Abstract: A surgical simulator having at least two holding elements on a support surface, wherein a bore for receiving a bearing pin is present laterally on the holding elements at least one location, and at least one bow is arranged coaxially with respect to the bearing pin which extends on a circular or rectangular line about the support surface, wherein, by a coaxial movement of the bow about the circular or rectangular line, a work field of variable size can be adjusted, and, by the movement of the bow as frame element on the holding elements, the support surface can be spanned in an arc shape, and the use of such a surgical simulator for medical and veterinary training purposes.

Abstract: Described is an integrated vertical structure for infrared sensors, Peltier cooling, and thermoelectric generator applications consisting of a thermally insulating layer which is kept at a distance to a substrate by at least two spacers. In addition, the spacers have conductor structures which serve as thermoelectric elements. A method realizes manufacturing the integrated thermoelectric structure, a method realizes the operation of the integrated thermoelectric structure as a detector, a further method realizes the operation of the integrated thermoelectric structure as a thermoelectric generator, and a method realizes the operation of the integrated thermoelectric structure as a thermoelectric Peltier element.

Abstract: The present invention pertains to an improved chemical synthesis method for Ahp-cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

Abstract: A heat assisted magnetic recording disk drive comprises a magnetic recording media with a heat sink layer including at least a material being defined by the general structure Mn+1AXn, wherein M is a transition metal, A is an A-group element, X is C or N or a mixture of C and N, and n is a positive integer, or a material defined by the general structure Mn+1AXn, wherein M is a transition metal, X is one or both of C and N, and n is a positive integer, or a mixture of the materials being defined by the general structure Mn+1AXn and the material defined by the general structure Mn+1Xn, wherein the crystal structure of the materials is hexagonal with repeated M-X-M (quasi 2D) atomic layers. The atomic layers are stacked along the {right arrow over (c)}-axis that is oriented substantially parallel to the surface normal of the heat sink layer.

Abstract: The present invention is directed towards a tubular nanosized magnetic wire, wherein the nanosized magnetic wire comprises: a tubular magnetic shell surrounding a longitudinal axis of the wire, at least one region of the tubular magnetic shell is capable of providing a 360° magnetic domain wall, wherein the 360° magnetic domain wall is self-stabilizing and has a magnetization going from a parallel alignment to a perpendicular alignment and to a parallel alignment with regards to the wire axis. The present invention also provides a practical method capable of making a tubular nanosized magnetic wire with a self-stabilizing, 360° magnetic domain wall. The present invention also relates to the use of the tubular nanosized magnetic wire in a racetrack memory device.

Abstract: The present invention is directed towards a tubular nanosized magnetic wire, wherein the nanosized magnetic wire comprises: a tubular magnetic shell surrounding a longitudinal axis of the wire, at least one region of the tubular magnetic shell is capable of providing a 360° magnetic domain wall, wherein the 360° magnetic domain wall is self-stabilizing and has a magnetization going from a parallel alignment to a perpendicular alignment and to a parallel alignment with regards to the wire axis. The present invention also provides a practical method capable of making a tubular nanosized magnetic wire with a self-stabilizing, 360° magnetic domain wall. The present invention also relates to the use of the tubular nanosized magnetic wire in a racetrack memory device.

Abstract: An implantable device for improving or remedying valvular incompetence, comprising a sealing body and at least one anchoring element (2) fastened thereto, by means of which the sealing body is able to be fastened in the heart, preferably in the atrium of the heart, wherein the sealing body comprises at least one cavity (6), which is also able to be filled with a fluid after implanting the sealing body and preferably not able to be emptied independently, and wherein, furthermore preferably, the sealing body remains expanded with constant volume during the cardiac phases as a result of the filling, characterized in that a plurality of cavities (6) are disposed about a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, or a single cavity (6) surrounds a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, wherein the main body (1) is embodied as a tube which is able to be bent out of the linear extent thereof and in

Abstract: A surgical simulator having at least two holding elements on a support surface, wherein a bore for receiving a bearing pin is present laterally on the holding elements at least one location, and at least one bow is arranged coaxially with respect to the bearing pin which extends on a circular or rectangular line about the support surface, wherein, by a coaxial movement of the bow about the circular or rectangular line, a work field of variable size can be adjusted, and, by the movement of the bow as frame element on the holding elements, the support surface can be spanned in an arc shape, and the use of such a surgical simulator for medical and veterinary training purposes.

Abstract: The present invention relates to a method for predicting the degree of radiosensitivity of a cell by determining the number of prompt double-strand breaks (prDSBs) and predicting the degree of radiosensitivity of the cell based on the number of prDSBs. The present invention relates furthermore to a method for predicting the degree of radiosensitivity of a cell by determining the number of thermally labile sugar lesion-dependent double-strand breaks (tlDSBs) and predicting the degree of radiosensitivity of the cell based on the number of tlDSBs.

Abstract: The present invention relates to an agent which inhibits Kallikrein-8 for use in the treatment or prevention of Alzheimer's disease and/or its precursor stages, as well as to methods, kits and uses relating thereto, including diagnostic tools.

Abstract: The invention provides an aerogel-concrete mixture, a high-performance aerogel concrete obtained therefrom, and a method for production thereof. The problem addressed by the present application is that of providing pressure-resistant but not very thermally conductive concretes, precast concrete components, screeds, screeds for precast components, (glassfibre-) reinforced concrete, fire protection panels, construction elements for thermal partition and blocks. The aerogel-concrete mixture contains: 10% to 85% by volume/m3 of aerogel pellets having a grain size in the range from 0.01 to 4 mm, 100 to 900 kg/m3 of inorganic hydraulic binder, 10% to 40% by weight based on the binder content of at least one silica gel suspension, 1% to 5% by weight based on the binder content of at least one plasticizer, 0.2% to 1% by weight based on the binder content of at least one stabilizer and 0% to 60% by volume/m3 of at least one lightweight aggregate.

Abstract: The invention provides a method for optical clearing of biological samples utilizing a composition comprising a cinnamate ester. The invention further provides a kit suitable for performing said method and the use of said composition for optical clearing of biological samples.

Abstract: An anti-CEACAM1 antibody includes at least one antibody heavy chain (VH) domain having antigen binding sites CDR1H, CDR2H and CDR3H, and at least one antibody light chain (VL) domain having antigen binding sites CDR1L, CDR2L and CDR3L. The antigen binding site CDR2H has a sequence homology of at least 80% to the amino acid sequence WINTYTGEPT (SEQ ID No. 21).

Abstract: The invention provides a process for the production of nanoparticles as well as a device that is disposed for the production of the nanoparticles. The process is especially characterized in that the nanoparticles are pure, especially free from organic carbon compounds, preferably carbon-free, and are obtained continuously. The nanoparticles which are obtainable by the process of the invention are characterized in that they are present without an organic ligand in suspension and are especially preferred stable as a suspension against agglomeration, wherein the medium having the particles suspended therein is free from organic carbon compounds, especially carbon-free.

Abstract: An arc reactor and a process for the production of nanoparticles are disclosed. The reactor has a crucible in a gas-tight housing having a carrier gas inlet and a spaced-apart carrier gas outlet. The carrier gas inlet is directed to the side of the crucible opposite the crucible opening. The inlet can be disposed below the crucible and directed to the side of the crucible opposite the crucible opening. The carrier gas outlet is disposed above the crucible and exits the housing above the crucible. The carrier gas outlet is formed by a hood disposed at a distance above the crucible, which is separated from the crucible and formed by an exhaust pipe that connects the hood to the carrier gas outlet of the housing. The reactor housing has at least one inlet for cooling gas. This can be directed at an interstice formed between the crucible and the hood.

Abstract: The present invention relates to the use of exosome-preparations derived from neonatal or adult tissue-derived mesenchymal stem-cells (MSCs) for the prevention or for therapy of inflammatory conditions, such as, for example, pre- and postnatally acquired damages of the brain (i.e. neuronal damages) or in complications following stem cell transplantation (“graft vs host-disease”, GvHD).

Abstract: The present invention relates to novel tumor-associated antigens, which elicit independently from a presentation via MHC a CD8-positive T-cell response. GM-CSF-Receptor alpha chain (CSF2RA) and Tyrosinase-related protein 2 (TRP-2) were found to be targets of CD8-positive T-cell clones which could detect the proteins on the surface of HLA I negative melanoma cells. Thus, the invention provides proteins, protein fragments and polypeptides of the novel antigens for use in medicine, for example for the treatment, diagnosis and prevention of a tumor disease. Furthermore provided are nucleic acids expressing the antigens of the invention, binding agents specific for the antigens of the invention, such as T-cell receptor chains and isolated T cells which are reactive against the antigens of the invention or which express the T-cell receptors of the invention.

Abstract: The disclosure relates to a pump for implantation into a vessel or a heart, with the pump being introduced in a first state into the vessel or heart in order then be functionally changed over to a second state in the vessel or in the heart, having a drive part and a delivery part, where the drive part is not functional in the first state and becomes functional as a result of the changeover to the second state, wherein the drive part has an electric motor, where the electric motor is embodied as a wet rotor, and where, in the first state, the rotor of the electric motor and the stator of the electric motor are arranged so as to be separate from one another, and where the rotor of the electric motor is moved into the stator of the electric motor in the second state, where the rotor can drive the delivery part in the second state.

Abstract: An anti-CEACAM1 antibody includes at least one antibody heavy chain (VH) domain having antigen binding sites CDR1H, CDR2H and CDR3H, and at least one antibody light chain (VL) domain having antigen binding sites CDR1L, CDR2L and CDR3L. The antigen binding site CDR2H has a sequence homology of at least 80% to the amino acid sequence WINTYTGEPT (SEQ ID No. 21).

Abstract: The present invention relates to a device for collimating electromagnetic radiation comprising a shielding structure at least partially surrounding a radiation source which has an opening in a transmission direction (A), a plurality of lamellae of a material that absorbs electromagnetic radiation which are positioned in the opening, and collimator channels between the lamellae which extend in the transmission direction (A), wherein the lamellae have a height (H) in the range of ?10 ?m to ?3000 ?m.