Patents Assigned to Universität Rostock
-
Patent number: 11959780Abstract: The invention relates to a method for determining shifts in position in at least two different spatial directions between a first element and a second element which are movable relative to each other, with at least two sensors which measure contactlessly and are spaced, in the at least two different spatial directions, from at least two standards which are fixed to the second element, sensor areas of the at least two sensors opposing the at least two standards in the respective spatial direction and sensing said standards, wherein: —the at least two sensors scan the at least two standards and generate, in interaction with the at least two standards, output signals with which in combination an absolute position of the second element is determined, said absolute position being associated with a linear movement in a further spatial direction or with a rotary movement, and—wherein the output signals of the at least two sensors are also used to determine values which characterise the distance between the respectivType: GrantFiled: September 3, 2020Date of Patent: April 16, 2024Assignee: Universitaet RostockInventor: Jens-Werner Falkenstein
-
Patent number: 11714093Abstract: The present invention relates to a method for prediction of response to cardiovascular regeneration comprising the use of biomarkers. Further, the present invention relates to a combination of the biomarkers for use in a method for prediction of response to cardiovascular regeneration, a computer device to perform a method according to the present invention and a device adapted for carrying out the inventive method.Type: GrantFiled: July 16, 2018Date of Patent: August 1, 2023Assignee: Universität RostockInventors: Gustav Steinhoff, Julia Nesteruk, Markus Wolfien
-
Patent number: 11661582Abstract: The electrical pacemakers currently being used for the therapeutic approaches for treatment of “sick sinus syndrome” are not hormonally regulatable and entail risks through infections or premature battery discharge. These problems could be overcome by means of “biological cardiac pacemakers” obtained from pluripotent stem cells (PSCs). It has been shown that the controlled differentiation of stem cells with TBX, inductors of sinoatrial node cells, and an additional Myh6 promoter-specific antibiotic selection can give cardiomyocyte aggregates consisting to an extent of more than 80% of physiologically functional pacemaker cells. These induced sinoatrial bodies (“iSABs”) for the first time exhibited very high beat frequencies (300-400 bpm), similar to those in a murine heart, and were able to stably rhythmically stimulate heart muscle cells ex vivo.Type: GrantFiled: December 10, 2014Date of Patent: May 30, 2023Assignee: UNIVERSITAET ROSTOCKInventors: Robert David, Julia Jung
-
Patent number: 11458009Abstract: A stent graft system (1) with a first stent graft (2) expandable in respect of a diameter, and with at least a second stent graft (3). The first stent graft (2) at least in some areas has a tubular net structure (4) which, in an expanded mode, has a net structure (4) with substantially round annular meshes (5). The at least second stent graft (3) has, at a distal end (6), outwardly extending barbs (7) via which the at least second stent graft (3) can be coupled to the first stent graft (2) in the expanded mode. The distal end (6) of the at least second stent graft (3) passes through a round annular mesh (5) of corresponding diameter and, with its outwardly extending barbs (7), engages on the round annular mesh (5). Also, a method for coupling stent grafts as a stent graft system.Type: GrantFiled: January 20, 2017Date of Patent: October 4, 2022Assignee: Universitaet RostockInventor: Justus Gross
-
Publication number: 20210371929Abstract: The present invention relates to a method for prediction of response to disease therapy, in particular to tissue regeneration, preferably to cardiovascular regeneration, comprising the use of a biomarker. Further, the present invention relates to a combination of biomarkers for use in a method for prediction of response to disease therapy, in particular to tissue regeneration, preferably to cardiovascular regeneration, a computer device to perform a method according to the present invention and a device adapted for carrying out the inventive method.Type: ApplicationFiled: October 11, 2019Publication date: December 2, 2021Applicant: UNIVERSITÄT ROSTOCKInventors: Gustav STEINHOFF, Markus WOLFIEN
-
Patent number: 11179407Abstract: The present invention relates to L-arabino-oligosaccharides, in particular synthetically produced L-arabino-oligosaccharides and their uses for the prophylaxis of allergic reactions in mammals.Type: GrantFiled: November 30, 2016Date of Patent: November 23, 2021Assignees: FORSCHUNGSZENTRUM BORSTEL LEIBNIZ-ZENTRUM FÜR MEDIZIN UND BIOWISSENSHAFTEN, UNIVERSITÄT ROSTOCK, RUHR-UNIVERSITÄT BOCHUMInventors: Marcus Peters, Otto Holst, Christian Vogel, Alice Voss
-
Patent number: 11083612Abstract: A trans-aortic proximal aortic stent graft [TAPAS graft] for introducing into a blood vessel. A a tubular sheath which encases a folded self-expanding stent from the inside as well as from the outside such that a sheath outer wall of the sheath lies against the self-expanding stent from the outside and a sheath inner wall lies against the self-expanding stent from the inside and keeps the self-expanding stent folded. The self-expanding stent is surrounded by the sheath at the distal end in the transition from the sheath inner wall to the sheath outer wall, and the self-expanding stent is provided with an anchor at the proximal end. Also, a method for using a trans-aortic proximal aortic stent graft [TAPAS graft].Type: GrantFiled: January 20, 2017Date of Patent: August 10, 2021Assignee: Universitaet RostockInventor: Justus Gross
-
Publication number: 20210078248Abstract: A device for producing a 3D-printed active substance-releasing system with active substance depots, such that a radiation source in operation causes a polymerisation of a layer of the base material on the construction platform and that an inkjet printhead incorporates an active substance mixture, which has at least one active substance, into the base material in a locationally selective manner. A trough is provided, in which a base material and a construction platform are arranged, and polymerising selected regions of a layer of the base material on the construction platform and introducing, by means of an inkjet printing method, an active substance mixture, which has at least one active substance, into the base material and/or polymerised base material in a locationally selective manner in order to thereby create active ingredient depots in the active ingredient-releasing system.Type: ApplicationFiled: September 29, 2020Publication date: March 18, 2021Applicant: UNIVERSITÄT ROSTOCKInventors: Hermann SEITZ, Roland MATZMOHR, Nils GRABOW, Michael TESKE, Thomas EICKNER, Robert MAU, Alexander RIESS, Klaus-Peter SCHMITZ
-
Publication number: 20200399743Abstract: The invention relates to composite materials based on tungsten carbide and comprising gold, palladium and/or platinum and to a method for producing said composite materials by sintering. By means of the FAST method, hard and biocompatible WC/(Au, Pd, Pt) composite materials can be produced, inter alia for use as coatings on tools and prostheses and as solid bodies in, for example, blood pumps.Type: ApplicationFiled: March 8, 2019Publication date: December 24, 2020Applicants: Universität Rostock, HNP Mikrosysteme GmbHInventors: Carsten DAMERAU, Wiktor BODNAR, Eberhard BURKEL
-
Publication number: 20200174020Abstract: The present invention relates to a method for prediction of response to cardiovascular regeneration comprising the use of biomarkers. Further, the present invention relates to a combination of the biomarkers for use in a method for prediction of response to cardiovascular regeneration, a computer device to perform a method according to the present invention and a device adapted for carrying out the inventive method.Type: ApplicationFiled: July 16, 2018Publication date: June 4, 2020Applicant: Universität Rostock Zentrale Universitätsverwaltung Referat 1.1 RechtInventors: Gustav STEINHOFF, Julia NESTERUK, Markus WOLFIEN
-
Patent number: 10646967Abstract: The invention relates to a welding assembly for the permanent joining of a first tubular component with a second component along a two- or three-dimensional intersection curve, along which both components contact, comprising a securing assembly for detachably securely joining on a tubular end of the first component facing away from the intersection curve, a manipulator unit mounted directly or indirectly on the securing assembly such that it can pivot about a tube longitudinal axis assigned to the first component. The manipulator unit has a freely positionable manipulator end, with a welding tool attached to the freely positionable manipulator end. The securing assembly comprises a clamping module that can at least partially be introduced into the tubular end of the first component on the end side and in an axial manner.Type: GrantFiled: March 16, 2016Date of Patent: May 12, 2020Assignees: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V., Universität RostockInventors: Martin Christoph Wanner, Steffen Dryba, Bjoern Weidemann, André Harmel
-
Publication number: 20200115743Abstract: The present invention relates to SH2B adapter protein 3 (SH2B3) for use as a diagnostic marker. Further, the present invention relates to a method for the determination of SH2B3 gene expression.Type: ApplicationFiled: April 10, 2018Publication date: April 16, 2020Applicant: UNIVERSITÄT ROSTOCK ZENTRALE UNIVERSITÄTSVERWALTUNG REFERAT 1.1 RECHTInventor: Gustav STEINHOFF
-
Patent number: 10342703Abstract: The invention relates to an ocular implant for treating glaucoma. The problem addressed by the invention is to make it possible to drain aqueous humor from the anterior chamber of the eye into the subconjunctival or suprachoroidal space in order to lower the intraocular pressure in glaucoma cases. The device is to do away with the drawbacks of known valve mechanisms and should be economical to produce. In order to solve said problem, the glaucoma drainage implant is composed of an elongate, hollow main member in which a flow-limiting membrane is arranged in the inflow region.Type: GrantFiled: February 23, 2015Date of Patent: July 9, 2019Assignee: Universitaet RostockInventors: Stefan Siewert, Frank Luderer, Wolfram Schmidt, Marian Loebler, Rudolf Guthoff, Katrin Sternberg, Klaus-Peter Schmitz
-
Patent number: 10260948Abstract: The invention relates to a device (1) and a method (20) for determining a spectrum (X) of scattered radiation (S). The invention further relates to a method (70) for calculating the spectrum (X) and a method for compressing unstructured data (60) of known distribution. To be able to determine the spectrum (X) as precisely as possible and to derive from this the characteristics of materials that scatter laser pulses (P), the invention proposes that at least one characteristic of the laser pulse (P) is determined and that a spectrum analyzer (5) is used for this. Frequencies (F) of laser pulses (P) and volumes (M) of backscattered radiation (S) are combined into frequency and volume values (F?, M?) to calculate the spectrum (X). The most frequent data values are deleted from the data to compress the data (60).Type: GrantFiled: November 26, 2013Date of Patent: April 16, 2019Assignee: LEIBNIZ-INSTITUT FUER ATMOSPHAERENPHYSIK E.V. AN DER UNIVERSITAET ROSTOCKInventor: Josef Hoeffner
-
Patent number: 10118293Abstract: The invention relates to an articulated arm robot for handling a payload, comprising a robot arm (R), which is attached to a base (1) that can be rotated about a first axis (A1), and at least two arm elements (2 and 3), which are arranged to form a kinematic chain and a first arm element (2) is mounted on the base (1) to pivot about a second axis (A2) that is oriented orthogonally relative to the first axis and a second arm element (3) which is attached to the first arm to be pivotal manner about a third axis (A3) that is oriented parallel to the second axis (A2).Type: GrantFiled: October 7, 2014Date of Patent: November 6, 2018Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., UNIVERSITÄT ROSTOCKInventors: Martin Christoph Wanner, Reinhart Kny, Michael Wollenberg, Steffen Dryba
-
Publication number: 20160367403Abstract: The invention relates to an ocular implant for treating glaucoma. The problem addressed by the invention is to make it possible to drain aqueous humor from the anterior chamber of the eye into the subconjunctival or suprachoroidal space in order to lower the intraocular pressure in glaucoma cases. The device is to do away with the drawbacks of known valve mechanisms and should be economical to produce. In order to solve said problem, the glaucoma drainage implant is composed of an elongate, hollow main member in which a flow-limiting membrane is arranged in the inflow region.Type: ApplicationFiled: February 23, 2015Publication date: December 22, 2016Applicant: UNIVERSITAET ROSTOCKInventors: Stefan SIEWERT, Frank LUDERER, Wolfram SCHMIDT, Marian LOEBLER, Rudolf GUTHOFF, Katrin STERNBERG, Klaus-Peter SCHMITZ
-
Publication number: 20160103116Abstract: The present invention relates to an electrophysiological measuring arrangement (100) and to an electrophysiological measuring method, in which a carrier (12) made of a carrier material (12?) and an aperture region (10) in the region of the carrier (12) are provided for the controlled sealing accumulation of a biological object (O). The aperture region (10) is formed with at least one aperture (14) and with a wall region (11) which, as the aperture inner wall (11i), surrounds the aperture (14), forming the latter.Type: ApplicationFiled: March 27, 2014Publication date: April 14, 2016Applicant: UNIVERSITAET ROSTOCKInventors: Oliver Klink, Philipp Julian Koester, Carsten Tautorat, Uwe Scheffler
-
Patent number: 9273348Abstract: The invention includes a method and array for replicating and analyzing one or a plurality of different target sequences in nucleic acid samples. The different reactions for replicating the target sequences occur simultaneously on an array with selectively heatable array elements with their reaction surfaces, some of which have been modified differently, and in the sample solution disposed thereabove. The target sequences are analyzed using molecular detection on reaction surfaces of said array that have been modified with probe strands. The target strands are replicated and analyzed simultaneously, successively, or alternately.Type: GrantFiled: February 10, 2006Date of Patent: March 1, 2016Assignee: Universitaet RostockInventors: Gerd-Uwe Flechsig, Joerg Peter
-
Patent number: 9138549Abstract: The invention relates to an insufflator with a supply connection (22) and a delivery connection (14) and a pressure and flow measuring device arranged between said connections (14, 22) for determining measured quantities characterizing a gas pressure at a delivery connection and a gas volume flow at the delivery connection. The pressure and flow measuring device comprises a multilayer board (20) which comprises on its interior at least one flow channel (26) that is connected at its input to the supply connection (22) and at its output (8) to the delivery connection (14). Arranged on the board (20) are pressure measurement sensors (32, 34) and electronic components (4, 6) for the wiring of the pressure measurement sensors.Type: GrantFiled: January 29, 2010Date of Patent: September 22, 2015Assignees: MGB ENDOSKOPISCHE GERAETE GMBH BERLIN, UNIVERSITAET ROSTOCKInventors: Lienhard Pagel, Stefan Gabmann, Johannes Tschepe
-
Patent number: 9107675Abstract: A device for in situ milling of joint surfaces, including a milling device and a joint clamping device. The joint clamp device is designed to be inserted between two joint components forming a joint, particularly bones, and for pushing the joint components apart with a predetermined or adjustable tension, wherein the joint clamping device includes a recess in which the milling device can be inserted, wherein the milling device includes a face milling cutter.Type: GrantFiled: June 16, 2010Date of Patent: August 18, 2015Assignee: UNIVERSITÄT ROSTOCKInventors: Attila Vasarhelyi, Rolf Hartmann