Abstract: The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.

Abstract: The present invention relates to peptides capable of inhibiting the formation of the complex between the Asf1 histone chaperone and histones H3-H4, and to the use thereof as a drug, particularly for treating cancer.

Abstract: The present invention relates to a novel bacterial strain isolated from groundwater. The invention also relates to bacterial extracts and to the use of same in the context of the treatment of inflammations. More particularly, the present invention relates to novel compositions of interest in the treatment and the prevention of inflammatory disorders, notably dermatological pathologies.

Abstract: The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfhydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.

Abstract: A device for detecting the improper adjustment of a ventilatory support machine used on a mammal. The device (12) includes measuring elements (40) for taking a measurement, as a function of time, of a neurophysiological signal involved in the respiratory process of the mammal for at least two successive breathing cycles, each breathing cycle comprising a respiratory initiation time; an input for receiving a respiratory initiation signal (to) which is different from the neurophysiological signal; elements (42) for processing the neurophysiological signals, which are configured to process the neurophysiological signals for each respiratory initiation time over a period of time starting from the respiratory initiation time; and elements (44) for detecting an improper adjustment of the ventilator using the processed signals.

Abstract: The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.

Abstract: In the receive subsystem, the analogue-to-digital converter (40) works on the output of the low-noise amplifier (33), at a chosen rate (F), which corresponds to a bandwidth sampling. The processing stages comprise a custom circuit (5), with * an input memory (510) arranged to contain N successive digital samples, renewed at the chosen rate in blocks of M samples, * a complex digital low-pass filtering function (511, 512), of chosen cut-off frequency, operating on the input memory to supply N filtered digital samples (515), * an M-periodic summing function (531) on the N filtered digital samples, supplying M filtered and summed digital samples (533), * an M?M discrete Fourier transform stage (55), operating on these M filtered and summed digital samples, the digital signals on the M outputs (559) of the Fourier transform representing M separate channels, of width defined by the cut-off frequency of the abovementioned low-pass filter.

Abstract: The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)-T wherein STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z(n) wherein n is 0 or 1 and when n is 1, Z is an amino-acid residue devoid of sulfydryl group, or is a polypeptide, Cys is the amino-acid residue for Cysteine, T is a molecule linked by a covalent bound to the S part of Cys, selected in a group comprising: agents for in vivo diagnosis, cytotoxic agents, prodrugs, or enzymes for the conversion of a prodrug to a drug, Y(m) wherein m is 0 or 1 and when m is 1, Y is a linker between T and Cys, said linker being either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into said cells.

Abstract: A system, method, device, and computer program product to extract and gather peak information from an automated sequencer of bioinformatics into a peak database, and to manipulate and analyze the peak information within the database.

Abstract: The present invention concerns modulators of the CX3CR1 receptor. More specifically, antagonists and agonists of the CX3CR1 receptor have been identified. These antagonists and agonists can be used for treating an inflammatory disorder, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a graft versus host disease, a behavioral disorder, a cicatrisation disorder, a viral infection, cancer or pain. They may also be used as an adjuvant in a vaccine composition.

Abstract: The endoprosthesis is designed to be implanted in an aneurysm (12) of a patient, the aneurysm (12) resulting from deformation of a vessel wall, in particular the wall of an artery (14), the endoprosthesis including: a tubular envelope (22, 24) that extends in a direction (Y-Y?), and a plurality of pressure probes (26) fixed on the envelope (22, 24), each probe (26) including: a sensor (28) for measuring pressure, and elements (34, 36) for transmitting the pressure measurement to a monitoring apparatus located outside the patient. The elements (34, 36) for transmitting the pressure measurement from each probe (26) are designed to generate an electromagnetic pressure measurement transmission signal including at least one distinctive characteristic of the probe (26) of which these elements (34, 36) form part.

Abstract: The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.

Abstract: The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)-T wherein STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z(n) wherein n is 0 or 1 and when n is 1, Z is an amino-acid residue devoid of sulfhydryl group, or is a polypeptide, Cys is the amino-acid residue for Cysteine, T is a molecule linked by a covalent bound to the S part of Cys, selected in a group comprising: agents for in vivo diagnosis, cytotoxic agents, prodrugs, or enzymes for the conversion of a prodrug to a drug, Y(m) wherein m is 0 or 1 and when m is 1, Y is a linker between T and Cys, said linker being either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into said cells.

Abstract: Anti-malarial alkyloid compounds have the formula: wherein R1-R11 have various disclosed values or their pharmaceutically acceptable salts, and pharmaceutical compositions containing the same.

Abstract: The present invention relates to a peptide labelled with fluorine-18 for the specific recognition of lipid vectors.

Abstract: The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.

Abstract: The present invention relates to compounds which can go to make up mesostructured porous hybrid organic-inorganic materials (MPHOIMs) and can serve, within these materials, as probe molecules for the detection or quantitative determination of halogenated gaseous compounds. It also relates to MPHOIMs in which these compounds are grafted by covalent or iono-covalent bonding, to a process for manufacturing these MPHOIMs, and also to chemical sensors for the detection or quantitative determination of halogenated gaseous compounds and comprising these MPHOIMs as sensitive materials. The invention applies, in particular, to the detection and quantitative determination of halogenated gaseous compounds used in the microelectronics field and, more especially, halogenated boron complexes.

Abstract: A method for assessing the proliferative state of cells in a human or non-human biological sample uses Chromatin Assembly Factor-1 (CAF-1) subunits as proliferation markers. The method can be used for breast cancer prognosis or diagnosis, and monitoring tumor response in therapy.

Abstract: The present invention relates to a peptide for the specific recognition of lipid vectors.

Abstract: The invention concerns a method for depositing a thin polymer film on a substrate for functionalizing the surface of said substrate, comprising a step which consists in electrohydrodynamic spraying of a polymerizable precursor towards the substrate so as to produce an electrostatic deposition of electrically charged droplets of said precursor and form the thin film on the surface by polymerizing the droplets. The method is characterized in that it further comprises a step for causing the excited species to interact with the droplets of the sprayed precursor, thereby promoting the polymerization reactions of said precursor. The invention also concerns a device for implementing the method, in particular for depositing a thin polymer film on a moving substrate-film.