Patents Assigned to Universita Degli Studi Di Cagliari
  • Patent number: 12195809
    Abstract: A method—implemented in vitro—for the diagnosis and/or prognosis, preferably in the early stage, of benign or malignant neoplasms of the biliary tract is provided. The method is based on the selection and measurement of the hypermethylation levels of a genetic locus in samples of nucleic acids extracted from tumor tissues and from minimally and/or non-invasive matrices from patients with BTC and a relative comparison of the hypermethylation levels with levels of the same marker in non-tumor samples. A kit for carrying out the above method is also provided.
    Type: Grant
    Filed: August 3, 2022
    Date of Patent: January 14, 2025
    Assignee: UNIVERSITÀ DEGLI STUDI DI CAGLIARI
    Inventors: Patrizia Zavattari, Mario Scartozzi, Eleonora Loi, Cesare Zavattari, Alessandro Tommasi, Sergio Alonso, Andrea Casadei Gardini, Matías A. Avila
  • Patent number: 12162827
    Abstract: The present invention relates to a method for the production of chromoplastid carotenoids that can be isolated from fruits. The procedure of the invention allows to selectively isolate, on the basis of the size (Size Exclusion Chromatography) and in pure form, the carotenoid in the form of regularly shaped and sized aggregates. The process includes the following steps: i) production, in suspension, of homogeneous fragments of the chromoplastidial membranes from the fruits; ii) solution isolation of the membrane components by solubilization with detergents; iii) selective and high-purity isolation of the carotenoid in the form of regular paracrystalline aggregates by a screening technique such as size exclusion chromatography (SEC—Size Exclusion Chromatography).
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: December 10, 2024
    Assignee: UNIVERSITA' DEGLI STUDI DI CAGLIARI
    Inventors: Dario Piano, Domenica Farci
  • Publication number: 20240400965
    Abstract: The present invention describes a technology to simulate extraterrestrial conditions for investigating the effect of microgravity and CO2 rich atmosphere on animal and vegetable cells cultivation and a process thereof exploiting extraterrestrial resources for producing edible biomass for the sustainment of manned space missions as well as the kit of materials and apparatus for implementing the same.
    Type: Application
    Filed: October 13, 2021
    Publication date: December 5, 2024
    Applicants: UNIVERSITA' DEGLI STUDI DI CAGLIARI (20%), UNIVERSITA' DEGLI STUDI DI SASSARI (20%), TOLO GREEN S.R.L. (20%), DISTRETTO AEROSPAZIALE SARDEGNA SOCIETA' CONSORTILE A R.L. (20%), CENTRO DI RICERCA, SVILUPPO E STUDI SUPERIORI IN SARDEGNA - CRS4 SRL (20%)
    Inventors: Giacomo Cao, Antonella Pantaleo, Alessandro Concas, Giacomo Fais, Federico Micheli, Alessia Manca, Gilberto Gabrielli
  • Publication number: 20240263249
    Abstract: A method—implemented in vitro—for the diagnosis and/or prognosis, preferably in the early stage, of benign or malignant neoplasms of the biliary tract is provided. The method is based on the selection and measurement of the hypermethylation levels of a genetic locus in samples of nucleic acids extracted from tumor tissues and from minimally and/or non-invasive matrices from patients with BTC and a relative comparison of the hypermethylation levels with levels of the same marker in non-tumor samples. A kit for carrying out the above method is also provided.
    Type: Application
    Filed: August 3, 2022
    Publication date: August 8, 2024
    Applicant: UNIVERSITÀ DEGLI STUDI DI CAGLIARI
    Inventors: Patrizia ZAVATTARI, Mario SCARTOZZI, Eleonora LOI, Cesare ZAVATTARI, Alessandro TOMMASI, Sergio ALONSO, Andrea CASADEI GARDINI, Matías A. AVILA
  • Publication number: 20240238121
    Abstract: An ophthalmological surgical instrument may include a hollow body having an oblong shape, and a cutting assembly. The cutting assembly may include at least one arm and at least one cutting element. The at least one arm may be pivotally hinged on a base that may be stabilized to the body and adapted to be placed in rotatable cooperation with a toothed rack. The toothed rack may be slidingly positionable with respect to the base and adapted to engage with at least one pinion gear. The at least one pinion gear is positioned along an axis of rotation and integral with the at least one arm. The rack is adapted to be manually and slidingly operated by a user.
    Type: Application
    Filed: May 19, 2022
    Publication date: July 18, 2024
    Applicant: UNIVERSITA' DEGLI STUDI DI CAGLIARI
    Inventors: Enrico Peiretti, Claudio IOVINO, Emanuele SIOTTO PINTOR, Pasquale BUONADONNA
  • Publication number: 20240041054
    Abstract: A natural extract from seeds of Rosa canina which has a high antimicrobial activity is provided. The extract, which is diluted in water at different concentrations, constitutes an antimicrobial solution used in various fields: in environmental disinfection, both in humans and animals, as a base for antibacterial/antifungal preparations for topical, cutaneous or mucosal use. The extract is used in the preparation of disinfectant solutions that are used in the outpatient, hospital and domestic field, for air conditioner filters and for environments used for the preparation of food, as an ingredient in mouthwashes, toothpastes and skin creams.
    Type: Application
    Filed: December 22, 2020
    Publication date: February 8, 2024
    Applicant: UNIVERSITA' DEGLI STUDI DI CAGLIARI
    Inventors: Alessandra PIRAS, Antonella IBBA, Germano ORRU', Silvia PORCEDDA
  • Publication number: 20220022815
    Abstract: A sensorized garment is provided. The sensorized garment includes an wearable element on a skin having a hand-tightening or a closure device to securely constrain sensors, for example electrodes to detect electrophysiological signals, during a physical activity. The wearable element has a three-dimensional shape to uniquely define a right side and a left part of a circumferential zone when the wearable element is worn. The sensorized garment further includes a band carried by the circumferential zone, and at least one conductor connected between the sensor and a zone of the sensorized garment.
    Type: Application
    Filed: December 5, 2019
    Publication date: January 27, 2022
    Applicants: LET'S - WEBEARABLE SOLUTIONS S.R.L. IN BREVE LET'S - S.R.L., UNIVERSITÀ DEGLI STUDI DI CAGLIARI, ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNA
    Inventors: Marta TESSAROLO, Giuseppe Arnaldo USAI, Danilo PANI, Annalisa BONFIGLIO, Eleonora SULAS, Beatrice FRABONI
  • Patent number: 11168037
    Abstract: A process that allows halogenation at the alpha-H position of alkylarenes, optionally further substituted on the aromatic or heteroaromatic ring, is described.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: November 9, 2021
    Assignees: UNIVERSITÀ DEGLI STUDI DI SASSARI, UNIVERSITÀ DEGLI STUDI DI CAGLIARI
    Inventors: Lidia Vera Giovanna De Luca, Silvia Gaspa, Antonio Valentoni, Gabriele Mulas, Andrea Porcheddu
  • Publication number: 20200375928
    Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.
    Type: Application
    Filed: August 19, 2020
    Publication date: December 3, 2020
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Università degli Studi di Cagliari
    Inventors: Satdarshan Pal Singh Monga, Amedeo Columbano
  • Patent number: 10780069
    Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: September 22, 2020
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Universitá degli Studi di Cagliari
    Inventors: Satdarshan Pal Singh Monga, Amedeo Columbano
  • Patent number: 10758557
    Abstract: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: September 1, 2020
    Assignees: Idenix Pharmaceuticals LLC, Universita degli Studi di Cagliari
    Inventors: Jean-Pierre Sommadossi, Paolo La Colla
  • Patent number: 10739304
    Abstract: An organic transistor-based system for electrophysiological monitoring of cells is disclosed. The system includes a plurality of organic transistors each comprising: a floating gate electrode; a source electrode and a drain electrode; an organic semiconductor; an insulating layer; and a sensing area. A barrier mechanically separates said sensing area and a transistor area. Each organic transistor includes a control gate electrode coupled to a second portion of said floating gate electrode external to said sensing area by a capacitor. The control gate electrode is separated from said floating gate electrode by said insulating layer. The control gate electrode sets a working point of the organic transistor to which the control gate electrode belongs to by a control voltage (VGS) applied to it. In each organic transistor, an overlapping area defined by said control gate electrode formed above said floating gate is comprised between 9*10?4 cm2 and 2*10?3 cm2.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: August 11, 2020
    Assignee: UNIVERSITA DEGLI STUDI DI CAGLIARI
    Inventors: MariaTeresa Tedesco, Annalisa Bonfiglio, Andrea Spanu, Stefano Lai, Sergio Martinoia, Piero Cosseddu
  • Patent number: 10525072
    Abstract: The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2?-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: January 7, 2020
    Assignees: Idenix Pharmaceuticals LLC, Universita Degli Studi Di Cagliari
    Inventors: Jean-Pierre Sommadossi, Paolo La Colla, David N. Standring, Vadim Bichko, Lin Qu
  • Patent number: 10363265
    Abstract: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: July 30, 2019
    Assignees: Idenix Pharmaceuticals LLC, Universita Degli Studi di Cagliari
    Inventors: Jean-Pierre Sommadossi, Paolo La Colla
  • Publication number: 20180333378
    Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 22, 2018
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Università degli Studi di Cagliari
    Inventors: Satdarshan Pal Singh Monga, Amedeo Columbano
  • Patent number: 9968628
    Abstract: A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: May 15, 2018
    Assignees: Idenix Pharmaceuticals LLC, Universita Degli Studi Di Cagliari
    Inventors: Jean-Pierre Sommadossi, Paolo LaColla
  • Publication number: 20180052177
    Abstract: A method is provided for in vitro identification of drug-resistant epilepsy, which is based on the evaluation, in a biological sample, of the concentration of the metabolites 3-OH-butyrate, acetoacetate, choline, alanine, glutamate, scyllo-inositol, glucose, lactate and citrate.
    Type: Application
    Filed: March 2, 2016
    Publication date: February 22, 2018
    Applicant: Universita' Degli Studi Di Cagliari
    Inventors: Luigi Atzori, Federica Murgia, Francesco Marrosu, Francesco Del Carratore
  • Publication number: 20180031520
    Abstract: An organic transistor-based system for electrophysiological monitoring of cells is disclosed. The system includes a plurality of organic transistors each comprising: a floating gate electrode; a source electrode and a drain electrode; an organic semiconductor; an insulating layer; and a sensing area. A barrier mechanically separates said sensing area and a transistor area. Each organic transistor includes a control gate electrode coupled to a second portion of said floating gate electrode external to said sensing area by a capacitor. The control gate electrode is separated from said floating gate electrode by said insulating layer. The control gate electrode sets a working point of the organic transistor to which the control gate electrode belongs to by a control voltage (VGS) applied to it. In each organic transistor, an overlapping area defined by said control gate electrode formed above said floating gate is comprised between 9*10?4 cm2 and 2*10?3 cm2.
    Type: Application
    Filed: February 4, 2016
    Publication date: February 1, 2018
    Applicants: Università degli Studi di Cagliari, Università degli Studi di Genova
    Inventors: MariaTeresa TEDESCO, Annalisa BONFIGLIO, Andrea SPANU, Stefano LAI, Sergio MARTINOIA, Piero COSSEDDU
  • Publication number: 20170258924
    Abstract: An ester of a phospholipid with conjugated linoleic acid for use in the therapeutic treatment of or as a food supplement for psychiatric disorders with neuroinflammatory and neurodegenerative basis, such as depression and schizophrenia.
    Type: Application
    Filed: July 27, 2015
    Publication date: September 14, 2017
    Applicant: UNIVERSITA' DEGLI STUDI DI CAGLIARI
    Inventors: Sebastiano Banni, Miriam Melis, Marco Pistis, Valeria Sogos
  • Patent number: 9435111
    Abstract: A process for manufacturing physical assets for civil and/or industrial facilities on Moon, Mars and/or asteroid, as well as the kit of materials and apparatus for implementing the same. Such a kit allows in fact to implement the process of the invention by providing all materials and apparatus that will be applied on Moon, Mars and/or asteroid, thus advantageously and significantly reducing, either the costs and the volume and bulk of the materials. The process comprises the steps of enriching the regolite present in the soil in ilmenite or in iron oxides, then mixing it with aluminum powder and sending the resulting mixture to a reaction chamber for the obtention of constructive elements.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: September 6, 2016
    Assignees: Università degli Studi di Cagliari Dipartimento di Ingegneria e Materiali, A.S.I Agenzia Italiana Spaziale
    Inventors: Giacomo Cao, Alessandro Concas, Massimo Pisu, Roberto Orru′, Roberta Licheri, Gianluca Corrias, Claudio Zanotti