Abstract: The present invention refers to the EMID2 protein or its EMI domain or a nucleic acid coding thereof for use for the treatment of a tumor or for the treatment or prevention of metastasis. Compositions, vectors and formulations for the administration of EMID2 or its EMI domain or a nucleic acid coding thereof for the above mentioned uses are also within the scope of the invention.

Abstract: The present invention relates to an inhibitor of the TGS1 enzyme and/or compositions comprising such inhibitor and one or more excipients for the therapeutic treatment of clinical conditions characterized and/or caused by telomeropathies.

Abstract: Method, device and machine for calculating an index representative of properties of a material of the bone type of an individual to be subjected to tests, particularly wherein the method includes a first acquisition step for acquiring at least one image having a plurality of elementary units of a sample of the material, wherein a generation step is provided for generating a grid of elementary geometric elements, or cells, which is associated with, in particular superimposed on, the image, an image processing step in which it is provided to calculate at least the apparent elastic modulus and a density coefficient of the material, both as a function of characteristic values of each cell, and a calculation step for calculating the index representative of the properties of a material, wherein the index is a function of the value of the apparent elastic modulus net of the contribution of the density coefficient.

Abstract: Disclosed are adducts of boric acid and chitosan wherein the amino groups of the D-glucosamine units are bonded to residues of polyol or alditol oligosaccharides, the molar ratio between boric acid and the repeating chitosan unit ranging between 0.001 and 4.

Abstract: Disclosed are adducts of boric acid and chitosan wherein the amino groups of the D-glucosamine units are bonded to residues of polyol or alditol oligosaccharides, the molar ratio between boric acid and the repeating chitosan unit ranging between 0.001 and 4.

Abstract: The present invention concerns the preparation of chemically modified derivatives of chitosan with acrylic groups and their use in the field of enamel-dentin adhesives. Chitosan derivatives have physical-chemical features (hydrophilicity, presence of electrical charges on the chain) which allow them to interact with the organic part of the demineralized tooth. At the same time, the acrylic groups incorporated in the polymer chain allow the formation of a covalent bond with the restorative material used in the dental field that is typically composed of acrylic resins. By combining the adhesion to the tooth surface and the bond with the restorative material, the chemically modified chitosan described herein is able to increase the lifespan of the dental restoration and can thus find use in the field of adhesives, in particular enamel-dentin adhesives.

Abstract: Disclosed are compounds of the formula (I) which are fluorescently labeled antagonists of the A3 adenosine receptor: wherein A, R1, R2, and Y are as described herein. Also disclosed are diagnostic compositions and a method of diagnosis of a patient for a possible treatment by an antagonist of the A3 adenosine receptor, involving the use of one or more of these compounds as diagnostic agents.

Abstract: A method for estimating the amount of carbohydrates needed by a DP-1 during a specific session of physical activity, comprises the following steps: defining of working constants and standard parameters; introducing of patient and therapy specific parameters, calculating of patient specific reference curves for a percentage carbohydrates consumption (% CHO); scheduling a training session; estimating the amount of carbohydrates (CHO) to be eaten before said physical activity; updating in real time the residual carbohydrates still available during said physical activity; and estimating the amount of carbohydrates to be restored after said physical activity.

Abstract: Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behavior with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behavior renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.

Abstract: In the present application isolated peptides and aptamers thereof able to interact with structural and conformational p53 mutants within the region of the wild-type p53 DNA binding core domain comprised from amino acids 74 to amino acids 298 using the yeast two-hybrid method are disclosed. These PAs are able to efficiently recognize several different p53 point mutants but not wild-type p53. Therefore the peptides and aptamers identified can be useful as inhibitors of mutant p53-associated pro-oncogenic functions for anticancer therapy or as diagnostic tools for mut-p53 or wild-type p53 or as template for designing new peptido-mimetic drugs able to specifically target tumor cells.

Abstract: It is described the influence of the presence of mutations in the TP53 gene in association with high levels of the enzyme prolyl isomerase Pin1 and a molecular signature of 10 genes expression correlated with the expression of Pin1 and p53 for the prognosis of breast tumors. The association between overexpression of Pin1 and the presence of protein p53 mutants induces transcriptional programs which promote tumor aggressiveness and in a cohort of patients the overexpression of Pin1 has proved to influence the prognostic value of the presence of mutations in the gene TP53. The assessment of the expression of Pin1 in the presence of mutations of the gene TP53, together with the detection of the expression of the genes forming the molecular signature can therefore be used for the prognosis of breast cancer.

Abstract: The present invention concerns a method for the identification of specific compounds which modulate brain-derived neurotrophic factor, which can be used as drugs for the treatment of neurological and neuropsychiatric diseases and which are suitable for the treatment of deleterious effects caused to the nervous system by abuse of illegal or legal drugs.

Abstract: 3D matrices or hydrogels made of human elastin-like polypeptides and their preparation are described. Said matrices can be obtained by enzymatic cross-linking of such polypeptides and can be used in the biomedical and pharmaceutical fields as support the growth of cells, isolated or as multicellular association, both on the surface and inside the matrix. Said matrices can also deliver pharmacologically active molecules, which are incorporated and then released in a controlled manner.

Abstract: Disclosed are compounds of the formula (I) which are fluorescently labeled antagonists of the A3 adenosine receptor: wherein A, R1, R2, and Y are as described herein. Also disclosed are diagnostic compositions and a method of diagnosis of a patient for a possible treatment by an antagonist of the A3 adenosine receptor, involving the use of one or more of these compounds as diagnostic agents.

Abstract: Mutations in the p53 tumor suppressor gene are frequently found in human tumors and mutant p53 proteins actively collaborate with tumor progression. Interfering with mutant p53 function may represent a valid strategy to block tumor growth and development of aggressive phenotypes. As a consequence of the characteristic of peptide aptamers (PAs) to efficiently and selectively bind a target protein, they are able to interfere with its function and in its ability to interact with other partners. In the present application isolated peptides and aptamers thereof able to interact with structural and conformational p53 mutants within the region of the wild-type p53 DNA binding core domain comprised from amino acids 74 to amino acids 298 using the yeast two-hybrid method are disclosed. These PAs are able to efficiently recognize several different p53 point mutants but not wild-type p53.

Abstract: The invention relates to a dimethylsulphoxide and limonene based paint stripping composition, preferably thickened by adding a thickener of cellulose type, and to a device for its application, formed from an absorbent layer in which the composition is included and a support layer. The device is suitable for a method of paint stripping by peeling.

Abstract: The present invention provides nanocomposite systems made of metallic nanoparticles stabilized with branched cationic polysaccharides, in particular alditolic or aldonic mono- and oligo-saccharidic derivatives of chitosan, and their preparation obtainable with aqueous solutions of these polysaccharides in the presence or absence of reducing agents. The peculiar chemical and physical-chemical features of these polysaccharides allow to form metallic nanoparticles homogeneously dispersed in the polysaccharidic matrix and an effective stabilization thereof. The properties associated with the nanometric dimensions and the presence of biological signals on polymeric chains may be exploited in applications with antimicrobial activities and of molecular biosensors.

Abstract: The present invention relates to the use of a carbon nanotube comprising positive and/or negative charges, the charges being carried by at least one charge-carrying group, the charge carrying group being covalently bound to the surface of the carbon nanotube, for the manufacture of a complex between the carbon nanotube and at least one charged molecule, the bond between the carbon nanotube and the charged molecule being essentially electrostatic, and the charged molecule comprising at least one negative charge if the carbon nanotube comprises positive charges and/or at least one positive charge if the carbon nanotube comprises negative charges.

Abstract: The present invention describes the preparation of hydrogels (or 3D matrices) obtainable from aqueous solutions of mixtures of acid polysaccharides and derivatives of basic polysaccharides, such as oligosaccharide derivatives of chitosan. Said solutions are suitably gelled with either chemical or physical gelling agents with the aim of encapsulating either cells, isolated or in multicellular associations, or pharmacologically active molecules, in solution or suspension, for use in the biomedical and pharmaceutical field.

Abstract: Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behaviour with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behaviour renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.