Abstract: A method—implemented in vitro—for the diagnosis and/or prognosis, preferably in the early stage, of benign or malignant neoplasms of the biliary tract is provided. The method is based on the selection and measurement of the hypermethylation levels of a genetic locus in samples of nucleic acids extracted from tumor tissues and from minimally and/or non-invasive matrices from patients with BTC and a relative comparison of the hypermethylation levels with levels of the same marker in non-tumor samples. A kit for carrying out the above method is also provided.

Abstract: An ophthalmological surgical instrument may include a hollow body having an oblong shape, and a cutting assembly. The cutting assembly may include at least one arm and at least one cutting element. The at least one arm may be pivotally hinged on a base that may be stabilized to the body and adapted to be placed in rotatable cooperation with a toothed rack. The toothed rack may be slidingly positionable with respect to the base and adapted to engage with at least one pinion gear. The at least one pinion gear is positioned along an axis of rotation and integral with the at least one arm. The rack is adapted to be manually and slidingly operated by a user.

Abstract: A natural extract from seeds of Rosa canina which has a high antimicrobial activity is provided. The extract, which is diluted in water at different concentrations, constitutes an antimicrobial solution used in various fields: in environmental disinfection, both in humans and animals, as a base for antibacterial/antifungal preparations for topical, cutaneous or mucosal use. The extract is used in the preparation of disinfectant solutions that are used in the outpatient, hospital and domestic field, for air conditioner filters and for environments used for the preparation of food, as an ingredient in mouthwashes, toothpastes and skin creams.

Abstract: A sensorized garment is provided. The sensorized garment includes an wearable element on a skin having a hand-tightening or a closure device to securely constrain sensors, for example electrodes to detect electrophysiological signals, during a physical activity. The wearable element has a three-dimensional shape to uniquely define a right side and a left part of a circumferential zone when the wearable element is worn. The sensorized garment further includes a band carried by the circumferential zone, and at least one conductor connected between the sensor and a zone of the sensorized garment.

Abstract: A process that allows halogenation at the alpha-H position of alkylarenes, optionally further substituted on the aromatic or heteroaromatic ring, is described.

Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.

Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.

Abstract: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

Abstract: An organic transistor-based system for electrophysiological monitoring of cells is disclosed. The system includes a plurality of organic transistors each comprising: a floating gate electrode; a source electrode and a drain electrode; an organic semiconductor; an insulating layer; and a sensing area. A barrier mechanically separates said sensing area and a transistor area. Each organic transistor includes a control gate electrode coupled to a second portion of said floating gate electrode external to said sensing area by a capacitor. The control gate electrode is separated from said floating gate electrode by said insulating layer. The control gate electrode sets a working point of the organic transistor to which the control gate electrode belongs to by a control voltage (VGS) applied to it. In each organic transistor, an overlapping area defined by said control gate electrode formed above said floating gate is comprised between 9*10?4 cm2 and 2*10?3 cm2.

Abstract: The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2?-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.

Abstract: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.

Abstract: A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

Abstract: A method is provided for in vitro identification of drug-resistant epilepsy, which is based on the evaluation, in a biological sample, of the concentration of the metabolites 3-OH-butyrate, acetoacetate, choline, alanine, glutamate, scyllo-inositol, glucose, lactate and citrate.

Abstract: An organic transistor-based system for electrophysiological monitoring of cells is disclosed. The system includes a plurality of organic transistors each comprising: a floating gate electrode; a source electrode and a drain electrode; an organic semiconductor; an insulating layer; and a sensing area. A barrier mechanically separates said sensing area and a transistor area. Each organic transistor includes a control gate electrode coupled to a second portion of said floating gate electrode external to said sensing area by a capacitor. The control gate electrode is separated from said floating gate electrode by said insulating layer. The control gate electrode sets a working point of the organic transistor to which the control gate electrode belongs to by a control voltage (VGS) applied to it. In each organic transistor, an overlapping area defined by said control gate electrode formed above said floating gate is comprised between 9*10?4 cm2 and 2*10?3 cm2.

Abstract: An ester of a phospholipid with conjugated linoleic acid for use in the therapeutic treatment of or as a food supplement for psychiatric disorders with neuroinflammatory and neurodegenerative basis, such as depression and schizophrenia.

Abstract: A process for manufacturing physical assets for civil and/or industrial facilities on Moon, Mars and/or asteroid, as well as the kit of materials and apparatus for implementing the same. Such a kit allows in fact to implement the process of the invention by providing all materials and apparatus that will be applied on Moon, Mars and/or asteroid, thus advantageously and significantly reducing, either the costs and the volume and bulk of the materials. The process comprises the steps of enriching the regolite present in the soil in ilmenite or in iron oxides, then mixing it with aluminum powder and sending the resulting mixture to a reaction chamber for the obtention of constructive elements.

Abstract: An apparatus for the local and/or remote rehabilitation and functional evaluation of the right and/or left hand of a user includes: a number of gym tools for the execution of hand exercises, each gym tool including a mechanical part, a sensor for the transformation of measured physical parameters into electrical signals; a user interface, configured to guide the user in the use of the gym tools, and providing feedbacks to the sequence of user actions; a first processing unit, configured to manage the apparatus functions, signal processing, storing and forwarding information on the measured physical parameters to at least one external device; a short-range communication module, configured to allow a real-time close-distance control of the apparatus; a wide-range communication module, configured to allow the connection to at least one long-distance tele-monitoring system.

Abstract: A process for the production of useful materials to sustain manned space missions on Mars, as well as the kit of materials and apparatus for implementing the same, is described. Said process uses as raw feedstock only natural resources available in-situ, namely Mars atmosphere and regolith. The kit allows to implement the process of the invention by providing all materials and apparatus that will be used on the Martian soil.

Abstract: A method of visualization and characterization of the nervous system, which combines two techniques for tissue staining, mercuric impregnation and immunohistochemistry, is described. The method disclosed makes compatible one with the other procedures of staining by carrying them out on tissues subjected to adequate fixing procedures. Thus, the method makes feasible to combine morphometric analysis, which can typically be carried out with mercuric impregnation, with antigenic and/or neurochemical cellular characterization, which can typically be obtained with immunohistochemistry. The method has proven simple, reliable, and suitable for both conventional microscopy and confocal laser scanning microscopy.