Patents Assigned to Universitaet Heidelberg
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Publication number: 20130101989Abstract: Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction of the expression or concentration of ISG15.Type: ApplicationFiled: April 29, 2011Publication date: April 25, 2013Applicants: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFUNG DES OEFFE, UNIVERSITAETSKLINIKUM HEIDELBERG, RUPRECHT-KARIS-UNIVERSITAET HEIDELBERGInventors: Nathalia Giese, Jens Werner, Markus Buechler, Thomas Giese, Laurent Daeffler, Celina Cziepluch, Jean Rommelaere, Zahari Raykov
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Patent number: 8414883Abstract: Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of a tumor. Tumors for which a parvovirus or the adjunction of the invention has particular utility include glioma, medulloblastoma, meningioma and pancreatic cancer. Preferred chemotherapeutic agents are gemcitabine and Temozolodine.Type: GrantFiled: December 23, 2008Date of Patent: April 9, 2013Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet HeidelbergInventors: Jean Rommelaere, Zahari Raykov, Joerg Schlehofer, Irina Kiprijanova, Tanja Heimberger, Assia Angelova, Karsten Geletneky, Marc Aprahamian
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Patent number: 8369925Abstract: A method to derive anatomical structures from non-invasive imaging technologies is provided. Non-invasive imaging technologies are computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), surface scans and others. Imaging data obtained by a non-invasive technology is used to create a surface contour. The imaging data is transmitted to a rapid prototyping apparatus as readable data. With this readable data the rapid prototyping apparatus establishes a positive or negative surface model, such as a fixation device, a mask, or a prosthesis, or other instruments for medical purposes.Type: GrantFiled: October 13, 2010Date of Patent: February 5, 2013Assignees: DKFZ Deutsches Krebforschungszentrum Stiftung des oeffentlichen Rechts, Ruprecht-Karls-Universitaet HeidelbergInventors: Frederik Giesel, Christian Zechmann, Hendrik Von Tengg-Kobligk, Marc Muenter, Juergen Debus, Rainer Neumann, Ulrike Ute Neumann née Pitsch
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Patent number: 8318185Abstract: The present invention refers to a recombinant malaria vaccine and a method for its manufacture.Type: GrantFiled: January 11, 2008Date of Patent: November 27, 2012Assignee: Ruprecht-Karls-Universität HeidelbergInventors: Hermann Bujard, Rolf Lutz, Christian Kauth, Christian Epp, Ute Wöhlbier
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Publication number: 20120237483Abstract: Described is a parvovirus for preventing recurrence of a tumor, preferably a malignant brain tumor or pancreas tumor.Type: ApplicationFiled: May 19, 2010Publication date: September 20, 2012Applicant: Ruprecht-Karls-Universitaet HeidelbergInventors: Jean Rommelaere, Zahari Raykov, Svitlana Grekova, Irina Kiprijanova, Karsten Geletneky, Ute Koch, Marc Aprahamian
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Publication number: 20120109151Abstract: The present invention relates to a system and method of computer assisted surgery in soft tissue. The system comprises a navigated instrument (14) suitable to be inserted into a living object's soft tissue body part, wherein said navigated instrument (14) when inserted into the body part is suitable to define at least a portion of a section plane with respect to said soft tissue body part. The system further comprises a computer assisted guiding means to assist or enable guiding the instrument (14) upon insertion into the body part such that the section plane defined by said inserted instrument (14) coincides with a planned section plane.Type: ApplicationFiled: March 4, 2010Publication date: May 3, 2012Applicants: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, Deutsches Krebsforschungszentrum Stiftung des öffentlichen RechtsInventors: Lena Maier-Hein, Hannes Kenngott, Hans-Peter Meinzer, Beat Peter Mueller-Stich
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Publication number: 20110293567Abstract: The present invention relates to the field of cancer therapy. Specifically, a chemotaxis fusion-receptor that directs bacteria towards tumors is disclosed. Further encompassed by the present invention is a bacterial cell that comprises at least one chemotaxis fusion-receptor and, preferably, a killing module for the destruction of tumor cells.Type: ApplicationFiled: October 26, 2009Publication date: December 1, 2011Applicants: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, DKFZ DEUTCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTSInventors: Roland Eils, Philip Hundeshagen, Yara Reis, Daniela Richter, Jens Keienburg, Michaela Reichenzeller, Michael Flossdorf, David Kentner, Erik Sommer, Victor Sourjik, Barbara Di Ventura, Philip Bayer, Yin Cai, Maximilian Hörner, Stephen Kraemer, Pascal Krämer, Andreas Kühne, Christian Moritz, Maria Renner, Dominik Niopek, Kathrin Nussbaum, Kolja Schleich, Markus Stahlberg, Anna Stöckl, Chenchen Zhu, Marika Ziesack, Adjana Eils, Nikita Vladimirov
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Patent number: 8058460Abstract: The present invention relates to anthraquinone derivatives which act as a fluorophore, to a process for producing said anthraquinone derivatives and their use as fluorophores for staining membranes in live or fixed cells.Type: GrantFiled: September 20, 2007Date of Patent: November 15, 2011Assignee: Universität HeidelbergInventors: Zuhal Kaya, Roland Krämer
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Publication number: 20110004065Abstract: An interventional aid for medical interventions, including a tube body with a tube jacket which permits intubation and which, while leaving a lumen to permit ventilation, includes a functional aid for performing an interventional function. The functional aid includes an orientation mechanism orienting the tube body during the medical intervention.Type: ApplicationFiled: December 3, 2007Publication date: January 6, 2011Applicant: RUPRECHT-KARLS-UNIVERSITAET HEIDELBERGInventor: Christoph SCHRAMM
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Publication number: 20100210907Abstract: An interventional aid for medical interventions, including a tube body with a tube jacket which permits intubation and which, while leaving a lumen to permit ventilation, includes a functional aid for performing an interventional function. The functional aid includes an orientation mechanism orienting the tube body during the medical intervention.Type: ApplicationFiled: December 3, 2007Publication date: August 19, 2010Applicant: RUPRECHT-KARLS-UNIVERSITAET HEIDELBERGInventor: Christoph SCHRAMM
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Publication number: 20090130686Abstract: The method for the microscopic localization in situ of a selected intracellular native genome segment with a known nucleotide sequence is characterized by the nature and the sequence of the following measures: (1.) The target DNA is analyzed, via genome databases, for partial sequences which constitute a unique pattern within the genome. (2.) Single-stranded probe sequences are provided which are identical to these partial sequences or complementary thereto, and which are suitable for hybridizing with the single strands of these subsequences via a Watson-Crick binding. (3.) The probe sequences are coupled with marker molecules, where all units of probe sequence and marker molecule(s) have the same binding behavior or the same melting point as the single strand of the target DNA complementary thereto. (4.Type: ApplicationFiled: February 21, 2007Publication date: May 21, 2009Applicant: RUPRECHT-KARLS-UNIVERSITAET- HEIDELBERGInventors: Michael Hausmann, Christoph Cremer
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Publication number: 20090068102Abstract: Methods of treating stroke with blocking agents of TWEAK or TWEAK receptor are presented.Type: ApplicationFiled: February 15, 2006Publication date: March 12, 2009Applicants: BIOGEN IDEC MA INC., RUPRECHT-KARLS-UNIVERSITAET HEIDELBERGInventors: Linda C. Burkly, Kyungmin Hahm, Marcus Schwaninger, Ionta Inta
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Patent number: 7342717Abstract: The present invention relates to two new wave field microscopes, type I and type II, which are distinguished by the fact that they each have an illumination and excitation system, which include at least one real and one virtual illumination source, and at least one objective lens (in the case of type II), i.e., two objective lenses (in the case of type I), with the illumination sources and objective lenses being so positioned with respect to one another that they are suited for generating one-, two-, and three-dimensional standing wave fields in the object space. The calibration method in accordance with the present invention is adapted to this wave field microscopy and permits geometric distance measurements between fluorochrome-labeled object structures, whose distance can be less than the width at half maximum intensity of the effective point spread function. The invention relates moreover to a method of wave-field microscopic DNA sequencing.Type: GrantFiled: July 9, 1998Date of Patent: March 11, 2008Assignee: Ruprecht Karts Universitaet HeidelbergInventors: Michael Hausmann, Christoph Cremer, Joachim Bradl, Bernhard Schneider
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Patent number: 7122179Abstract: Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a gene whose expression is up-regulated in liver stage parasites and whose function is not required for entry into hose hepatocytes.Type: GrantFiled: March 11, 2005Date of Patent: October 17, 2006Assignees: Seattle Biomedical Research Institute, Ruprecht-Karls-Universität HeidelbergInventors: Stefan H. I. Kappe, Kai-Uwe C. Matuschewski, Ann-Kristin Mueller
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Patent number: 7115367Abstract: The invention relates to a method for specifically detecting and identifying retroviral nucleic acids/retroviruses in any item to be examined using RT-PCR and reverse dot blot hybridization (RDBH) as well as to diagnosis kits for carrying out said method. The invention also relates to retrovirus-specific, oligonucleotide/primer mixtures (MOP) which comprise forward primers and reverse primers and which are provided for generating amplification products of retrovirus-specific nucleic acids from the item to be examined. These inventive primary mixtures (MOP-ABD, MOP-C) are comprised of retrovirus-specific, degenerated oligonucleotides which correspond to the highly conserved regions located within the reverse transcriptase gene (RT-gene) of all known human retroviruses and which have a head or extension sequence consisting of a clamping and interface sequence.Type: GrantFiled: April 4, 2000Date of Patent: October 3, 2006Assignee: Ruprecht-Karls-Universität HeidelbergInventors: Wolfgang Seifarth, Christine Leib-Mösch, Corinna Baust
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Patent number: 6579306Abstract: The inventive expansion catheter has a catheter tube (11) and a perfusion tube (12) which can be moved inside the catheter tube (11). The perfusion tube (12) is connected to a stent (13) formed of a wire-type material. The stent (13) is constricted by the catheter tube (11). When, the catheter tube (11) is withdrawn, the stent (13) expands, hereby taking up two expansion areas, (16, 18) which border an area (26) to be protected from the pressure of the blood. A bypass (28) can be fixed in this area (26) by means of an anastomosis (27). The perfusion tube (26) ensures that the blood vessel (21) is supplied behind the obturation point so that the operation can be carried out as non-invasively as possible while the heart is beating.Type: GrantFiled: June 30, 2000Date of Patent: June 17, 2003Assignees: Klinikum Mannheim gGmbH, Universitaet HeidelbergInventors: Wolfram Voelker, Georg Ertl
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Patent number: 6424421Abstract: The invention concerns a method and devices for far field microscopy and flow fluorometry for geometric distance measurements between object structures, i.e. measurement structures, marked with fluorochromes, whereby the distances can be smaller than the half-intensity width of the principle maximum of the point spread function. In this method, the measurement structures are marked with fluorescent dyes with different or identical spectral signatures, according to their distances. Calibration targets with defined dimensions and arrays are marked with the same fluorescent dyes. Calibration targets and measurement structures are prepared separately or together on an object support and investigated microscopically or flow fluorometrically.Type: GrantFiled: August 25, 1999Date of Patent: July 23, 2002Assignee: Ruprecht-Karls-Universität HeidelbergInventors: Christoph Cremer, Michael Hausmann, Joachim Bradl, Bernd Rinke