Patents Assigned to Universita' Degli Studi Di Treiste
  • Peptidomimetic inhibitors of retroviral proteases and their use as antivirals
    Patent number: 7691818
    Abstract: New peptidomimetic inhibitors of retroviral proteases are in particular for human immunodeficiency virus (HIV) protease. These inhibitors include as the core structure a new diamiriodiol isostere of the dipeptide Phe-Pro having four stereogenic centers. The inhibitors have been shown to inhibit HIV-protease and can therefore be usefully employed as antivirals for post-exposure prophylaxis and as a therapy for viral infections by a retrovirus, in particular HIV. The syntheses processes of the isosteres and inhibitors are also described.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: April 6, 2010
    Assignee: Universita' Degli Studi Di Treiste
    Inventors: Fabio Benedetti, Alessandro Tossi, Federico Berti, Pietro Campaner, Francesca Dinon