Abstract: The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.

Abstract: Disclosed herein inter alia are Boron containing compounds and methods for treating infections related to antibiotic resistant microorganisms.

Abstract: A method is described for the diagnosis and/or monitoring of active or previous infection by Mucor which consists in the identification of Mucorales-specific T cells in samples from biological fluids taken from the patient and put into contact with a Mucor antigen. These specific immune responses can be detected by the execution of immunoenzymatic assays (ELISPOT, Quantiferon) or of immunocytofluorimetric assays [Cytokine Secretion Assay (CSA), Intracellular Cytokine Staining (ICS)] in vitro. In greater detail, the method in question provides for checking for the presence of specific IFN-? producing T cells, of specific IL-10 producing T cells and/or specific IL-4 producing T cells.

Abstract: Various embodiments select at least one service provider from a plurality of service providers in a computing environment. In one embodiment, a service request is received from a user. The service request comprises at least a set of service requirements to be satisfied by at least one service provider. A satisfaction level is predicted for each of a plurality of service providers with respect to each of the set of service requirements. The prediction is based on a prediction satisfaction model associated with each of the plurality of service providers. A probability of an actual observed satisfaction level being higher than at least a user defined threshold is calculated for each of the predicted satisfaction levels. At least one service provider is selected from the plurality of service providers for satisfying the service request based on the probability that has been calculated for each satisfaction level predicted.

Abstract: Various embodiments select at least one service provider from a plurality of service providers in a computing environment to satisfy at least one service request. In one embodiment, a service request is received from a user. The service request includes at least a set of service requirements to be satisfied by at least one service provider. A satisfaction level is predicted for each of a plurality of service providers with respect to each of the set of service requirements. The prediction is based on a prediction satisfaction model associated with each of the plurality of service providers. At least one service provider is selected from the plurality of service providers for satisfying the service request based on the satisfaction level predicted for each of the plurality of service providers.

Abstract: Provided are peptides that bind to the thymidylate synthase protein, in particular to human thymidylate synthase (hTS) protein, for the treatment of cancer. Further provided are peptides that can bind at a binding site located at the interface of thymidylate synthase protein. These peptides range from 3 to 10, preferably 4-8 amino acids and have a sequence that binds to each subunit of the thymidylate synthase dimer at the level of dimer interface, stabilizing the dimeric inactive form of the thymidylate synthase enzyme. In addition, provided are pharmaceutical compositions including these compounds as active agents, and uses thereof for the treatment of cancer and to reverse or/and be active in cancer drug resistance.

Abstract: Disclosed herein inter alia are Boron containing compounds and methods for treating infections related to antibiotic resistant microorganisms.

Abstract: A nozzle is capable of producing a mixing of two primitive fluid jets and a selective and controllable angular deviation of the synthetic jet obtained by mixing the primitive jets without any moving mechanical part. The nozzle is also capable of generating a controllable deviation of the synthetic jet and of changing the direction of this jet in a continuous and dynamic manner so as to allow the jet to sweep a preset and arbitrary angle. The nozzle is constituted, in a first part thereof, by a conduit divided into two channels by a central baffle and, in a second part thereof, by a convergence zone and an outflow mouth whose walls have a curvilinear profile and are connected seamlessly to the walls of the conduit.

Abstract: A method is described for the diagnosis and/or monitoring of active or previous infection by Mucor which consists in the identification of Mucorales-specific T cells in samples from biological fluids taken from the patient and put into contact with a Mucor antigen. These specific immune responses can be detected by the execution of immunoenzymatic assays (ELISPOT, Quantiferon) or of immunocytofluorimetric assays [Cytokine Secretion Assay (CSA), Intracellular Cytokine Staining (ICS)] in vitro. In greater detail, the method in question provides for checking for the presence of specific IFN-? producing T cells, of specific IL-10 producing T cells and/or specific IL-4 producing T cells.

Abstract: A control system for controlling horizontal trim of a flying saucer comprises a plurality of horizontal vanes, automatically and passively selectively movable between a first rest configuration and a perturbed configuration, in response to an undesired variation in a flight trim of the flying saucer.