Abstract: The invention relates to a mechanical wheelchair drive, comprising a rotatably mounted lever, a handle fastened to the lever, and a force transfer unit for transferring rotational motion of the lever to a wheelchair wheel, wherein the lever has a variable length and is guided along a closed guide of a guide plate, said guide deviating from the circular form, such that the length of the lever changes during the rotational motion.

Abstract: Method and system for executing a one-time program comprising at least one instruction operating on at least one input value (a, b) and returning at least one output value (O), wherein each instruction of the one-time program is encoded onto a state of an elementary quantum system, comprising: encoding the at least one input value (a, b) onto a quantum gate according to a pre-defined input-encoding scheme; applying the quantum gate to the at least one elementary quantum system; making a measurement of a resulting state of the at least one elementary quantum system after the quantum gate; and determining the at least one output value from a result of the measurement.

Abstract: A method of stabilising a biological sample including glutathione (GSH) and glutathione disulfide (GSSG), including a) providing the biological sample having GSH and GSSG; b) contacting GSH and GSSG of the sample with a maleimide to obtain maleimide-alkylated GSH; c) separating excess maleimide from maleimide-alkylated GSH and GSSG; d) contacting maleimide-alkylated GSH and GSSG with a reducing agent such as TCEP under conditions which allow reduction of GSSG by the reducing agent such as TCEP to obtain further GSH; and e) contacting maleimide-alkylated GSH and GSH with a heavy isotopologue of the maleimide to obtain a heavy isotopologue of the maleimide-alkylated GSH. A stabilised biological sample is provide containing maleimide-alkylated GSH and a heavy isotopologue thereof, as well as a mass-spectrometric method for quantifying maleimide-alkylated GSH and a heavy isotopologue thereof in a sample and a kit for stabilising a biological sample including GSH and GSSG for mass spectrometric analysis.

Abstract: The invention relates to a medical analysis device (1) for assessing a patient's suitability for anaesthesia by analysing at least one physiological biosignal (S) detected during an apnoea, wherein the medical analysis device (1) comprises the following: —an input interface (2) for detecting a time curve of at least one physiological biosignal (S) of a patient, —a computing unit (3) which is configured to compare a time curve of the at least one physiological biosignal (S) with at least one predefinable curve or a limit value according to an algorithm (4) in order to determine a patient's suitability for anaesthesia and to calculate an assessment result (E) depending thereon, wherein the time curve of the at least one physiological biosignal (S) comprises at least the duration of a patient's apnoea, and —an output interface (5) connected to the computing unit (3), to output the assessment result.

Abstract: The present invention relates to a microfluidic device (1; 8) for the production of cellular spheroids comprising at least one chamber (2; 9) comprising a fluid inlet (3) for introducing fluid into the chamber (2; 9) and a fluid outlet (4) for removing said fluid from the chamber (2, 9), wherein said at least one chamber (2; 9) comprises a base formed by a substrate (5; 10) comprising at least two recesses (6; 11) to collect a fluid comprising biological cells when the substrate (5, 10) is contacted with the fluid, wherein the size of the at least two recesses (6; 11) decreases from the fluid inlet (3) to the fluid outlet (4) of the at least one chamber (2; 9).

Abstract: A gas-sensing apparatus is provided. The gas-sensing apparatus comprises a test chamber formed in a body and comprising a pair of micromirrors. One of the pair of micromirrors is disposed on a first surface of the body and the other of the pair of micromirrors is disposed on a second surface of the body, forming an optical cavity. A light inlet is arranged to couple light into the optical cavity, and light outlets are arranged to receive light from the optical cavity. A gas inlet configured to allow gas from outside of the detector to enter the test chamber. A gas detector comprising a gas-sensing apparatus, a light emitting system, and a light detecting system is also provided.

Abstract: Method for producing a light-curable resin composition capable of producing a magnetic resonance imaging-signal, in particular for the lithography-based additive production of magnetic resonance imaging phantoms, the method comprising at least the following steps: providing particles at least partially filled with a magnetic resonance imaging-signal producing liquid, and mixing the at least partially filled particles with a light-curable resin.

Abstract: A Histomonas meleagridis strain having at least one of the following attenuating features (a) an inactivation of a gene, wherein the gene has the sequence identified by SEQ ID NO: 1 or a sequence with at least 90% sequence identity thereto, (b) an inactivation of a gene, wherein the gene has the sequence identified by SEQ ID NO: 2 or a sequence with at least 90% sequence identity thereto, (c) a truncating mutation in the coding sequence of a gene, wherein the gene has the unmutated coding sequence identified by SEQ ID NO: 3 or an unmutated coding sequence with at least 95% sequence identity thereto, and (d) a truncating mutation in the coding sequence of a gene, wherein the gene has the unmutated coding sequence identified by SEQ ID NO: 4 or an unmutated coding sequence with at least 95% sequence identity thereto. An anti-histomonosis vaccine containing the strain.

Abstract: A process for carrying out an allergy test is based on a blood sample being taken. The blood sample is contacted in vitro with at least one allergen. At least one allergic reaction or the absence of the at least one allergic reaction is observed via a microscope (11) directly and/or optically. To make it possible to carry out an allergy test with a higher validity and/or better accuracy, a position of granules is observed via the microscope (11). The granules are observed in different planes or horizontal planes.

Abstract: The present invention relates to the provision of new means and methods for the treatment of proliferative and inflammatory diseases. In particular, the invention relates to a pharmaceutical composition comprising a modified Filamin A encoded by a nucleic acid molecule, wherein the nucleic acid molecule is characterized in that the codon in the wildtype sequence encoding glutamine corresponding to position 2333 of SEQ ID NO: 27 is replaced by a codon encoding arginine and/or a modified Filamin B encoded by a nucleic acid molecule, wherein the nucleic acid molecule is characterized in that the codon in the wildtype sequence encoding glutamine corresponding to position 2327 of SEQ ID NO: 29 is replaced by a codon encoding arginine.

Abstract: A quantum optical memristor for manipulating photon quantum states includes a Mach-Zehnder interferometer having a first optical input and a first optical output and a second optical output. The first optical input and the first optical output of the Mach-Zehnder interferometer are a first optical input and a first optical output of the quantum optical memristor respectively. A detector is configured to detect a time-dependent optical signal at the second optical output of the Mach-Zehnder interferometer. A controller is configured to compute a target reflectivity of the Mach-Zehnder interferometer, wherein the controller is configured to update the reflectivity of the Mach-Zehnder interferometer to match the computed target reflectivity. The controller is configured to compute the target reflectivity based on the derivative of the reflectivity with respect to time. The derivative of the reflectivity with respect to time is a linear function of the detected signal.

Abstract: A method for analyzing or optimizing the operation of waste incinerator systems. The content of CO2 is measured in the exhaust gas and is used to determine the ratio of biogenic carbon to fossil carbon in the incinerated waste, if necessary after resetting to the CO2 reference quantity. The variability of the CO2 reference or the ratio of biogenic carbon to fossil carbon in the incinerated waste is determined and recorded according to quantity and duration. When optimizing the operation, the location of the waste in the bunker, from which the incinerated waste originates with a composition or variability that has now been ascertained using the method, is used to further remove or mix the waste.

Abstract: In a method of controlling a lithography-based additive manufacturing device capable of manufacturing a three-dimensional component from a plurality of volume elements, a check is made to determine whether the volume elements are entirely within the three-dimensional virtual model by identifying at least first and second boundary points of the volume element or virtual model in x-y planes spaced apart in the z-direction, and the volume element in question is provided for the manufacturing process only if it is within the model with respect to the first and second boundary points.

Abstract: A method for demodulation including the following steps: exciting a vibrationally mounted, at least sectionally bar-shaped oscillating element for oscillating in the range of a resonance frequency of the oscillating element, wherein a temporally varying, in particular periodic, excitation signal is used for excitation, and wherein at least the temporal variation of the excitation signal is known or determined; detecting a modulated oscillation of the oscillating element by means of at least one sensor, wherein the sensor supplies a sensor measurement variable that varies versus time as a function of an amplitude and a phase of the modulated oscillation of the oscillating element. According to the present teaching, it is provided that the method includes the following step: generate a first comparison signal by amplitude modulating a known temporally varying, in particular periodic, demodulation signal by means of the temporally varying sensor measurement variable.

Abstract: A redirecting rotating mirror arrangement includes a directional antenna subcomponent having a direction of maximum received or transmitted beam intensity. The redirecting rotating mirror arrangement also includes a rotatable mirror that reflects an electromagnetic beam to or from the directional antenna subcomponent. The rotatable mirror is inclined at an inclination angle with respect to a horizontal plane. The arrangement also includes a motor that rotates the rotatable mirror about the direction of maximum received or transmitted beam intensity such that the electromagnetic beam is either received from or transmitted to a range of angles as the rotatable mirror rotates.

Abstract: A laser assembly comprising: a semiconductor laser with a fast gain medium, wherein the gain relaxation time of the gain medium is smaller than the round-trip time in a standing wave cavity; a DC source coupled to the standing wave cavity; and an AC injection device for injecting an electrical AC signal within a range and/or within an integer multiple of the range into the standing wave cavity, the range within ±1% of the natural round-trip frequency in the standing wave cavity, comprising at least a first and second electric contact section extending along a first longitudinal side of the longitudinal extension of the standing wave cavity, the AC injection device coupled to the first and/or second electric contact section such that the complex amplitude of the electrical AC signal differs for the first and second longitudinal electric contact section.

Abstract: A device for attaching a primary implant as a fixation point for a vascular prosthesis on a vessel wall of a blood vessel, the device at least including a carrier element, which is designed to drive a plurality of penetration elements, for penetrating the vessel wall, radially outwards in relation to a longitudinal axis of the carrier element. In the device, a limiting element is formed on the carrier element as a radial stop for the penetration elements.

Abstract: The invention relates to a tunnel lining segment of reinforced concrete, wherein the tunnel lining segment has a load transfer area for a longitudinal joint, with at least one steel bar with an end face being installed in the tunnel lining segment, the steel bar being arranged in the tunnel lining segment in such a way that a tangent to a centroidal axis of the steel bar encloses an angle of between 0° and 45° in the end face with a normal to the load transfer area, and wherein the end face is arranged at a distance (a) from the load transfer area which is between 0 mm and 50 mm, preferably between 0 mm and 10 mm.

Abstract: The present invention relates to a method for producing shaped bodies (5) from a building material, in which a layered structure of a shaped body (5) takes place by successively solidifying layers of the building material by exposure to electromagnetic radiation in a layer area having a contour specified for the respective layer. The method provides that together with the shaped body (5), a sleeve-like frame (6) surrounding the shaped body at a distance is constructed layer by layer from the building material, and that in addition, a plurality of pin-like connections (10) are constructed integral with the frame (6) and the shaped body (5), which are distributed around the shaped body (5) and which connect the shaped body (5) with the frame (6).

Abstract: Method for producing a light-curable resin composition capable of producing a magnetic resonance imaging-signal, in particular for the lithography-based additive production of magnetic resonance imaging phantoms, the method comprising at least the following steps: providing particles at least partially filled with a magnetic resonance imaging-signal producing liquid, and mixing the at least partially filled particles with a light-curable resin.