Patents Assigned to Universitätsklinikum Schleswig-Holstein
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Publication number: 20180267018Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: May 18, 2018Publication date: September 20, 2018Applicants: METANOMICS HEALTH GMBH, Universitätsklinikum Schleswig-HolsteinInventors: Hennicke Kamp, Ulrike Rennefahrt, Jens Fuhrmann, Dietrich Rein, Jochen Hampe, Clemens Schafmayer
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Patent number: 9786420Abstract: Photosensitive molecular switch, having a chelate ligand, a metal ion bonded coordinatively to the chelate ligand, the metal ion being selected from the group of metal ions consisting of Mn2+, Mn3+, Fe2+, Fe3+, Co2+ and Ni2+, a photochromic system which is bonded covalently to the chelate ligand and can be isomerized by irradiation, this system being bonded coordinatively to the metal ion in one configuration and not bonded to the metal ion in the other configuration.Type: GrantFiled: August 10, 2011Date of Patent: October 10, 2017Assignees: Christian-Albrechts-Universität zu Kiel, Universitätsklinikum Schleswig-HolsteinInventors: Rainer Herges, Olav Jansen, Felix Tuczek, Sugumar Venkataramani
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Publication number: 20150355197Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: August 18, 2015Publication date: December 10, 2015Applicants: Universitätsklinikum Schleswig-Holstein, METANOMICS HEALTH GMBHInventors: Hennicke Kamp, Ulrike Rennefahrt, Jens Fuhrmann, Dietrich Rein, Jochen Hampe, Clemens Schafmayer
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Patent number: 9140686Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: June 10, 2011Date of Patent: September 22, 2015Assignees: Metanomics Health GmbH, Universitätsklinikum Schleswig-HolsteinInventors: Hennicke Kamp, Ulrike Rennefahrt, Jens Fuhrmann, Dietrich Rein, Jochen Hampe, Clemens Schafmayer
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Patent number: 8311608Abstract: The invention relates to a method for the MRT representation of a blood vessel (A) and/or of the territory supplied by the blood vessel (A) by labeling the blood, which is guided by this blood vessel (A), by means of continuous arterial spin labeling (CASL), in a specified labeling plane (E). The position of the labeling plan (E) is varied with the provision that a specified location of the blood vessel (A) remains in the labeling plane (E). This enables, for example, a selective labeling of a blood vessel of interest to be saturated by varying the position of the labeling plane.Type: GrantFiled: October 21, 2005Date of Patent: November 13, 2012Assignee: Universitaetsklinikum Schleswig-HolsteinInventors: Richard Werner, David G. Norris
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Publication number: 20110027783Abstract: The invention relates to an exonuclease 1 (EXO1) promoter polymorphism associated with exceptional life expectancy in humans. More specifically, the invention relates to the promoter region of EXO1 where the gene has been found to be mutated. Moreover, the invention relates to a gene regulation mechanism involving transcription factor E47 as a transcriptional repressor of EXO1.Type: ApplicationFiled: December 22, 2008Publication date: February 3, 2011Applicant: UNIVERSITAETSKLINIKUM SCHLESWIG-HOLSTEINInventors: Stefan Schreiber, Almut Nebel, Andreas Till, Friederike Flachsbart, Philip Rosenstiel
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Publication number: 20110015118Abstract: The present invention relates to novel C-terminal ifapsoriasin fragments as antimicrobially acting peptides and their production and use as pharmaceuticals.Type: ApplicationFiled: November 28, 2008Publication date: January 20, 2011Applicant: UNIVERSITAETSKLINIKUM SCHLESWIG-HOLSTEINInventors: Jens-Michael Schroeder, Britta Hansmann, Zihong Wu
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Publication number: 20100121356Abstract: Apparatus for minimum invasive fasciectomy, characterized by a tubular fixation element, including two detachably interconnected semitubular shells with in each case a wedge-shaped recess formed at a proximal end and at a distal end, a deflecting bar, whose length essentially corresponds to the portion between the recesses, and lifting wedges with in each case receptacles located at the lower portion thereof for the detachable connection of the lifting wedges to the deflecting bar, wherein the titling wedges can be introduced into the wedge-shaped recesses, accompanied by a sliding apart of the detachably interconnected semitubular shells.Type: ApplicationFiled: July 10, 2007Publication date: May 13, 2010Applicant: UNIVERSITAETSKLINIKUM SCHLESWIG-HOLSTEINInventors: Rolf Hartmann, Martin Russlies, Rudolf Ascherl, Wolfgang Koller
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Publication number: 20070167388Abstract: The present invention relates to a novel system for the trans-membrane transport including the cellular uptake/delivery of nucleic acids, substances that contain a nucleic acid component, recombinant genetic material or substances that can be attached to a nucleic acid, in biological systems. In particular, the present invention relates to a nucleic acid comprising a first nucleotide sequence having a specific signal sequence, wherein said signal sequence increases or causes the uptake of the nucleic acid into a cell, and a pharmaceutical composition containing said nucleic acid.Type: ApplicationFiled: September 10, 2004Publication date: July 19, 2007Applicant: Universitätsklinikum Schleswig-Holstein Campus LübeckInventors: Georg Sczakiel, Anne Hopert, Winfried Wunsche, Marita Overhoff