Abstract: The present invention relates to an isolated antisense oligonucleotide for use in a method of preventing or treating an inflammatory disease or condition of the buccal cavity in a canine subject, wherein said antisense oligonucleotide is directed against canine ICAM-1. The present invention further relates to compositions or articles of manufacture comprising said antisense oligonucleotide.

Abstract: The present invention relates to a specific antisense oligonucleotide which inhibits the expression of the adhesion molecule ICAM-1 in human cells. The present invention further relates to a vector containing said oligonucleotide and a host cell containing said vector or oligonucleotide and a pharmaceutical composition containing said oligonucleotide as well as uses thereof, in particular in the treatment of an inflammatory disease or condition in humans.

Abstract: The present invention relates to an isolated antisense oligonucleotide for use in a method of preventing or treating an inflammatory disease or condition of the buccal cavity in a canine subject, wherein said antisense oligonucleotide is directed against canine ICAM-1. The present invention further relates to compositions or articles of manufacture comprising said antisense oligonucleotide.

Abstract: The present invention relates to an isolated antisense oligonucleotide for use in a method of preventing or treating an inflammatory disease or condition of the buccal cavity in a canine subject, wherein said antisense oligonucleotide is directed against canine ICAM-1. The present invention further relates to compositions or articles of manufacture comprising said antisense oligonucleotide.

Abstract: An apparatus and methods for high-speed non-linear spectrally encoded multi-photon imaging that are particularly suited for use in two photon fluorescence and fluorescence lifetime imaging. The system is capable of optical image compression and scale invariant digital zoom. A wavelength agile laser with digitally synthesized electro-optic modulation in a master oscillator-power amplifier configuration is combined with spectral encoding to eliminate the speed limitations of inertial scanning. The technique for fast two photon fluorescent imaging with simultaneous lifetime imaging independently detects the location, amplitude and lifetime of fluorescent emission by synthesizing a sequential excitation beam via digital electro-optic modulation of a quasi-CW swept source followed by time encoded detection. For fluorescent imaging, spectral and temporal mappings are employed separately, with quasi-CW spectral encoding used for pumping and time encoding for constructing the image at fluorescence wavelength.

Abstract: An apparatus and methods for high-speed non-linear spectrally encoded multi-photon imaging that are particularly suited for use in two photon fluorescence and fluorescence lifetime imaging. The system is capable of optical image compression and scale invariant digital zoom. A wavelength agile laser with digitally synthesized electro-optic modulation in a master oscillator-power amplifier configuration is combined with spectral encoding to eliminate the speed limitations of inertial scanning. The technique for fast two photon fluorescent imaging with simultaneous lifetime imaging independently detects the location, amplitude and lifetime of fluorescent emission by synthesizing a sequential excitation beam via digital electro-optic modulation of a quasi-CW swept source followed by time encoded detection. For fluorescent imaging, spectral and temporal mappings are employed separately, with quasi-CW spectral encoding used for pumping and time encoding for constructing the image at fluorescence wavelength.

Abstract: The invention relates to a method and an MPIS scanner for tomographic imaging of an object with magnetic particles distributed in the interior of the object, comprising the steps of generating a selection magnetic field with a predetermined magnetic field gradient in at least one field-free point (FFP) in a predetermined scanning plane, generating a time-dependent, periodic excitation magnetic field with a predetermined maximum frequency, repeatedly displacing the at least one FFP along a predetermined closed trajectory with a predetermined repetition time in the scanning plane, moving the object through the scanning plane along a predetermined advance direction with a predetermined advance speed, detecting the change in the magnetization state of the magnetic particles at the points in the object interior through which the at least one FFP passes, reconstructing the local particle concentrations at the points through which the at least one FFP passes in respect of an object coordinate system, interpolating t

Abstract: The invention relates to a method and an apparatus for reducing artefacts that are caused particularly by disturbance bodies and/or metal bodies in computed tomography (CT) images by means of a regulated iteration process that can be integrated particularly into a process for processing measurement data and preferably into a superordinate process for data alignment.

Abstract: A laser cutting device for transparent material (23), which device is designed to focus the laser light (2) into a plurality of predetermined spots within the material (23), wherein the spots lie on a predetermined cutting line or cutting area (24) running substantially perpendicularly to the direction of incidence of the laser light (2), wherein the device comprises means for mode conversion (3) into laser light having a helical phase front (5), which means can be brought into and out of the beam path of the laser light (2).

Abstract: A cardiac support system comprising an intake region for the intake of blood, an outlet region for discharging the intake blood, a pump arrangement for conveying the blood from the intake region to the outlet region, a pump-aorta connection, and a suction connection from the intake region to the pump, parts of the function of the heart being taken on by said cardiac support system, and a cardiac support method having the steps of taking in blood from within the left half of the heart, pumping, and transferring aspirated blood into the aorta with the cardiac support system.

Abstract: A laser cutting device for transparent material (23), which device is designed to focus the laser light (2) into a plurality of predetermined spots within the material (23), wherein the spots lie on a predetermined cutting line or cutting area (24) running substantially perpendicularly to the direction of incidence of the laser light (2), wherein the device comprises means for mode conversion (3) into laser light having a helical phase front (5), which means can be brought into and out of the beam path of the laser light (2).

Abstract: A method for detecting the position of a transducer for monitoring the position and motion of one or more target structures for the preparation or during an operation, with creating at least one volume data set (CT or MRI) showing the target structure(s), possible contact surfaces for the positioning of the ultrasonic transducer and the tissue between contact surfaces and target structure(s), determining from the volume data set one or more contact surfaces on which the best reflection of the ultrasound is or are to be expected, and positioning the ultrasonic transducer which monitors the operation on the contact surface(s).

Abstract: A method for crystallizing a substance dissolved in a solvent, including the following steps: introducing a solvent volume containing the substance into a chamber having a preset temperature, humidity, and gas composition, adding a predetermined volume of a precipitant to the solvent volume containing the substance, allowing the solvent to evaporate while simultaneously observing structural changes in the solvent volume containing the substance and the precipitant by means of dynamic light scattering, detecting weight changes and determining the molarities, making an association with the location in the phase diagram on the basis of the DLS measurement and the results of the molarity determination, allowing a predetermined number of crystal nuclei to form by adding solvent or adding precipitant, putting the solvent volume containing the substance and the precipitant into a metastable state by adding solvent and/or protein solution or by allowing the concentration of the dissolved substance to decrease by allo

Abstract: A method is provided for the electronic scanning of the intensity distribution of an optical interference pattern by means of a linear image sensor, wherein the interference pattern is produced by overlapping two temporally partly coherent beams striking at an arbitrarily predefined angle ? in relation to one another and is provided with an interference strip having a carrier frequency greater than the scanning frequency, and amplitude modulation that can be varied slowly in relation to the pixel width, wherein at least one optical grating is disposed in the beam path of at least one of two incident beams and the image sensor is disposed in the diffraction image of the grating(s) such that, at the site of the image sensor, the beams interfere, and the beams enclose an angle ? at the site of the image sensor, the angle being smaller than ?.

Abstract: A method is provided for the electronic scanning of the intensity distribution of an optical interference pattern by means of a linear image sensor, wherein the interference pattern is produced by overlapping two temporally partly coherent beams striking at an arbitrarily predefined angle ? in relation to one another and is provided with an interference strip having a carrier frequency greater than the scanning frequency, and amplitude modulation that can be varied slowly in relation to the pixel width, wherein at least one optical grating is disposed in the beam path of at least one of two incident beams and the image sensor is disposed in the diffraction image of the grating(s) such that, at the site of the image sensor, the beams interfere, and the beams enclose an angle ? at the site of the image sensor, the angle being smaller than ?.

Abstract: Device for white light interferometry comprising a light source of main emission wavelength ?0 and spectral width ?? and an evaluating unit with a line sensor of pixel width P for detecting an interference fringe pattern with a fringe spacing F, a mask being placed in front of the line sensor having a periodically modulated light transmittance along said line sensor, characterized in that the period length M of the mask is such as to fulfill the condition ? ? ? ? ? 0 < ? 1 - F M ? < 1 2 ? F P - ? ? ? ? ? 0 .