Abstract: The present invention relates to a method for determining the likelihood of a patient being responsive to cancer immunotherapy by determining the amount of T cells expressing the markers PD-1, CTLA-4, TIM-3, and CD38 and the amount of regulatory T cells (T-regs).

Abstract: The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second polypeptide ligand that binds to HER2 extracellular domain 4, and (c) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.

Abstract: A model-order reduction system and methods are described for providing a fast fluid flow simulation model of fluid flow in a conduit such as a blood vessel with stenosis. A first method is described for generating a reduced generic numerical model (20) for predicting fluid flow characteristics of fluid flowing through a subject conduit (7?). In steps 11, 12 and 13, geometric and fluid-flow parameter data are derived from CT image scans for each sampled conduit (7) in a reference set. A 3D model is generated (13) for each sampled conduit (7). The geometric parameter data, the 3D model and the fluid flow parameter data are used to generate solutions to fluid dynamics (such as the Navier-Stokes) equations for each sampled conduit (7), and a full order model is created comprising the geometric parameters data, the fluid flow parameter data and the Navier Stokes solutions.

Abstract: The invention relates a method for generating a motion-corrected image for visual-inertial odometry comprising an event camera rigidly connected to an inertial measurement unit (IMU), wherein the event camera comprises pixels arranged in an image plane that are configured to output events in presence of brightness changes in a scene at the time they occur, wherein each event comprises the time at which it is recorded and a position of the respective pixel that detected the brightness change, the method comprising the steps of: Acquiring at least one set of events (S), wherein the at least one set (S) comprises a plurality of subsequent events (e); Acquiring IMU data (D) for the duration of the at least one set (S); Generating a motion-corrected image from the at least one set (S) of events (e), wherein the motion-corrected image is obtained by assigning the position (xj) of each event (ej) recorded at its corresponding event time (tj) at an estimated event camera pose (Ttj) to an adjusted event position (x?j)

Abstract: The invention relates to a method for preparing a polymer scaffold that comprises the steps of providing a piece of a fabric of filaments of a first biodegradable or biocompatible polymer, applying a coating of a second polymer to said arrangement of filaments, and stretching the piece along its axis of longitudinal extension, thereby obtaining an aligned microfibrillar scaffold. The invention further relates to a method for providing an artificial tissue, and to a microfibrillar scaffold of aligned filaments obtained by the method of the invention.

Abstract: Circuits for generating random weights, such as for neuromorphic processors, include a first voltage node (VDD) for providing a supply voltage for the circuit and a second voltage node (VG) at a given electric potential. A first circuit element (Ma1) has a first electric current carrier concentration for outputting a first circuit element output signal. A second circuit element (Mb1) has a second electric current carrier concentration for outputting a second circuit element output signal. The first and second circuit elements are located between the first and second voltage nodes, which have a given voltage difference therebetween. The first and second circuit element output signals are different due to the first and second electric carrier concentrations being mismatched. The circuit further includes a subtraction unit configured to generate a respective random weight, which is represented by a difference between the first and second circuit element output signals.

Abstract: The present invention concerns a method of programming an analogue electronic neural network comprising a plurality of layers of somas. Any two consecutive layers of somas are connected by a matrix of synapses. The method comprises: applying test signals to inputs of the neural network; measuring at a plurality of measurement locations in the neural network responses of at least some somas and synapses to the test signals; extracting from the neural network, based on the responses, a first parameter set characterising the behaviour of the at least some somas; carrying out a training of the neural network by applying to a training algorithm the first parameter set and training data for obtaining a second parameter set; and programming the neural network by using the second parameter set. The invention also relates to the neural network and to a method of operating it.

Abstract: An apparatus and method for non-invasively determining the blood oxygen saturation within a subject's tissue by near-infrared spectroscopy is disclosed. Embodiments of the apparatus and method use the multi-distance method and take into account the attenuation of the light signal due to light absorbers other than hemoglobin and deoxyhemoglobin and the scattering properties of a subject's tissue.

Abstract: A spectrophotometric apparatus for determining optical parameters in a scattering medium based on the measurement of attenuation of light propagating through said medium by diffusion. To eliminate the detrimental effect of light being guided in an intermediate optical layer between a surface of the medium and a contact surface of the apparatus, either a multitude of optical barriers may be formed in the contact surface or the angular range over which light is emitted or received by the apparatus may be limited by appropriate means. With both of these alternative approaches, light propagation in the intermediate layer can be suppressed, leading to increased measurement accuracy. This is particularly beneficial for building an oximeter with improved precision. Further aspects include features for improving the applicability of the apparatus on curved surfaces such as the strongly curved skulls of neonates.

Abstract: The invention relates to a method for predicting mycobacterial drug resistance by isolating mycobacterial nucleic acid from a sample, obtaining a sample sequence from the nucleic acid, aligning and comparing the sample sequence to a reference sequence and determining for each reference position whether the sample sequence value is the same as a particular sequence value assigned to the position in a table. If both values are the same, a position weight value is assigned to the position. A predictor value is obtained by adding all position weight values and the predictor value is compared to a threshold value. If the predictor value is smaller than the threshold value, drug resistance is predicted. The invention encompasses a system for practicing the method, and the use of certain antibacterial drugs to treat infections by pathogens, resistance of which has been determined by the method of the invention.

Abstract: A magnetic resonance (MR) apparatus comprises magnet means for generating a main magnetic field in a sample region, encoding means for generating encoding magnetic fields superimposed to the main magnetic field, RF transmitter means for generating MR radiofrequency fields, driver means for operating said encoding means and RF transmitter means to generate superimposed time dependent encoding fields and radiofrequency fields according to an MR sequence for forming images or spectra; and acquisition means for acquiring an MR signal from said object. The magnet means comprise a primary magnetic field source providing a static magnetic field B0 and at least one secondary magnetic field source providing an adjustable magnetic field B?.

Abstract: The invention relates to a method for labeling a target compound with a radiometal by photochemically induced conjugation. Furthermore, a chelating compound for use in said method is provided. The chelating compound is characterized by an arylazide moiety which can be photo-conjugated to a target compound and a chelator moiety which can be radiolabelled. The photo-conjugation and radiolabelling are both performed at basic pH performed in a simultaneous one-pot reaction.

Abstract: The invention relates to computation of optical flow using event-based vision sensors.

Abstract: The present invention relates to novel compositions comprising specific consortia of living bacteria strains; to the manufacturing of such compositions, particularly by co-cultivation; and to the use of such compositions in pharmaceutical applications, such as the treatment of diseases associated with intestinal microbiota dysbiosis, particularly intestinal infections such as CDI (Clostridium difficile infection) and IBD (Inflammatory bowel diseases). When compared to the traditional FMT therapy () the inventive compositions () are more efficient and safer as demonstrated on an acute colitis model and therefore more appropriate for therapeutic use.

Abstract: A method for generating an image data set of an image area located in a measurement volume of a magnetic resonance system comprising a gradient system and an RF transmission/reception system, comprises the following method steps: —reading out k-space corresponding to the imaging area, by: (a) activating a frequency encoding gradient in a predetermined spatial direction and with a predetermined strength G0 by means of said gradient system, (b) after the activated frequency encoding gradient achieves its strength G0, radiating a non-slice-selective RF excitation pulse by means of said RF transmission/reception system, (c) after a transmit-receive switch time ?tTR following the radiated excitation pulse, acquiring FID signals with said RF transmission/reception system and storing said FID signals as raw data points in k-space along a radial k-space trajectory that is predetermined by the direction and strength G0 of the frequency encoding gradient, (d) repeating (a) through (c) with respectively different freque

Abstract: The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of a condition or disorder selected from a pruritic condition or an allergic condition, of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating pruritus, preferably pruritus associated with a pruritic condition or an allergic condition such as allergic dermatitis, of equine mammals, preferably of horses.

Abstract: Multinuclear complexes and methods for preparing them are provided. The discrete multinuclear complexes include a one or more transition metals and a radioisotope having the same coordination geometry as the transition metal. A bridging ligand is coordinated to the transition metal and the radioisotope to link the transition metal and the radioisotope and pendent ligands are coordinated to each of the transition metal and the radioisotope to stabilise the complex. The multinuclear complexes may include a radioisotope or radioelement that can be detected by medical equipment and may find use in therapy and/or the diagnosis of disease in patients.

Abstract: The invention relates to a tetrameric polypeptide comprising a first polypeptide chain comprising a first VL antigen binding domain and a first CL constant domain, a second polypeptide chain comprising a first VH antigen binding domain, a first CH1 constant domain, a first CH2 constant domain and a first CH3 constant domain, a first ligand binding to a HER2 D4 epitope linked to the N-terminus of said first VL antigen binding domain or said first VH antigen binding domain by a first interdomain amino acid linker, a third polypeptide chain comprising a second VL antigen binding domain and a second CL constant domain, a fourth polypeptide chain comprising a second VH antigen binding domain, a second CH1 constant domain, a second CH2 constant domain and a second CH3 constant domain and a third ligand binding to a HER2 D4 epitope linked to the N-terminus of said second VL antigen binding domain or said second VH antigen binding domain by a second interdomain amino acid linker, wherein the VL antigen binding domain

Abstract: The present invention relates to a cell culture device (1) for use with an optical microscope (40), comprising a housing (10) that is configured to be placed onto a stage of an optical microscope (40) in front of an objective (41) of the microscope (40), the housing (10) enclosing an internal space (11) of the housing (10), a removable flow chamber (2) enclosing an internal space (20) for accommodating a cell culture (CC) comprising living biological cells, a heater (3) arranged in the internal space (11) of the housing (10) for heating said fluid medium (M) to be guided through the flow chamber (2), a first flow path (P1) arranged in the internal space (11) of the housing (10) for guiding said fluid medium (M) towards the flow chamber (2) via said heater (3), and a second flow path (P2) arranged in the internal space (11) of the housing (2) for guiding said fluid medium (M) away from the flow chamber (2), and a pump (4) for pumping said fluid medium (M) through the first flow path (P1) into the internal spac