increasing heme oxygenase-1 (HO-1) activity and HO-1 protein expression and simultaneously releasing CO, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases.
    Type: Application
    Filed: March 20, 2015
    Publication date: June 22, 2017
    Applicants: UNIVERSITE PARIS EST CRETEIL VAL DE MARNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Roberto MOTTERLINI, Roberta FORESTI, Thierry MARTENS, Michael RIVARD
  • Methods for treating myocardial infarction comprising administering sonic hedgehog
    Patent number: 9504732
    Abstract: The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: November 29, 2016
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE MONTPELLIER, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Alain Lacampagne, Jerome Thireau, Olivier Cazorla, Jean-Yves Le Guennec, Jeremy Fauconnier, Maria del Carmen Martinez, Ramaroson Andriantsitohaina, Bijan Ghaleh-Marzban, Raffaella Soleti
  • Method for diagnosing a hemoglobin-related disorder
    Patent number: 9494603
    Abstract: The invention relates to a method for diagnosing, staging and/or monitoring a hemoglobin-related disorder such as ?-thalassemia or a treatment against said hemoglobin-related disorder in a subject in need thereof based on the detection and/or quantification the presence of free ?-Hb pool in a biological sample obtained from said subject.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: November 15, 2016
    Assignees: Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud, Assistance Publique—Hopitaux de Paris, Universite Paris Est Creteil Val de Marne
    Inventors: Veronique Baudin-Creuza, Corinne Vasseur, Frederic Galacteros
  • Methods and pharmaceutical compositions for treatment of cystic fibrosis
    Patent number: 9402821
    Abstract: The present invention relates to a method and compositions for the treatment of cystic fibrosis.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: August 2, 2016
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paris-Est Creteil Val de Marne, Assistance Publique-Hopitaux de Paris
    Inventors: Agathe Tarze, Pascale Fanen
  • KIR3DL2 IS A BIOMARKER AND A THERAPEUTIC TARGET USEFUL FOR RESPECTIVELY PREVENTING AND TREATING A SUBSET OF CUTANEOUS AND NON-CUTANEOUS PERIPHERAL T-CELL LYMPHOMAS
    Publication number: 20160130346
    Abstract: The present invention relates to a ligand molecule that specifically binds to KTR3DL2 at the surface of KTR3DL2 expressing malignant T-cells for the treatment of lymphomas. It also relates to the in vitro use of a level of expression of KIR3DL2 is a biomarker useful for diagnosing and/or monitoring a lymphoma.
    Type: Application
    Filed: May 28, 2014
    Publication date: May 12, 2016
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE, UNIVERSITE PARIS DIDEROT - PARIS 7
    Inventors: Philippe GAULARD, Nicolas ORTONNE, Anne MARIE-CARDINE, Armand BENSUSSAN
  • Tyrosine kinase receptor TYRO3 as a therapeutic target in the treatment of cancer
    Patent number: 9233144
    Abstract: The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: January 12, 2016
    Assignees: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE
    Inventors: Isabelle Bernard-Pierrot, Francois Radvanyi, Yves Allory, Nicolas Stransky
  • Method for Diagnosing a Hemoglobin-Related Disorder
    Publication number: 20150293126
    Abstract: The invention relates to a method for diagnosing, staging and/or monitoring a hemoglobin-related disorder such as ?-thalassemia or a treatment against said hemoglobin-related disorder in a subject in need thereof based on the detection and/or quantification the presence of free ?-Hb pool in a biological sample obtained from said subject.
    Type: Application
    Filed: June 24, 2015
    Publication date: October 15, 2015
    Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris-Sud, Assistance Publique - Hopitaux de Paris, Universite Paris Est Creteil Val de Marne
    Inventors: Veronique Baudin-Creuza, Corinne Vasseur, Frederic Galacteros
  • Method for diagnosing a hemoglobin-related disorder
    Patent number: 9097728
    Abstract: A method for diagnosing and/or staging a hemoglobin disorder such as ?-thalassemia involves contacting a blood sample of a subject with an Alpha-Hemoglobin Stabilizing Protein which may be present on a solid support, and detecting and/or quantifying free ?-Hb. Detection or quantification can be achieved by photometry such as HTRF or immunological procedures such as EIA and ELISA. The free ?-Hb is compared to a reference value, and can be used to correlate with the diagnosis and/or staging of the hemoglobin disorder for the subject.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: August 4, 2015
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris-Sud, Assistance Publique-Hopitaux de Paris, Universite Paris Est Creteil Val de Marne
    Inventors: Veronique Baudin-Creuza, Corinne Vasseur, Frederic Galacteros
  • Synthetic gene construct coding for an HIV1 GAG and use thereof for obtaining anti-HIV-1 vaccines
    Patent number: 8932599
    Abstract: The invention relates to a synthetic gene coding for the Gag protein of the human immunodeficiency virus HIV-1. Said gene may optionally be fused with one or more other HIV sequences. The invention may notably be used within the scope of obtaining anti-HIV vaccines.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: January 13, 2015
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Paris Est Creteil Val de Marne
    Inventors: Yves Levy, Jean-Marc Balloul, Doris Schmitt, Caterina Riconda Guillet
  • Inhibitors of cyclophilins and uses thereof
    Patent number: 8901295
    Abstract: The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2; A is in particular CH or N; X is in particular CO, SO2, CS, and R1 is in particular H, R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group, R6 is in particular H or an alkyl group, and R7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 2, 2014
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Montpellier 1, Universite Paris-EST Creteil val de Marne, Assistance Publique-Hopitaux de Paris, Centre National de la Recherche Scientifique
    Inventors: Jean-Francois Guichou, Lionel Colliandre, Hakim Ahmed-Belkacem, Jean-Michel Pawlotsky
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PULMONARY HYPERTENSION
    Publication number: 20140271680
    Abstract: The present invention relates to uses, methods and compositions for the treatment of pulmonary hypertension.
    Type: Application
    Filed: August 10, 2012
    Publication date: September 18, 2014
    Applicant: UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE
    Inventors: Serge Adnot, Valerie Amsellem
  • METHOD FOR PREDICTING THE SENSITIVITY OF A TUMOR TO AN EPIGENETIC TREATMENT
    Publication number: 20120282167
    Abstract: The present invention provides a method for determining the RES phenotype in a tumor. The present invention further provides a method for predicting the sensitivity of a tumor to an epigenetic treatment, the method comprising determining the RES phenotype in said tumor, the presence of the RES phenotype in a tumor being indicative of a tumor sensitive to an epigenetic therapy. The present invention also provides a method for diagnosing an aggressive tumor and for selecting a patient affected with a tumor for an epigenetic therapy.
    Type: Application
    Filed: August 9, 2010
    Publication date: November 8, 2012
    Applicants: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE, UNIVERSITE PARIS-SUD 11
    Inventors: Céline Vallot, Francois Radvanyi, Nicolas Stransky, Yves Allory
  • DERMASEPTIN B2 USED AS AN INHIBITOR OF THE GROWTH OF A TUMOR
    Publication number: 20120184498
    Abstract: The invention relates to the use of peptides corresponding to dermaseptin B2 or fragments thereof for treating proliferative diseases such as cancer or ocular lesions, and to pharmaceutical compositions containing such peptides.
    Type: Application
    Filed: June 29, 2010
    Publication date: July 19, 2012
    Applicants: UNIVERSITÉ PARIS EST CRETEIL VAL DE MARNE, UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Jean Delbe, Mohamed Amiche, Ali Ladram, Cécile Galanth, Pierre Nicolas, Yamina Hamma, Johanna Allegonda Anna Van Zoggel, José Courty
  • TYROSINE KINASE RECEPTOR TYRO3 AS A THERAPEUTIC TARGET IN THE TREATMENT OF CANCER
    Publication number: 20120034167
    Abstract: The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer.
    Type: Application
    Filed: September 18, 2009
    Publication date: February 9, 2012
    Applicants: INSTITUT CURIE, UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Isabelle Bernard-Pierrot, Francois Radvanyi, Yves Allory, Nicolas Stransky