Patents Assigned to Universitaet Ulm
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Patent number: 11940510Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.Type: GrantFiled: March 31, 2021Date of Patent: March 26, 2024Assignees: NVision Imaging Technologies Gmbh, Universität UlmInventors: Ilai Schwartz, Michael Keim, Martin Plenio, Benedikt Tratzmiller
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Patent number: 11932958Abstract: A method for preparing a Cr(III)-plating solution is disclosed. The method comprises or consists of the steps of (a) providing an aged aqueous Cr(III)-solution; (b) adding a polycarbonate or a derivative thereof to the solution of step (a); and (c) adding a borate to the solution of step (b). In addition, a plating solution obtainable by the present method is disclosed, and a plating solution comprising or consisting of Cr(III)-ions, a polycarbonate or a derivative thereof, a borate, water, sulfate, and positive ions selected from the group consisting of hydrogen ions, alkali metal ions and earth alkali metal ions.Type: GrantFiled: November 2, 2021Date of Patent: March 19, 2024Assignee: Universitaet UlmInventors: Yasser Sheasha, Ludwig Kibler, Timo Jacob
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Patent number: 11788950Abstract: Disclosed is a method for analysing cells, in which cells are separated and the individual cells pass via a measurement region of a unit for spatially resolved radiation intensity measurement, wherein, for at least one of the separated cells, when passing via the measurement region, a time sequence of spatial intensity patterns of an electromagnetic radiation emitted from and/or influenced by the cell is created, the optical flow of a respective two of the spatial intensity patterns is calculated for at least one portion of the sequence of intensity patterns using a computer unit, and an evaluation of the calculated optical flows occurs. Also disclosed is a device for analysing cells, comprising a device for separating cells, a unit for spatially resolved radiation intensity measurement, and a computer unit for calculating the optical flow of a respective two of the created intensity patterns, and for evaluating the calculated optical flows.Type: GrantFiled: January 26, 2018Date of Patent: October 17, 2023Assignee: Universität UlmInventors: Daniel Geiger, Tobias Neckernuss, Othmar Marti
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Publication number: 20230215535Abstract: The invention relates to a method for providing a medication combination, wherein at least one medication of the medication combination to be provided is selected on the basis of the result of a molecular in vitro characterization of tumor tissue of a glioblastoma of a patient. The selection is made on the basis of eliminating and not selecting medications from a list of non-oncological medications for which no benefit has been acknowledged for treating the patient on the basis of the result of the molecular in vitro characterization. The medication combination which can be provided using the method is inexpensive, exhibits a low degree of toxicity, and is characterized by an improved efficacy in comparison to known medication combinations. The invention additionally relates to a data carrier with software which can support or simplify the process of carrying out the method according to the invention.Type: ApplicationFiled: April 20, 2021Publication date: July 6, 2023Applicant: UNIVERSITÄT ULMInventor: Marc-Eric HALATSCH
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Publication number: 20230152399Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.Type: ApplicationFiled: March 31, 2021Publication date: May 18, 2023Applicants: NVISION IMAGING TECHNOLOGIES GMBH, UNIVERSITÄT ULMInventors: Ilai SCHWARTZ, Michael KEIM, Martin PLENIO, Benedikt TRATZMILLER
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Publication number: 20220348615Abstract: The present invention relates to the production of bacteriocins, and in particular the production of bacteriocins of class I or II by recombinant expression in coryneform bacteria as the bacterial cell host. Also provided are modified coryneform bacteria for use as production hosts for production of bacteriocins.Type: ApplicationFiled: April 20, 2022Publication date: November 3, 2022Applicants: Norwegian University of Science and Technology (NTNU), UNIVERSITÄT ULM, NORWEGIAN UNIVERSITY OF LIFE SCIENCES, DANMARKS TEKNISKE UNIVERSITET, UNIVERSITÄT DES SAARLANDESInventors: Gerd Michael SEIBOLD, Christoph WITTMANN, Dzung DIEP, Nadav BAR, Christian U. REIDEL, Dominik WEIXLER, Oliver GOLDBECK
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Publication number: 20220214331Abstract: An apparatus for detecting a spatial elongation of at least one adherent biological cell is provided. The apparatus contains at least one biological cell, which is adhered to a substrate, a laser for irradiating the at least one biological cell for a spatial elongation of the cell in a direction parallel to the irradiation direction and a detector for detecting the spatial elongation of the cell in the direction parallel to the radiation direction. Further, a corresponding method for spatial elongation of an adherent biological cell is provided and the uses of the apparatus and of the method proposed. Using the apparatus and method, it is possible to ascertain, from parts of adherent cells to entire groups of adherent cells, the mechanical properties in the natural, adherent state of the cell(s) in spatially selective, temporally selective and contactless fashion.Type: ApplicationFiled: August 20, 2019Publication date: July 7, 2022Applicant: UNIVERSITÄT ULMInventors: Tobias NECKERNUSS, Daniel GEIGER, Othmar MARTI
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Publication number: 20210325293Abstract: Disclosed is a method for analysing cells, in which cells are separated and the individual cells pass via a measurement region of a unit for spatially resolved radiation intensity measurement, wherein, for at least one of the separated cells, when passing via the measurement region, a time sequence of spatial intensity patterns of an electromagnetic radiation emitted from and/or influenced by the cell is created, the optical flow of a respective two of the spatial intensity patterns is calculated for at least one portion of the sequence of intensity patterns using a computer unit, and an evaluation of the calculated optical flows occurs. Also disclosed is a device for analysing cells, comprising a device for separating cells, a unit for spatially resolved radiation intensity measurement, and a computer unit for calculating the optical flow of a respective two of the created intensity patterns, and for evaluating the calculated optical flows.Type: ApplicationFiled: January 26, 2018Publication date: October 21, 2021Applicant: UNIVERSITÄT ULMInventors: Daniel GEIGER, Tobias NECKERNUSS, Othmar MARTI
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Patent number: 11052082Abstract: The invention relates to novel strategies for the treatment of cancer patients based on a combination of an opioid receptor agonist and an anticancer compound.Type: GrantFiled: June 5, 2018Date of Patent: July 6, 2021Assignee: UNIVERSITÄT ULMInventors: Claudia Friesen, Erich Miltner
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Patent number: 10649044Abstract: A method of hyperpolarisation of nuclear spins in one or more particle(s) moving relatively to a polarisation structure, wherein a polarisation of electron spins in the polarisation structure is transferred to the nuclear spins in the particle(s), wherein for one or more of the moving particle(s) within 20 nm from a surface of the polarisation structure, the correlation time of the interaction with the nearest polarisation structure electron spin due to the molecular motion is larger than the inverse of the nuclear Larmor frequency; the electron spins in the polarisation structure are polarised above thermal equilibrium; and the polarisation transfer is performed resonantly.Type: GrantFiled: May 22, 2015Date of Patent: May 12, 2020Assignee: UNIVERSITÄT ULMInventors: Fedor Jelezko, Martin Plenio, Ilai Schwartz, Qiong Chen, Alex Retzker
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Publication number: 20190391216Abstract: The invention concerns a method for the hyperpolarisation of 13C nuclear spin in a diamond, comprising an optical pumping step, in which colour centre electron spins in the diamond are optically pumped. The method further comprises a transfer step in which the polarisation of a long-lived state of the colour centre electron spins is transferred to 13C nuclear spins in the diamond via a long-range interaction.Type: ApplicationFiled: May 24, 2019Publication date: December 26, 2019Applicant: Universitaet UlmInventors: Fedor JELEZKO, Jianming CAI, Martin PLENIO, Alex RETZKER, Boris NAYDENOV, Ilai SCHWARZ
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Patent number: 10384230Abstract: The invention relates to a method for producing a substrate structured by nanowires, characterized in that no lubricant and no lithographic resist mask is used in the method, and only by moving a donor substrate having nanowires relative to a substrate and by locally tribological properties on the surface of the substrate, a specified number of nanowires is deposited selectively at locally defined points of the substrate. The invention further relates to a substrate that can be produced using the method according to the invention, and which selectively contains a specified number of nanowires on a surface at locally defined points. The invention further relates to the use of the substrate according to the invention in microelectronics, microsystems technology, and/or micro-sensor systems.Type: GrantFiled: December 14, 2015Date of Patent: August 20, 2019Assignee: UNIVERSITÄT ULMInventors: Steffen Strehle, Daniel Markus Rosskopf, Andreas Magnus Probst
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Patent number: 10345400Abstract: The invention concerns a method for the hyperpolarisation of 13C nuclear spin in a diamond, comprising an optical pumping step, in which colour centre electron spins in the diamond are optically pumped. The method further comprises a transfer step in which the polarisation of a long-lived state of the colour centre electron spins is transferred to 13C nuclear spins in the diamond via a long-range interaction.Type: GrantFiled: April 7, 2014Date of Patent: July 9, 2019Assignee: UNIVERSITAET ULMInventors: Fedor Jelezko, Jianming Cai, Martin Plenio, Alex Retzker, Boris Naydenov, Ilai Schwarz
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Patent number: 9980942Abstract: The present invention relates generally to methods and pharmaceutical compositions for rejuvenating hematopoietic stem cells and progenitor cells from blood, intestinal tissue and dermal tissue by administration of at least one inhibitor of a GT-Pase, such as Cdc42 GTPase.Type: GrantFiled: April 30, 2013Date of Patent: May 29, 2018Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, UNIVERSITAET ULMInventors: Hartmut Geiger, Maria Carolina Florian, Yi Zheng
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Publication number: 20170348727Abstract: The invention relates to a method for producing a substrate structured by nanowires, characterized in that no lubricant and no lithographic resist mask is used in the method, and only by moving a donor substrate having nanowires relative to a substrate and by locally tribological properties on the surface of the substrate, a specified number of nanowires is deposited selectively at locally defined points of the substrate. The invention further relates to a substrate that can be produced using the method according to the invention, and which selectively contains a specified number of nanowires on a surface at locally defined points. The invention further relates to the use of the substrate according to the invention in microelectronics, microsystems technology, and/or micro-sensor systems.Type: ApplicationFiled: December 14, 2015Publication date: December 7, 2017Applicant: UNIVERSITÄT ULMInventors: Steffen STREHLE, Daniel Markus ROSSKOPF, Andreas Magnus PROBST
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Publication number: 20160206699Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.Type: ApplicationFiled: March 15, 2016Publication date: July 21, 2016Applicants: Ruprecht-Karls-Universität Heidelberg, Universität UlmInventors: Ziya KAYA, Hugo KATUS, Oliver ZIMMERMANN, Wolfgang ROTTBAUER, Jan TORZEWSKI
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Patent number: 9315558Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.Type: GrantFiled: November 14, 2011Date of Patent: April 19, 2016Assignees: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, UNIVERSITÄT ULMInventors: Ziya Kaya, Hugo Katus, Oliver Zimmermann, Wolfgang Rottbauer, Jan Torzewski
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Publication number: 20150265594Abstract: The invention relates to novel strategies for the treatment of cancer patients based on a combination of an opioid receptor agonist and an anticancer compound.Type: ApplicationFiled: October 8, 2013Publication date: September 24, 2015Applicant: UNIVERSITÄT ULMInventors: Claudia Friesen, Erich Miltner
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Patent number: 9005886Abstract: The present invention discloses a method for cryopreservation of human spermatozoa: the method comprises providing spermatozoa free from seminal liquid; mixing the spermatozoa with vitrification medium, wherein the main cryoprotectant agent is 0.1-0.3 M sucrose; placing the sample inside straws and rapidly freezing them; refrigerating the straws with no need of liquid N2; and devitrifying the sample in a medium of the present invention. The present invention furthermore discloses a portable kit that makes easy to implement the method, said kit comprising vitrification and devitrification solutions in the volumes required to develop the method and the physical support to carry out the same, i.e. the straws. The use of this kit is also disclosed for the treatment of disorders related to reproductive failures.Type: GrantFiled: February 16, 2011Date of Patent: April 14, 2015Assignees: Universidad de La Frontera, Universitaet UlmInventors: Raul Sanchez Gutierrez, Jennie Risopatron Gonzalez, Mabel Schulz Rubilar, Evgenia Isachenko, Vladimir Isachenko
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Patent number: 8901175Abstract: The use of opioids or opioid mimetics is suggested for the manufacture of a medicament for the treatment of resistant cancer patients.Type: GrantFiled: January 29, 2009Date of Patent: December 2, 2014Assignee: Universität UlmInventors: Erich Miltner, Claudia Friesen, Andreas Alt