Patents Assigned to Universität Zurich
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Publication number: 20200234762Abstract: A differential memristive circuit includes a normaliser; a first memristor connected between first top and bottom nodes, the first memristive element having a first adjustable resistance value; a first switch connected between the first bottom node and the normaliser; a second memristor connected between a second top node and a second bottom node the second memristor having a second adjustable resistance value; a second switch connected between the second bottom node and the normaliser; and a set of voltage sources that generate voltages greater than 0V. The set of voltage sources generate a first voltage value across the first memristor and a second voltage value across the second memristor. A first output signal depends on the first adjustable resistance value, while a second output signal depends on the second adjustable resistance value. A memristive circuit net output signal is obtained as the difference between the first and second output signals.Type: ApplicationFiled: July 22, 2018Publication date: July 23, 2020Applicant: UNIVERSITÄT ZÜRICHInventors: Giacomo INDIVERI, Manu Vijayagopalan NAIR
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Publication number: 20200219267Abstract: The invention relates a method for generating a motion-corrected image for visual-inertial odometry comprising an event camera rigidly connected to an inertial measurement unit (IMU), wherein the event camera comprises pixels arranged in an image plane that are configured to output events in presence of brightness changes in a scene at the time they occur, wherein each event comprises the time at which it is recorded and a position of the respective pixel that detected the brightness change, the method comprising the steps of: Acquiring at least one set of events (S), wherein the at least one set (S) comprises a plurality of subsequent events (e); Acquiring IMU data (D) for the duration of the at least one set (S); Generating a motion-corrected image from the at least one set (S) of events (e), wherein the motion-corrected image is obtained by assigning the position (xj) of each event (ej) recorded at its corresponding event time (tj) at an estimated event camera pose (Ttj) to an adjusted event position (x?j)Type: ApplicationFiled: September 3, 2018Publication date: July 9, 2020Applicant: UNIVERSITÄT ZÜRICHInventors: Henri REBECQ, Davide SCARAMUZZA
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Patent number: 10702214Abstract: A method for monitoring and visualizing a patient's medical condition, wherein a graphical representation of the patient comprising a body having at least a torso and a head, as well as particularly two legs and two arms, is displayed using a display device, wherein said displayed graphical representation comprises at least one region which is allocated to at least one or several provided (e.g. measured and/or determined) patient monitoring quantities, and wherein the appearance of the at least one region is altered in real-time when the at least one patient monitoring quantity to which said at least one region is allocated changes.Type: GrantFiled: November 17, 2017Date of Patent: July 7, 2020Assignee: UNIVERSITÄT ZÜRICHInventors: David Tscholl, Christoph Nothiger, Patrick Neubauer
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Publication number: 20200205650Abstract: The Invention relates to a medical device (1) for oral procedures, particularly for use in oral intubation and fixation procedures, comprising at least one protective device (2) for teeth, the protective device (2) comprising the a rigid support component (3), and at least one push button (4), arranged at the support component (3), wherein each of the at least one the push button (4) comprises a rigid surface (42) that is facing towards the teeth, when the medical device (1) is applied orally, wherein the support component (3) is configured such that each of the at least one push button (4) is displaceable separately relative to the support component (3) between a first position and a second position.Type: ApplicationFiled: July 2, 2018Publication date: July 2, 2020Applicant: UNIVERSITÄT ZÜRICHInventors: Andreas SCHLICKER, Carsten SCHRÖDER, Sascha WEIDNER
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Publication number: 20200196884Abstract: The invention relates to a device for determining a parameter for the diagnostics of hydrocephalus and other disorders of intracranial pressure, wherein information about the volume elasticity is obtained from a pressure signal or another characteristic signal which contains information about the pressure or the volume composition in the skull. The characteristic parameter determined according to the invention is the ratio of the amplitude of a modulating wave in the processed characteristic signal to the amplitude of the modulated wave in the course of the pulse amplitude of the modulated wave of the processed characteristic signal.Type: ApplicationFiled: May 11, 2018Publication date: June 25, 2020Applicant: UNIVERSITÄT ZÜRICHInventors: Andreas SPIEGELBERG, Vartan KURTCUOGLU
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Publication number: 20200171227Abstract: An implantable pump system can deliver blood within the body of a patient, with a blood pump which delivers a fluid in an axial direction. The blood pump can include a rotatingly drivable rotor as well as a pump casing surrounding the rotor, as well as a support tube, in which the pump casing is arranged and held, wherein an annular gap is formed between the support tube and the pump casing. An almost physiological blood flow is rendered possible in this manner, by way of the combination of a flow through the pump casing on the one hand, and the annular gap on the other hand.Type: ApplicationFiled: November 4, 2019Publication date: June 4, 2020Applicants: Berlin Heart GmbH, Universität ZürichInventors: Ulrich Tim Opfermann, Andreas Arndt, Volkmar Falk
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Patent number: 10655145Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.Type: GrantFiled: March 21, 2018Date of Patent: May 19, 2020Assignee: UNIVERSITÄT ZÜRICHInventors: Daniel D. Pinschewer, Lukas Flatz, Andreas Bergthaler, Rolf Zinkernagel
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Publication number: 20200111220Abstract: The invention relates to computation of optical flow using event-based vision sensors.Type: ApplicationFiled: May 29, 2018Publication date: April 9, 2020Applicant: UNIVERSITÄT ZÜRICHInventors: Tobias DELBRUCK, Min LIU
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Publication number: 20200054793Abstract: The invention relates to a method for preparing a polymer scaffold that comprises the steps of providing a piece of a fabric of filaments of a first biodegradable or biocompatible polymer, applying a coating of a second polymer to said arrangement of filaments, and stretching the piece along its axis of longitudinal extension, thereby obtaining an aligned microfibrillar scaffold. The invention further relates to a method for providing an artificial tissue, and to a microfibrillar scaffold of aligned filaments obtained by the method of the invention.Type: ApplicationFiled: October 27, 2017Publication date: February 20, 2020Applicants: ETH ZÜRICH, UNIVERSITÄT ZÜRICHInventors: Simon Philipp HOERSTRUP, Seyedvahid HOSSEINI, Viola VOGEL
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Patent number: 10556003Abstract: The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of insect bite hypersensitivity of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating insect bite hypersensitivity of equine mammals, preferably of horses.Type: GrantFiled: September 7, 2016Date of Patent: February 11, 2020Assignee: UNIVERSITÄT ZÜRICHInventors: Antonia Fettelschoss, Martin Bachmann
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Publication number: 20200008788Abstract: Disclosed embodiments relate to a membrane closure device (100) for closing a perforation in a membrane (10), comprising: a patch guiding mechanism (110) for guiding at least one expandable patch (120) to a perforation site (12) of a membrane (10); and a fastener delivery mechanism (130, 330) for delivering a fastener (140) to the perforation site (12) and for fastening the at least one expandable patch by the fastener (140) to the membrane (10) to seal the perforation in the membrane (10) by the at least one expandable patch (120).Type: ApplicationFiled: February 5, 2018Publication date: January 9, 2020Applicant: UNIVERSITAET ZÜRICHInventors: Yannick DEVAUD, Vincent MILLERET, Roland ZIMMERMANN, Martin EHRBAR, Nicole OCHSENBEIN
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Patent number: 10425063Abstract: A band-pass filter is described comprising a first first-order filter stage comprising a first resistor characterized by a first impedance and connected to a first node, referred to as a filter input node, and, through a second node to a first reactive component connected to a third node, the first impedance being such that a first current therethrough is dependent on the difference between the voltages at the first and second nodes; and a second first-order filter stage comprising a second resistor characterized by a second impedance and connected to the second node, and, through a fourth node, to a second reactive component connected to a fifth node. The second impedance is such that a second current therethrough is dependent on the negative of the sum of the voltages at the second and fourth nodes. The band-pass filter further comprises summing means for summing the voltages at the second and fourth nodes to output a voltage at a sixth node.Type: GrantFiled: January 5, 2017Date of Patent: September 24, 2019Assignee: UNIVERSITÄT ZÜRICHInventors: Minhao Yang, Shih-Chii Liu
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Publication number: 20190276819Abstract: The invention relates to a method for identifying and quantifying a polypeptide from a library of polypeptides. The method comprises the steps of: 1—providing a polypeptide library and a detection tag library, 2—generating a nested library comprising the polypeptides and the detection tags, 3—sequencing the nested library, 4—selecting a member of the nested library in one or several selection steps that are independent of a physical genotype-phenotype linkage, 5—isolating the detection tag from the selected polypeptide, 6—identifying and quantifying the detection tag by mass spectrometry, 7—obtaining the sequence of the selected polypeptide. The invention also relates to a collection of polypeptides, a collection of detection tags, and a collection of plasmid vectors.Type: ApplicationFiled: October 30, 2017Publication date: September 12, 2019Applicant: Universität ZürichInventors: Markus SEEGER, Pascal EGLOFF, Iwan ZIMMERMANN
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Publication number: 20190127481Abstract: The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second polypeptide ligand that binds to HER2 extracellular domain 4, and (c) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.Type: ApplicationFiled: October 8, 2018Publication date: May 2, 2019Applicant: UNIVERSITÄT ZÜRICHInventors: Andreas Plückthun, Florian Kast, Martin Schwill, Annemarie Honegger, Rastislav Tamaskovic, Christian Jost
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Patent number: 10227308Abstract: The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.Type: GrantFiled: February 27, 2017Date of Patent: March 12, 2019Assignees: HOFFMANN-LA ROCHE INC., EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRCIH, UNIVERSITÄT ZÜRICHInventors: Simon M. Ametamey, Juergen Fingerle, Luca Gobbi, Uwe Grether, Ahmed Haider, Thomas Hartung, Linjing Mu, Leo Nicholls, Mark Rogers-Evans, Christoph Ullmer
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Publication number: 20190062784Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.Type: ApplicationFiled: March 21, 2018Publication date: February 28, 2019Applicant: UNIVERSITÄT ZÜRICHInventors: Daniel D. Pinschewer, Lukas Flatz, Andreas Bergthaler, Rolf Zinkernagel
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Publication number: 20190050720Abstract: The present invention concerns a method of programming an analogue electronic neural network comprising a plurality of layers of somas. Any two consecutive layers of somas are connected by a matrix of synapses. The method comprises: applying test signals to inputs of the neural network; measuring at a plurality of measurement locations in the neural network responses of at least some somas and synapses to the test signals; extracting from the neural network, based on the responses, a first parameter set characterising the behaviour of the at least some somas; carrying out a training of the neural network by applying to a training algorithm the first parameter set and training data for obtaining a second parameter set; and programming the neural network by using the second parameter set. The invention also relates to the neural network and to a method of operating it.Type: ApplicationFiled: February 17, 2017Publication date: February 14, 2019Applicant: UNIVERSITÄT ZÜRICHInventors: Jonathan Jakob Moses BINAS, Daniel Lawrence NEIL
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Patent number: 10195310Abstract: The invention relates to a device and a method for compressing a hydrogel layer (H), wherein a separate piston (600) that is designed to be connected to a second component (400) of the device in a releasable manner in an operating mode of the device, particularly by means of a latching connection, presses along a compression direction (C) against said hydrogel layer (H) residing on a membrane bottom (501) of a graft frame (500) so as to compress the hydrogel layer (H) between the piston (600) and the membrane bottom (501).Type: GrantFiled: June 27, 2014Date of Patent: February 5, 2019Assignee: UNIVERSITÄT ZÜRICHInventor: Ernst Reichmann
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Publication number: 20190020331Abstract: A band-pass filter is described comprising a first first-order filter stage comprising a first resistor characterised by a first impedance and connected to a first node, referred to as a filter input node, and, through a second node to a first reactive component connected to a third node, the first impedance being such that a first current therethrough is dependent on the difference between the voltages at the first and second nodes; and a second first-order filter stage comprising a second resistor characterised by a second impedance and connected to the second node, and, through a fourth node, to a second reactive component connected to a fifth node. The second impedance is such that a second current therethrough is dependent on the negative of the sum of the voltages at the second and fourth nodes. The band-pass filter further comprises summing means for summing the voltages at the second and fourth nodes to output a voltage at a sixth node.Type: ApplicationFiled: January 5, 2017Publication date: January 17, 2019Applicant: UNIVERSITÄT ZÜRICHInventors: Minhao YANG, Shih-Chii LIU
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Publication number: 20190016797Abstract: The present invention relates to antibodies binding to human interleukin-2 (hIL-2). The invention more specifically relates to humanized antibodies specifically binding a particular epitope of hIL-2 and, when bound to this epitope, displaying a unique capability of inhibiting binding of hIL-2 to CD25.Type: ApplicationFiled: January 11, 2017Publication date: January 17, 2019Applicants: Novartis AG, Universität ZürichInventors: Natalia Arenas-Ramirez, Iwan Beuvink, Onur Boyman, Barbara Brannetti, Andreas Katopodis, Simone Popp, Catherine Regnier, Chao Zou