Patents Assigned to Universitaet Leipzig
  • Publication number: 20210164892
    Abstract: The invention relates to a device for conducting radiation, a photodetector arrangement, and a method for spatially resolved spectral analysis.
    Type: Application
    Filed: August 14, 2019
    Publication date: June 3, 2021
    Applicant: UNIVERSITÄT LEIPZIG
    Inventor: Marius Grundmann
  • Publication number: 20210164901
    Abstract: The invention relates to a device and a method for determining a wavelength of radiation.
    Type: Application
    Filed: August 14, 2019
    Publication date: June 3, 2021
    Applicant: UNIVERSITÄT LEIPZIG
    Inventor: Marius GRUNDMANN
  • Patent number: 10774097
    Abstract: The invention relates to chemical compound of the general structure [A-R3—X—R4] where A=[R1-R2] or [R1] R1=aryl, heteroaryl R2=alkyl, aryl, heteroaryl, carbonyl, thiocarbonyl, alkyl ester, alkyl thioester R3=O, S, NH X=closo- or nido-boron cluster R4= where Z=OH, SH, NH2 where R5 is selected from H, alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and R6 is selected from alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and where R3 and R4 are in meta or para positions to one another, to a process for preparation thereof and to the use thereof, especially in medicine, for example in the inhibition of lipoxygenase.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 15, 2020
    Assignee: UNIVERSITÄT LEIPZIG
    Inventors: Evamarie Hey-Hawkins, Robert Kuhnert
  • Patent number: 10670576
    Abstract: The present invention refers to a device for measuring impedance in organotypic tissue comprising at least one recording chamber with a liquid permeable membrane supporting the organotypic tissue, at least one bottom electrode and at least one top electrode, wherein the liquid permeable membrane divides the recording chamber into a top chamber and a bottom chamber, wherein at least the bottom chamber contains culture medium for the organotypic tissue, and the bottom electrode(s) is/are located in the bottom chamber and the top electrode(s) is/are located in the top chamber, and wherein the organotypic tissue is located between the bottom electrode(s) and the top electrode(s). The present invention also refers to the use of the device according to the present invention for measuring impedance in organotypic tissue.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: June 2, 2020
    Assignee: Universität Leipzig
    Inventors: Andrea Robitzki, Andrée Rothermel, Heinz-Georg Jahnke, Ina Sternberger, Frank Striggow, Till Mack
  • Patent number: 10571498
    Abstract: A system for analyzing a microwave-frequency signal by imaging is provided, comprising: a solid material at least one optical property of which is modifiable in at least one zone of the material, when the zone is simultaneously in the presence of an optical excitation or electrical excitation and a microwave-frequency signal having at least one frequency coinciding with a resonant frequency of the material, the material furthermore being such that a value of the resonant frequency varies as a function of the amplitude of a magnetic field, a magnetic field generator configured to generate a magnetic field having, in the interior of a portion of the zone, a spatial amplitude variation in a direction X, the material then having a resonant frequency that is dependent on a position in the direction X, and a detector configured to receive an image of the zone in said direction X.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: February 25, 2020
    Assignees: THALES, UNIVERSITAET LEIPZIG
    Inventors: Mayeul Chipaux, Loic Toraille, Thierry Debuisschert, Christian Larat, Loic Morvan, Jan Meijer, Sébastien Pezzagna
  • Patent number: 10519354
    Abstract: The invention relates to a hydrophobed porous oil binder in the form of a nonwoven fabric composed of lignocellulose-containing raw materials having a biologically functionalized surface for removing mineral-oil-based contaminants in seas, rivers, inland waters, and stormwater basins or wastewater treatment plants, wherein the density of the oil binder is 10 to 900 kg/m3, the oil binder is 1 to 25 mm thick, the broad surface of the oil binder has a dimension of 9 to 200 cm2, the porosity of the oil binder is 30 to 96%, measured with respect to the total fraction of the oil binder, and the flexural strength of the oil binder is at least 1.5 N/mm2.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: December 31, 2019
    Assignees: Technische Universitaet Dresden, Universitaet Leipzig
    Inventors: Holger Unbehaun, Soren Tech, Swetlana Konig, Elena Safonova, Andre Wagenfuhr, Christian Wilhelm
  • Patent number: 10460472
    Abstract: A method for adapting a matching model of an object comprising the step of providing an electronic image of the object; providing a matching model of the object, the matching model consisting of a plurality of points; determining a pose of the object in said electronic image by using a matching approach that uses said matching model; transforming the matching model according to said pose, yielding a transformed model; determining for at least one point of said transformed model a corresponding point in said electronic image; and adapting the matching model according to the at least one determined corresponding point.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITÄT LEIPZIG
    Inventors: Tobias Böttger, Markus Ulrich, Carsten Steger
  • Patent number: 10435437
    Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: October 8, 2019
    Assignee: UNIVERSITAET LEIPZIG
    Inventors: Ralf Hoffmann, Daniel Knappe, Kai Hilpert, Ralf Mikut, Serge Ruden
  • Patent number: 10426663
    Abstract: The invention provides a device for a medical treatment of a sclera, the device comprising a single applicator connected to a shaft, wherein the applicator is configured to be placed into the Tenon's space; the applicator has a first surface, wherein the first surface of the applicator is superficially contactable to the surface of an area of the sclera so as to superficially cover said area; and the applicator comprises a single optical outlet connected to a single optical guiding element extending from a proximal end of the shaft to the single distal optical outlet at the first surface of the applicator, the optical guiding element being configured for guiding electromagnetic waves towards the optical outlet, wherein the optical guiding element is configured to guide electromagnetic waves of a wavelength adapted for thermal treatment of the sclera by protein coagulation.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: October 1, 2019
    Assignee: UNIVERSITÄT LEIPZIG
    Inventors: Hans Peter Iseli, Mike Francke, Peter Wiedemann
  • Publication number: 20190055268
    Abstract: The invention relates to chemical compound of the general structure [A-R3—X—R4] where A=[R1-R2] or [R1] R1=aryl, heteroaryl R2=alkyl, aryl, heteroaryl, carbonyl, thiocarbonyl, alkyl ester, alkyl thioester R3=O, S, NH X=closo- or nido-boron cluster R4= where Z=OH, SH, NH2 where R5 is selected from H, alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and R6 is selected from alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and where R3 and R4 are in meta or para positions to one another, to a process for preparation thereof and to the use thereof, especially in medicine, for example in the inhibition of lipoxygenase.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 21, 2019
    Applicant: UNIVERSITÄT LEIPZIG
    Inventors: Evamarie HEY-HAWKINS, Robert KUHNERT
  • Patent number: 9856298
    Abstract: The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: January 2, 2018
    Assignee: UNIVERSITAET LEIPZIG
    Inventors: Ralf Hoffmann, Nicole Berthold, Friederike Nollmann
  • Patent number: 9835560
    Abstract: The invention relates to a method for the Raman spectroscopic, in ovo sex determination of fertilized and hatched birds' eggs (1), wherein the embryo, including the extra-embryonic structures, can move in the egg, and is not yet attached to the shell at the time of measuring.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: December 5, 2017
    Assignees: TECHNISCHE UNIVERSITAET DRESDEN, UNIVERSITAET LEIPZIG
    Inventors: Roberta Galli, Grit Preusse, Edmund Koch, Gerald Steiner, Maria-Elisabeth Krautwald-Junghanns, Thomas Bartels
  • Patent number: 9801977
    Abstract: The present invention relates to the field of biology and medicine, and more specifically, to the field of stem-cell biology, involving producing or generating melanocytes from stem-cells and precursors derived from human hair root. Additionally, the present invention relates to the materials and method for producing autografts, homografts or allografts comprising melanocytes in general, as well as the materials and methods for producing autografts, homografts and allografts comprising melanocytes for the treatment of diseases related to depigmentation of the skin and for the treatment of scars.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: October 31, 2017
    Assignee: UNIVERSITÄT LEIPZIG
    Inventors: Vuk Savkovic, Christina Dieckmann, Jan-Christoph Simon, Michaela Schulz-Siegmund, Michael Hacker
  • Patent number: 9718861
    Abstract: The present invention relates to highly potent ligands at the ghrelin receptor to influence food intake or other conditions.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: August 1, 2017
    Assignee: Universitaet Leipzig
    Inventors: Annette Beck-Sickinger, Sylvia Els-Heindl, Enrico Schild, Thue W. Schwartz, Birgitte Holst Lange
  • Publication number: 20170205353
    Abstract: The invention relates to a method for the Raman spectroscopic, in ovo sex determination of fertilised and hatched birds' eggs (1), wherein the embryo, including the extra-embryonic structures, can move in the egg, and is not yet attached to the shell at the time of measuring.
    Type: Application
    Filed: July 3, 2015
    Publication date: July 20, 2017
    Applicants: TECHNISCHE UNIVERSITAET DRESDEN, UNIVERSITAET LEIPZIG
    Inventors: Roberta GALLI, Grit PREUSSE, Edmund KOCH, Gerald STEINER, Maria-Elisabeth KRAUTWALD-JUNGHANNS, Thomas BARTELS
  • Publication number: 20170191980
    Abstract: The present invention refers to a device for measuring impedance in organotypic tissue comprising at least one recording chamber with a liquid permeable membrane supporting the organotypic tissue, at least one bottom electrode and at least one top electrode, wherein the liquid permeable membrane divides the recording chamber into a top chamber and a bottom chamber, wherein at least the bottom chamber contains culture medium for the organotypic tissue, and the bottom electrode(s) is/are located in the bottom chamber and the top electrode(s) is/are located in the top chamber, and wherein the organotypic tissue is located between the bottom electrode(s) and the top electrode(s). The present invention also refers to the use of the device according to the present invention for measuring impedance in organotypic tissue.
    Type: Application
    Filed: January 18, 2017
    Publication date: July 6, 2017
    Applicant: Universität Leipzig
    Inventors: Andrea ROBITZKI, Andrée Rothermel, Heinz-Georg Jahnke, Ina Sternberger, Frank Striggow, Till Mack
  • Patent number: 9683982
    Abstract: In a method for diagnosing and/or prognosis of cancers, diagnosing origin of tumor cells, optimizing cancer therapy, and screening active substances for oncology, the mechanical properties of tumor cells and reference cells are analyzed under mechanical load that causes linear or non-linear deformation of the loaded cell. The engineering strain of the cells caused by directed mechanical stress being introduced is used to determine metastasis risk and the presence of uncontrollably proliferating and/or invasive cells, or the origin of the tumor. The metastasis risk is determined based on the proportion of cells in the sample exhibiting engineering strain in a direction opposite to the stressing direction. The risk of the presence of uncontrollably proliferating cells for non-linear deformation of the cell is determined in the sample based on the mean value of the engineering strain in the direction of cell stressing.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: June 20, 2017
    Assignee: Universität Leipzig
    Inventors: Josef Käs, Jochen Guck
  • Publication number: 20170045533
    Abstract: The invention relates to a method and means for the non-invasive diagnosis of type II diabetes mellitus. The glycation state is determined in at least one glycation position of selected plasma proteins.
    Type: Application
    Filed: December 5, 2014
    Publication date: February 16, 2017
    Applicants: UNIVERSITÄT LEIPZIG, OHIO UNIVERSITY
    Inventors: Ralf HOFFMANN, Andrej FROLOV, Sandro SPILLER, Yichao LI, Lonnie R. WELCH
  • Patent number: 9556228
    Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to compositions and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: January 31, 2017
    Assignee: UNIVERSITAET LEIPZIG
    Inventors: Ralf Hoffmann, Daniel Knappe, Kai Hilpert, Ralf Mikut, Serge Ruden
  • Patent number: 9551681
    Abstract: The present invention relates to a device and a method for parallel recording of impedance spectra and field potential of cells in vitro.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: January 24, 2017
    Assignee: Universitaet Leipzig
    Inventors: Andrea Robitzki, Heinz-Georg Jahnke, Ronny Azendorf