Patents Assigned to Universita Degli Studi Di Cagliari
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Patent number: 12195809Abstract: A method—implemented in vitro—for the diagnosis and/or prognosis, preferably in the early stage, of benign or malignant neoplasms of the biliary tract is provided. The method is based on the selection and measurement of the hypermethylation levels of a genetic locus in samples of nucleic acids extracted from tumor tissues and from minimally and/or non-invasive matrices from patients with BTC and a relative comparison of the hypermethylation levels with levels of the same marker in non-tumor samples. A kit for carrying out the above method is also provided.Type: GrantFiled: August 3, 2022Date of Patent: January 14, 2025Assignee: UNIVERSITÀ DEGLI STUDI DI CAGLIARIInventors: Patrizia Zavattari, Mario Scartozzi, Eleonora Loi, Cesare Zavattari, Alessandro Tommasi, Sergio Alonso, Andrea Casadei Gardini, Matías A. Avila
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Patent number: 12162827Abstract: The present invention relates to a method for the production of chromoplastid carotenoids that can be isolated from fruits. The procedure of the invention allows to selectively isolate, on the basis of the size (Size Exclusion Chromatography) and in pure form, the carotenoid in the form of regularly shaped and sized aggregates. The process includes the following steps: i) production, in suspension, of homogeneous fragments of the chromoplastidial membranes from the fruits; ii) solution isolation of the membrane components by solubilization with detergents; iii) selective and high-purity isolation of the carotenoid in the form of regular paracrystalline aggregates by a screening technique such as size exclusion chromatography (SEC—Size Exclusion Chromatography).Type: GrantFiled: July 26, 2019Date of Patent: December 10, 2024Assignee: UNIVERSITA' DEGLI STUDI DI CAGLIARIInventors: Dario Piano, Domenica Farci
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Publication number: 20240400965Abstract: The present invention describes a technology to simulate extraterrestrial conditions for investigating the effect of microgravity and CO2 rich atmosphere on animal and vegetable cells cultivation and a process thereof exploiting extraterrestrial resources for producing edible biomass for the sustainment of manned space missions as well as the kit of materials and apparatus for implementing the same.Type: ApplicationFiled: October 13, 2021Publication date: December 5, 2024Applicants: UNIVERSITA' DEGLI STUDI DI CAGLIARI (20%), UNIVERSITA' DEGLI STUDI DI SASSARI (20%), TOLO GREEN S.R.L. (20%), DISTRETTO AEROSPAZIALE SARDEGNA SOCIETA' CONSORTILE A R.L. (20%), CENTRO DI RICERCA, SVILUPPO E STUDI SUPERIORI IN SARDEGNA - CRS4 SRL (20%)Inventors: Giacomo Cao, Antonella Pantaleo, Alessandro Concas, Giacomo Fais, Federico Micheli, Alessia Manca, Gilberto Gabrielli
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Publication number: 20240263249Abstract: A method—implemented in vitro—for the diagnosis and/or prognosis, preferably in the early stage, of benign or malignant neoplasms of the biliary tract is provided. The method is based on the selection and measurement of the hypermethylation levels of a genetic locus in samples of nucleic acids extracted from tumor tissues and from minimally and/or non-invasive matrices from patients with BTC and a relative comparison of the hypermethylation levels with levels of the same marker in non-tumor samples. A kit for carrying out the above method is also provided.Type: ApplicationFiled: August 3, 2022Publication date: August 8, 2024Applicant: UNIVERSITÀ DEGLI STUDI DI CAGLIARIInventors: Patrizia ZAVATTARI, Mario SCARTOZZI, Eleonora LOI, Cesare ZAVATTARI, Alessandro TOMMASI, Sergio ALONSO, Andrea CASADEI GARDINI, Matías A. AVILA
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Publication number: 20240238121Abstract: An ophthalmological surgical instrument may include a hollow body having an oblong shape, and a cutting assembly. The cutting assembly may include at least one arm and at least one cutting element. The at least one arm may be pivotally hinged on a base that may be stabilized to the body and adapted to be placed in rotatable cooperation with a toothed rack. The toothed rack may be slidingly positionable with respect to the base and adapted to engage with at least one pinion gear. The at least one pinion gear is positioned along an axis of rotation and integral with the at least one arm. The rack is adapted to be manually and slidingly operated by a user.Type: ApplicationFiled: May 19, 2022Publication date: July 18, 2024Applicant: UNIVERSITA' DEGLI STUDI DI CAGLIARIInventors: Enrico Peiretti, Claudio IOVINO, Emanuele SIOTTO PINTOR, Pasquale BUONADONNA
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Publication number: 20240041054Abstract: A natural extract from seeds of Rosa canina which has a high antimicrobial activity is provided. The extract, which is diluted in water at different concentrations, constitutes an antimicrobial solution used in various fields: in environmental disinfection, both in humans and animals, as a base for antibacterial/antifungal preparations for topical, cutaneous or mucosal use. The extract is used in the preparation of disinfectant solutions that are used in the outpatient, hospital and domestic field, for air conditioner filters and for environments used for the preparation of food, as an ingredient in mouthwashes, toothpastes and skin creams.Type: ApplicationFiled: December 22, 2020Publication date: February 8, 2024Applicant: UNIVERSITA' DEGLI STUDI DI CAGLIARIInventors: Alessandra PIRAS, Antonella IBBA, Germano ORRU', Silvia PORCEDDA
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Publication number: 20220022815Abstract: A sensorized garment is provided. The sensorized garment includes an wearable element on a skin having a hand-tightening or a closure device to securely constrain sensors, for example electrodes to detect electrophysiological signals, during a physical activity. The wearable element has a three-dimensional shape to uniquely define a right side and a left part of a circumferential zone when the wearable element is worn. The sensorized garment further includes a band carried by the circumferential zone, and at least one conductor connected between the sensor and a zone of the sensorized garment.Type: ApplicationFiled: December 5, 2019Publication date: January 27, 2022Applicants: LET'S - WEBEARABLE SOLUTIONS S.R.L. IN BREVE LET'S - S.R.L., UNIVERSITÀ DEGLI STUDI DI CAGLIARI, ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNAInventors: Marta TESSAROLO, Giuseppe Arnaldo USAI, Danilo PANI, Annalisa BONFIGLIO, Eleonora SULAS, Beatrice FRABONI
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Patent number: 11168037Abstract: A process that allows halogenation at the alpha-H position of alkylarenes, optionally further substituted on the aromatic or heteroaromatic ring, is described.Type: GrantFiled: October 17, 2018Date of Patent: November 9, 2021Assignees: UNIVERSITÀ DEGLI STUDI DI SASSARI, UNIVERSITÀ DEGLI STUDI DI CAGLIARIInventors: Lidia Vera Giovanna De Luca, Silvia Gaspa, Antonio Valentoni, Gabriele Mulas, Andrea Porcheddu
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Publication number: 20200375928Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.Type: ApplicationFiled: August 19, 2020Publication date: December 3, 2020Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Università degli Studi di CagliariInventors: Satdarshan Pal Singh Monga, Amedeo Columbano
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Patent number: 10780069Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.Type: GrantFiled: May 15, 2018Date of Patent: September 22, 2020Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Universitá degli Studi di CagliariInventors: Satdarshan Pal Singh Monga, Amedeo Columbano
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Patent number: 10758557Abstract: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.Type: GrantFiled: June 13, 2019Date of Patent: September 1, 2020Assignees: Idenix Pharmaceuticals LLC, Universita degli Studi di CagliariInventors: Jean-Pierre Sommadossi, Paolo La Colla
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Patent number: 10739304Abstract: An organic transistor-based system for electrophysiological monitoring of cells is disclosed. The system includes a plurality of organic transistors each comprising: a floating gate electrode; a source electrode and a drain electrode; an organic semiconductor; an insulating layer; and a sensing area. A barrier mechanically separates said sensing area and a transistor area. Each organic transistor includes a control gate electrode coupled to a second portion of said floating gate electrode external to said sensing area by a capacitor. The control gate electrode is separated from said floating gate electrode by said insulating layer. The control gate electrode sets a working point of the organic transistor to which the control gate electrode belongs to by a control voltage (VGS) applied to it. In each organic transistor, an overlapping area defined by said control gate electrode formed above said floating gate is comprised between 9*10?4 cm2 and 2*10?3 cm2.Type: GrantFiled: February 4, 2016Date of Patent: August 11, 2020Assignee: UNIVERSITA DEGLI STUDI DI CAGLIARIInventors: MariaTeresa Tedesco, Annalisa Bonfiglio, Andrea Spanu, Stefano Lai, Sergio Martinoia, Piero Cosseddu
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Patent number: 10525072Abstract: The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2?-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.Type: GrantFiled: December 16, 2015Date of Patent: January 7, 2020Assignees: Idenix Pharmaceuticals LLC, Universita Degli Studi Di CagliariInventors: Jean-Pierre Sommadossi, Paolo La Colla, David N. Standring, Vadim Bichko, Lin Qu
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Patent number: 10363265Abstract: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.Type: GrantFiled: December 28, 2012Date of Patent: July 30, 2019Assignees: Idenix Pharmaceuticals LLC, Universita Degli Studi di CagliariInventors: Jean-Pierre Sommadossi, Paolo La Colla
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Publication number: 20180333378Abstract: Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.Type: ApplicationFiled: May 15, 2018Publication date: November 22, 2018Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Università degli Studi di CagliariInventors: Satdarshan Pal Singh Monga, Amedeo Columbano
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Patent number: 9968628Abstract: A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1?, 2? or 3?-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.Type: GrantFiled: November 13, 2012Date of Patent: May 15, 2018Assignees: Idenix Pharmaceuticals LLC, Universita Degli Studi Di CagliariInventors: Jean-Pierre Sommadossi, Paolo LaColla
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Publication number: 20180052177Abstract: A method is provided for in vitro identification of drug-resistant epilepsy, which is based on the evaluation, in a biological sample, of the concentration of the metabolites 3-OH-butyrate, acetoacetate, choline, alanine, glutamate, scyllo-inositol, glucose, lactate and citrate.Type: ApplicationFiled: March 2, 2016Publication date: February 22, 2018Applicant: Universita' Degli Studi Di CagliariInventors: Luigi Atzori, Federica Murgia, Francesco Marrosu, Francesco Del Carratore
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Publication number: 20180031520Abstract: An organic transistor-based system for electrophysiological monitoring of cells is disclosed. The system includes a plurality of organic transistors each comprising: a floating gate electrode; a source electrode and a drain electrode; an organic semiconductor; an insulating layer; and a sensing area. A barrier mechanically separates said sensing area and a transistor area. Each organic transistor includes a control gate electrode coupled to a second portion of said floating gate electrode external to said sensing area by a capacitor. The control gate electrode is separated from said floating gate electrode by said insulating layer. The control gate electrode sets a working point of the organic transistor to which the control gate electrode belongs to by a control voltage (VGS) applied to it. In each organic transistor, an overlapping area defined by said control gate electrode formed above said floating gate is comprised between 9*10?4 cm2 and 2*10?3 cm2.Type: ApplicationFiled: February 4, 2016Publication date: February 1, 2018Applicants: Università degli Studi di Cagliari, Università degli Studi di GenovaInventors: MariaTeresa TEDESCO, Annalisa BONFIGLIO, Andrea SPANU, Stefano LAI, Sergio MARTINOIA, Piero COSSEDDU
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Publication number: 20170258924Abstract: An ester of a phospholipid with conjugated linoleic acid for use in the therapeutic treatment of or as a food supplement for psychiatric disorders with neuroinflammatory and neurodegenerative basis, such as depression and schizophrenia.Type: ApplicationFiled: July 27, 2015Publication date: September 14, 2017Applicant: UNIVERSITA' DEGLI STUDI DI CAGLIARIInventors: Sebastiano Banni, Miriam Melis, Marco Pistis, Valeria Sogos
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Patent number: 9435111Abstract: A process for manufacturing physical assets for civil and/or industrial facilities on Moon, Mars and/or asteroid, as well as the kit of materials and apparatus for implementing the same. Such a kit allows in fact to implement the process of the invention by providing all materials and apparatus that will be applied on Moon, Mars and/or asteroid, thus advantageously and significantly reducing, either the costs and the volume and bulk of the materials. The process comprises the steps of enriching the regolite present in the soil in ilmenite or in iron oxides, then mixing it with aluminum powder and sending the resulting mixture to a reaction chamber for the obtention of constructive elements.Type: GrantFiled: July 28, 2011Date of Patent: September 6, 2016Assignees: Università degli Studi di Cagliari Dipartimento di Ingegneria e Materiali, A.S.I Agenzia Italiana SpazialeInventors: Giacomo Cao, Alessandro Concas, Massimo Pisu, Roberto Orru′, Roberta Licheri, Gianluca Corrias, Claudio Zanotti