Abstract: The invention relates to a process for producing one or more polyunsaturated fatty acids by means of heterologous gene expression comprising the steps of providing a production organism which comprises a heterologous gene cluster encoding a polyunsaturated fatty acid biosynthetic pathway encompassing a subsequence ER encoding an enoylreductase and a subsequence AT encoding an acyltransferase, growing the production organism in the presence of a fermentable carbon source whereby one or more polyunsaturated fatty acids are produced, and optionally recovering the one or more polyunsaturated fatty acids.

Abstract: A method for displaying pixels on display devices, comprising the steps of (a) Providing virtual pixel storage means, preferably one or more virtual frame buffers (6), for temporarily storing the pixel data, (b) Receiving pixel data into the virtual pixel storage means (6) from one or more pixel sources (5), (c) Processing the pixel data stored in the virtual pixel storage means, based on characteristic display parameters characterizing the display devices; and (d) Transmitting the pixel data from the virtual pixel storage means (6) to one or more virtual displays attached to the virtual pixel storage means via a network (7), based on a network transmission protocol. The invention further relates to a system for displaying pixels on display devices.

Abstract: The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

Abstract: The invention relates to an assistance system (1, 25) for providing support in situation-dependent planning and/or guidance tasks of a controlled system (2), comprising a state detection unit (3) for detecting at least one state (5, 5a) of the controlled system (2), an acoustic receiving unit (9, 27), which is designed to receive acoustic voice signals of voice communication (24) between at least two persons (21, 22), and a voice processing unit (7), which is designed to detect voice information (10) regarding the controlled system (2) from the received acoustic voice signals, wherein the state detection unit (3) is designed to adapt the detected state (5) and/or a predicted state (5a) of the controlled system (2) that can be derived from the current state, according to the detected voice information (10).

Abstract: A head-rest of a vehicle seat with a deformable central supporting body which forms an impact zone for the head of a vehicle occupant and into which the kinetic energy of the head in the event of an accident is admitted. On both sides of the impact zone the central supporting bodies are joined by lateral supporting surfaces which are extendable out of the plane of the head-rest in the direction of travel in order to laterally support the head. In order to avoid or at least to reduce the risk of a cervical-spine whiplash injury, it is proposed according to the invention that the head-rest comprises a device for absorbing the energy admitted into the central supporting body and for outputting the absorbed energy in order to activate lateral supporting surfaces.

Abstract: The invention relates to bioactive pre-tubulysin derivatives, their preparation and pharmacological use.

Abstract: The invention relates to reactive metallic systems and to methods of producing reactive metallic systems. Such systems consist of metallic particles in the form of powders or pastes, or of metallic multilayer structures. To prevent the reaction product of the described self-propagating reactions from being a brittle material, it is suggested in the invention that the reactive metallic system be designed as a multilayer structure made up of thin layers of ruthenium and aluminium deposited sequentially one upon the other, or as a powder consisting of ruthenium and aluminium particles. The object is established according to the invention by selecting Ru/Al as the basic system. The strongest exothermic reaction and thus the greatest amount of liberated heat are to be expected from stoichiometrically constructed reactive systems. The heat of formation is highest here.

Abstract: The invention relates to the use of non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment and prophylaxis of hormone-dependent, particularly estrogen-dependent, diseases. The invention further relates to suitable inhibitors and to a method for the production thereof.

Abstract: A process for the electrochemical deposition of nanoscale catalyst particles using a sacrificial hydrogen anode as counter electrode for the working electrode is disclosed, whereby a concurrent development of hydrogen at the working electrode is mostly or completely avoided.

Abstract: The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences encoding the synthetic pathway enzymes participating in the production of Argyrins, as well as genetically manipulated micro-organisms containing nucleic acid sequences encoding the synthetic pathway enzymes for the production of Argyrins, e.g. for inserting one or more of these coding sequences, mutating in a targeted manner one or more of these nucleic acid sequences, in a wild type producer micro-organism or in a heterologous micro-organism, for the production of Argyrins.

Abstract: There is described an open cell porous structure the cells of which are optionally filled with an elastomeric or thermosetting plastic comprising a nanocrystalline metallic or nanocrystalline metal matrix composite coating wherein the nanocrystals have a crystallite size of from about 5 nm to about 150 nm. A process for preparing the coated open cell porous structures is also disclosed.

Abstract: The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

Abstract: The present invention provides a mutant form of a protein kinase its production and its use for identifying compounds that bind to the PIF-binding pocket allosteric site of the protein kinase.

Abstract: The invention relates to a method and a device for two-dimensionally representing a three-dimensional world, in which rays are combined into packets during ray tracing, and said packets of rays are processed in adequate steps.