Abstract: The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of insect bite hypersensitivity of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating insect bite hypersensitivity of equine mammals, preferably of horses.

Abstract: A system for generating a traveling field free line, traveling along a propagation direction different from the orientation of said traveling field free line, said system comprising at least a first and a second coil assembly, wherein said first coil assembly is configured for generating a first stationary field free line at a first location when a current is flowing in the first coil assembly and the second coil assembly is current free, and wherein said second coil assembly is configured for generating a second stationary field free line at a second location, when a current is flowing in the second coil assembly and the first coil assembly is current free. The system further comprises a controller configured for driving the first and second coil assemblies with corresponding driving currents synchronized with each other, such that said traveling field free line travels along the propagation direction from a first location towards a second location.

Abstract: An apparatus for detecting a spatial elongation of at least one adherent biological cell is provided. The apparatus contains at least one biological cell, which is adhered to a substrate, a laser for irradiating the at least one biological cell for a spatial elongation of the cell in a direction parallel to the irradiation direction and a detector for detecting the spatial elongation of the cell in the direction parallel to the radiation direction. Further, a corresponding method for spatial elongation of an adherent biological cell is provided and the uses of the apparatus and of the method proposed. Using the apparatus and method, it is possible to ascertain, from parts of adherent cells to entire groups of adherent cells, the mechanical properties in the natural, adherent state of the cell(s) in spatially selective, temporally selective and contactless fashion.

Abstract: Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated front the microfluidic substrate except at or proximate the location where the droplets arc sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.

Abstract: A method of replacing components of a gearbox and a gearbox of the wind power plant for a wind turbine includes a gearbox with a sun gear couplable to a rotor of a wind power plant. The sun gear is arranged rotatably about a rotor axis. The gearbox has a plurality of satellite units and a plurality of generators. Each satellite unit has two gear shafts and one output shaft. The two gear shafts are respectively in engagement with the sun gear and the output shaft. Each generator is associated with one of the plurality of satellite units. The plurality of satellite units are arranged and distributed over a periphery of the sun gear and are operatively connected with the sun gear. The plurality of satellite units have a modular configuration design and are releasably arranged at the sun gear.

Abstract: The present invention relates to a device for the photocatalytic reduction of a substance with a structured reaction plate and/or a structured housing, wherein the reaction plate has, at least in some regions, a surface which contains a material with negative electron affinity and which can be electronically excited with radiation having a wavelength of ?180 nm.

Abstract: A method for in-ova fertilisation determination and gender determination on a closed egg. The aim is to specify a method for the in-ovo fertilisation determination and gender determination on a closed egg. This aim is achieved by a method in which a closed egg is positioned, candled and/or illuminated, next an image of the closed egg is recorded, then the captured data are evaluated and the position of the cardiovascular system located in the egg is calculated. A detection unit is adjusted via the calculated position of the cardiovascular system by means of a positioning unit and subsequently the blood is stimulated, then the blood-specific and blood-foreign absorption spectra are detected and selected, the fertilisation is ascertained and then the spectra containing blood-foreign information are compensated by a compensation method and the spectra are classified for sex determination.

Abstract: The invention relates to a method for stably transmitting laser radiation through an optical waveguide (3), wherein two or more modes of the laser radiation propagating in the optical waveguide (3) interfere and form a mode interference pattern in the optical waveguide, as a result of which a thermally induced refractive index grating is produced in the optical waveguide (3). It is an object of the invention to demonstrate an effective approach for stabilizing the output signal of the optical waveguide (3) in a fiber-based laser/amplifier combination at high output powers, i.e. for avoiding mode instability. The invention achieves this object by virtue of the fact that a relative spatial phase shift between the mode interference pattern and the thermally induced refractive index grating is set in the direction of propagation of the laser radiation.

Abstract: The invention relates to protein particles comprising a cluster of one or more types of assembled self-contained protein, wherein the particle has a size from 50 nm to 50 micrometers; is in form of a pellet in aqueous media; is mechanically stable; and it release a particular percentage by weight of the self-contained protein within a predetermined period of time, and any other compound contained in the particle. Particular methods for obtaining the particles are also disclosed, said methods comprising the addition of salts to allow precipitation of proteins. Particular protein particles comprising lipids associated with the assembly of self-contained proteins are also disclosed. The invention also relates to several uses of the particle, in particular medical uses and to pharmaceutical and cosmetic compositions comprising the particles.

Abstract: Printing device comprising an ink reservoir that supplies ink to an exit of a nozzle forming an ink drop and comprising also a power supply that creates an electrostatic field which generates an inkjet, said inkjet carrying a net electrostatic charge and being deposited on a substrate for printing a three-dimensional item by means of a continuous fiber, characterized in that the printing device also comprises one or a plurality of electrodes that deflect said inkjet from a default trajectory in a continually controlled manner through modifying the voltage applied to each jet-deflection electrode. The printing method comprises the step of deflecting said inkjet from a default trajectory by continually modifying the electrostatic field generated around the inkjet by one or a plurality of electrodes.

Abstract: The present invention relates to a recombinant virus of the family Paramyxoviridae comprising an expressible polynucleotide encoding at least one of (i) a tumor antigen, (ii) a fragment of a tumor antigen, and (iii) a variant of (i) or (ii). The present invention further relates to a polynucleotide encoding said recombinant virus of the family Paramyxoviridae and to a host cell comprising said recombinant virus of the family Paramyxoviridae and/or said polynucleotide encoding said recombinant virus of the family Paramyxoviridae. Moreover, the present invention relates to a method for activating immune cells with antitumor activity in a sample comprising cancer cells and to further means, methods, and uses related to the present invention.

Abstract: The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents. Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+ T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.

Abstract: A method is provided for preparing a water-insoluble lignosulfonate polymer from a first solution containing lignosulfonate precursors, which involves a) separating the lignosulfonate precursors from the first solution and providing a second solution with at least 5 wt % of lignosulfonate precursors obtained from the first solution, wherein the separating comprises filtering out components with a predefined particle diameter and separating low-molecular weight components including salts and low-molecular organic compounds, b) adding a radical-forming enzyme and gas to the second solution, wherein the gas comprises oxygen, and c) polymerizing the lignosulfonate precursors of the resultant solution of b). Other related aspects are described and claimed.

Abstract: Ephrin type receptor tyrosine kinase inhibitors, also known as Eph tyrosine kinase receptor inhibitors, for treating cancer, an inflammatory disease, an autoimmune disease, or a degenerative disease characterized at least in part by the abnormal activity or expression of the Eph receptor tyrosine kinase. The inhibitors are particularly useful for treating certain cancers.

Abstract: The present invention relates to an autonomous omnidirectional drive unit including a chassis (40) defining a front third (41), which contains a first drive wheel (11) with a first gearbox (13), a second drive wheel (21) with a second gearbox (23) coaxial with a horizontal geometric axis (EH), and a battery (30) between same, an intermediate third (42) which contains a first motor (12) and a second motor (22) connected to the first and second drive wheels (11, 21) and a vertical housing (70) between same concentric with a vertical geometric axis (EV); and a rear third which contains at least one caster wheel (50), the first and second motors (12, 22) being controlled by a control device (80) which generates control commands considering the distance (D) existing between the horizontal and vertical geometric axes (EH, EV).

Abstract: A magnetic field probe (1) having a capsule (3), in which an MR-active substance (5) is encapsulated. Two coils (7, 9) are preferably arranged in the capsule (3). Advantageous production methods for magnetic field probes (1) are also described, as well as advantageous uses of the magnetic field probe (1) and methods in which magnetic field probes (1) of this kind and arrangements of magnetic field probes (1) are used.

Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.

Abstract: A device for generating laser radiation comprises a temperature-controlled optical setup comprising an optically non-linear solid state medium arranged in a resonator and an active region. The outgoing laser radiation is generated from a pump beam introduced into the optically non-linear solid state medium. A first temperature actuator and a second temperature actuator configured to independently adjust temperature values in the active region of the optically non-linear solid state medium. The first temperature actuator is configured regulate a length of the resonator by setting a first temperature value within a first portion of the active region. The second temperature actuator is configured to match phases of wavelengths generated by the outgoing laser radiation and phases of wavelengths of the pump beam radiation by setting a second temperature value within a second portion of the active region.

Abstract: Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.

Abstract: The invention relates to a method for detecting and/or identifying magnetic supraparticles using magnet particle spectroscopy (MPS) or magnet particle imaging (MPI), wherein magnetic supraparticles are provided, each of which contains a plurality of magnetic nanoparticles and which have a specific composition and/or structure. The magnetic supraparticles are exposed to at least one magnetic field, whereby at least one voltage and/or a voltage curve is induced based on the magnetic moment of the magnetic supraparticles. The at least one voltage and/or the voltage curve is detected as at least one measurement signal, and at least one spectrum is generated from the at least one measurement signal, said spectrum containing harmonics, each of which has an amplitude and a phase. The magnetic supraparticles are (uniquely) detected and/or identified using the at least one generated spectrum.