Patents Assigned to Universität Leipzig
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Publication number: 20240010704Abstract: The present invention provides polypeptides and nucleic acid molecules that are useful in identifying.Type: ApplicationFiled: September 23, 2021Publication date: January 11, 2024Applicant: Universitaet LeipzigInventors: Tobias LANGENHAN, Nicole SCHOLZ
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Patent number: 11543346Abstract: The invention relates to a device for conducting radiation, a photodetector arrangement, and a method for spatially resolved spectral analysis.Type: GrantFiled: August 14, 2019Date of Patent: January 3, 2023Assignee: UNIVERSITÄT LEIPZIGInventor: Marius Grundmann
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Publication number: 20220026421Abstract: The invention relates to a method, to a surface, to a particle, and to a kit for the detection of low molecular weight analytes such as crop protection agents in samples. In particular, the invention relates to a method for the detection of glyphosate through protein-functionalised surfaces and functionalised particles by means of reflection interference contrast microscopy (RICM).Type: ApplicationFiled: November 18, 2019Publication date: January 27, 2022Applicants: TECHNISCHE UNIVERSITÄT DRESDEN, UNIVERSITÄT LEIPZIGInventors: Gerhard RÖDEL, Kai OSTERMANN, Julia DÖRING, Christian DAHMANN, Tilo POMPE, David RETTKE, Steve MARTIN
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Publication number: 20210164901Abstract: The invention relates to a device and a method for determining a wavelength of radiation.Type: ApplicationFiled: August 14, 2019Publication date: June 3, 2021Applicant: UNIVERSITÄT LEIPZIGInventor: Marius GRUNDMANN
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Publication number: 20210164892Abstract: The invention relates to a device for conducting radiation, a photodetector arrangement, and a method for spatially resolved spectral analysis.Type: ApplicationFiled: August 14, 2019Publication date: June 3, 2021Applicant: UNIVERSITÄT LEIPZIGInventor: Marius Grundmann
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Patent number: 10774097Abstract: The invention relates to chemical compound of the general structure [A-R3—X—R4] where A=[R1-R2] or [R1] R1=aryl, heteroaryl R2=alkyl, aryl, heteroaryl, carbonyl, thiocarbonyl, alkyl ester, alkyl thioester R3=O, S, NH X=closo- or nido-boron cluster R4= where Z=OH, SH, NH2 where R5 is selected from H, alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and R6 is selected from alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and where R3 and R4 are in meta or para positions to one another, to a process for preparation thereof and to the use thereof, especially in medicine, for example in the inhibition of lipoxygenase.Type: GrantFiled: October 21, 2016Date of Patent: September 15, 2020Assignee: UNIVERSITÄT LEIPZIGInventors: Evamarie Hey-Hawkins, Robert Kuhnert
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Patent number: 10670576Abstract: The present invention refers to a device for measuring impedance in organotypic tissue comprising at least one recording chamber with a liquid permeable membrane supporting the organotypic tissue, at least one bottom electrode and at least one top electrode, wherein the liquid permeable membrane divides the recording chamber into a top chamber and a bottom chamber, wherein at least the bottom chamber contains culture medium for the organotypic tissue, and the bottom electrode(s) is/are located in the bottom chamber and the top electrode(s) is/are located in the top chamber, and wherein the organotypic tissue is located between the bottom electrode(s) and the top electrode(s). The present invention also refers to the use of the device according to the present invention for measuring impedance in organotypic tissue.Type: GrantFiled: January 18, 2017Date of Patent: June 2, 2020Assignee: Universität LeipzigInventors: Andrea Robitzki, Andrée Rothermel, Heinz-Georg Jahnke, Ina Sternberger, Frank Striggow, Till Mack
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Patent number: 10571498Abstract: A system for analyzing a microwave-frequency signal by imaging is provided, comprising: a solid material at least one optical property of which is modifiable in at least one zone of the material, when the zone is simultaneously in the presence of an optical excitation or electrical excitation and a microwave-frequency signal having at least one frequency coinciding with a resonant frequency of the material, the material furthermore being such that a value of the resonant frequency varies as a function of the amplitude of a magnetic field, a magnetic field generator configured to generate a magnetic field having, in the interior of a portion of the zone, a spatial amplitude variation in a direction X, the material then having a resonant frequency that is dependent on a position in the direction X, and a detector configured to receive an image of the zone in said direction X.Type: GrantFiled: October 22, 2015Date of Patent: February 25, 2020Assignees: THALES, UNIVERSITAET LEIPZIGInventors: Mayeul Chipaux, Loic Toraille, Thierry Debuisschert, Christian Larat, Loic Morvan, Jan Meijer, Sébastien Pezzagna
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Patent number: 10519354Abstract: The invention relates to a hydrophobed porous oil binder in the form of a nonwoven fabric composed of lignocellulose-containing raw materials having a biologically functionalized surface for removing mineral-oil-based contaminants in seas, rivers, inland waters, and stormwater basins or wastewater treatment plants, wherein the density of the oil binder is 10 to 900 kg/m3, the oil binder is 1 to 25 mm thick, the broad surface of the oil binder has a dimension of 9 to 200 cm2, the porosity of the oil binder is 30 to 96%, measured with respect to the total fraction of the oil binder, and the flexural strength of the oil binder is at least 1.5 N/mm2.Type: GrantFiled: August 27, 2014Date of Patent: December 31, 2019Assignees: Technische Universitaet Dresden, Universitaet LeipzigInventors: Holger Unbehaun, Soren Tech, Swetlana Konig, Elena Safonova, Andre Wagenfuhr, Christian Wilhelm
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Patent number: 10460472Abstract: A method for adapting a matching model of an object comprising the step of providing an electronic image of the object; providing a matching model of the object, the matching model consisting of a plurality of points; determining a pose of the object in said electronic image by using a matching approach that uses said matching model; transforming the matching model according to said pose, yielding a transformed model; determining for at least one point of said transformed model a corresponding point in said electronic image; and adapting the matching model according to the at least one determined corresponding point.Type: GrantFiled: July 13, 2017Date of Patent: October 29, 2019Assignee: UNIVERSITÄT LEIPZIGInventors: Tobias Böttger, Markus Ulrich, Carsten Steger
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Patent number: 10435437Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.Type: GrantFiled: December 23, 2016Date of Patent: October 8, 2019Assignee: UNIVERSITAET LEIPZIGInventors: Ralf Hoffmann, Daniel Knappe, Kai Hilpert, Ralf Mikut, Serge Ruden
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Patent number: 10426663Abstract: The invention provides a device for a medical treatment of a sclera, the device comprising a single applicator connected to a shaft, wherein the applicator is configured to be placed into the Tenon's space; the applicator has a first surface, wherein the first surface of the applicator is superficially contactable to the surface of an area of the sclera so as to superficially cover said area; and the applicator comprises a single optical outlet connected to a single optical guiding element extending from a proximal end of the shaft to the single distal optical outlet at the first surface of the applicator, the optical guiding element being configured for guiding electromagnetic waves towards the optical outlet, wherein the optical guiding element is configured to guide electromagnetic waves of a wavelength adapted for thermal treatment of the sclera by protein coagulation.Type: GrantFiled: April 2, 2015Date of Patent: October 1, 2019Assignee: UNIVERSITÄT LEIPZIGInventors: Hans Peter Iseli, Mike Francke, Peter Wiedemann
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Publication number: 20190055268Abstract: The invention relates to chemical compound of the general structure [A-R3—X—R4] where A=[R1-R2] or [R1] R1=aryl, heteroaryl R2=alkyl, aryl, heteroaryl, carbonyl, thiocarbonyl, alkyl ester, alkyl thioester R3=O, S, NH X=closo- or nido-boron cluster R4= where Z=OH, SH, NH2 where R5 is selected from H, alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and R6 is selected from alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and where R3 and R4 are in meta or para positions to one another, to a process for preparation thereof and to the use thereof, especially in medicine, for example in the inhibition of lipoxygenase.Type: ApplicationFiled: October 21, 2016Publication date: February 21, 2019Applicant: UNIVERSITÄT LEIPZIGInventors: Evamarie HEY-HAWKINS, Robert KUHNERT
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Patent number: 9856298Abstract: The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.Type: GrantFiled: July 11, 2016Date of Patent: January 2, 2018Assignee: UNIVERSITAET LEIPZIGInventors: Ralf Hoffmann, Nicole Berthold, Friederike Nollmann
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Patent number: 9835560Abstract: The invention relates to a method for the Raman spectroscopic, in ovo sex determination of fertilized and hatched birds' eggs (1), wherein the embryo, including the extra-embryonic structures, can move in the egg, and is not yet attached to the shell at the time of measuring.Type: GrantFiled: July 3, 2015Date of Patent: December 5, 2017Assignees: TECHNISCHE UNIVERSITAET DRESDEN, UNIVERSITAET LEIPZIGInventors: Roberta Galli, Grit Preusse, Edmund Koch, Gerald Steiner, Maria-Elisabeth Krautwald-Junghanns, Thomas Bartels
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Patent number: 9801977Abstract: The present invention relates to the field of biology and medicine, and more specifically, to the field of stem-cell biology, involving producing or generating melanocytes from stem-cells and precursors derived from human hair root. Additionally, the present invention relates to the materials and method for producing autografts, homografts or allografts comprising melanocytes in general, as well as the materials and methods for producing autografts, homografts and allografts comprising melanocytes for the treatment of diseases related to depigmentation of the skin and for the treatment of scars.Type: GrantFiled: October 29, 2012Date of Patent: October 31, 2017Assignee: UNIVERSITÄT LEIPZIGInventors: Vuk Savkovic, Christina Dieckmann, Jan-Christoph Simon, Michaela Schulz-Siegmund, Michael Hacker
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Patent number: 9718861Abstract: The present invention relates to highly potent ligands at the ghrelin receptor to influence food intake or other conditions.Type: GrantFiled: August 24, 2012Date of Patent: August 1, 2017Assignee: Universitaet LeipzigInventors: Annette Beck-Sickinger, Sylvia Els-Heindl, Enrico Schild, Thue W. Schwartz, Birgitte Holst Lange
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Publication number: 20170205353Abstract: The invention relates to a method for the Raman spectroscopic, in ovo sex determination of fertilised and hatched birds' eggs (1), wherein the embryo, including the extra-embryonic structures, can move in the egg, and is not yet attached to the shell at the time of measuring.Type: ApplicationFiled: July 3, 2015Publication date: July 20, 2017Applicants: TECHNISCHE UNIVERSITAET DRESDEN, UNIVERSITAET LEIPZIGInventors: Roberta GALLI, Grit PREUSSE, Edmund KOCH, Gerald STEINER, Maria-Elisabeth KRAUTWALD-JUNGHANNS, Thomas BARTELS
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Publication number: 20170191980Abstract: The present invention refers to a device for measuring impedance in organotypic tissue comprising at least one recording chamber with a liquid permeable membrane supporting the organotypic tissue, at least one bottom electrode and at least one top electrode, wherein the liquid permeable membrane divides the recording chamber into a top chamber and a bottom chamber, wherein at least the bottom chamber contains culture medium for the organotypic tissue, and the bottom electrode(s) is/are located in the bottom chamber and the top electrode(s) is/are located in the top chamber, and wherein the organotypic tissue is located between the bottom electrode(s) and the top electrode(s). The present invention also refers to the use of the device according to the present invention for measuring impedance in organotypic tissue.Type: ApplicationFiled: January 18, 2017Publication date: July 6, 2017Applicant: Universität LeipzigInventors: Andrea ROBITZKI, Andrée Rothermel, Heinz-Georg Jahnke, Ina Sternberger, Frank Striggow, Till Mack
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Patent number: 9683982Abstract: In a method for diagnosing and/or prognosis of cancers, diagnosing origin of tumor cells, optimizing cancer therapy, and screening active substances for oncology, the mechanical properties of tumor cells and reference cells are analyzed under mechanical load that causes linear or non-linear deformation of the loaded cell. The engineering strain of the cells caused by directed mechanical stress being introduced is used to determine metastasis risk and the presence of uncontrollably proliferating and/or invasive cells, or the origin of the tumor. The metastasis risk is determined based on the proportion of cells in the sample exhibiting engineering strain in a direction opposite to the stressing direction. The risk of the presence of uncontrollably proliferating cells for non-linear deformation of the cell is determined in the sample based on the mean value of the engineering strain in the direction of cell stressing.Type: GrantFiled: April 3, 2015Date of Patent: June 20, 2017Assignee: Universität LeipzigInventors: Josef Käs, Jochen Guck