Abstract: The present invention relates to the field of the formulation of bioactive compounds. More specifically, it relates to the use of wet silica-based polymers obtained with the sol-gel technology for the incorporation and prolonged release of an active ingredient, preferably of a protein for topical use, for example in the treatment of chronic ulcers and for the improvement of the trophism of skin appendages. The composition of the invention has several advantages, in particular it has a long permanence in the application point, by avoiding that the composition drips or dries up in contact with air.

Abstract: The present invention concerns the therapeutic use of extracellular vesicles isolated from a genetically modified cell line over-expressing SerpinB3. In particular, said therapeutic use aimed at the treatment of acute pathologies characterized by ischemic or inflammatory tissue damage or by cell injury due to oxidative stress, such as cardiac, cerebral, intestinal, renal or limb ischaemia. Further examples of use consist of the preservation of transplant organs, including heart, lung, liver, bladder, pancreas and intestine. In a further aspect the invention relates to the use of a pharmaceutical composition comprising extracellular vesicles isolated from a genetically modified cell line over-expressing SerpinB3 and a pharmaceutically acceptable vehicle.

Abstract: A device (12) for measuring the water content of the ground, vegetation and snow, comprises: at least one first module (20) adapted to measure a flow of cosmic rays incident to the ground; at least one second module (40) adapted to measure an ambient neutron flow; and a control unit (60) connected to said at least one first module (20) and said at least one second module (40). The control unit (60) is adapted to process the measurements of said at least one first module (20) and said at least one second module (40) to determine the measurement of the water content.

Abstract: The present invention relates to a promoter sequence for efficient and sufficient expression of transgenes as well as to gene transfer vectors comprising said promoter sequence for use in therapy. In particular, the present invention relates to lentiviral vectors that provide gene therapy for pathological conditions of the central nervous system.

Abstract: A polarization modulation method of photonic pulses, in particular for generating quantum cryptographic keys, ensures an optimum stability of the outgoing polarization states, and comprises the steps of: generating a plurality of photonic pulses with an unspecified polarization state obtained by the overlapping of both the horizontal and vertical polarization modes thereof, and routing them in a first polarization-maintaining fiber; splitting said horizontal and vertical polarization modes and routing them in respective terminals of a second polarization-maintaining fiber forming a ring, whereby they travel such ring clockwise and counter-clockwise respectively, or vice versa; inducing a respective phase modulation (oe, ol) of both said polarization modes, in one point of said ring which is spaced from said terminals by optical paths having different length along said ring, thereby a polarization-maintaining fiber delay line is determined; and recombining said polarization modes in one single photonic pulse b

Abstract: A polarization modulation method of photonic pulses includes: generating a plurality of photonic pulses with an unspecified polarization state obtained by the overlapping of both the horizontal and vertical polarization modes thereof, and routing them in a first polarization-maintaining fiber; splitting the horizontal and vertical polarization modes and routing them in respective terminals of a second polarization-maintaining fiber forming a ring, whereby they travel clockwise and counter-clockwise respectively, or vice versa; inducing a respective phase modulation of both polarization modes, in one point of the ring which is spaced from said terminals by optical paths having different length along said ring, thereby a polarization-maintaining fiber delay line is determined; and recombining the polarization modes in one single photonic pulse beam, and routing the resulting beam through the first polarization-maintaining fiber, by obtaining, at the output thereof, a polarization state of the pulses depending u

Abstract: An active-clamped isolated SEPIC DC-DC power converter (ACISC) to convert a DC voltage to supply a variety of DC loads. The single-ended primary-inductor converter (SEPIC) of the ACISC may be configured to perform both buck and boost converter functions. The ACISC of this disclosure may be configured to operate over a wide input voltage range to provide an output voltage for DC electronic loads supplied by the power converter. In the example of an automobile, a back-up twelve volt battery may output voltages to the ACISC over a wide voltage range, e.g., nine volts to eighteen volts. The wide input voltage range of the ACISC may be desirable when used as the converter for a back-up battery supply. The circuitry arrangement and component selection of the ACISC of this disclosure cause the power converter to operate in resonant DCM mode in the megahertz (MHz) frequency range.

Abstract: An active-clamped isolated SEPIC DC-DC power converter (ACISC) to convert a DC voltage to supply a variety of DC loads. The single-ended primary-inductor converter (SEPIC) of the ACISC may be configured to perform both buck and boost converter functions. The ACISC of this disclosure may be configured to operate over a wide input voltage range to provide an output voltage for DC electronic loads supplied by the power converter. In the example of an automobile, a back-up twelve volt battery may output voltages to the ACISC over a wide voltage range, e.g., nine volts to eighteen volts. The wide input voltage range of the ACISC may be desirable when used as the converter for a back-up battery supply. The circuitry arrangement and component selection of the ACISC of this disclosure cause the power converter to operate in resonant DCM mode in the megahertz (MHz) frequency range.

Abstract: The present invention relates to a cleaning apparatus (100) for metal smallware, comprising: a washing chamber (1) apt to receive a solvent and at least one batch of metal smallware soiled with lubricant and configured to carry out a washing cycle to remove at least part of said lubricant from said batch of metal smallware soiled with lubricant by means of said solvent and; suction means (2) connected to said washing chamber (1) and configured to carry out a discharge cycle by sucking said gaseous mixture comprising air and solvent from said washing chamber (1); a main absorption column (4) having a first side (41) and a second side (42) opposite each other, and wherein said first side (41) is hydraulically connected to said suction means (2) so as to receive said gaseous mixture comprising air and solvent and said second side (42) is hydraulically connected to a supply duct (3) so as to receive an absorption liquid from the latter.

Abstract: The invention relates to the field of gene therapy and more specifically to hematopoietic stem and progenitor cells that have been genetically modified to express functional progranulin. Suitably, HSPCs that have gene edited using CRISPR/Cas technology, or have been transduced with lentiviral gene delivery vehicles. The invention also relates to the use of such modified HSPCs in therapy. In particular, the invention relates to use of the modified progranulin expressing HSPCs in the prevention or treatment of a neurodegenerative disease mediated by dysfunctional progranulin expression, such as frontotemporal dementia (FTD).

Abstract: A configurable hardware device comprises a configuration memory of a known total size, and a configurable fabric arranged for being configured according to information from the configuration memory and segmented in a static partition and at least one dynamic partition. A static partition is arranged for receiving a bit stream and a cryptographic nonce and comprises a read/write mechanism for interacting with the configuration memory. The received bit stream is stored in the configuration memory and used to configure an intended application in the dynamic partition. The static partition is arranged for computing, based on the cryptographic nonce, a checksum of the entire configuration memory and for outputting the checksum.

Abstract: The present invention relates to a rapid method for the direct quantification of Aflatoxin M1 (AFM1) in a sample of milk. The invention also relates to a device and the use thereof in implementing said method.

Abstract: The present description relates to 1-piperidinepropionic acid or pharmaceutically acceptable salts thereof, or pharmaceutical compositions comprising it, for use in the treatment of chronic fibrosing diseases.

Abstract: A field kit for a death scene investigation includes: a first table of values corresponding to causes of death; a second table of values corresponding to a victim's history of mental illness; a third table of values corresponding to consistency between death scene evidence and a suicidal dynamic; a fourth table of values corresponding to a number of suicidal methods involved in the victim's death; a fifth table of values corresponding to a compatibility of suicidal methods and injuries to the victim with a suicidal dynamic; a sixth table of values corresponding to a presence of positive indicators of suicide; a seventh table of values corresponding to a classification of death between a death compatible with a suicide and a death incompatible with a suicide; a telecommunications device; and a computing device comprising a memory and a processor.

Abstract: Method for detecting biomechanical and functional parameters of the knee in a situation of performance stress, which comprises: a step for the set up of video recording means (1); a step for the set up of multiple optical markers (4) at specific landmark anatomic points (PA) of the foot and of the knee of a person; a step for the set up, at the plantar surface of the foot, of baropodometric means (5); a step for the acquisition, by means of the video recording means (1), of images of at least one reference action, and a step for the detection, by means of the baropodometric means (5), of baropodometric parameters; a step for calculating, from the baropodometric parameters, the coordinates of the center of pressure (COP) of the foot and of the constraining reaction force (FV) acting on the foot; a step for calculating a force arm (BF) given by the distance between the center of pressure (COP) and a reference point (PR) of the knee; a step for calculating a biomechanical parameter indicative of the valgus momen

Abstract: The present invention relates to a colorimetric sensor for measuring pH based on the H coordinate of the HSV color space.

Abstract: The invention concerns the use of 1-Piperidinpropionic acid or salts thereof, for the treatment of tumors that express SerpinB3.

Abstract: The invention provides a modified bio-related substance that shows further prolonged half-life in blood and further improved stability in the blood of living organisms. In particular, the invention provides a conjugate of a block polymer and a bio-related substance, which conjugate is represented by the following formula (I), wherein each symbol is as described herein.

Abstract: Sarcoglycanopathies are autosomal recessive diseases caused by mutations in the one of the genes coding for any sarcoglycans (SG). The inventors previously showed that the application of small molecules developed to rescue ?F508-CFTR trafficking, and known as CFTR correctors, improved the maturation of several ?-sarcoglycan mutants that were consequently rescued at the plasma membrane (WO 014086687). Now, the inventors show that some specific CFTR correctors provide additive and even synergic effect when administered in combination.

Abstract: The invention relates to new peptides and their use as pesticides. In particular, these peptides have been advantageously used for the treatment of vine peronospora (downy mildew).