Patents Assigned to UNIVERSITÉ PARIS-SUD
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Publication number: 20230192772Abstract: Peptides endowed with an anti-inflammatory, anti-angiogenic and/or antimicrobial activity, a medicament or a pharmaceutical composition including such peptides, and the use thereof in the prevention or treatment of inflammatory diseases, and more particularly inflammatory diseases due to or associated with microbial infections, or in the prevention or treatment of angiogenesis-related diseases.Type: ApplicationFiled: December 22, 2017Publication date: June 22, 2023Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PARIS-SUD 11, UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICOInventors: Claire LACOMBE, Constance AUVYNET, Yvonne ROSENSTEIN, Emmanuelle SACHON
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Patent number: 11484569Abstract: The invention concerns a Reg3? polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for use in the protection of oxygen sensitive gram-positive bacteria, compositions comprising the polypeptide and their use. The inventors have shown that an increase in the concentration of the h Reg3? lectin into the gastrointestinal tract (GIT) lumen of hReg3?-transgenic mice induced significant changes in the composition of the gut microbiota, and dramatically improved host resistance to intestinal inflammation. hReg3? exerted a potent antioxidant activity on intestinal epithelial cells during colitis, and in particular the ROS scavenging activity, in particular, by promoting the survival of highly oxygen sensitive bacteria. Inventors also showed that h Reg3?-transgenic mice resist better to DSS-induced colitis after antibiotherapy.Type: GrantFiled: July 13, 2018Date of Patent: November 1, 2022Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), UNIVERSITÉ PARIS-SUDInventors: Joël Dore, Jamila Faivre, Nicolas Moniaux, Christian Brechot, Marion Darnaud
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Publication number: 20220280498Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.Type: ApplicationFiled: May 26, 2022Publication date: September 8, 2022Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SUD, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP), HOPITAL MARIE LANNELONGUEInventors: Sylvia COHEN-KAMINSKY, Marc HUMBERT, Sebastien DUMAS, Gilles BRU-MERCIER, Samir MESSAOUDI, Jean-Daniel BRION, Mouad ALAMI, Gilles GALVANI
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Patent number: 11376245Abstract: The present invention relates to compounds of formula (I) for use as peripheral NMDA receptor antagonists.Type: GrantFiled: June 13, 2017Date of Patent: July 5, 2022Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SUD, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), HOPITAL MARIE LANNELONGUEInventors: Sylvia Cohen-Kaminsky, Marc Humbert, Sebastien Dumas, Gilles Bru-Mercier, Samir Messaoudi, Jean-Daniel Brion, Mouad Alami, Gilles Galvani
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Patent number: 11285133Abstract: The present application relates to novel 3-imidazolines of formula (I?) and (I) below: (I?) (I) Wherein Ar1, Ar2, Ar3, and R1 to R6 are as defined in the claims. The 3-imidazolines of the invention are useful in antibiotic therapies, in particular as inhibitors of carbapenemases. They are also useful as antibiotics themselves. The present invention also concerns a method for preparing more specifically the 3-imidazolines of formula (I). The present invention further relates to conjugates of said compounds with known antibiotics.Type: GrantFiled: March 8, 2018Date of Patent: March 29, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS-SUD, ASSISTANCE PUBLIQUE—HOPITAUX DE PARISInventors: Kevin Cariou, Robert Dodd, Eugénie Romero, Mohamed Benchekroun, Bogdan Iorga, Thierry Naas, Saoussen Oueslati
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Publication number: 20220042016Abstract: The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.Type: ApplicationFiled: September 29, 2021Publication date: February 10, 2022Applicants: Institut Gustave-Roussy, Institut National de la Sante et de la Recherche Medicale (INSERM), Assistance Publique - Hopitaux de Paris, Universite de Versailles - St Quentin en Yvelines, Universite Paris - SUDInventors: William VAINCHENKER, Valerie UGO, Chloe James, Jean-Pierre LE COUEDIC, Nicole CASADEVALL
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Patent number: 11235174Abstract: Device including a multileaf collimator, the multileaf collimator including an array of leaves and slits, the array having an alternation of leaves and slits and extending in a longitudinal direction, the longitudinal direction being defined as a direction extending from an entrance plane of the array toward an exit plane of the array, each leaf being located between two slits; the device having a source for emitting an incident electromagnetic beam or a source for emitting an incident beam of subatomic particles, the source being arranged to emit the beam in the direction of the entrance plane of the array, the multileaf collimator being arranged to obtain an arrangement of beams from the incident beam, and the arrangement of beams forms an alternation of high-energy lines and lower-energy lines.Type: GrantFiled: November 2, 2017Date of Patent: February 1, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SUD, UNIVERSITE PARIS DIDEROTInventors: Yolanda Prezado, Morgane Dos Santos, Batiste Janvier
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Patent number: 11221341Abstract: Process for in vitro diagnosis and/or monitoring and/or prognosis and/or theranosis of hepatic disorders from a biological sample originating from a subject, in which process the presence and/or the concentration of the marker ADH1B (SEQ ID NO.2) and/or the presence and/or the concentration of the combination of the markers ADH1B (SEQ ID NO.2) and ADH1A (SEQ ID NO.1) is determined.Type: GrantFiled: January 16, 2017Date of Patent: January 11, 2022Assignees: Commissariat a 1'Energie Atomique et aux Energies Alternatives, Centre Hospitalier Universitaire, Universite Grenoble Alpes, Institut National de la Sante et de la Recherche Medicale, Universite Paris SudInventors: Virginie Brun, Jérôme Garin, Christophe Bruley, Jamila Faivre, Jean-Pierre Zarski, Vincent Leroy
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Patent number: 11203788Abstract: The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.Type: GrantFiled: April 8, 2020Date of Patent: December 21, 2021Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT GUSTAVE-ROUSSY, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE HENRI BECQUEREL, UNIVERSITE PIERRE ET MARIE CURIE, UNIVERSITE PARIS-SUDInventors: Franck Viguie, Olivier Bernard, Michaela Fontenay, Christian Bastard, Francois Delhommeau, William Vainchenker
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Patent number: 11162100Abstract: The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.Type: GrantFiled: January 6, 2020Date of Patent: November 2, 2021Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE (INSERM), INSTITUT GUSTAVE-ROUSSY, UNIVERSITE DE VERSAILLES-ST QUENTIN EN YVELINES, UNIVERSITE PARIS-SUDInventors: William Vainchenker, Valerie Ugo, Chloe James, Jean-Pierre Le Couedic, Nicole Casadevall
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Patent number: 11162095Abstract: The present invention relates to the combination of a PARP inhibitor with a Dbait molecule for treating cancer.Type: GrantFiled: February 14, 2020Date of Patent: November 2, 2021Assignees: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ONXEO, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS-SUD 11Inventors: Marie Dutreix, Wael Jdey
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Patent number: 11085921Abstract: The present invention relates to a sensor for an electronic tongue or nose for analysing a sample or detecting a target. The sensor comprises a support, on one surface of which a plurality of sensitive areas are located, each sensitive area comprising at least one receptor and being capable of transmitting a measurable signal generated by the interaction of at least one constituent of the sample or one target with at least one receptor. The sensor is characterised in that it comprises at least three sensitive areas that differ from one another in terms of their respective receptor compositions, at least one of the sensitive areas comprising a mixture of at least two different receptors, while the two other sensitive areas each comprise at least one of the two receptors.Type: GrantFiled: February 21, 2013Date of Patent: August 10, 2021Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre National de la Recherche Scientifique, Universite Paris-SudInventors: Thierry Livache, Arnaud Buhot, David Bonnaffe, Yanxia Hou-Broutin
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Publication number: 20210230626Abstract: The invention relates to a method for increasing the yield and biomass of a plant, by means of an increase in the expression of the L-aspartate oxidase in the plant. The method according to the invention allows an increase in the photosynthetic capacities of the plants as a result of an increase in the quantities of NAO and the derivatives thereof in said plants. The invention relates to the plants produced by such a method.Type: ApplicationFiled: April 14, 2021Publication date: July 29, 2021Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUDInventors: Linda DE BONT, Bertrand GAKIERE
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Patent number: 11046657Abstract: A subject of the present invention is a compound having the general formula (I): a pharmaceutically acceptable salt thereof or a tautomeric form thereof, wherein A, B3, B4, B5, Y, X, B1 and B2 are as defined in any one of claims 1 to 10. Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.Type: GrantFiled: July 13, 2017Date of Patent: June 29, 2021Assignees: Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite de Strasbourg, Universite Paris-Sud, Centre International de Recherche aux Frontieres de la ChimieInventors: Dominique Bonnet, Nelly Frossard, Jean-Luc Galzi, Christophe Guignabert, Marcel Hibert, Frédéric Simonin, Sylviane Muller
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Patent number: 11014871Abstract: The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.Type: GrantFiled: January 5, 2017Date of Patent: May 25, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUDInventors: Mouâd Alami, Abdallah Hamze, Jean-Daniel Brion, Jérôme Bignon, Joëlle Dubois
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Patent number: 10955654Abstract: Disclosed is an imaging device including a light source arranged so as to generate an optical signal, an optical support coupled to the light source and arranged so as to project a luminous excitation signal with a substantially constant light intensity, from the light source to a body to be observed during the use of the device, and an asynchronous camera coupled to the optical support and designed so as to generate a signal including, for each pixel of a first pixel matrix, a signal sequence representing asynchronous events corresponding to variations of the light backscattered by the body to be observed for the pixel.Type: GrantFiled: December 16, 2015Date of Patent: March 23, 2021Assignees: SORBONNE UNIVERSITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS-SUD, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS—APHPInventors: Guillaume Chenegros, Ryad Benosman, Nicolas Libert, Jacques Durenteau, Anatole Harrois, Serge Picaud, Jose-Alain Sahel
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Patent number: 10895551Abstract: A system for “signal-on” electrochemical detection of molecules of interest and to a method implementing said system.Type: GrantFiled: November 14, 2016Date of Patent: January 19, 2021Assignees: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Hafsa Korri-Youssoufi, Anna Miodek, Nawel Mejri
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Patent number: 10890583Abstract: The present invention relates to the field of Clostridium difficile infections. Methods of diagnosing, treating and preventing Clostridium difficile-associated disease and recurrent CDAD are disclosed herein.Type: GrantFiled: April 1, 2015Date of Patent: January 12, 2021Assignees: INSTITUT PASTEUR, UNIVERSITE PARIS-SUD, CENTRE HOSPITALIER DE VERSAILLES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARISInventors: Marie-Lise Gougeon, Alban Le Monnier, Anne Collignon, Michel Robert Popoff
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Patent number: 10867237Abstract: An artificial neuron includes a single-component electric dipole including a single material which belongs to the class of Mott insulators and is connected to first and second electric electrodes.Type: GrantFiled: April 24, 2015Date of Patent: December 15, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE DE NANTES, UNIVERSITE PARIS-SUD XIInventors: Laurent Cario, Benoit Corraze, Pablo Stoliar, Julien Tranchant, Etienne Janod, Marie-Paule Besland, Marcelo Rozenberg
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Publication number: 20200388388Abstract: The invention proposes a new method for monitoring a health event in a mammal, comprising detecting at least one abnormal value within a series of values related to at least one biomarker, based on appropriate Z-scores.Type: ApplicationFiled: November 14, 2018Publication date: December 10, 2020Applicants: Universite Paris-SUD, Universite De Paris, Institut National De Sport De L'Expertise Et De La Performance, Centre National de la Recherche Scientifique (CNRS)Inventors: Geoffroy Berthelot, Jérôme Dedecker, Guillaume Sauliere